2. Metabolic Enzyme/Protease
  3. Glucokinase
  4. Glucokinase activator 3

Glucokinase activator 3 is a potent and full Glucokinase (GK) activator with an AC50 of 38 nM. Glucokinase activator 3 has the potential for the research of type 2 diabetes.

For research use only. We do not sell to patients.

Glucokinase activator 3 Chemical Structure

Glucokinase activator 3 Chemical Structure

CAS No. : 1001417-92-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 607 In-stock
Solution
10 mM * 1 mL in DMSO USD 607 In-stock
Solid
5 mg USD 450 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2550 In-stock
100 mg USD 3800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Glucokinase activator 3 is a potent and full Glucokinase (GK) activator with an AC50 of 38 nM. Glucokinase activator 3 has the potential for the research of type 2 diabetes[1].

IC50 & Target

AC50: 38 nM (GK)[1]
Molecular Weight

612.65

Formula

C26H33N2O9PS2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC(CP(OCC)(OCC)=O)=CS1)C2=CC(OC3=CC=C(S(=O)(C)=O)C=C3)=CC(O[C@@H](C)COC)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (163.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6323 mL 8.1613 mL 16.3225 mL
5 mM 0.3265 mL 1.6323 mL 3.2645 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6323 mL 8.1613 mL 16.3225 mL 40.8063 mL
5 mM 0.3265 mL 1.6323 mL 3.2645 mL 8.1613 mL
10 mM 0.1632 mL 0.8161 mL 1.6323 mL 4.0806 mL
15 mM 0.1088 mL 0.5441 mL 1.0882 mL 2.7204 mL
20 mM 0.0816 mL 0.4081 mL 0.8161 mL 2.0403 mL
25 mM 0.0653 mL 0.3265 mL 0.6529 mL 1.6323 mL
30 mM 0.0544 mL 0.2720 mL 0.5441 mL 1.3602 mL
40 mM 0.0408 mL 0.2040 mL 0.4081 mL 1.0202 mL
50 mM 0.0326 mL 0.1632 mL 0.3265 mL 0.8161 mL
60 mM 0.0272 mL 0.1360 mL 0.2720 mL 0.6801 mL
80 mM 0.0204 mL 0.1020 mL 0.2040 mL 0.5101 mL
100 mM 0.0163 mL 0.0816 mL 0.1632 mL 0.4081 mL
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Glucokinase activator 3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glucokinase activator 31001417-92-0Glucokinase activator3Glucokinase activator-3GlucokinaseHexokinase IVHexokinase Dtype 2 diabetesphosphonateaqueous solubilityfull activatorInhibitorinhibitorinhibit

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