1. Immunology/Inflammation
  2. NO Synthase
  3. L-NMMA

L-NMMA (Tilarginine; Methylarginine) competitively antagonizes L-arginine, and thus inhibits production of nitric oxide (NO). L-NMMA is utilized as NO synthase antagonist in experimental settings.

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L-NMMA Chemical Structure

L-NMMA Chemical Structure

CAS No. : 17035-90-4

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Description

L-NMMA (Tilarginine; Methylarginine) competitively antagonizes L-arginine, and thus inhibits production of nitric oxide (NO). L-NMMA is utilized as NO synthase antagonist in experimental settings[1].

Cellular Effect
Cell Line Type Value Description References
BV-2 CC50
> 200 μM
Compound: L-NMMA
Cytotoxicity against mouse BV-2 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against mouse BV-2 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 34161733]
BV-2 IC50
10 μM
Compound: L-NMMA
Anti-neuroinflammatory activity in mouse BV-2 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs by Griess reagent based assay
Anti-neuroinflammatory activity in mouse BV-2 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs by Griess reagent based assay
[PMID: 34161733]
BV-2 IC50
13.2 μM
Compound: L-NMMA
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 30 mins followed by LPS-stimulation after 24 hrs by Griess assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 30 mins followed by LPS-stimulation after 24 hrs by Griess assay
[PMID: 28841320]
BV-2 IC50
14.29 μM
Compound: L-NMMA
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by Griess reagent method
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by Griess reagent method
[PMID: 23411079]
BV-2 IC50
14.4 μM
Compound: L-NMMA
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 4 hrs followed by LPS stimulation for 24 hrs by Griess assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 4 hrs followed by LPS stimulation for 24 hrs by Griess assay
[PMID: 27140807]
BV-2 IC50
14.4 μM
Compound: L-NMMA
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production preincubated for 4 hrs followed by LPS challenge measured after 24 hrs by Griess assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production preincubated for 4 hrs followed by LPS challenge measured after 24 hrs by Griess assay
[PMID: 26126961]
BV-2 IC50
15.41 μM
Compound: L-NMMA
Anti-neuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS-stimulation measured after 24 hrs by Griess reaction
Anti-neuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS-stimulation measured after 24 hrs by Griess reaction
[PMID: 21936523]
BV-2 IC50
16.05 μM
Compound: N-NMMA
Anti-inflammatory activity in mouse BV2 cells assessed as reduction in LPS-induced NO production pre-treated before LPS stimulation for 24 hrs by Griess reagent-based assay
Anti-inflammatory activity in mouse BV2 cells assessed as reduction in LPS-induced NO production pre-treated before LPS stimulation for 24 hrs by Griess reagent-based assay
[PMID: 30530196]
BV-2 IC50
16.27 μM
Compound: NMMA
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
[PMID: 26774654]
BV-2 IC50
16.27 μM
Compound: NMMA
Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
[PMID: 23149227]
BV-2 IC50
16.32 μM
Compound: L-NMMA
Anti-neuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 10 mins by Griess assay relative to control
Anti-neuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 10 mins by Griess assay relative to control
[PMID: 23462643]
BV-2 IC50
16.8 μM
Compound: L-NMMA
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reagent method
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reagent method
[PMID: 19900811]
BV-2 IC50
16.8 μM
Compound: L-NMMA
Antiinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 30 mins prior to LPS-challenge measured after 24 hrs by Griess assay
Antiinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 30 mins prior to LPS-challenge measured after 24 hrs by Griess assay
[PMID: 23815260]
BV-2 IC50
17 μM
Compound: L-NMMA
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitrite production after 24 hrs by Griess assay
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitrite production after 24 hrs by Griess assay
[PMID: 31082231]
BV-2 IC50
17.6 μM
Compound: NG-monomethyl-L-arginine
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
[PMID: 27700070]
BV-2 IC50
18.25 μM
Compound: NMMA
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production treated 30 mins before LPS stimulation measured after 24 hrs by Griess reaction
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production treated 30 mins before LPS stimulation measured after 24 hrs by Griess reaction
[PMID: 22951040]
BV-2 IC50
18.26 μM
Compound: NMMA
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
[PMID: 23707257]
BV-2 IC50
18.3 μM
Compound: NMMA
Inhibition of LPS-induced nitric oxide production in mouse BV2 cells treated for 30 mins prior to LPS stimulation for 24 hrs by Griess assay
