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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

HIV-1 protease inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV (46) HIV Protease (71) Ser/Thr Protease (1) Virus Protease (3) Apoptosis (3) Autophagy (2) Cytochrome P450 (6) Drug Metabolite (1) EBV (2) Endogenous Metabolite (6) ERK (2) Flavivirus (2) Fungal (1) HSV (2) Isotope-Labeled Compounds (9) MMP (3) P-glycoprotein (6) Phosphatase (2) Phospholipase (2) Renin (1) Reverse Transcriptase (1) SARS-CoV (16)
By Research Areas:	Cancer (23) Infection (85) Inflammation/Immunology (10)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: HIV Protease HIV HIV Integrase Virus Protease HCV Protease Protease Activated Receptor (PAR) Ser/Thr Protease ClpP Enteropeptidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155691

HIV-1 protease-IN-12	HIV Protease	Infection
HIV-1 protease-IN-12 (compound 35b) is a **HIV-1 protease** inhibitor with an IC₅₀ of 0.51 nM. HIV-1 protease-IN-12 also inhibits drug-resistant variant .

HY-155690

HIV-1 protease-IN-11	HIV Protease	Infection
HIV-1 protease-IN-11 (compound 34a) is a **HIV-1 protease** inhibitor with an IC₅₀ of 0.41 nM. HIV-1 protease-IN-11 also exhibits significant activity against drug-resistant variant .

HY-146804

HIV-1 protease-IN-3	HIV HIV Protease	Infection
HIV-1 protease-IN-3 (compound 14) is a potent inhibitor of **HIV-1 protease (IC₅₀=71 nM; EC₅₀**=0.86 μM) .

HY-161270

HIV-1 protease-IN-13	HIV Protease	Infection
HIV-1 protease-IN-13 (compound 18d) is a potent **HIV-1 protease** inhibitor with an IC₅₀ value of 0.54 nM. HIV-1 protease-IN-13 also shows potent activity against HIV-1DRVRS (DRV-resistant mutation) and HIV-1NL4_3 variant (wild type) .

HY-15899

Des(benzylpyridyl) Atazanavir	HIV Protease HIV Drug Metabolite	Infection
Des(benzylpyridyl) Atazanavir (compound M1) is a N-dealkylation product of Atazanavir (HY-17367) metabolite. Atazanavir is a highly selective **HIV-1 protease** inhibitor. Des(benzylpyridyl) Atazanavir may contribute to the effectiveness Atazanavir but also to the toxicity and interactions. Des(benzylpyridyl) Atazanavir can be used for further research of Atazanavir effects .

HY-130366

JG-365	Others	Others
JG-365 is an HIV-1 protease inhibitor that binds to the active site of HIV-1 protease.

HY-146888

HIV-1 protease-IN-2	HIV Protease	Infection
HIV-1 protease-IN-2 is a potent **HIV-1 protease** inhibitor with an IC₅₀ of 2.53 nM. HIV-1 protease-IN-2 shows antiviral activity against DRV (Darunavir)-sensitive or DRV-resistant HIV-1 variants .

HY-147650

HIV-1 protease-IN-5	HIV Protease	Infection
HIV-1 protease-IN-5 (Compound 13c) is a **HIV-1 protease** inhibitor with an IC₅₀ of 1.64 nM. HIV-1 protease-IN-5 shows remarkable activity against wild-type and DRV-resistant HIV-1 variants .

HY-155076

HIV-1 protease-IN-9	HIV Protease	Infection
HIV-1 protease-IN-9 (compound 5b) is a **HIV-1 protease** inhibitor, with a K_i of 0.028 nM. HIV-1 protease-IN-9 shows potent antiviral activity, with an IC₅₀ of 66.8 nM .

HY-169166

HIV-1 protease-IN-14	HIV Protease	Infection
HIV-1 protease-IN-14 (compound 5ae) is a potent **HIV-1 protease** inhibitor with K_i values of 0.28, 56.9 nM for WT HIV-1 PR, R41T HIV-1 PR, respectively. HIV-1 protease-IN-14 shows low cytotoxicity .

HY-123415

PD 134922	HIV Protease Renin	Infection
PD 134922 is a potent renin and **HIV-1 protease** inhibitor with an IC₅₀ of 15 nM against HIV-1 protease .

HY-125712

CGP 53820	HIV HIV Protease	Infection
CGP 53820 is an inhibitor for HIV protease, inhibits the complex of HIV-1 and HIV-2 protease with K_i of 9 and 53 nM for **HIV-1 protease** and HIV-2 protease. CGP 53820 can be used in AIDS research .

