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Enantiomers

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80

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2

Biochemical Assay Reagents

12

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6

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14507
    YK-4-279
    Maximum Cited Publications
    6 Publications Verification

    		 DNA/RNA Synthesis Apoptosis Cancer
    YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer .
    YK-4-279
  • HY-131445B
    RR-RJW100

    		Others Metabolic Disease
    RR-RJW100, the enantiomer of RJW100, is an nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1) agonist. RJW100 can be synthesized as two enantiomers, RR-RJW100 and SS-RJW100, with RR-RJW100 shown to be the more potent LRH-1 agonist. RR-RJW100 is involved in the regulation of metabolic homeostasis and is used in studies of diabetes, liver disease and inflammatory bowel disease .
    RR-RJW100
  • HY-147180
    Dansyl-DL-valine cyclohexylammonium

    		Others Others
    Dansyl-DL-valine cyclohexylammonium is a salt form of Dansyl-DL-valine. Dansyl-DL-valine cyclohexylammonium can be used as analyte in chromatographic separation and separation column for the separation of enantiomers and diastereomers for dansyl amino acids, aromatic carboxylic acids, and isoxazolines .
    Dansyl-DL-valine cyclohexylammonium
  • HY-125630
    Decacyclene

    		Others Others
    Decacyclene is a large polycyclic aromatic hydrocarbon with a triple symmetry. Decacyclene is a three-blade molecular propeller in the solid state, and crystal structure analysis shows that the molecule has a non-planar twisted form, and the crystal is chiral, which may correspond to the enantiomers of the Decacyclene propeller. Decacyclene can be used for research in chemical synthesis and materials science .
    Decacyclene
  • HY-N12962A
    11R(12S)-EET

    		Others Others
    11R(12S)-EET is a cis-epoxytrienoic acid (EETs) derivative that is metabolized by cytoplasmic cyclooxygenases. Studies have shown that 14(R), 15(S)-, 11(S),12(R)-, and 8(S),9(R)-EETs are metabolized at significantly higher rates than their enantiomers. Enzyme-catalyzed hydration revealed that water addition was non-regioselective for the 11,12-EET enantiomers, whereas water addition occurred primarily at the C9 position for both enantiomers of 8,9-EET. These results suggest that the metabolic properties of 11R(12S)-EET and other EET enantiomers in enzyme-catalyzed processes are significantly affected by their stereostructures .
    11R(12S)-EET
  • HY-N9761
    Murrayanine

    		Others Others
    Murrayanine is a dimeric pyranoquinoline alkaloid, a mixture of two enantiomers with a predominant configuration on the chiral axis .
    Murrayanine
  • HY-W425671
    N-Isobutyryl-L-cysteine

    		Others Others
    N-Isobutyryl-L-cysteine serves as a chiral derivatizing agent that is extensively utilized for the separation of amino acid enantiomers.
    N-Isobutyryl-L-cysteine
  • HY-W017442
    DL-Asparagine

    		Endogenous Metabolite Others
    DL-Asparagine is a racemic melange of the Aparagine L and D-enantiomers. DL-Asparagine has been used in growth-media for bacteria-growth .
    DL-Asparagine
  • HY-121665
    Rosaprostol

    		Others Others
    Rosaprostol is a compound with antiulcer activity, and its enantiomers can be synthesized from the corresponding building blocks via a specific synthetic route involving multistep reactions and stereoselective transformations.
    Rosaprostol
  • HY-114635
    Dexecadotril

    Retorphan

    		 Neprilysin Metabolic Disease
    Dexecadotril (Retorphan) is a powerful and selective neprilysin (NEP) inhibitor. Dexecadotril is a prodrug of the R-enantiomers of Thiorphan (HY-W013375). Dexecadotril shows intestinal antisecretatory action .
    Dexecadotril
  • HY-116974
    ent-Thiamphenicol

    ent-Thiophenicol; ent-Dextrosulphenidol

    		 Antibiotic Others
    ent-Thiamphenicol (ent-Dextrosulphenidol) is a enantiomer of Thiamphenicol (HY-B0479). Thiamphenicol, a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria) .
    ent-Thiamphenicol
  • HY-18621B
    (S)-OTS514

    		Others Others
    (S)-OTS514 is the S enantiomer of OTS514 (HY-18621). OTS514 is a highly potent TOPK inhibitor with an IC50 of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells . OTS514 induces cell cycle arrest and apoptosis .
    (S)-OTS514
  • HY-B0105B
    (-)-Ketoconazole

