ROCK2 - Rho associated coiled-coil containing protein kinase 2 Gene

Homo sapiens

Also known as ROCK-II

Gene ID: 9475 | Gene type: protein coding

About ROCK2

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:11,179,759-11,345,437 (from NCBI)

This gene has 12 transcripts (splice variants), 309 orthologues and 5 paralogues. Ubiquitous expression in fat (RPKM 15.2), colon (RPKM 13.4) and 25 other tissues.

Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-Fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]

ROCK2 Products(6)

mRNA	Protein	Name
XM_011510417.3	XP_011508719.1	rho-associated protein kinase 2 isoform X3
XM_017005379.3	XP_016860868.1	rho-associated protein kinase 2 isoform X3
XM_017005378.3	XP_016860867.1	rho-associated protein kinase 2 isoform X2
XM_005246190.4	XP_005246247.1	rho-associated protein kinase 2 isoform X1
NM_004850.5	NP_004841.2	rho-associated protein kinase 2 isoform 1
NM_001321643.2	NP_001308572.1	rho-associated protein kinase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Rho-dependent protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	24065547	GOA
enables endopeptidase activator activity	IMP IMP: Inferred from mutant phenotype	24305806	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	24305806	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17015463	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	16574662	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	24305806	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in cellular response to testosterone stimulus	IMP IMP: Inferred from mutant phenotype	24065547	GOA
involved in centrosome duplication	IMP IMP: Inferred from mutant phenotype	17015463	GOA
involved in cortical actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	25816133	GOA
involved in cortical actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in modulation by host of viral process	IMP IMP: Inferred from mutant phenotype	19376974	GOA
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	19181962	GOA
involved in negative regulation of bicellular tight junction assembly	IGI IGI: Inferred from genetic interaction	25816133	GOA
involved in negative regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	29353861	GOA
involved in negative regulation of protein localization to lysosome	IMP IMP: Inferred from mutant phenotype	24305806	GOA
involved in positive regulation of amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	24305806	GOA
involved in positive regulation of amyloid-beta formation	IMP IMP: Inferred from mutant phenotype	24305806	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20232393	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	24065547	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24065547	GOA
involved in positive regulation of protein localization to early endosome	IMP IMP: Inferred from mutant phenotype	24305806	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24065547	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	20232393	GOA
involved in protein localization to plasma membrane	IGI IGI: Inferred from genetic interaction	25816133	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	18559669	GOA
involved in regulation of establishment of endothelial barrier	IGI IGI: Inferred from genetic interaction	25816133	GOA
involved in regulation of establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	19997641	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	17015463	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ROCK2 Protein Structure

Pkinase

HR1

Rho_Binding

0
300
600
900
1200
1388 a.a.

Protein Preferred Names

Protein Names

rho-associated protein kinase 2

p164 ROCK-2

rho-associated, coiled-coil-containing protein kinase II

ROCK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ROCK2	O75116	STAT3	Homo sapiens	P40763	Anti Bait CoIP	30413785
Intra	ROCK2	O75116	STAT3	Homo sapiens	P40763	CH-IP	30413785
Intra	ROCK2	O75116	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	ROCK2	O75116	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	ROCK2	O75116	APP	Homo sapiens	P05067	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

ROCK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81922	ROCK2 Antibody (YA1667)	WB, ICC/IF	Human, Rat

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Hepatomas
Liver Neoplasm	Liver Carcinoma
Liver And Intrahepatic Biliary Tract Carcinoma	Malignant Hepatobiliary Neoplasm
Adult Primary Hepatocellular Carcinoma	Hepatoblastoma
Carcinoma Of Liver	Malignant Liver Tumour
Malignant Hepatic Tumour