HY-152200

HIV-1 inhibitor-53	HIV Protease Reverse Transcriptase	Infection Inflammation/Immunology
HIV-1 inhibitor-53 is a *dual HIV-1* protease and reverse transcriptase** inhibitor. HIV-1 inhibitor-53 inhibits HIV-1 protease (PR) and reverse transcriptase (RT) activity with IC₅₀ values of 1.93 nM and 2.35 μM, respectively. HIV-1 inhibitor-53 can be used for the research of acquired immune deficiency syndrome (AIDS) .

HY-144688

HIV-1 protease-IN-1	HIV	Infection
HIV-1 protease-IN-1 (Compound 1e) is a potent inhibitor of *HIV-1* protease with an IC₅₀ of 90 pM. HIV-1 protease-IN-1 demonstrates antiviral activity with EC₅₀ value of 89 nM against B-HIV. HIV-1 protease-IN-1 exhibits activity with EC₅₀ value of 13.59 nM against C-HIV strain ZM246. HIV-1 protease-IN-1 shows remarkable activity with EC₅₀ value of 8.23 nM against C-HIV strain Indie ^[1].

HY-146012

HIV-1 protease-IN-4	HIV	Infection
HIV-1 protease-IN-4 (Compound II-22) is a potent *HIV-1* protease inhibitor. HIV-1 protease-IN-4 is a proagent of atazanavir. HIV-1 protease-IN-4 as a proagent that delivers the parent 1 to rat plasma with a 5-fold higher AUC and 67-fold higher C24 when compared to oral administration of the parent agent .

HY-149936

HIV-1 protease-IN-8	HIV Protease	Infection
HIV-1 protease-IN-8 (compound 34b) is a potent **HIV-1 protease** inhibitor with an IC₅₀ value of 0.32 nM. HIV-1 protease-IN-8 displays IC₅₀s of 0.29 μM and 1.90 μM for wild-type HIV-1 (HIV-1_NL4-3) and drug-resistant variant (HIV-1_MDR), respectively. HIV-1 protease-IN-8 displays robust antiviral activity against both wild-type HIV-1 and drug-resistant variant .

HY-116537

A76889	Others	Infection
A76889 is an HIV-1 protease inhibitor.

HY-151250

HIV-1 protease-IN-7	HIV Protease	Infection
HIV-1 protease-IN-7 (compound 16) is an orally active **HIV-1 protease** inhibitor (IC₅₀=3.52 nM, EC₅₀=37 nM) .

HY-150549

HIV-1 protease-IN-6	HIV Protease HIV	Infection Inflammation/Immunology
HIV-1 protease-IN-6 (compound 17d) is a potent **HIV-1 protease** inhibitor, with an IC₅₀ of 21 pM and a K_i of 4.7 pM, respectively. HIV-1 protease-IN-6 exhibits potent antiviral activity to DRV (darunavir)-resistant variant, even more than wild type virus .

HY-120331

U-89360E	HIV HIV Protease	Infection
U-89360E is an inhibitor for **HIV-1 protease*. U-89360E inhibits* the protease of HIV-1 wildtype, V82D mutant and V82N mutant with K_i of 20 nM, 560 nM and 2100 nM, respectively .

HY-100212

JE-2147 AG1776; KNI-764	HIV HIV Protease	Infection
JE-2147 (AG1776) is a potent dipeptide protease inhibitor with a K_i of 0.33 nM for **HIV-1 protease. JE-2147 has effective activities against a wide spectrum of HIV-1, HIV-2*, simian immunodeficiency virus, and various clinical HIV-1* strains in vitro .

HY-N12716

Longipedunin A	HIV Protease	Infection
Longipedunin A is a **HIV-1 Protease** inhibitor with an IC₅₀ value of 50 µg/mL .

HY-125148

AQ148	HIV Protease	Infection
AQ148 is a **HIV-1 protease** inhibitor (K_i=137 nM). The IC₅₀ values ??of AQ148 for the inhibition of *HIV-1, HIV-2* and SIV aspartic proteases are 1.5 μM, 3.4 μM and 5 μM, respectively .

HY-P4543

HIV-IN petide	HIV HIV Protease	Infection
HIV-IN petide is a competitive inhibitor of *HIV-1* protease (K_i=50 nM) .

HY-N2786

8-Prenylluteone	HIV Protease	Infection
8-Prenylluteone is a **HIV-1 protease** inhibitor, with an IC₅₀ of 4 μM .

HY-118057

L-739594	HIV	Inflammation/Immunology
L-739594 is a **HIV-1 protease** inhibitor, with an IC₅₀ of 1.8 nM .