    (-)-Ketoconazol; (-)-R 41400

    		 Fungal Infection Inflammation/Immunology
    (-)-Ketoconazole ((-)-R 41400) is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(−)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole).
    (-)-Ketoconazole
  • HY-N12970
    14S(15R)-EET

    		Others Others
    14S(15R)-EET is an endogenous epoxytrienoic acid derivative that mainly exists in rat organs. By studying its metabolic process, it was found that its stereoselective hydration and formation of chiral diols were significantly affected by epoxidase. Different 14,15-EET enantiomers showed different regions and stereochemistry of hydration reactions, among which 14(R),15(S)-EET showed specific hydration for C15. These findings reveal the important role of epoxidase in the metabolism of endogenous EETs, and the differences in enzyme affinity and reaction rate for individual EET enantiomers may lead to their stereoselective metabolism .
    14S(15R)-EET
  • HY-I0636
    (R)-Apremilast

    (R)-CC-10004

    		 Others Inflammation/Immunology
    (R)-Apremilast ((R)-CC-10004) is a enantiomer of Apremilast .
    (R)-Apremilast
  • HY-124300A
    (S)-JNJ-54166060

    		P2X Receptor Neurological Disease
    (S)-JNJ-54166060 is an enantiomer of JNJ 54166060. JNJ 54166060 is a potent P2X7 antagonist .
    (S)-JNJ-54166060
  • HY-141551B
    (R)-GNE-274

    		Others Others
    (R)-GNE-274 is a enantiomer of GNE-274. GNE-274 is a non-degrader that is structurally related to GDC-0927 (estrogen receptor degrader) .
    (R)-GNE-274
  • HY-109022A
    (3R,5R,6S)-Atogepant

    (3R,5R,6S)-MK-8031; (3R,5R,6S)-AGN-241689

    		 CGRP Receptor Neurological Disease
    (3R,5R,6S)-Atogepant ((3R,5R,6S)-MK-8031) is the enantiomer of Atogepant (HY-109022). Atogepant is a calcitonin gene-related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine.
    (3R,5R,6S)-Atogepant
  • HY-128888A
    (S,S)-GSK321

    		Isocitrate Dehydrogenase (IDH) Cancer
    (S,S)-GSK321 is a (S,S)-enantiomer of GSK321 .
    (S,S)-GSK321
  • HY-121161B
    (2S,3R)-Brassinazole

    		Others Metabolic Disease
    (2S,3R)-Brassinazole, the enantiomer of Brassinazole (BRZ). Brassinazole inhibits brassinosteroid (BR) biosynthesis, via acting on the oxidative processes from 6-oxo-campestanol to teasterone. (2S,3R)-Brassinazole might be the most active form of Brz .
    (2S,3R)-Brassinazole
  • HY-121161C
    (2R,3S)-Brassinazole

    		Others Metabolic Disease
    Brassinazole (0.5, 1, 5 μM) causes markedly deformed seedlings, whose morphology is similar to that of BR-deficient mutants. Brassinazole causes cress dwarfism, altering leaf morphology such as the typical downward curl and dark green appearance of Arabidopsis BR-deficient mutants. However, administration of 10 nM BR reversed dwarfism .
    (2R,3S)-Brassinazole
  • HY-155079A
    (R)-DZD1516

    		Others Others
    (R)-DZD1516 is the R enantiomer of DZD1516 (HY-155079). DZD1516 is a potent and selective HER2 inhibitor .
    (R)-DZD1516
  • HY-W420033
    (S)-(+)-Etomoxir

    		Others Others
    (S)-(+)-Etomoxir is the S enantiomer of Etomoxir (HY-50202). Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig .
    (S)-(+)-Etomoxir
  • HY-157294A
    (R)-GSK866

    		Glucocorticoid Receptor Cancer
    (R)-GSK866 is the (R)-enantiomer of GSK866 (HY-157294). GSK866 is a selective agonist for glucocorticoid receptor with an IC50 of 4.6 nM .
    (R)-GSK866
  • HY-112653A
    (±)8-HETE

    8-Hydroxy-5(Z),9(E),11(Z),14(Z)-eicosatetraenoic acid

    		 Endogenous Metabolite Metabolic Disease
    (±)8-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of Arachidonic acid (HY-109590). The biological activity of (±)8-HETE is likely to resemble that of its constituent enantiomers (8(R)-HETE and 8(S)-HETE).
    (±)8-HETE
  • HY-B0105BS
    (-)-Ketoconazole-d3

