DYNLL1 - dynein light chain LC8-type 1 Gene

Homo sapiens

Also known as LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1

Gene ID: 8655 | Gene type: protein coding

About DYNLL1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,469,842-120,498,493 (from NCBI)

This gene has 11 transcripts (splice variants), 166 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 141.7), esophagus (RPKM 133.4) and 25 other tissues.

Summary

Cytoplasmic dyneins are large Enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

DYNLL1 Products(3)

mRNA	Protein	Name
NM_001037494.2	NP_001032583.1	dynein light chain 1, cytoplasmic
NM_001037495.2	NP_001032584.1	dynein light chain 1, cytoplasmic
NM_003746.3	NP_003737.1	dynein light chain 1, cytoplasmic

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables deoxyribonuclease inhibitor activity	IDA IDA: Inferred from direct assay	30464262	GOA
enables enzyme inhibitor activity	IDA IDA: Inferred from direct assay	30464262	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14607844	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA strand resection involved in replication fork processing	IDA IDA: Inferred from direct assay	30464262	GOA
involved in negative regulation of phosphorylation	IDA IDA: Inferred from direct assay	18579519	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	8628263	GOA
part of cytoplasmic dynein complex	IDA IDA: Inferred from direct assay	25830415	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	20921139	GOA
part of dynein complex	IPI IPI: Inferred from physical interaction	24986880	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	20133940	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	20133940	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15891768	GOA
is active in site of double-strand break	IDA IDA: Inferred from direct assay	37696958	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYNLL1 Protein Structure

Dynein_light

0
89 a.a.