HY-120880

SKF107457	HIV Protease	Infection
SKF107457 is an **HIV-1 protease** inhibitor that can be used in AIDS research .

HY-125551

L-687908	HIV Protease	Infection
L-687908 is a **HIV-1 protease** inhibitor (CIC₉₅: 12 nM) .

HY-129678

UK-88947 hydrochloride	Others	Infection
UK-88947 hydrochloride is a protease inhibitor with activity in inhibiting the replication of human immunodeficiency virus HIV-1. UK-88947 hydrochloride can be added to cells before infection to block the early steps of HIV-1 replication. The use of UK-88947 hydrochloride shows its specific inhibitory effect on HIV-1. At the same time, when the virus infects cells, it inhibits the action of viral protease and affects the virus replication process .

HY-19194

A-80987	HIV Protease	Infection
A-80987 is an inhibitor of human immunodeficiency virus type 1 (HIV-1) protease .

HY-15148

Tipranavir 5+ Cited Publications PNU-140690	HIV Protease HIV SARS-CoV	Infection
Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of **HIV-1 protease*, exerts potent activity against multi-protease* inhibitor (PI)-resistant HIV-1 isolates with IC₅₀s of 66-410 nM . Tipranavir inhibits SARS-CoV-2 3CL ^pro activity .

HY-107468

PL-100	HIV Protease	Infection Inflammation/Immunology
PL-100 is a potent **HIV-1 protease** inhibitor with a K_i of 36 pM and an EC₅₀ of 16 nM. PL-100 inhibits viral replication by suppressing *HIV-1* protease activity and demonstrates excellent antiviral efficacy against drug-resistant HIV strains. PL-100 can be used in research on drug-resistant HIV disease .

HY-17041

Darunavir Ethanolate 10+ Cited Publications TMC114 Ethanolate	HIV HIV Protease	Infection
Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. Darunavir has a K_i of 1 nM for wild type HIV-1 protease.

HY-125571

A 74704	HIV Protease	Infection
A 74704 is a pseudo C2-symmetric inhibitor of **HIV-1 protease** and its diester analog .

HY-139794

SDZ283-910	HIV	Infection
SDZ283-910 is a potent human immunodeficiency virus type-1 (HIV-1) protease inhibitor .

HY-N11288

Methyl salvionolate A	HIV	Infection
Methyl salvionolate A is a potent inhibitor of *HIV-1. Methyl salvionolate A inhibits* P24 antigen in HIV-1 infected MT-4 cell with an EC₅₀ of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC₅₀s of 50.58, 10.73 and 7.58 μg/ml, respectively .

HY-124360

NIT	HIV Protease	Infection
NIT is an inhibitor of HIV-1 protease (HIV-1p) with K_i values of 96 and 91 μM for WT HIV-1p and MDR HIV-1p, respectively .

HY-19400

DPC-681 DPH-153893	HIV Protease HIV	Infection
DPC-681 is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM.

HY-P1436

Acetyl-pepstatin	HIV	Infection
Acetyl-pepstatin is a potent classical inhibitor of aspartic proteases (PRs) with XMRV PR and HIV-1 PR K_i values of 712 nM and 13 nM .

HY-P2054

Mvt-101	HIV Protease	Infection
Mvt-101 is a hexapeptide-based inhibitor of **HIV-1 protease*. Mvt-101 is also reduced-peptide-bond inhibitor. Mvt-101 inhibits* reproduction of the HIV virus by blocking protease action .

HY-14588

Lopinavir Maximum Cited Publications 14 Publications Verification ABT-378	HIV HIV Protease SARS-CoV	Infection Cancer
Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the **HIV-1 protease, with K_is** of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 14.2 μM .

HY-120812

HIV-IN-11	HIV Protease	Infection
HIV-IN-11 is part of the hydroxylaminoglutaramide (HAPA) transition state isomeric series of HIV protease inhibitors and is a potent and selective inhibitor of HIV-1 protease. HIV-IN-11 competitively inhibits HIV-1 PR (Ki: 0.049 nM) and potently inhibits replication of HIV(IIIb)-infected MT4 lymphocytes at concentrations of 25.0-50.0 nM. HIV-IN-11 displays a longer half-life than indinavir sulfate in animal models and serves as a promising second-generation HIV protease inhibitor .

HY-17367S

Atazanavir-d15 BMS-232632-d₁₅	Isotope-Labeled Compounds HIV	Infection
Atazanavir-d15 is the d₁₅ labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor .

HY-17367S1

Atazanavir-d18 BMS-232632-d₁₈	Isotope-Labeled Compounds HIV	Infection
Atazanavir-d18 is the d₁₈ labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor .

HY-120863

(Rac)-PD 135390	Virus Protease	Infection
(Rac)-PD 135390 is a dipeptide and an **HIV-1 protease** inhibitor with an IC₅₀ of 2 nM. (Rac)-PD 135390 can be utilized in antiviral research .

HY-15148R

Tipranavir (Standard)	HIV Protease HIV SARS-CoV	Infection
Tipranavir (Standard) is the analytical standard of Tipranavir. This product is intended for research and analytical applications. Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of **HIV-1 protease*, exerts potent activity against multi-protease* inhibitor (PI)-resistant HIV-1 isolates with IC₅₀s of 66-410 nM . Tipranavir inhibits SARS-CoV-2 3CL ^pro activity .

HY-15148S1

Tipranavir-d7 PNU-140690-d7	HIV Protease HIV SARS-CoV Isotope-Labeled Compounds	Infection
Tipranavir-d₇ is deuterated labeled Tipranavir (HY-15148). Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of **HIV-1 protease*, exerts potent activity against multi-protease* inhibitor (PI)-resistant HIV-1 isolates with IC₅₀s of 66-410 nM . Tipranavir inhibits SARS-CoV-2 3CL ^pro activity .

HY-120390

L 694746	HIV Protease HIV	Infection
L 694746 is the metabolite of L-689502 (HY-U00261). L 694746 is an inhibitor for **HIV-1 protease with an IC₅₀ of 1 nM and a K_i** of 0.34 nM .

HY-107123

TMC310911 ASC-09	HIV Protease	Infection
TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC₅₀ values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant *HIV-1* isolates. TMC310911 has strong antiviral activity .

HY-134851

HIV-1 inhibitor-6 1 Publications Verification	HIV	Infection
HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC₅₀s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to agents targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC₅₀s ranging from 0.9 to 1.5 μM .

Cat. No.	Product Name	Target	Research Area

HY-151250

HIV-1 protease-IN-7	HIV Protease	Infection
HIV-1 protease-IN-7 (compound 16) is an orally active **HIV-1 protease** inhibitor (IC₅₀=3.52 nM, EC₅₀=37 nM) .

HY-P2138

U-85548E	Peptides	Others
U-85548E is an HIV protease inhibitor with nanomolar affinity for HIV-1 aspartic protease. By studying its structure-activity relationship, a potent nanomolar inhibitor with inhibitory effects on both HIV-1 and HIV-2 proteases was designed, and its binding mode was studied by X-ray crystallography and molecular modeling.

HY-P4543

HIV-IN petide	HIV HIV Protease	Infection
HIV-IN petide is a competitive inhibitor of *HIV-1* protease (K_i=50 nM) .

HY-120880

SKF107457	HIV Protease	Infection
SKF107457 is an **HIV-1 protease** inhibitor that can be used in AIDS research .

HY-P1436

Acetyl-pepstatin	HIV	Infection
Acetyl-pepstatin is a potent classical inhibitor of aspartic proteases (PRs) with XMRV PR and HIV-1 PR K_i values of 712 nM and 13 nM .

HY-P2054

Mvt-101	HIV Protease	Infection
Mvt-101 is a hexapeptide-based inhibitor of **HIV-1 protease*. Mvt-101 is also reduced-peptide-bond inhibitor. Mvt-101 inhibits* reproduction of the HIV virus by blocking protease action .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17367

Atazanavir Maximum Cited Publications 11 Publications Verification BMS-232632	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (BMS-232632), a highly selective **HIV-1 protease** inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 3.49 μM .

HY-17367A

Atazanavir sulfate Maximum Cited Publications 11 Publications Verification BMS-232632 sulfate	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (BMS-232632) sulfate, a highly selective **HIV-1 protease** inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir sulfate is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 3.49 μM .

HY-N2006

Ganoderic acid B	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields	EBV HIV Protease
Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against **HIV-1 protease** (IC₅₀: 170 μM) .

HY-N6773

Cytochalasin A	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields	HIV Protease Fungal
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of **HIV-1 protease (IC₅₀*=3 μM) and inhibits* actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

HY-N12716

Longipedunin A	Structural Classification Source classification Lignans Phenylpropanoids Plants Kadsura longipedunculata Finet et Gagnep. Schisandraceae	HIV Protease
Longipedunin A is a **HIV-1 Protease** inhibitor with an IC₅₀ value of 50 µg/mL .

HY-N2786

8-Prenylluteone	Structural Classification Flavonoids Erythrinasenegalensis DC. Leguminosae Source classification Plants Isoflavones	HIV Protease
8-Prenylluteone is a **HIV-1 protease** inhibitor, with an IC₅₀ of 4 μM .