    (-)-Ketoconazol-d3; (-)-R 41400-d3

    		 Fungal Infection Inflammation/Immunology
    (-)-Ketoconazole-d3 is deuterium labeled (-)-Ketoconazole. (-)-Ketoconazole ((-)-R 41400) is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(−)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole).
    (-)-Ketoconazole-d3
  • HY-118839
    trans-Phenothrin

    		Others Infection
    Trans-Phenothrin is a synthetic pyrethroid with activity against adult fleas and ticks. Trans-Phenothrin has shown significant differences in biological activity between its different enantiomers in comparison with fenvalerate and d-trans-phenothrin. Trans-Phenothrin is used in agriculture for its potential insecticide activity against pests such as Plutella xylostella .
    trans-Phenothrin
  • HY-116196
    17-HETE

    		Na+/K+ ATPase Cytochrome P450 Cardiovascular Disease Inflammation/Immunology
    17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy .
    17-HETE
  • HY-147041A
    (2S)-Selvigaltin

    (2S)-GB1211

    		 Galectin Cancer
    (2S)-Selvigaltin is the S-enantiomer of Selvigaltin (HY-147041). Selvigaltin is an orally active galectin-3 (Gal-3) inhibitor .
    (2S)-Selvigaltin
  • HY-120967A
    (2S)-OMPT

    		Biochemical Assay Reagents Others
    (2S)-OMPT triethylamine, a chiral oxirane derivative, is commonly used as a ligand in asymmetric catalysis, especially in the enantioselective synthesis of bioactive molecules such as amino acids and drugs. (2S)-OMPT triethylamine has unique chemical properties that allow it to selectively bind certain metal complexes and activate them in a way that favors the formation of specific enantiomers.
    (2S)-OMPT
  • HY-120967
    (2S)-OMPT (triethylamine), in ethanol:chloroform (1:1), 98%

    		Biochemical Assay Reagents Others
    (2S)-OMPT (triethylamine), in ethanol:chloroform (1:1), 98%, is commonly used as a ligand in asymmetric catalysis, especially in the enantioselective synthesis of bioactive molecules such as amino acids and drugs. (2S)-OMPT triethylamine has unique chemical properties that allow it to selectively bind certain metal complexes and activate them in a way that favors the formation of specific enantiomers.
    (2S)-OMPT (triethylamine), in ethanol:chloroform (1:1), 98%
  • HY-137618B
    Rp-dGTPαS

    		Others Others
    Rp-dGTPαS is the nucleotide substrate of SAMHD1 and is one of the enantiomers of the dNTPαS nucleotide. SAMHD1 is an essential regulator of cellular dNTPs that limits virus (HIV-1, etc.) replication in the CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex catalyzes the hydrolysis of Rp-dGTPαS into 2'-deoxynucleosides and triphosphates .
    Rp-dGTPαS
  • HY-W012885
    (S)-Methyl 3-hydroxybutanoate

    		Biochemical Assay Reagents Others
    (S)-Methyl 3-hydroxybutanoate consists of a chiral center, resulting in two enantiomers, where (S)-Methyl 3-hydroxybutanoate means that the hydroxyl group is located on the third carbon atom of the S-configuration carboxylic acid group stereoisomers. This compound is often used as a building block for the synthesis of various pharmaceuticals and natural products. Due to its fruity taste, it is also used as a flavor and fragrance ingredient.
    (S)-Methyl 3-hydroxybutanoate
  • HY-N0424
    Cyclogalegenin

    Cyclogalegigenin

    		 Others Others
    Cyclogalegenin (Cyclogalegigenin) is a isoprenoid that can be isolated from Astragalus galegiformis. Cyclogalegenin is the enantiomer of Cycloastragenol .
    Cyclogalegenin
  • HY-12085S2
    (Rac)-Apremilast-d5

    (Rac)-CC-10004 d5

    		 Apoptosis Phosphodiesterase (PDE) TNF Receptor Isotope-Labeled Compounds Inflammation/Immunology
    (Rac)-Apremilast-d5 is a deuterium labeled (R)-Apremilast. (R)-Apremilast ((R)-CC-10004) is a enantiomer of Apremilast[1].
    (Rac)-Apremilast-d5
  • HY-B1370A
    (S)-Hydroxychloroquine

    (S)-HCQ

    		 Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy Infection
    (S)-Hydroxychloroquine ((S)-HCQ) is the enantiomer of Hydroxychloroquine . Hydroxychloroquine, a synthetic antimalarial agent, inhibits Toll-like receptor 7/9 (TLR7/9) signaling, and shows efficiently inhibits SARS-CoV-2 infection in vitro .
    (S)-Hydroxychloroquine
  • HY-B1370B
    (R)-Hydroxychloroquine

