2. GPCR/G Protein Neuronal Signaling NF-κB Apoptosis Autophagy PI3K/Akt/mTOR Stem Cell/Wnt MAPK/ERK Pathway
  3. mAChR NF-κB Apoptosis Autophagy Akt GSK-3 ERK
  4. Penehyclidine hydrochloride

Penehyclidine hydrochloride  (Synonyms: Penequinine hydrochloride)

Cat. No.: HY-137976 Purity: 99.2%
SDS
COA
Handling Instructions Technical Support

Penehyclidine (Penequinine) hydrochloride, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation.

For research use only. We do not sell to patients.

Penehyclidine hydrochloride Chemical Structure

Penehyclidine hydrochloride Chemical Structure

CAS No. : 151937-76-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Penehyclidine hydrochloride:

Penehyclidine hydrochloride Related Antibodies

Top Publications Citing Use of Products

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Akt Akt1 Akt2 Akt3

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GSK-3 GSK-3α GSK-3β

View All ERK Isoform Specific Products:

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ERK ERK1 ERK2 ERK5 ERK8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Penehyclidine (Penequinine) hydrochloride, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1].

IC50 & Target[1]

mAChR1

 

mAChR3

 

NF-κB

 

In Vitro

Penehyclidine (0.01-1.0 μM, 2 h) reduces the levels of IFN-γ, TNF-α, IL-1β, IL-6, promotes LPS (HY-D1056)-induced cell proliferation of BEAS-2B, inhibits the apoptosis, and promotes the LPS (HY-D1056)-induced autophagy in BEAS-2B[2].
Penehyclidine (0.1 μM, 2 h) activates the Akt/GSK-3β signaling pathway, and alleviates the A/R-induced cell injury in H9c2 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Penehyclidine hydrochloride Related Antibodies

Apoptosis Analysis[2]

Cell Line: BEAS-2B
Concentration: 0.01-1.0 μM
Incubation Time: 2 h
Result: Inhibited cell apoptosis.

Western Blot Analysis[2]

Cell Line: BEAS-2B
Concentration: 0.01-1.0 μM
Incubation Time: 2 h
Result: Increased the expression of Bcl-2.
In Vivo

Penehyclidine (0.3-3 mg/kg, ip, single dose) exhibits protective activity in rats ALI models[2].
Penehyclidine (1 mg/kg, ip, single dose) enhances the expression of BDNF and phosphorylation of ERK1/2 in the hippocampus, exhibits antidepressant-like effects in mouse CUMS model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: rats ALI models[2]
Dosage: 0.3-3 mg/kg
Administration: ip, single dose
Result: Alleviated LPS-induced lung injury in rats.
Animal Model: Mouse chronic unpredictable mild stress (CUMS) model[4]
Dosage: 1 mg/kg
Administration: ip, single dose
Result: Reduced the immobility time in the forced swimming test (FST) and tail suspension test (TST).
Clinical Trial
Molecular Weight

351.91

Formula

C20H30ClNO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1CCCC1)(COC2CN3CCC2CC3)C4=CC=CC=C4.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (355.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (284.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8416 mL 14.2082 mL 28.4164 mL
5 mM 0.5683 mL 2.8416 mL 5.6833 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.2%

SDS (393 KB)

COA (254 KB) Elemental Analysis Report (111 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.8416 mL 14.2082 mL 28.4164 mL 71.0409 mL
5 mM 0.5683 mL 2.8416 mL 5.6833 mL 14.2082 mL
10 mM 0.2842 mL 1.4208 mL 2.8416 mL 7.1041 mL
15 mM 0.1894 mL 0.9472 mL 1.8944 mL 4.7361 mL
20 mM 0.1421 mL 0.7104 mL 1.4208 mL 3.5520 mL
25 mM 0.1137 mL 0.5683 mL 1.1367 mL 2.8416 mL
30 mM 0.0947 mL 0.4736 mL 0.9472 mL 2.3680 mL
40 mM 0.0710 mL 0.3552 mL 0.7104 mL 1.7760 mL
50 mM 0.0568 mL 0.2842 mL 0.5683 mL 1.4208 mL
60 mM 0.0474 mL 0.2368 mL 0.4736 mL 1.1840 mL
80 mM 0.0355 mL 0.1776 mL 0.3552 mL 0.8880 mL
100 mM 0.0284 mL 0.1421 mL 0.2842 mL 0.7104 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Penehyclidine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Penehyclidine151937-76-7PenequininemAChRNF-κBApoptosisAutophagyAktGSK-3ERKMuscarinic acetylcholine receptorNuclear factor-κBNuclear factor-kappaBPKBProtein kinase BGlycogen synthase kinase-3Glycogen synthase kinase 3Extracellular signal regulated kinasesAnticholinergicM1M3NF-kβpulmonary inflammatorychronic obstructive pulmonary diseaseCOPDInhibitorinhibitorinhibit

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