HY-N11288

Methyl salvionolate A	Structural Classification Labiatae Source classification Phenols Polyphenols Salvia yunnanensis C. H. Wright Plants	HIV
Methyl salvionolate A is a potent inhibitor of *HIV-1. Methyl salvionolate A inhibits* P24 antigen in HIV-1 infected MT-4 cell with an EC₅₀ of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC₅₀s of 50.58, 10.73 and 7.58 μg/ml, respectively .

HY-116700

Hinnuliquinone	Structural Classification Natural Products Nepenthes mirabilis (Lour.) Druce Source classification Plants Nepenthaceae	HIV Protease HIV
Hinnuliquinone is a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of **HIV-1 protease*. Hinnuliquinone is a bis-indolyl-2,5-dihydroxybenzoquinone pigment, that can be isolated from Nodulisphorium hinnuleum* .

HY-17367R

Atazanavir (Standard)	Structural Classification Alkaloids Source classification Pyridine Alkaloids Endogenous metabolite	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (Standard) is the analytical standard of Atazanavir. This product is intended for research and analytical applications. Atazanavir (BMS-232632), a highly selective **HIV-1 protease** inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 3.49 μM .

HY-17367AR

Atazanavir sulfate (Standard)	Structural Classification Alkaloids Source classification Pyridine Alkaloids Endogenous metabolite	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (sulfate) (Standard) is the analytical standard of Atazanavir (sulfate). This product is intended for research and analytical applications. Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 3.49 μM .

HY-N0554

Escin IA	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Hippocastanaceae Aesculus hippocastanum Source classification Plants Disease Research Fields Cancer	HIV Protease
Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits **HIV-1 protease with IC₅₀** values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-N2006R

Ganoderic acid B (Standard)	Triterpenes Structural Classification Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants	EBV HIV Protease
Ganoderic acid B (Standard) is the analytical standard of Ganoderic acid B. This product is intended for research and analytical applications. Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC₅₀: 170 μM) .

HY-N1992

Theaflavin 3,3'-digallate 5 Publications Verification TF-3; ZP10	Infection Structural Classification Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae	Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (K_d=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and *HIV-1* . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N0554R

Escin IA (Standard)	Triterpenes Structural Classification other families Terpenoids Hippocastanaceae Aesculus hippocastanum Source classification Plants	HIV Protease
Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-N1992R

Theaflavin 3,3'-digallate (Standard)	Structural Classification Flavonoids Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Theaceae	Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (Standard) is the analytical standard of Theaflavin 3,3'-digallate. This product is intended for research and analytical applications. Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N2996

Ganodermanondiol	Infection Triterpenes Structural Classification Microorganisms Classification of Application Fields Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields	HIV Protease
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum .Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 *protease* activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

Cat. No.	Product Name	Chemical Structure

HY-17367S

Atazanavir-d15
Atazanavir-d15 is the d₁₅ labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor .

HY-17367S1

Atazanavir-d18
Atazanavir-d18 is the d₁₈ labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor .

HY-15148S1

Tipranavir-d7
Tipranavir-d₇ is deuterated labeled Tipranavir (HY-15148). Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of **HIV-1 protease*, exerts potent activity against multi-protease* inhibitor (PI)-resistant HIV-1 isolates with IC₅₀s of 66-410 nM . Tipranavir inhibits SARS-CoV-2 3CL ^pro activity .

HY-14588S2

Lopinavir-d7

Lopinavir-d₇ is deuterated labeled Lopinavir (HY-14588). Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with K_is of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 14.2 μM .

HY-14588S1

Lopinavir-d8

Lopinavir-d₈ (ABT-378-d8) is the deuterium labeled Lopinavir. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity[1][2]. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM[3].

HY-14588S

(rel)-Lopinavir-d8

(rel)-Lopinavir-d₈ ((rel)-ABT-378-d₈)is the deuterium labeledLopinavir(HY-14588) . Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with K_is of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 14.2 μM .

HY-15287S1

Nelfinavir-d4
Nelfinavir-d₄ is deuterated labeled Nelfinavir (HY-15287). Nelfinavir (AG-1341) is a potent and orally bioavailable **HIV-1 protease** inhibitor (K_i=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent .

HY-17367S3

Atazanavir-d5

Atazanavir-d₅ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-17367S2

Atazanavir-d9

Atazanavir-d₉ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-15287S

Nelfinavir-d3
Nelfinavir-d₃ (AG1341-d3) is the deuterium labeled Nelfinavir. Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent[1][2][3].

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