2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. (-)-Domesticine

(-)-Domesticine is an anti-α-1D-adrenoceptor compound with cytotoxic activity. (-)-Domesticine showed activity in MTS cytotoxicity assays against human colon cancer cell lines HCT-116 and Caco-2. (-)-Domesticine tolerates alkoxy substituents and benzoate functional groups at the C1 position in modifications of its chemical structure. The most potent compounds of (-)-Domesticine have IC50 values in the range of 23-38 μM, similar to the known cytotoxic compound etoposide.

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(-)-Domesticine Chemical Structure

(-)-Domesticine Chemical Structure

CAS No. : 54325-07-4

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(-)-Domesticine Related Antibodies

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Description

(-)-Domesticine is an anti-α-1D-adrenoceptor compound with cytotoxic activity. (-)-Domesticine showed activity in MTS cytotoxicity assays against human colon cancer cell lines HCT-116 and Caco-2. (-)-Domesticine tolerates alkoxy substituents and benzoate functional groups at the C1 position in modifications of its chemical structure. The most potent compounds of (-)-Domesticine have IC50 values in the range of 23-38 μM, similar to the known cytotoxic compound etoposide[1].

Molecular Weight

325.36

Formula

C19H19NO4
CAS No.
SMILES

OC(C(OC)=C1)=C2C3=C1CCN(C)[C@]3([H])CC4=C2C=C5OCOC5=C4
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Purity & Documentation
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(-)-Domesticine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Domesticine54325-07-4Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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