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Results for "

DIO

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (2) Acyltransferase (2) Akt (3) Apoptosis (3) Bcl-2 Family (2) Biochemical Assay Reagents (1) Bombesin Receptor (2) Casein Kinase (1) Cytochrome P450 (2) ELOVL (1) Endogenous Metabolite (10) Enteropeptidase (2) Epigenetic Reader Domain (2) Fluorescent Dye (4) FXR (2) GCGR (2) Gli (1) GLP Receptor (2) Glucocorticoid Receptor (1) Glucokinase (2) Interleukin Related (1) IPK Superfamily (1) Isotope-Labeled Compounds (4) JNK (1) LDLR (1) Liposome (1) MCHR1 (GPR24) (2) MDM-2/p53 (2) Neurokinin Receptor (1) NF-κB (2) NOD-like Receptor (NLR) (1) Notch (2) Nucleoside Antimetabolite/Analog (1) p38 MAPK (2) PKA (1) Reference Standards (4) Small Interfering RNA (siRNA) (5) Sodium Channel (2) Thyroid Hormone Receptor (15)
By Research Areas:	Cancer (11) Cardiovascular Disease (2) Endocrinology (14) Infection (1) Inflammation/Immunology (3) Metabolic Disease (23) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Cationic Lipids (1) Phospholipids (1) Human Pre-designed siRNA Sets (3) siRNAs (5)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0969

*DiO* Maximum Cited Publications 15 Publications Verification DIOC18(3); 3,3'-DIOctadecyloxacarbocyanine perchlorate	Fluorescent Dye	Others
DiO is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins .

HY-RS03769

DIO1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DIO1 Human Pre-designed siRNA Set A contains three designed siRNAs for DIO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DIO1 Human Pre-designed siRNA Set A DIO1 Human Pre-designed siRNA Set A

HY-RS22137

Dio3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dio3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dio3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dio3 Mouse Pre-designed siRNA Set A Dio3 Mouse Pre-designed siRNA Set A

HY-RS28658

Dio3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dio3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dio3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dio3 Rat Pre-designed siRNA Set A Dio3 Rat Pre-designed siRNA Set A

HY-RS03771

DIO3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DIO3 Human Pre-designed siRNA Set A contains three designed siRNAs for DIO3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DIO3 Human Pre-designed siRNA Set A DIO3 Human Pre-designed siRNA Set A

HY-RS03770

DIO2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DIO2 Human Pre-designed siRNA Set A contains three designed siRNAs for DIO2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DIO2 Human Pre-designed siRNA Set A DIO2 Human Pre-designed siRNA Set A

HY-D0969Y

DiO (solution) DIOC18(3) (solution); 3,3'-DIOctadecyloxacarbocyanine perchlorate (solution)	Fluorescent Dye	Others
DiO (solution) (DiOC18(3) (solution)) is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins .

HY-129990

Dios-Arg diTFA	Liposome	Cancer
Dios-Arg diTFA, a cationic lipid with an arginine-bearing headgroup, shows obvious double bond proton signals at around 5.2-5.3 ppm. Dios-Arg diTFA is used, coupled to DOPE, to bind siRNA and plasmid to for cationic LNPs for intracellular transport .

HY-D1073

DiOC7(3) 3,3'-Diheptyloxacarbocyanine iodide	Fluorescent Dye	Cardiovascular Disease
DiOC7(3) (3,3'-Diheptyloxacarbocyanine iodide) is a green membrane potential probe (Ex=450-490 nm, Em=510-520 nm). DiOC7(3) can be used to quantify the vascular densities .

HY-177297

LCZ960 NVP-LCZ960	Glucokinase	Metabolic Disease
LCZ960 is an orally active glucokinase (GK) activator. LCZ960 stimulates GK activity in hepatocytes in vitro and stimulates glucose uptake in vivo through hepatic GK activation. LCZ960 lowers blood glucose in mice with diet-induced obesity (DIO). LCZ960 maintains normoglycemia and improves glucose tolerance in DIO mice and rats. LCZ960 stimulates glycogen synthase flux and increases hepatic glycogen turnover in rats. LCZ960 induces increased hepatic glycogen recycling. LCZ960 can be used to study high-fat diet-induced obesity and type 2 diabetes .