Protein Preferred Names

Protein Names

dynein light chain 1, cytoplasmic

8 kDa dynein light chain

DYNLL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DYNLL1	P63167	AMOTL2	Homo sapiens	Q9Y2J4-4	Validated Y2H	25416956
Intra	DYNLL1	P63167	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Array	25416956
Intra	DYNLL1	P63167	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Prey Pooling	25416956
Intra	DYNLL1	P63167	IQUB	Homo sapiens	Q8NA54	Y2H Prey Pooling	25416956
Intra	DYNLL1	P63167	IQUB	Homo sapiens	Q8NA54	Y2H Array	25416956
Intra	DYNLL1	P63167	CCDC28A	Homo sapiens	Q7Z6N9	Validated Y2H	32296183
Intra	DYNLL1	P63167	REDIC1	Homo sapiens	Q86WS4	Y2H Prey Pooling	32296183
Intra	DYNLL1	P63167	REDIC1	Homo sapiens	Q86WS4	Validated Y2H	32296183
Intra	DYNLL1	P63167	REDIC1	Homo sapiens	Q86WS4	Y2H Array	32296183
Intra	DYNLL1	P63167	NEK9	Homo sapiens	Q8TD19	TAP	27173435
Intra	DYNLL1	P63167	NEK9	Homo sapiens	Q8TD19	Anti Tag CoIP	33961781
Intra	DYNLL1	P63167	NEK9	Homo sapiens	Q8TD19	Anti Tag CoIP	26496610
Intra	DYNLL1	P63167	NEK9	Homo sapiens	Q8TD19	Anti Tag CoIP	35271311
Intra	DYNLL1	P63167	SEPTIN4	Homo sapiens	O43236	Validated Y2H	32296183
Intra	DYNLL1	P63167	PKIG	Homo sapiens	Q9Y2B9	Validated Y2H	32296183
Intra	DYNLL1	P63167	DYRK1A	Homo sapiens	Q13627	Anti Tag CoIP	35271311
Intra	DYNLL1	P63167	DYRK1A	Homo sapiens	Q13627	Anti Tag CoIP	33961781
Intra	DYNLL1	P63167	OTUD6A	Homo sapiens	Q7L8S5	Validated Y2H	32296183
Intra	DYNLL1	P63167	CIMAP1A	Homo sapiens	Q96PU9	Validated Y2H	32296183
Intra	DYNLL1	P63167	C19orf44	Homo sapiens	Q9H6X5-2	Validated Y2H	32296183
Intra	DYNLL1	P63167	DPPA3	Homo sapiens	Q6W0C5	Validated Y2H	32296183
Intra	DYNLL1	P63167	FAM53B	Homo sapiens	Q14153-2	Validated Y2H	32296183
Intra	DYNLL1	P63167	BACH1	Homo sapiens	O14867	Anti Tag CoIP	35271311
Intra	DYNLL1	P63167	BACH1	Homo sapiens	O14867	Anti Tag CoIP	33961781
Intra	DYNLL1	P63167	RASGRP4	Homo sapiens	Q8TDF6-2	Validated Y2H	32296183
Intra	DYNLL1	P63167	ZNF710	Homo sapiens	Q8N1W2	Validated Y2H	32296183
Intra	DYNLL1	P63167	ZNF710	Homo sapiens	Q8N1W2	Y2H Prey Pooling	32296183
Intra	DYNLL1	P63167	ZNF710	Homo sapiens	Q8N1W2	Y2H Array	32296183
Intra	DYNLL1	P63167	ZNF710	Homo sapiens	Q8N1W2	Anti Tag CoIP	35271311
Intra	DYNLL1	P63167	GPHN	Homo sapiens	Q9NQX3	Anti Tag CoIP	33961781
Intra	DYNLL1	P63167	GPHN	Homo sapiens	Q9NQX3	TAP	27173435
Intra	DYNLL1	P63167	GPHN	Homo sapiens	Q9NQX3	Anti Tag CoIP	35271311
Intra	DYNLL1	P63167	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	32296183
Intra	DYNLL1	P63167	HMBOX1	Homo sapiens	Q6NT76	Anti Tag CoIP	33961781
Intra	DYNLL1	P63167	MORC3	Homo sapiens	Q14149	Anti Tag CoIP	35271311
Intra	DYNLL1	P63167	MORC3	Homo sapiens	Q14149	Anti Tag CoIP	33961781
Intra	DYNLL1	P63167	MORC3	Homo sapiens	Q14149	TAP	27173435
Intra	DYNLL1	P63167	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	DYNLL1	P63167	KANK2	Homo sapiens	Q63ZY3	Y2H Array	25416956
Intra	DYNLL1	P63167	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	DYNLL1	P63167	KANK2	Homo sapiens	Q63ZY3	Anti Tag CoIP	33961781
Intra	DYNLL1	P63167	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	25416956
Intra	DYNLL1	P63167	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	25416956
Intra	DYNLL1	P63167	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	DYNLL1	P63167	KANK2	Homo sapiens	Q63ZY3	Anti Tag CoIP	35271311
Intra	DYNLL1	P63167	FAM153A	Homo sapiens	Q9UHL3	Validated Y2H	32296183
Intra	DYNLL1	P63167	RACK1	Homo sapiens	P63244	Anti Bait CoIP	18420585
Intra	DYNLL1	P63167	RACK1	Homo sapiens	P63244	Anti Tag CoIP	18420585
Intra	DYNLL1	P63167	RACK1	Homo sapiens	P63244	Density Sedimentation	18420585
Intra	DYNLL1	P63167	FAM117B	Homo sapiens	Q6P1L5	Anti Tag CoIP	33961781
Intra	DYNLL1	P63167	FAM117B	Homo sapiens	Q6P1L5	Y2H Prey Pooling	32296183
Intra	DYNLL1	P63167	FAM117B	Homo sapiens	Q6P1L5	TAP	27173435
Intra	DYNLL1	P63167	FAM117B	Homo sapiens	Q6P1L5	Anti Tag CoIP	26496610
Intra	DYNLL1	P63167	FAM117B	Homo sapiens	Q6P1L5	Validated Y2H	32296183
Intra	DYNLL1	P63167	FAM117B	Homo sapiens	Q6P1L5	Y2H Array	32296183
Intra	DYNLL1	P63167	FAM117B	Homo sapiens	Q6P1L5	Anti Tag CoIP	35271311
Intra	DYNLL1	P63167	BMF	Homo sapiens	Q96LC9	Validated Y2H	32296183
Intra	DYNLL1	P63167	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	DYNLL1	P63167	DNAL4	Homo sapiens	O96015	Y2H Array	32296183
Intra	DYNLL1	P63167	DNAL4	Homo sapiens	O96015	Y2H Prey Pooling	32296183
Intra	DYNLL1	P63167	DNAL4	Homo sapiens	O96015	Anti Tag CoIP	33961781
Intra	DYNLL1	P63167	THAP10	Homo sapiens	Q9P2Z0	Validated Y2H	32296183
Intra	DYNLL1	P63167	THAP10	Homo sapiens	Q9P2Z0	Y2H Array	32296183
Intra	DYNLL1	P63167	THAP10	Homo sapiens	Q9P2Z0	Y2H Prey Pooling	32296183
Intra	DYNLL1	P63167	GNL3L	Homo sapiens	Q9NVN8	Validated Y2H	32296183
Intra	DYNLL1	P63167	GABARAPL1	Homo sapiens	Q9H0R8	Validated Y2H	32296183
Intra	DYNLL1	P63167	DCTN5	Homo sapiens	Q9BTE1	Validated Y2H	32296183
Intra	DYNLL1	P63167	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
Intra	DYNLL1	P63167	SMCP	Homo sapiens	P49901	MAPPIT	32296183
Intra	DYNLL1	P63167	SMCP	Homo sapiens	P49901	Y2H Prey Pooling	32296183
Intra	DYNLL1	P63167	SMCP	Homo sapiens	P49901	Y2H Array	32296183
Intra	DYNLL1	P63167	MYZAP	Homo sapiens	P0CAP1	Pull Down	20412299
Intra	DYNLL1	P63167	MYZAP	Homo sapiens	P0CAP1	Peptide Array	20412299
Intra	DYNLL1	P63167	IHO1	Homo sapiens	Q8IYA8	Y2H Array	32296183
Intra	DYNLL1	P63167	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	25416956
Intra	DYNLL1	P63167	IHO1	Homo sapiens	Q8IYA8	Validated Y2H	25416956
Intra	DYNLL1	P63167	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	32296183
Intra	DYNLL1	P63167	IHO1	Homo sapiens	Q8IYA8	Validated Y2H	32296183
Intra	DYNLL1	P63167	MORN3	Homo sapiens	Q6PF18	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DYNLL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70048	PIN/DYNLL1 Protein, Human (His)	P63167 (M1-G89)	≥95%