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Ureteral Obstruction

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Idiopathic Pulmonary Hypertension
Idiopathic Pulmonary Arterial Hypertension	Pulmonary Htn - [Hypertension]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10071	Y-27632	Inhibitor	99.91%	Unkown
HY-10583	Y-27632 dihydrochloride	Inhibitor	99.98%	Unkown
HY-10341	Fasudil Hydrochloride	Inhibitor	99.96%	Yes
HY-15307	Belumosudil	Inhibitor	99.83%	Yes
HY-15685	Ripasudil	Inhibitor	99.95%	Unkown
HY-13911	Hydroxyfasudil	Inhibitor	98.78%	Unkown
HY-15307A	Belumosudil mesylate	Inhibitor	99.89%	Yes
HY-13911A	Hydroxyfasudil hydrochloride	Inhibitor	98.88%	Unkown
HY-10341A	Fasudil	Inhibitor	/	Unkown
HY-10341C	Fasudil dihydrochloride	Inhibitor	/	Unkown
HY-10341B	Fasudil hydrochloride semihydrate	Inhibitor	/	Unkown
HY-15685A	Ripasudil free base	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109191	Sovesudil	Inhibitor	98.54%	Phase 3
HY-109191A	Sovesudil hydrochloride	Inhibitor	99.45%	Phase 3
HY-12659	LX7101	Inhibitor	99.75%	Phase 2
HY-15687A	SAR407899	Inhibitor	99.60%	Phase 2
HY-15687	SAR407899 hydrochloride	Inhibitor	99.14%	Phase 2
HY-16071	AT13148	Inhibitor	99.21%	Phase 1

Pre-clinical Phase

Bioactive Molecules (39)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15392	Chroman 1	Inhibitor	99.42%	Unkown
HY-15556	GSK269962A	Inhibitor	99.83%	Unkown
HY-15720A	H-1152 dihydrochloride	Inhibitor	99.09%	Unkown
HY-119937	ROCK inhibitor-2	Inhibitor	99.92%	Unkown
HY-103045	CMPD101	Inhibitor	98.95%	Unkown
HY-15755	RKI-1447	Inhibitor	98.29%	Unkown
HY-13300	SR-3677	Inhibitor	99.83%	Unkown
HY-15720	H-1152	Inhibitor	98.63%	Unkown
HY-18713	CRT0066854	Inhibitor	99.54%	Unkown
HY-10319	BAY-549	Inhibitor	99.46%	Unkown
HY-108518	SB-772077B dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-12437	BDP5290	Inhibitor	98.80%	Unkown
HY-150640	Rho-Kinase-IN-2	Inhibitor	99.29%	Unkown
HY-100270	Rho-Kinase-IN-1	Inhibitor	99.91%	Unkown
HY-16758	Verosudil	Inhibitor	99.18%	Unkown
HY-103620	ROCK2-IN-2	Inhibitor	98.02%	Unkown
HY-110339	RKI-1447 dihydrochloride	Inhibitor	98.04%	Unkown
HY-126275	HSD1590	Inhibitor	99.54%	Unkown
HY-18713A	CRT0066854 hydrochloride	Inhibitor	99.29%	Unkown
HY-U00351	ROCK-IN-1	Inhibitor	98.17%	Unkown
HY-149266	THK01	Inhibitor	99.80%	Unkown
HY-15392A	Chroman 1 dihydrochloride	Inhibitor	99.11%	Unkown
HY-122011	PF-4950834	Inhibitor	/	Unkown
HY-14227	LIMK-IN-1	Inhibitor	99.33%	Unkown
HY-107209	RKI-1313	Inhibitor	98.2%	Unkown
HY-15720B	Glycyl H-1152 hydrochloride	Inhibitor	/	Unkown
HY-125221	DJ4	Inhibitor	98.48%	Unkown
HY-15556A	GSK269962A hydrochloride	Inhibitor	/	Unkown
HY-145294	ROCK2-IN-5	Inhibitor	/	Unkown
HY-13300A	SR-3677 dihydrochloride	Inhibitor	/	Unkown
HY-162596	NRL-1049	Inhibitor	/	Unkown
HY-153564	ROCK-IN-6	Inhibitor	/	Unkown
HY-162798	ROCK2-IN-9	Inhibitor	/	Unkown
HY-167832	PT109	Inhibitor	/	Unkown
HY-16758A	Verosudil hydrochloride	Inhibitor	/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-149700	ROCK2-IN-7		/	Unkown
HY-103045A	CMPD101 hydrochloride	Inhibitor	/	Unkown
HY-12659B	LX7101 monohydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ROCK2	VGNC	VGNC:34082
Mus musculus	ROCK2	MGD	MGI:107926
Felis catus	ROCK2	VGNC	VGNC:64715
Rattus norvegicus	ROCK2	RGD	RGD:3590
Macaca mulatta	ROCK2	VGNC	VGNC:76714
Canis familiaris	ROCK2	VGNC	VGNC:49640
Others	ROCK2	NCBI

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