HY-165674S

11-dehydro-2,3-dinor Thromboxane B2-d9 11-dehydo-2,3-DIO TXB2-d₉	Isotope-Labeled Compounds	Others
11-dehydro-2,3-dinor Thromboxane B2-d₉ (11-dehydo-2,3-dio TXB2-d₉) is deuterium labeled 11-dehydro-2,3-dinor Thromboxane B2 .

HY-165660S

2,3-Dinor-6-ketoProstaglandinF1α-d9(sodium salt) 2,3-DIO-6-ketoPGF1α-d₉(sodium salt)	Isotope-Labeled Compounds	Others
2,3-Dinor-6-ketoProstaglandinF1α-d₉ (2,3-Dio-6-ketoPGF1α-d₉) sodium saltis deuterium labeled 2,3-Dinor-6-ketoProstaglandinF1α(sodium salt) .

HY-101699A

AMG-076	MCHR1 (GPR24)	Metabolic Disease
AMG-076 is an orally bioavailable and selective MCHR1 antagonist. AMG-076 results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice .

HY-101699

AMG-076 free base	MCHR1 (GPR24)	Metabolic Disease
AMG-076 free base is an orally bioavailable and selective MCHR1 antagonist. AMG-076 free base results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice .

HY-147927

Human enteropeptidase-IN-1	Enteropeptidase	Metabolic Disease
Human enteropeptidase-IN-1 (compound 6b) is a highly potent, orally active and low systemic exposure enteropeptidase inhibitor. Human enteropeptidase-IN-1 boosts the increase in fecal protein output, and exhibits potent body weight loss in diet-induced obese (DIO) rat model. Human enteropeptidase-IN-1 can be used for anti-obesity research .

HY-151959

FXR agonist 4	FXR	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
FXR agonist 4 (compound 10a) is an agonist of farnesoid X receptor (FXR) with an EC₅₀ value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of non-alcoholic fatty liver disease (NAFLD) .

HY-14342

MK-5046 2 Publications Verification	Bombesin Receptor	Metabolic Disease
MK-5046 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC₅₀ and an EC₅₀ value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity .

HY-147927A

(S)-Human enteropeptidase-IN-1	Enteropeptidase	Metabolic Disease
(S)-Human enteropeptidase-IN-1 (Compound 6c) is an orally active enteropeptidase inhibitor with low systemic exposure (IC₅₀ (initial): 26 nM; IC₅₀ (app): 1.8 nM). (S)-Human enteropeptidase-IN-1 promotes increased fecal protein output and effectively reduces body weight in a diet-induced obese (DIO) rat model. (S)-Human enteropeptidase-IN-1 inhibits enteropeptidase via a reversible covalent mechanism and prolongs the enzyme inactivation time. (S)-Human enteropeptidase-IN-1 can be used in anti-obesity research .

HY-14342A

(R)-MK-5046	Bombesin Receptor	Metabolic Disease
(R)-MK-5046 is the isomer of MK-5046 (HY-14342), and can be used as an experimental control. MK-5046 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC₅₀ and an EC₅₀ value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity .

HY-N3795

Thiophene E Echinoynethiophene A; Thiophene A DIO	Others	Others
Thiophene E (Echinoynethiophene A) is a natural product .

HY-157718

1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine	Biochemical Assay Reagents
1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine is a surfactant that has the activity of promoting liposome formation. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine can effectively study the biological effects of ceramide and ceramide phosphate. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine shows important application in the determination of phospholipase A activity of lecithin-cholesterol acyltransferase in ether matrix.

HY-P11075

[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10)	Neurokinin Receptor	Metabolic Disease
[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC₅₀ of 3.7  nM for hNK2R. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) significantly inhibits weight loss in diet-induced obese (DIO) mice model and improves Loperamide (HY-156131)-induced dysfunctional voiding in wild-type mice. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) can be used for neurokinin receptor mediated disorders, such as obesity, insulin resistance and type 2 diabetes research .

HY-W412313

Methyl 3,5-di-O-(2,4-dichlorobenzyl)-D-ribofuranoside	Nucleoside Antimetabolite/Analog	Others
Methyl 3,5-di-O-(2,4-dichlorobenzyl)-D-ribofuranoside is a ribofuranose nucleoside analogue.

