2. Neuronal Signaling
  3. α-synuclein
  4. LETC

LETC is an orally active α-synuclein (α-Syn) aggregation inhibitor with an EC50 of 66 nM in transfected DH60.21 neuroblastoma cells. LETC can cross the blood-brain barrier. LETC can be used for the study of synucleinopathies.

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LETC Chemical Structure

LETC Chemical Structure

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LETC Related Antibodies

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Description

LETC is an orally active α-synuclein (α-Syn) aggregation inhibitor with an EC50 of 66 nM in transfected DH60.21 neuroblastoma cells. LETC can cross the blood-brain barrier. LETC can be used for the study of synucleinopathies[1].

In Vitro

LETC inhibits α-syn aggregation in transfected DH60.21 neuroblastoma cells, with an EC50 of 66 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LETC Related Antibodies
In Vivo

LETC (10 mg/kg; po; for 5 days per week; for 6 weeks) significantly decreases α-Syn-positive neurons in multiple brain regions and this resulted in a rescue of movement deficits in the open field in these mice. LETC does not improve activity deficits of L62 mice in the home cage environment[1].
In α-Syn transgenic L62 mice, LETC accumulated in the brain with a half-life of about 6 h after oral administration[1].
Pharmacokinetic parameters obtained in L62 mice after a single oral dose of LETC (15 mg/kg).
1.19

parameter Plasma Brain
Cmax (ng/mL) 155.0 1013.5
Tmax (h) 1.0 1.0

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Full-length human α-Syn overexpressing Line 62 (L62) mice mice[1]
Dosage: 10 mg/kg
Administration: Oral gavage; for 5 days per week; for 6 weeks
Result: Significantly decreased α-Syn-positive neurons in multiple brain regions.
Molecular Weight

414.44

Formula

C20H29Cl2N3S
SMILES

CCN(CC)C1=CC=C2C(SC3=C(N2)C=CC(N(CC)CC)=C3)=C1.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LETC Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LETCα-synucleinα-Synα-Syn aggregation inhibitororally activesynucleinopathiesblood-brain barrierInhibitorinhibitorinhibit

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