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IMP

" in MedChemExpress (MCE) Product Catalog:

57

Inhibitors & Agonists

1

Fluorescent Dye

1

Biochemical Assay Reagents

2

Inhibitory Antibodies

9

Natural
Products

8

Recombinant Proteins

2

Isotope-Labeled Compounds

6

Antibodies

1

Click Chemistry

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108213
    Inosinic acid
    2 Publications Verification

    5'-IMP; IMP; Inosine 5'-dihydrogen phosphate

    Endogenous Metabolite Others
    Inosinic acid is an endogenous metabolite. Inosinic acid is used as umami tastant and dietary supplement .
    Inosinic acid
  • HY-138995

    Deubiquitinase Cancer
    IMP-1710 is a potent and selective deubiquitylating enzyme UCHL1 inhibitor with an IC50 value of 38 nM. IMP-1710 has antifibrotic activity. IMP-1710 is a UCHL1 probe to identify and quantify target proteins in intact human cells . IMP-1710 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    IMP-1710
  • HY-112258
    IMP-1088
    4 Publications Verification

    DNA/RNA Synthesis Infection
    IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a Kd of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection .
    IMP-1088
  • HY-146178

    Insulin Receptor Cancer
    IMP2-IN-1 (compound 4) is a potent IMP2 inhibitor with IC50 value of 81.3~127.5 for IMP2 RNA sequence. IMP2-IN-1 reduces IMP2 in SW480 cells. IMP2-IN-1 significantly reduces the viability of both differentiated and non-differentiated Huh7 cells .
    IMP2-IN-1
  • HY-D2188

    Fluorescent Dye Deubiquitinase Cancer
    IMP-2373 is the activity-based probe (ABP). IMP-2373 is a covalent pan- deubiquitinase(DUB) ABP to monitor DUB activity in physiologically relevant live cells .
    IMP-2373
  • HY-161175

    Hedgehog Cancer
    IMP-1575 is the most potent Hedgehog acyltransferase (HHAT) inhibitor, with an IC50 of 0.75 μM for inhibition of purified HHAT. IMP-1575 can be used for the research of cancer .
    IMP-1575
  • HY-155470

    Biochemical Assay Reagents Cancer
    IMP 243 is a symmetric di-HSG (histamine-succinyl-glycine) bivalent hapten containing a Tscg-Cys ligand and two HSG groups. IMP 243 can be radiolabeled with 99mTc-pertechnetate. IMP 243 can be conjugated to other peptides to design bispecific antibodies (bsMAbs) for cancer research .
    IMP 243
  • HY-150255

    Others Cancer
    IMP2-IN-3 is a potent IMP2 inhibitor. IMP2-IN-3 shows anticancer effects .
    IMP2-IN-3
  • HY-155471

    Others Others
    IMP 245 is a symmetric di-HSG bivalent hapten. IMP 245 has low toxicity, high affinity binding to available antibodies and absence of cross reactivity or non-specific binding with body components .
    IMP 245
  • HY-155469

    Others Others
    IMP 241 is a di-HSG bivalent hapten .
    IMP 241
  • HY-146179

    Insulin Receptor Cancer
    IMP2-IN-2 (compound 6) is a potent and selective IMP2 inhibitor, with IC50s of 120.9 μM and 236.7 μM for IMP2 interaction with RNA_A and RNA_B, respectively. IMP2-IN-2 can be used for the research of cancer .
    IMP2-IN-2
  • HY-137450

    IMP4297; JS109

    PARP Cancer
    Senaparib (IMP4297) is a highly potent, selective and orally active PARP1/2 inhibitor. Senaparib (IMP4297) exhibits strong antitumor activity in animal models .
    Senaparib
  • HY-103056

    IMP-366

    DNA/RNA Synthesis Parasite Infection
    DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .
    DDD85646
  • HY-108213A
    Inosinic acid (disodium)(hydrate)(1:2:X)
    2 Publications Verification

    5'-IMP (disodium)(hydrate)(1:2:X); IMP (disodium)(hydrate)(1:2:X); Inosine 5'-dihydrogen phosphate (disodium)(hydrate)(1:2:X)