HY-18341B

L-Thyroxine sodium 5+ Cited Publications Levothyroxine sodium; T4 sodium	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-147318

PBENZ-DBRMD	Apoptosis	Cancer
PBENZ-DBRMD is a potent iodothyronine deiodinase type 3 (DIO3) inhibitor. PBENZ-DBRMD has anti-proliferative activity and induces apoptosis. PBENZ-DBRMD can be used for cancer research .

HY-W010669

L-Thyroxine sodium xhydrate 5+ Cited Publications Sodium levothyroxine	Thyroid Hormone Receptor	Endocrinology
L-Thyroxine sodium xhydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

HY-B0346

Propylthiouracil 3 Publications Verification 6-n-Propylthiouracil; 6-Propyl-2-thiouracil; PTU	Thyroid Hormone Receptor	Endocrinology
Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research .

HY-18341

L-Thyroxine 5+ Cited Publications Levothyroxine; T4	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-18341A

L-Thyroxine sodium salt pentahydrate 5+ Cited Publications Sodium levothyroxine pentahydrate	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-P10032

NN1177 NNC9204-1177	GCGR GLP Receptor Cytochrome P450	Metabolic Disease
NN1177 is a long-acting GLP-1/glucagon receptor co-agonist. NN1177 can induce a dose-dependent body weight loss in diet-induced obese (DIO) mice .

HY-18341F

Biotin-(L-Thyroxine)	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology
Biotin-(L-Thyroxine) is the biotinylated L-Thyroxine (HY-18341). L-Thyroxine is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from Biotin-(L-Thyroxine) (T4) .

HY-P10032A

NN1177 TFA NNC9204-1177 TFA	GCGR Cytochrome P450 GLP Receptor	Metabolic Disease
NN1177 (NNC9204-1177) TFA is a long-acting GLP-1/glucagon receptor co-agonist. NN1177 TFA can induce a dose-dependent body weight loss in diet-induced obese (DIO) mice .

HY-B0346R

Propylthiouracil (Standard) 6-n-Propylthiouracil (Standard); 6-Propyl-2-thiouracil (Standard); PTU (Standard)	Thyroid Hormone Receptor Reference Standards	Endocrinology
Propylthiouracil (Standard) is the analytical standard of Propylthiouracil. This product is intended for research and analytical applications. Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research .

HY-18341BR

L-Thyroxine sodium (Standard) Levothyroxine sodium (Standard); T4 sodium (Standard)	Reference Standards Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
L-Thyroxine (sodium) (Standard) is the analytical standard of L-Thyroxine (sodium). This product is intended for research and analytical applications. L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-18341S1

Thyroxine hydrochloride-13C6 Levothyroxine-¹³C₆; T4-¹³C₆	Isotope-Labeled Compounds Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology
Thyroxine hydrochloride- ¹³C₆ is the ¹³C-labeled L-Thyroxine. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-18341S2

L-Thyroxine-13C6	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology
L-Thyroxine- ¹³C₆ is the ¹³C labeled L-Thyroxine . L-Thyroxine (Levothyroxine;T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-18341R

L-Thyroxine (Standard) Levothyroxine (Standard); T4 (Standard)	Reference Standards Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
L-Thyroxine (Standard) is the analytical standard of L-Thyroxine. This product is intended for research and analytical applications. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-W010669R

L-Thyroxine sodium xhydrate (Standard) Sodium levothyroxine (Standard)	Reference Standards Thyroid Hormone Receptor	Endocrinology
L-Thyroxine sodium xhydrate (Standard) is the analytical standard of L-Thyroxine sodium xhydrate. This product is intended for research and analytical applications. L-Thyroxine sodium xhydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

HY-18341AR

L-Thyroxine sodium salt pentahydrate (Standard)	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
L-Thyroxine (sodium salt pentahydrate) (Standard) is the analytical standard of L-Thyroxine (sodium salt pentahydrate). This product is intended for research and analytical applications. L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-133876

4-Di-16-ASP DiA	Fluorescent Dye	Others
4-Di-16-ASP is a green fluorescent membrane dye. 4-Di-16-ASP is a lipophilic aminostyryl probe with a broad emission spectrum (can be detected with green, orange or even red filters). It is commonly used for neuronal membrane tracing (it diffuses faster than DiO) .