Inhibition of LPS-induced nitric oxide production in mouse BV2 cells treated for 30 mins prior to LPS stimulation for 24 hrs by Griess assay
[PMID: 25466198]
BV-2 IC50
20.53 μM
Compound: L-NMMA
Anti-neuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
Anti-neuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
[PMID: 26706168]
BV-2 IC50
20.78 μM
Compound: L-NMMA
Anti-neuroinflammatory activity in LPS-activated mouse BV2 cells assessed as inhibition of NO production after 24 hrs by Griess assay
Anti-neuroinflammatory activity in LPS-activated mouse BV2 cells assessed as inhibition of NO production after 24 hrs by Griess assay
[PMID: 26988298]
BV-2 IC50
21.25 μM
Compound: L-NMMA
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitrite production after 24 hrs by Griess assay
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitrite production after 24 hrs by Griess assay
[PMID: 28165740]
BV-2 IC50
21.37 μM
Compound: L-NMMA
Anti-neuroinflammatory activity in mouse BV-2 cells assessed as inhibition of LPS-induced NO production incubated for 48 hrs by Griess reagent based assay
Anti-neuroinflammatory activity in mouse BV-2 cells assessed as inhibition of LPS-induced NO production incubated for 48 hrs by Griess reagent based assay
[PMID: 34546050]
BV-2 IC50
21.4 μM
Compound: L-NMMA
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess assay
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess assay
[PMID: 30063340]
BV-2 IC50
21.4 μM
Compound: L-NMMA
Cytotoxicity against mouse BV2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against mouse BV2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 30232882]
BV-2 IC50
21.8 μM
Compound: L-NMMA
Anti-inflammatory in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production pre-incubated before LPS challenge for 24 hrs by Griess reagent based assay
Anti-inflammatory in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production pre-incubated before LPS challenge for 24 hrs by Griess reagent based assay
[PMID: 28358502]
BV-2 IC50
21.9 μM
Compound: L-NMMA
Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition in LPS-induced NO production preincubated for 30 mins followed b LPS addition and measured after 24 hr by griess reagent based assay
Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition in LPS-induced NO production preincubated for 30 mins followed b LPS addition and measured after 24 hr by griess reagent based assay
[PMID: 31625742]
BV-2 IC50
22.1 μM
Compound: L-NMMA
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production by Griess assay
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production by Griess assay
[PMID: 28262525]
BV-2 IC50
24.3 μM
Compound: L-NMMA
Antineuroinflammatory activity against human BV2 cells assessed as inhibition of LPS-induced NO production treated with compound 30 mins and challenged with LPS for 24 hrs
Antineuroinflammatory activity against human BV2 cells assessed as inhibition of LPS-induced NO production treated with compound 30 mins and challenged with LPS for 24 hrs
[PMID: 25098650]
BV-2 IC50
24.8 μM
Compound: L-NMMA
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
[PMID: 26812172]
BV-2 IC50
24.8 μM
Compound: L-NMMA
Antiinflammatory activity against LPS-stimulated mouse BV2 cells assessed as inhibition of nitric oxide production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess assay
Antiinflammatory activity against LPS-stimulated mouse BV2 cells assessed as inhibition of nitric oxide production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess assay
[PMID: 25894905]
BV-2 IC50
26.58 μM
Compound: L-NMMA
Anti-inflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay
Anti-inflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay
[PMID: 30472026]
BV-2 IC50
28.8 μM
Compound: L-NMMA
Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess assay
Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess assay
[PMID: 32520551]
BV-2 IC50
31.8 μM
Compound: L-NMMA
Antineuroinflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced NO production by Griess assay
Antineuroinflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced NO production by Griess assay
[PMID: 34964626]
BV-2 IC50
39.28 μM
Compound: L-NMMA
Inhibition of LPS-induced NO production in human BV2 cells preincubated for 2 hrs followed by LPS-stimulation measured after 18 hrs by Griess assay
Inhibition of LPS-induced NO production in human BV2 cells preincubated for 2 hrs followed by LPS-stimulation measured after 18 hrs by Griess assay
[PMID: 27525351]
DLD-1 IC50
0.3 μM
Compound: 8 (L-NMMA)
Ability to inhibit the conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by i-NOS from human DLD-1 cells
Ability to inhibit the conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by i-NOS from human DLD-1 cells
[PMID: 11327581]
DLD-1 IC50
0.3 μM
Compound: 1
Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells
Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells
[PMID: 11327580]
HUVEC IC50
0.3 μM
Compound: 8 (L-NMMA)
Ability to inhibit the conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by e-NOS from HUVEC cells
Ability to inhibit the conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by e-NOS from HUVEC cells
[PMID: 11327581]
HUVEC IC50
0.3 μM
Compound: 1
Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells
Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells
[PMID: 11327580]
J774.1 IC50
13.8 μg/mL
Compound: L-NMMA
Inhibition of LPS-induced nitric oxide production in mouse J774.1 cells after 24 hrs by griess assay
Inhibition of LPS-induced nitric oxide production in mouse J774.1 cells after 24 hrs by griess assay
[PMID: 21428417]
J774.1 IC50
26 μM
Compound: L-NMMA
Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs
Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs
[PMID: 12608860]
J774.1 IC50
27.1 μM
Compound: L-NMMA
Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay
Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay
[PMID: 15974608]
J774.1 IC50
27.1 μM
Compound: L-NMMA
Cytotoxicity against LPS induced mouse J774.1 cells by MTT assay
Cytotoxicity against LPS induced mouse J774.1 cells by MTT assay
[PMID: 18154272]
J774.1 IC50
35.7 μM
Compound: L-NMMA
Inhibition of LPS-induced NO production in mouse J774.1cells after 24 hrs
Inhibition of LPS-induced NO production in mouse J774.1cells after 24 hrs
[PMID: 15104497]
Macrophage IC50
28 μM
Compound: L-NMMA
Inhibition of LPS-induced NO production in ddY mouse macrophages assessed as nitrate accumulation after 20 hrs by Griess reagent method
Inhibition of LPS-induced NO production in ddY mouse macrophages assessed as nitrate accumulation after 20 hrs by Griess reagent method
[PMID: 12398545]
Macrophage IC50
57 μM
Compound: L-NMMA
Inhibition of LPS-induced NO production in ddY mouse macrophages after 20 hrs by Griess reagent assay
Inhibition of LPS-induced NO production in ddY mouse macrophages after 20 hrs by Griess reagent assay
[PMID: 15270564]
RAW IC50
19.7 μM
Compound: L-NMMA
Inhibition of LPS-induced iNOS activity in mouse RAW 264.7 cells assessed as inhibition of NO production pretreated with compound for 30 mins before LPS challenge after 24 hrs by Griess reagent method
Inhibition of LPS-induced iNOS activity in mouse RAW 264.7 cells assessed as inhibition of NO production pretreated with compound for 30 mins before LPS challenge after 24 hrs by Griess reagent method
[PMID: 23142320]
RAW IC50
22.1 μM
Compound: L-NG-monomethyl arginine
Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells pretreated 15 mins before LPS challenge measured after 20 hrs relative to control
Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells pretreated 15 mins before LPS challenge measured after 20 hrs relative to control
[PMID: 21978950]
RAW IC50
25 μM
Compound: 2
Inhibition of radiolabeled arginine conversion to citrulline by isomeric form of Inducible nitric oxide synthase from mouse RAW 264.7 cells
Inhibition of radiolabeled arginine conversion to citrulline by isomeric form of Inducible nitric oxide synthase from mouse RAW 264.7 cells
[PMID: 9651169]
RAW264.7 IC50
> 40.5 μM
Compound: N-monomethyl-L-arginine
Inhibition of LPS-induced NO release in mouse RAW264.7 cells after 24 hrs by Griess reaction
Inhibition of LPS-induced NO release in mouse RAW264.7 cells after 24 hrs by Griess reaction
[PMID: 26052978]
RAW264.7 IC50
> 50 μM
Compound: L-NMMA
Cytotoxicity against mouse RAW264.7 cells by MTT assay
Cytotoxicity against mouse RAW264.7 cells by MTT assay
[PMID: 16643064]
RAW264.7 IC50
16.11 μM
Compound: L-NMMA
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 18 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 18 hrs by Griess assay
[PMID: 29685654]
RAW264.7 IC50
19.2 μM
Compound: L-NMMA
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation after 20 hrs
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation after 20 hrs
[PMID: 16643064]
RAW264.7 IC50
19.7 μM
Compound: L-NMMA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 30 mins measured 24 hrs post LPS challenge by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 30 mins measured 24 hrs post LPS challenge by Griess method
[PMID: 22386564]
RAW264.7 IC50
19.7 μM
Compound: L-NMMA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 30 mins before LPS challenge measured after 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 30 mins before LPS challenge measured after 24 hrs by Griess method
[PMID: 22115839]
RAW264.7 IC50
19.9 μM
Compound: 1, L-NMMA
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 20 hrs by Griess reaction
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 20 hrs by Griess reaction
[PMID: 21377876]
RAW264.7 IC50
2.3 μM
Compound: L-NMMA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS activity incubated for 30 mins prior to LPS challenge measured after 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS activity incubated for 30 mins prior to LPS challenge measured after 24 hrs by Griess assay
