2. GPCR/G Protein
  3. Taste Receptor
  4. Nα,Nα-Bis(carboxymethyl)-L-lysine

Nα,Nα-Bis(carboxymethyl)-L-lysine 

Cat. No.: HY-100047 Purity: 98.80%
COA Handling Instructions

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Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study.

For research use only. We do not sell to patients.

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Nα,Nα-Bis(carboxymethyl)-L-lysine Chemical Structure

Nα,Nα-Bis(carboxymethyl)-L-lysine Chemical Structure

CAS No. : 113231-05-3

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Based on 1 publication(s) in Google Scholar

Nα,Nα-Bis(carboxymethyl)-L-lysine Related Antibodies

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Description

Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study[1][2][3].

In Vitro

Nα,Nα-Bis(carboxymethyl)-L-lysine (59 nM) decreases the basal activity of H214A (constitutively active mutant of T2R4) by 40%[1].
Nα,Nα-Bis(carboxymethyl)-L-lysine (60 nM, 15 mins) blocks the decrease of basal activation state of Rac1 caused by quinine in HEK293T cells overexpressing T2R4 and Ga16/44, but has no effect in HEK293T control cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nα,Nα-Bis(carboxymethyl)-L-lysine Related Antibodies
In Vivo

Nα,Nα-Bis(carboxymethyl)-L-lysine (10 μM) has no effect on lick responses to bitter compounds in adult C57BL6/J[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

262.26

Formula

C10H18N2O6
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 1.82 mg/mL (6.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8130 mL 19.0650 mL 38.1301 mL
5 mM 0.7626 mL 3.8130 mL 7.6260 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.80%

COA (247 KB) HNMR (510 KB) RP-HPLC (247 KB) MS (82 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8130 mL 19.0650 mL 38.1301 mL 95.3252 mL
5 mM 0.7626 mL 3.8130 mL 7.6260 mL 19.0650 mL
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Nα,Nα-Bis(carboxymethyl)-L-lysine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nα,Nα-Bis(carboxymethyl)-L-lysine113231-05-3Taste ReceptorRac1 GTPaseBitter taste receptorsLick responsesInhibitorinhibitorinhibit

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