HY-149971

XJ02862-S2	FXR	Inflammation/Immunology
XJ02862-S2 shows potent FXR agonistic activity. XJ02862-S2 is a promising lead compound for the research of NAFLD .

HY-120643

BMS-823778 hydrochloride	11β-HSD	Metabolic Disease
BMS-823778 hydrochloride is a potent, selective and orally active 11β-HSD1 inhibitor with an IC₅₀ of 2.3 nM against human 11β-HSD1 .

HY-19325

SKI2852	11β-HSD	Metabolic Disease
SKI2852 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC₅₀s of 1.6 nM and 2.9 nM against mHSD1 and hHSD1, respectively .

HY-144287

Glucokinase activator 3	Glucokinase Sodium Channel	Metabolic Disease
Glucokinase activator 3 is an orally active Glucokinase (GK) activator with an AC₅₀ of 38 nM. Glucokinase activator 3 inhibits hERG channel and sodium channel in patch clamp assays. Glucokinase activator 3 exhibits high efficacy in reducing blood glucose in diet-induced obese (DIO) mice. Glucokinase activator 3 has the potential for the research of type 2 diabetes .

HY-159422

S-309309	Acyltransferase	Metabolic Disease
S-309309 is an orally active and selective MGAT2 inhibitor. S-309309 can be used in metabolism-related research .

HY-N12744

2-O-trans-p-Coumaroylalphitolic acid	Glucocorticoid Receptor	Metabolic Disease
2-O-trans-p-Coumaroylalphitolic acid (Zj7) is a triterpene which can be extracted from jujube plants. 2-O-trans-P-Coumaroyl alphitolic acid is a selective modulator of glucocorticoid receptor (GR). 2-O-trans-P-coumaroyl alphitolic acid can be used in the study of obesity .

HY-122706A

IP6K2-IN-2	IPK Superfamily	Metabolic Disease
IP6K2-IN-2 (Compound 6) is an IP6K2 inhibitor, with IC₅₀ values of 0.58 μM (IP6K2), 0.86 μM (IP6K1) and 3.08 μM (IP6K3). IP6K2-IN-2 can be used in research of obesity .

HY-18341S4

L-Thyroxine-13C6-1 Levothyroxine-¹³C₆-1; T4-¹³C₆-1	Isotope-Labeled Compounds Endogenous Metabolite Thyroid Hormone Receptor	Endocrinology
L-Thyroxine- ¹³C₆-1 (Levothyroxine- ¹³C₆-1; T4- ¹³C₆-1) is a ¹³C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-161297A

NT-0249 free base	NOD-like Receptor (NLR)	Inflammation/Immunology
NT-0249 free base is an orally active NLRP3 inhibitor. NT-0249 has anti-inflammatory activity .

HY-P4860

Adropin (34-76) (human, mouse, rat) 1 Publications Verification	Akt Gli JNK PKA	Metabolic Disease
Adropin (34-76) is a secretory domain of Adropin. Adropin (34-76) can inhibit cAMP level and glucose production in hepatocytes, and has a hypoglycemic effect. Adropin (34-76) plays an antifibrotic role by inhibiting the GLI1 signaling pathway .

Cat. No.	Product Name	Type

HY-D0969

*DiO* 10+ Cited Publications DIOC18(3); 3,3'-DIOctadecyloxacarbocyanine perchlorate	Fluorescent Dyes/Probes
DiO is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins .

HY-133876

4-Di-16-ASP DiA	Fluorescent Dyes/Probes
4-Di-16-ASP is a green fluorescent membrane dye. 4-Di-16-ASP is a lipophilic aminostyryl probe with a broad emission spectrum (can be detected with green, orange or even red filters). It is commonly used for neuronal membrane tracing (it diffuses faster than DiO) .

HY-D0969Y

DiO (solution) DIOC18(3) (solution); 3,3'-DIOctadecyloxacarbocyanine perchlorate (solution)	Fluorescent Dyes/Probes
DiO (solution) (DiOC18(3) (solution)) is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins .

HY-D1073

DiOC7(3) 3,3'-Diheptyloxacarbocyanine iodide	Fluorescent Dyes/Probes
DiOC7(3) (3,3'-Diheptyloxacarbocyanine iodide) is a green membrane potential probe (Ex=450-490 nm, Em=510-520 nm). DiOC7(3) can be used to quantify the vascular densities .

HY-18341F

Biotin-(L-Thyroxine)	Dyes
Biotin-(L-Thyroxine) is the biotinylated L-Thyroxine (HY-18341). L-Thyroxine is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from Biotin-(L-Thyroxine) (T4) .

Cat. No.	Product Name	Type

HY-W010669

L-Thyroxine sodium xhydrate 5+ Cited Publications Sodium levothyroxine	Biochemical Assay Reagents
L-Thyroxine sodium xhydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

HY-157718

1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine

Drug Delivery

1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine is a surfactant that has the activity of promoting liposome formation. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine can effectively study the biological effects of ceramide and ceramide phosphate. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine shows important application in the determination of phospholipase A activity of lecithin-cholesterol acyltransferase in ether matrix.

HY-W010669R

L-Thyroxine sodium xhydrate (Standard) Sodium levothyroxine (Standard)	Biochemical Assay Reagents
L-Thyroxine sodium xhydrate (Standard) is the analytical standard of L-Thyroxine sodium xhydrate. This product is intended for research and analytical applications. L-Thyroxine sodium xhydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

Cat. No.	Product Name	Target	Research Area

HY-P10032

NN1177 NNC9204-1177	GCGR GLP Receptor Cytochrome P450	Metabolic Disease
NN1177 is a long-acting GLP-1/glucagon receptor co-agonist. NN1177 can induce a dose-dependent body weight loss in diet-induced obese (DIO) mice .

HY-P10032A

NN1177 TFA NNC9204-1177 TFA	GCGR Cytochrome P450 GLP Receptor	Metabolic Disease
NN1177 (NNC9204-1177) TFA is a long-acting GLP-1/glucagon receptor co-agonist. NN1177 TFA can induce a dose-dependent body weight loss in diet-induced obese (DIO) mice .

HY-P4860

Adropin (34-76) (human, mouse, rat) 1 Publications Verification	Akt Gli JNK PKA	Metabolic Disease
Adropin (34-76) is a secretory domain of Adropin. Adropin (34-76) can inhibit cAMP level and glucose production in hepatocytes, and has a hypoglycemic effect. Adropin (34-76) plays an antifibrotic role by inhibiting the GLI1 signaling pathway .

HY-P11075

[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10)	Neurokinin Receptor	Metabolic Disease
[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC₅₀ of 3.7  nM for hNK2R. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) significantly inhibits weight loss in diet-induced obese (DIO) mice model and improves Loperamide (HY-156131)-induced dysfunctional voiding in wild-type mice. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) can be used for neurokinin receptor mediated disorders, such as obesity, insulin resistance and type 2 diabetes research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18341B

L-Thyroxine sodium Maximum Cited Publications 8 Publications Verification Levothyroxine sodium; T4 sodium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Cancer	Thyroid Hormone Receptor Endogenous Metabolite
L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-18341

L-Thyroxine Maximum Cited Publications 8 Publications Verification Levothyroxine; T4	Structural Classification Classification of Application Fields Source classification Endocrine diseases Endogenous metabolite Monophenols Immune System Disorder Ketones, Aldehydes, Acids Disease markers Phenols Nervous System Disorder Disease Research Fields Endocrinology	Thyroid Hormone Receptor Endogenous Metabolite
L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-18341A

L-Thyroxine sodium salt pentahydrate Maximum Cited Publications 8 Publications Verification Sodium levothyroxine pentahydrate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Cancer	Thyroid Hormone Receptor Endogenous Metabolite
L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-18341R

L-Thyroxine (Standard) Levothyroxine (Standard); T4 (Standard)	Structural Classification Monophenols Immune System Disorder Ketones, Aldehydes, Acids Source classification Disease markers Phenols Endocrine diseases Nervous System Disorder Endogenous metabolite	Reference Standards Thyroid Hormone Receptor Endogenous Metabolite
L-Thyroxine (Standard) is the analytical standard of L-Thyroxine. This product is intended for research and analytical applications. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-N3795

Thiophene E Echinoynethiophene A; Thiophene A DIO	Structural Classification Natural Products Source classification Plants Compositae Laggera crispata (Vahl) Hepper & J. R. I. Wood	Others
Thiophene E (Echinoynethiophene A) is a natural product .