    Endogenous Metabolite Metabolic Disease
    Inosinic acid (disodium)(hydrate)(1:2:X) (5'-IMP (disodium)(hydrate)(1:2:X)) is an endogenous metabolite.
    Inosinic acid (disodium)(hydrate)(1:2:X)
  • HY-RS06793

    Small Interfering RNA (siRNA) Others

    IMP3 Human Pre-designed siRNA Set A contains three designed siRNAs for IMP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    IMP3 Human Pre-designed siRNA Set A
    IMP3 Human Pre-designed siRNA Set A
  • HY-RS06794

    Small Interfering RNA (siRNA) Others

    IMP4 Human Pre-designed siRNA Set A contains three designed siRNAs for IMP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    IMP4 Human Pre-designed siRNA Set A
    IMP4 Human Pre-designed siRNA Set A
  • HY-137450A

    IMP4297 hydrochloride; JS109 hydrochloride

    PARP Cancer
    Senaparib hydrochloride (IMP4297 hydrochloride) is an oral, selective PARP1/2 inhibitor with potent anti-tumor activity. Senaparib hydrochloride shows antitumor activity against advanced ovarian cancer .
    Senaparib hydrochloride
  • HY-P99027

    LAG525; IMP701

    LAG-3 Cancer
    Ieramilimab (LAG525; IMP701) is a humanized IgG4 monoclonal antibody that binds to LAG-3, resulting in inhibition of LAG-3 interaction with MHC-II molecules .
    Ieramilimab
  • HY-108213S1

    5'-IMP15N4 dilithium; IMP-15N4 dilithium; Inosine 5'-dihydrogen phosphate-15N4 dilithium

    Isotope-Labeled Compounds Metabolic Disease
    Inosinic acid- 15N4 dilithium (5'-IMP-15N4 (dilithium); IMP-15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-15N4 (dilithium)) is 15N-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite .
    Inosinic acid-15N4 dilithium
  • HY-D0887
    Disodium 5'-inosinate
    1 Publications Verification

    IMP disodium salt; Disodium inosinate

    Biochemical Assay Reagents Metabolic Disease
    Disodium 5'-inosinate (IMP disodium salt) is a nucleotide-based umami agent. Disodium 5'-inosinate can bind to umami receptors and stimulate taste nerves, allowing the brain to perceive umami. In addition, Disodium 5'-inosinate produces a transient behavioral excitement in mice .
    Disodium 5'-inosinate
  • HY-P99933

    IMP321; LAG-3Ig

    LAG-3 Cancer
    Eftilagimod alfa (IMP321) is a recombinant LAG-3Ig fusion protein that binds to MHC class II. Eftilagimod alfa mediates antigen-presenting cell (APC) activation followed by CD8 T-cell activation. Eftilagimod alfa can be used for metastatic melanoma and metastatic breast carcinoma research .
    Eftilagimod alfa
  • HY-108213S

    5'-IMP-13C10,15N4 dilithium; IMP-13C10,15N4 dilithium; Inosine 5'-dihydrogen phosphate-13C10,15N4 dilithium

    Isotope-Labeled Compounds Metabolic Disease
    Inosinic acid- 13C10, 15N4 dilithium (5'-IMP-13C10,15N4 (dilithium); IMP-13C10,15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-13C10,15N4 (dilithium)) is 13C- and 15N-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite .
    Inosinic acid-13C10,15N4 dilithium
  • HY-108213R

    5'-IMP (Standard); IMP (Standard); Inosine 5'-dihydrogen phosphate (Standard)

    Endogenous Metabolite Others
    Inosinic acid (Standard) is the analytical standard of Inosinic acid. This product is intended for research and analytical applications. Inosinic acid is an endogenous metabolite. Inosinic acid is used as umami tastant and dietary supplement .
    Inosinic acid (Standard)
  • HY-137724

    Cyclic-di-IMP

    STING Cancer
    C-di-IMP (Cyclic-di-IMP) is a STING agonist. C-di-IMP can be used for the research of tumor .
    C-di-IMP
  • HY-137724A

