Glucokinase activator 3

Cat. No.: HY-144287 Purity: 98.36%: FAQs
Data Sheet SDS COA Handling Instructions

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Glucokinase activator 3 is a potent and full Glucokinase (GK) activator with an AC₅₀ of 38 nM. Glucokinase activator 3 has the potential for the research of type 2 diabetes.

For research use only. We do not sell to patients.

Glucokinase activator 3 Chemical Structure

CAS No. : 1001417-92-0

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 607	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 607	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1650	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2550	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3800	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Glucokinase activator 3 is a potent and full Glucokinase (GK) activator with an AC₅₀ of 38 nM. Glucokinase activator 3 has the potential for the research of type 2 diabetes^[1].

IC₅₀ & Target

AC₅₀: 38 nM (GK)^[1]

Molecular Weight

612.65

Formula

C₂₆H₃₃N₂O₉PS₂

CAS No.

1001417-92-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC(CP(OCC)(OCC)=O)=CS1)C2=CC(OC3=CC=C(S(=O)(C)=O)C=C3)=CC(O[C@@H](C)COC)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (163.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6323 mL	8.1613 mL	16.3225 mL
5 mM	0.3265 mL	1.6323 mL	3.2645 mL
10 mM	0.1632 mL	0.8161 mL	1.6323 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.36%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (252 KB) HNMR (132 KB) RP-HPLC (168 KB) LCMS (261 KB)

Handling Instructions (2659 KB)

References

[1]. Shi Y, et al. Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132). J Med Chem. 2022, 65(5):4291-4317. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6323 mL	8.1613 mL	16.3225 mL	40.8063 mL
	5 mM	0.3265 mL	1.6323 mL	3.2645 mL	8.1613 mL
	10 mM	0.1632 mL	0.8161 mL	1.6323 mL	4.0806 mL
	15 mM	0.1088 mL	0.5441 mL	1.0882 mL	2.7204 mL
	20 mM	0.0816 mL	0.4081 mL	0.8161 mL	2.0403 mL
	25 mM	0.0653 mL	0.3265 mL	0.6529 mL	1.6323 mL
	30 mM	0.0544 mL	0.2720 mL	0.5441 mL	1.3602 mL
	40 mM	0.0408 mL	0.2040 mL	0.4081 mL	1.0202 mL
	50 mM	0.0326 mL	0.1632 mL	0.3265 mL	0.8161 mL
	60 mM	0.0272 mL	0.1360 mL	0.2720 mL	0.6801 mL
	80 mM	0.0204 mL	0.1020 mL	0.2040 mL	0.5101 mL
	100 mM	0.0163 mL	0.0816 mL	0.1632 mL	0.4081 mL