    (R)-HCQ

    		 Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy Infection
    (R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine . Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro .
    (R)-Hydroxychloroquine
  • HY-W012874
    D-Threonine

    H-D-Thr-OH

    		 Endogenous Metabolite Metabolic Disease
    D-Threonine (H-D-Thr-OH) is an enantiomer of L-threonine. D-Threonine is a metabolite of Saccharomyces cerevisiae.
    D-Threonine
  • HY-A0295
    (R)-Propranolol hydrochloride

    		Adrenergic Receptor Cardiovascular Disease Neurological Disease Endocrinology
    (R)-Propranolol hydrochloride is a less active enantiomer of the β-adrenoceptor antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively .
    (R)-Propranolol hydrochloride
  • HY-N2267
    (+)-Schisandrin B

    		Reactive Oxygen Species Inflammation/Immunology
    (+)-Schisandrin B is an enantiomer of Schisandrin B. Schisandrin B is an active dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis, has antioxidant effect on rodent liver and heart .
    (+)-Schisandrin B
  • HY-22385B
    (S)-Salsolidine

    		Monoamine Oxidase Endogenous Metabolite Neurological Disease
    (S)-Salsolidine is a weak monoamine oxidase (MAO) inhibitor (Ki=63 μM). The R enantiomer of Salsolidine is more potent than the S form (Ki=26 μM) .
    (S)-Salsolidine
  • HY-N11965
    4'-Methoxyisoagarotetrol

    		Phosphodiesterase (PDE) Inflammation/Immunology
    4'-Methoxyisoagarotetrol is chromone derivative and shows moderate PDE?3A inhibitory activity (IC50=54 μM) .
    4'-Methoxyisoagarotetrol
  • HY-W010042S3
    L-Glucose-13C6

    L-(-)-Glucose-13C6

    		 Isotope-Labeled Compounds Metabolic Disease
    L-Glucose- 13C6 (L-(-)-Glucose- 13C6) is C13-labeled L-Glucose. L-Glucose is an enantiomer of D-glucose. L-Glucose enhances food intake .
    L-Glucose-13C6
  • HY-107657
    (+)-Blebbistatin
    1 Publications Verification

    		 Myosin Others
    (+)-Blebbistatin is the inactive enantiomer of (–)-Blebbistatin. (–)-Blebbistatin is a selective inhibitor of myosin II ATPase .
    (+)-Blebbistatin
  • HY-15997A
    (+)-U-50488 hydrochloride

    (+)-Trans-(1R,2R)-U-50488 hydrochloride

    		 Opioid Receptor Neurological Disease
    (+)-U-50488 (hydrochloride) (+)-Trans-(1R,2R)-U-50488 hydrochloride) is a less active κ opioid receptor (KOR) agonist than the enantiomer of (-)-Trans-(1S,2S)-U-50488 (HY-15997) .
    (+)-U-50488 hydrochloride
  • HY-119813
    (S,S)-Sinogliatin

    (S,S)-HMS-5552; (S,S)-RO-5305552

    		 Glucokinase Metabolic Disease
    (S,S)-Sinogliatin ((S,S)-HMS-5552) is the (S,S) -enantiomer of Sinogliatin. Sinogliatin is a glucokinase activator that can be used to study type 2 diabetes .
    (S,S)-Sinogliatin
  • HY-160932
    RS-15385-198

    		Others Endocrinology
    RS-15385-198 is the enantiomer of Delequamine (RS-15385-197) (HY-106874). RS-15385-198 exhibits a pKi of 6.32 for α2-adrenoceptors in the rat cortex. RS-15385-198 is an antagonist for UK-14304 (HY-B0659) in the rat vas deferens and in the guinea-pig ileum .
    RS-15385-198
  • HY-135396
    (1S,2S)-Bortezomib

    		Proteasome Apoptosis Cancer
    (1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans .
    (1S,2S)-Bortezomib
  • HY-13856
    (R)-PS210

    		PDK-1 Cancer
    (R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment .
    (R)-PS210
  • HY-108908A
    Modipafant

    UK-80067

    		 Platelet-activating Factor Receptor (PAFR) Inflammation/Immunology
    Modipafant (UK-80067), the (+)-enantiomer of UK-74505, is a potent, orally active, and selective platelet-activating factor (PAF) antagonist. Modipafant exhibits approximately double the intrinsic potency of UK-74505 .
    Modipafant

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