Picamilon (Synonyms: Nicotinoyl-GABA; Nicotinoyl-γ-aminobutyric acid)

Cat. No.: HY-107482 Purity: 98.25%: FAQs
Data Sheet SDS COA Handling Instructions

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Picamilon is an orally active derivative of γ-aminobutyric acid that has nootropic effect. Picamilon improves the epilepsy model in rats and promotes correction of functional disorders of the pancreas during Alloxan (HY-W017227)-induced diabetes mellitus in rats.

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Picamilon Chemical Structure

CAS No. : 34562-97-5

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100 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
1 g	USD 135	In-stock	Estimated Time of Arrival: December 31
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Other Forms of Picamilon:

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Description

In Vivo

Picamilon (PM) (20 or 50 mg/kg; i.p.) significantly decreases the frequency and duration of seizure spike-wave discharges (SWDs) in Picrotoxin (HY-101391)-induced convulsive activity in rats^[2].
Picamilon (250 mg/kg; p.o.) inhibits NLRP3 inflammasome activation in pancreatic cells during Alloxan (HY-W017227) -induced diabetes mellitus rats model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Picrotoxin (HY-101391)-induced epilepsy model in rats ^[2]
Dosage:	20 or 50 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Significantly decreased the frequency and duration of seizure spike-wave discharges (SWDs) in doses of 50 mg/kg. Decreased the intensity of SWDs in smaller doses (20 mg/kg).

Animal Model:	Alloxan (HY-W017227)-induced diabetes mellitus model in rats ^[3]
Dosage:	250 mg/ kg
Administration:	Oral gavage (p.o.)
Result:	Suppressed NLRP3 activity, as indicated by a significant decrease in the area of immunopositive pancreatocytes to (21,30 ± 5,44) and (39,31 ± 5,24) %, respectively, relative to the value in the group of animals that were not treated (75,19±7,69%). Promoted correction of functional disorders of the pancreas during alloxan-induced diabetes mellitus by inhibiting activation of NLRP3 inflammasome in pancreatocytes.

Molecular Weight

208.21

Formula

C₁₀H₁₂N₂O₃

CAS No.

34562-97-5

Appearance

Solid

Color

White to off-white

SMILES

OC(CCCNC(C1=CN=CC=C1)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (300.18 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8028 mL	24.0142 mL	48.0284 mL
5 mM	0.9606 mL	4.8028 mL	9.6057 mL
10 mM	0.4803 mL	2.4014 mL	4.8028 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.25%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (244 KB) HNMR (240 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Mirzoian RS, et al. Vliianie pikamilona na krovosnabzhenie kory i mikrotsirkuliatsiiu v sisteme pial'nykh arteriol [Effect of pikamilon on the cortical blood supply and microcirculation in the pial arteriole system]. Biull Eksp Biol Med. 1989 May;107(5):581-2. Russian. [Content Brief]

[2]. Denisenko, et al. Effects of Picamilon and Isopicamilon on the Formation of Picrotoxin-Induced Convulsive Activity in Rats. Neurophysiology 46, 284–287 (2014).

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.8028 mL	24.0142 mL	48.0284 mL	120.0711 mL
	5 mM	0.9606 mL	4.8028 mL	9.6057 mL	24.0142 mL
	10 mM	0.4803 mL	2.4014 mL	4.8028 mL	12.0071 mL
	15 mM	0.3202 mL	1.6009 mL	3.2019 mL	8.0047 mL
	20 mM	0.2401 mL	1.2007 mL	2.4014 mL	6.0036 mL
	25 mM	0.1921 mL	0.9606 mL	1.9211 mL	4.8028 mL
	30 mM	0.1601 mL	0.8005 mL	1.6009 mL	4.0024 mL
	40 mM	0.1201 mL	0.6004 mL	1.2007 mL	3.0018 mL
	50 mM	0.0961 mL	0.4803 mL	0.9606 mL	2.4014 mL
	60 mM	0.0800 mL	0.4002 mL	0.8005 mL	2.0012 mL
	80 mM	0.0600 mL	0.3002 mL	0.6004 mL	1.5009 mL
	100 mM	0.0480 mL	0.2401 mL	0.4803 mL	1.2007 mL

Picamilon Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Picamilon34562-97-5Nicotinoyl-GABA Nicotinoyl-γ-aminobutyric acidGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorseizure spike-wave dischargesseizureratdiabetes mellitusInhibitorinhibitorinhibit

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