[PMID: 25975638]
RAW264.7 IC50
2.69 μM
Compound: L-NMMA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 18 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 18 hrs by Griess assay
[PMID: 26898337]
RAW264.7 IC50
2.73 μM
Compound: L-NMMA
Cytotoxicity against mouse RAW264.7 cells assessed as decrease in cell proliferation rate after 24 hrs by MTS assay
Cytotoxicity against mouse RAW264.7 cells assessed as decrease in cell proliferation rate after 24 hrs by MTS assay
[PMID: 27777005]
RAW264.7 IC50
21.72 μM
Compound: L-NMMA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 15 mins prior to LPS challenge measured after 20 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 15 mins prior to LPS challenge measured after 20 hrs by Griess assay
[PMID: 24016057]
RAW264.7 IC50
23.5 μM
Compound: L-NMMA
Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 30 mins before LPS stimulation for 20 hrs by Griess reagent based assay
Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 30 mins before LPS stimulation for 20 hrs by Griess reagent based assay
[PMID: 27210437]
RAW264.7 IC50
25.1 μM
Compound: L-NMMA
Inhibition of nitric oxide production in LPS-stimulated mouse RAW264.7 cells preincubated for 15 mins followed by LPS challenge measured after 20 hrs by Griess assay
Inhibition of nitric oxide production in LPS-stimulated mouse RAW264.7 cells preincubated for 15 mins followed by LPS challenge measured after 20 hrs by Griess assay
[PMID: 26343828]
RAW264.7 IC50
25.8 μM
Compound: L-NMMA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 18 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 18 hrs by Griess assay
[PMID: 29400471]
RAW264.7 IC50
27.2 μM
Compound: L-NMMA
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs
[PMID: 31710213]
RAW264.7 IC50
30.92 μM
Compound: L-NMMA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production pretreated for 2 hrs followed by LPS-stimulation measured after 20 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production pretreated for 2 hrs followed by LPS-stimulation measured after 20 hrs by Griess assay
[PMID: 28753309]
RAW264.7 IC50
32.9 μM
Compound: L-NMMA
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 18 hrs by Griess assay
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 18 hrs by Griess assay
[PMID: 30296083]
RAW264.7 IC50
35.5 μM
Compound: L-NMMA
Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
[PMID: 33939429]
RAW264.7 IC50
39.2 μM
Compound: L-NMMA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 2 hrs prior to LPS-challenge measured after 24 hrs by Greiss assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 2 hrs prior to LPS-challenge measured after 24 hrs by Greiss assay
[PMID: 25924023]
RAW264.7 IC50
40.4 μM
Compound: N-monomethyl-L-arginine
Inhibition of nitric oxide production in LPS-stimulated mouse RAW264.7 cells by Griess reagent assay
Inhibition of nitric oxide production in LPS-stimulated mouse RAW264.7 cells by Griess reagent assay
[PMID: 23394284]
RAW264.7 IC50
44.36 μM
Compound: L-NMMA
Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production incubated for 1 hrs followed by LPS stimulation for 18 hrs by Griess reagent based assay
Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production incubated for 1 hrs followed by LPS stimulation for 18 hrs by Griess reagent based assay
[PMID: 35427124]
RAW264.7 IC50
45 μM
Compound: L-NMMA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 18 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 18 hrs by Griess assay
[PMID: 26741483]
RAW264.7 IC50
73.3 μM
Compound: L-NMMA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production compound pretreated for 1 hr followed by addition of 100 ng/ml LPS for 24 hrs by griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production compound pretreated for 1 hr followed by addition of 100 ng/ml LPS for 24 hrs by griess method
[PMID: 26681510]
Sf9 IC50
0.65 μM
Compound: L-NMMA
Inhibition of human eNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by radiometric method
Inhibition of human eNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by radiometric method
[PMID: 22335555]
Sf9 IC50
0.95 μM
Compound: L-NMMA
Inhibition of human nNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by radiometric method
Inhibition of human nNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by radiometric method
[PMID: 22335555]
Sf9 IC50
1.8 μM
Compound: L-NMMA
Inhibition of human recombinant iNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by radiometric method
Inhibition of human recombinant iNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by radiometric method
[PMID: 22335555]
Molecular Weight

188.23

Formula

C7H16N4O2

CAS No.
SMILES

OC([C@@H](N)CCCNC(NC)=N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Product Name:
L-NMMA
Cat. No.:
HY-18732
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