    Cyclic-di-IMP disodium

    STING Cancer
    C-di-IMP disodium is a STING agonist. C-di-IMP disodium can be used in tumor research .
    C-di-IMP disodium
  • HY-164434

    5'-Xanthylic acid

    Endogenous Metabolite Others
    Xanthosine-5'-monophosphate can be obtained by catalyzing inosine 5'-monophosphate (IMP) with inosine 5'-monophosphate dehydrogenase (IMPDH) .
    Xanthosine-5'-monophosphate
  • HY-10250A

    TCN-P sodium

    ATP Synthase Metabolic Disease Cancer
    Triciribine phosphate sodium inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate sodium also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity .
    Triciribine phosphate sodium
  • HY-10250

    TCN-P

    ATP Synthase Metabolic Disease Cancer
    Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits  IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity .
    Triciribine phosphate
  • HY-161712

    Others Cancer
    Nampt-IN-12 (compound 9) is a derivative of N-Pyridinylthiophene carboxamide, exhibiting activity against peripheral nerve sheath tumor cells. Nampt-IN-12 is metabolized via the enzymes NAMPT and NMNAT1, both integral to the NAD salvage pathway, into an adenosine diphosphate (AD) derivative, which is an analog of NAD and capable of inhibiting inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) within cells. With its favorable ability to cross the blood-brain barrier, Nampt-IN-12 holds potential for research in cancers affecting both the central and peripheral nervous systems .
    Nampt-IN-12
  • HY-131965

    Others Others
    Imidacloprid impurity 1 (IMP-2) is the impurity found during the synthesis of Ivermectin (HY-15310) .
    Imidacloprid impurity 1
  • HY-124447

    c-Myc Cancer
    BTYNB is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA (IC50=5 μM). BTYNB exhibits selectivity and effectiveness against IMP1-postive cancer cell lines. BTYNB can be used for cancer research .
    BTYNB
  • HY-158375

    Beta-lactamase Bacterial Infection
    MBL-IN-4 (compound 4b) is a MBL inhibitor with the IC50 of 4.81 and 33 μM against IMP-1 and NDM-1 .
    MBL-IN-4
  • HY-152105

    Beta-lactamase Bacterial Infection
    Metallo-β-lactamase-IN-9 (Compound 23) is a pan metallo-beta-lactamase (MBL) inhibitor with IC50s of 35, 269 and 369 nM against NDM-1, VIM-1 and IMP-1, respectively .
    Metallo-β-lactamase-IN-9
  • HY-161310

    Beta-lactamase Infection
    Metallo-β-lactamase-IN-15 (Compound ±13) is a potent MBL inhibitor, the IC50 values for NDM-1、IMP-1 and VIM-2 were 0.29 μM, 0.088 μM and 0.063 μM, respectively .
    Metallo-β-lactamase-IN-15
  • HY-144259

    Beta-lactamase Bacterial Infection
    Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC50 values of 0.1 μM (VIM-1), 1.3 μM (NDM-1), and 5.0 μM (IMP-7), respectively .
    Metallo-β-lactamase-IN-2
  • HY-144262

    Beta-lactamase Bacterial Infection
    Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC50 values of 0.5 μM (VIM-1), 2.1 μM (NDM-1), and 3.3 μM (IMP-7), respectively .
    Metallo-β-lactamase-IN-4
  • HY-I0454

    Drug Metabolite Others
    Rivaroxaban EP Impurity I (Imp I) is the impurity reference for Rivaroxaban EP .
    Rivaroxaban EP Impurity I
  • HY-108213AR

    Endogenous Metabolite Metabolic Disease
    Inosinic acid (disodium)(hydrate)(1:2:X) (Standard) is the analytical standard of Inosinic acid (disodium)(hydrate)(1:2:X). This product is intended for research and analytical applications. Inosinic acid (disodium)(hydrate)(1:2:X) (5'-IMP (disodium)(hydrate)(1:2:X)) is an endogenous metabolite.
    Inosinic acid (disodium)(hydrate)(1:2:X) (Standard)
  • HY-131391

    Others Others
    m-Isobutyl Ibuprofen (Compound IMP-A) is the impurity found during synthesis of Ibuprofen (HY-78131) .
    m-Isobutyl Ibuprofen
  • HY-144261