DYNLL1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82979	DYNLL1 Antibody (YA2724)	WB, IHC-P, IP	Human, Mouse

Related Diseases

Diseases

Alias

Rabies

Lyssa	Hydrophobia
St Hubert Disease

Prostate Carcinoma In Situ

Carcinoma In Situ Of Prostate	Grade Iii Pin
Pin Iii

Breast Adenoid Cystic Carcinoma

Adenoid Cystic Breast Carcinoma	Adenoid Cystic Carcinoma Of Breast
Mammary Adenocystic Carcinoma

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Asphyxiating Thoracic Dystrophy

Jeune Thoracic Dystrophy	Jeune Syndrome
Asphyxiating Thoracic Dysplasia	Short-Rib Thoracic Dysplasia With Or Without Polydactyly
Thoracic Pelvic Phalangeal Dystrophy	Asphyxiating Thoracic Chondrodystrophy
Atd	Chondroectodermal Dysplasia-Like Syndrome
Infantile Thoracic Dystrophy	Jeune Thoracic Dysplasia
Thoracic Asphyxiant Dystrophy	Thoracic-Pelvic-Phalangeal Dystrophy
Short-Rib Thoracic Dysplasia Without Polydactyly	Asphyxiating Thoracic Dystrophy Of The Newborn
Asphyxiating Thorax Dystrophy

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04088	DYNLL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DYNLL1	MGD	MGI:1861457
Canis familiaris	DYNLL1	VGNC	VGNC:40150
Rattus norvegicus	DYNLL1	RGD	RGD:619866
Felis catus	DYNLL1	VGNC	VGNC:107702
Macaca mulatta	DYNLL1	VGNC	VGNC:99924
Others	DYNLL1	NCBI

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