HY-18341F

Biotin-(L-Thyroxine)	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Thyroid Hormone Receptor Endogenous Metabolite
Biotin-(L-Thyroxine) is the biotinylated L-Thyroxine (HY-18341). L-Thyroxine is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from Biotin-(L-Thyroxine) (T4) .

HY-18341BR

L-Thyroxine sodium (Standard) Levothyroxine sodium (Standard); T4 sodium (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Reference Standards Thyroid Hormone Receptor Endogenous Metabolite
L-Thyroxine (sodium) (Standard) is the analytical standard of L-Thyroxine (sodium). This product is intended for research and analytical applications. L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-18341AR

L-Thyroxine sodium salt pentahydrate (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Thyroid Hormone Receptor Endogenous Metabolite
L-Thyroxine (sodium salt pentahydrate) (Standard) is the analytical standard of L-Thyroxine (sodium salt pentahydrate). This product is intended for research and analytical applications. L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-N12744

2-O-trans-p-Coumaroylalphitolic acid	Triterpenes Structural Classification Terpenoids Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H.F.Chow. Source classification Plants Rhamnaceae	Glucocorticoid Receptor
2-O-trans-p-Coumaroylalphitolic acid (Zj7) is a triterpene which can be extracted from jujube plants. 2-O-trans-P-Coumaroyl alphitolic acid is a selective modulator of glucocorticoid receptor (GR). 2-O-trans-P-coumaroyl alphitolic acid can be used in the study of obesity .

Cat. No.	Product Name	Chemical Structure

HY-18341S2

L-Thyroxine-13C6
L-Thyroxine- ¹³C₆ is the ¹³C labeled L-Thyroxine . L-Thyroxine (Levothyroxine;T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-18341S4

L-Thyroxine-13C6-1
L-Thyroxine- ¹³C₆-1 (Levothyroxine- ¹³C₆-1; T4- ¹³C₆-1) is a ¹³C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-165674S

11-dehydro-2,3-dinor Thromboxane B2-d9
11-dehydro-2,3-dinor Thromboxane B2-d₉ (11-dehydo-2,3-dio TXB2-d₉) is deuterium labeled 11-dehydro-2,3-dinor Thromboxane B2 .

HY-165660S

2,3-Dinor-6-ketoProstaglandinF1α-d9(sodium salt)
2,3-Dinor-6-ketoProstaglandinF1α-d₉ (2,3-Dio-6-ketoPGF1α-d₉) sodium saltis deuterium labeled 2,3-Dinor-6-ketoProstaglandinF1α(sodium salt) .

HY-18341S1

Thyroxine hydrochloride-13C6
Thyroxine hydrochloride- ¹³C₆ is the ¹³C-labeled L-Thyroxine. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

Cat. No.	Product Name		Classification

HY-RS03769

DIO1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DIO1 Human Pre-designed siRNA Set A contains three designed siRNAs for DIO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS22137

Dio3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Dio3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dio3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS28658

Dio3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Dio3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dio3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03771

DIO3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DIO3 Human Pre-designed siRNA Set A contains three designed siRNAs for DIO3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03770

DIO2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DIO2 Human Pre-designed siRNA Set A contains three designed siRNAs for DIO2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-129990

Dios-Arg diTFA		Cationic Lipids
Dios-Arg diTFA, a cationic lipid with an arginine-bearing headgroup, shows obvious double bond proton signals at around 5.2-5.3 ppm. Dios-Arg diTFA is used, coupled to DOPE, to bind siRNA and plasmid to for cationic LNPs for intracellular transport .

HY-157718

1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine		Phospholipids
1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine is a surfactant that has the activity of promoting liposome formation. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine can effectively study the biological effects of ceramide and ceramide phosphate. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine shows important application in the determination of phospholipase A activity of lecithin-cholesterol acyltransferase in ether matrix.

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