    Beta-lactamase Bacterial Infection
    Metallo-β-lactamase-IN-3 (compound 35) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-3 shows high activity against VIM-1 and NDM-1, with IC50 of 0.6 and 1.0 μM, respectively. Metallo-β-lactamase-IN-3 does not show inhibition of IMP-7 .
    Metallo-β-lactamase-IN-3
  • HY-148493

    Bacterial Infection
    MK-3402 (Compound303) is a metallo-beta-lactamase inhibitor, with IC50 values of 0.53, 0.25 and 0.169 nM against IMP-1, NDM-1, and VIM-1, respectively. MK-3402 can be used in bacterial research and shows a synergistic effect when used in combination with beta-lactam antibiotics .
    MK-3402
  • HY-155201

    Bacterial Infection
    YJ182 is a NDM-1 inhibitor (IC50: 0.23 μM). YJ182 also inhibits IMP-1, VIM-2, GIM-1, and MMP-2, with IC50s of 0.25, 0.61, 0.49, and 6.92 μM respectively. YJ182 can be used for bacterial infection research .
    YJ182
  • HY-146165

    Beta-lactamase Bacterial Infection
    Metallo-β-lactamase-IN-8 (compound 17) is a potent, reversible and competitive broad-spectrum inhibitor of metallo-β-lactamases (MβLs), with IC50s of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM for L1, ImiS, IMP-1 and VIM-2, respectively. Metallo-β-lactamase-IN-8 exhibits antibacterial activity .
    Metallo-β-lactamase-IN-8
  • HY-161094

    Beta-lactamase Bacterial Infection
    Metallo-β-lactamase-IN-12 is a dual inhibitor of metal β-lactamases (MβLs (NDM-1, IMP-1)) and serine β-lactamases (SβLs (OXA-48, KPC-2)), with IC50 values of 0.64 μM, 1.32 μM, 1.01 μM, and 0.57 μM, respectively. Metallo-β-lactamase-IN-12 has antibacterial activity .
    Metallo-β-lactamase-IN-12
  • HY-118061

    Others Infection
    VCC234718 is a molecule with mycobacterial growth inhibitory activity, specifically targeting Mycobacterium tuberculosis (Mtb). The primary molecular target of VCC234718 is inosine monophosphate dehydrogenase (GuaB2), and it inhibits the growth of Mtb by affecting the function of this enzyme. VCC234718 inhibits GuaB2 with a K value of 100 nM and exhibits non-competitive inhibition with IMP and NAD+. VCC234718 exerts its inhibitory effect by directly interacting with IMP and binding at the NAD+ site .
    VCC234718
  • HY-12826

    Beta-lactamase Bcl-2 Family Bacterial Cancer
    IMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1) . IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC50s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively .
    IMB-XH1
  • HY-168500

    Beta-lactamase Bacterial Infection
    Metallo-β-lactamase-IN-16 (compound 18) is a sulfone containing metallo-β-lactamase inhibitor with an anti-bacterial activity. Metallo-β-lactamase-IN-16 inhibits NDM-1 (New Dehli metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona integron-encoded metallo-β-lactamase), and VIM-2 with IC50 values of 0.16 nM, 0.23 nM, 0.31 nM and 1.0 nM, respectively .
    Metallo-β-lactamase-IN-16
  • HY-136498

    Drug Metabolite Infection
    T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC50 of 601 μM .
    T-705RMP
  • HY-133155

    Endogenous Metabolite Metabolic Disease
    5-Aminoimidazole ribonucleotide (AIR) is an intermediate in the biosynthesis of purines, as AIR is further modified by additional enzymes to eventually produce inosine monophosphate (IMP), which can then be converted into the purine bases adenine (A) and guanine (G) .
    5-Aminoimidazole ribonucleotide
  • HY-136498A

    Drug Metabolite Infection
    T-705RMP (ammonium) is the ammonium form of T-705RMP. T-705RMP (ammonium)’s the inhibition of IMP dehydrogenase (IMPDH) activity is weak .
    T-705RMP ammonium

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