Search Result

Pathways Recommended:	NF-κB

Results for "

NF-κB-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NF-κB (46) Akt (2) AMPK (1) Antibiotic (4) AP-1 (2) Apoptosis (23) Autophagy (10) Bacterial (5) Bcl-2 Family (3) Caspase (1) Complement System (1) COX (13) DNA/RNA Synthesis (3) Drug Derivative (1) EGFR (1) Endogenous Metabolite (11) ERK (2) Estrogen Receptor/ERR (1) FAK (2) Fungal (2) Glucocorticoid Receptor (1) HIF/HIF Prolyl-Hydroxylase (2) HSV (1) IKK (5) Influenza Virus (2) Interleukin Related (5) Isotope-Labeled Compounds (1) JAK (1) JNK (2) Keap1-Nrf2 (1) MDM-2/p53 (2) Mitophagy (3) MMP (3) mTOR (1) NO Synthase (2) NOD-like Receptor (NLR) (1) Opioid Receptor (4) p38 MAPK (2) PAK (1) Parasite (2) PARP (1) Phosphatase (1) PPAR (1) RAR/RXR (1) Reactive Oxygen Species (8) Ribosomal S6 Kinase (RSK) (2) Src (1) STAT (2) Survivin (1) TNF Receptor (3) Toll-like Receptor (TLR) (3) Topoisomerase (2) VEGFR (3)
By Research Areas:	Cancer (34) Cardiovascular Disease (6) Endocrinology (1) Infection (12) Inflammation/Immunology (44) Metabolic Disease (4) Neurological Disease (9)

By Targets:

NF-κB (46)

Akt (2)

AMPK (1)

Antibiotic (4)

AP-1 (2)

Apoptosis (23)

Autophagy (10)

Bacterial (5)

Bcl-2 Family (3)

Caspase (1)

Complement System (1)

COX (13)

DNA/RNA Synthesis (3)

Drug Derivative (1)

EGFR (1)

Endogenous Metabolite (11)

ERK (2)

Estrogen Receptor/ERR (1)

FAK (2)

Fungal (2)

Glucocorticoid Receptor (1)

HIF/HIF Prolyl-Hydroxylase (2)

HSV (1)

IKK (5)

Influenza Virus (2)

Interleukin Related (5)

Isotope-Labeled Compounds (1)

JAK (1)

JNK (2)

Keap1-Nrf2 (1)

MDM-2/p53 (2)

Mitophagy (3)

MMP (3)

mTOR (1)

NO Synthase (2)

NOD-like Receptor (NLR) (1)

Opioid Receptor (4)

p38 MAPK (2)

PAK (1)

Parasite (2)

PARP (1)

Phosphatase (1)

PPAR (1)

RAR/RXR (1)

Reactive Oxygen Species (8)

Ribosomal S6 Kinase (RSK) (2)

Src (1)

STAT (2)

Survivin (1)

TNF Receptor (3)

Toll-like Receptor (TLR) (3)

Topoisomerase (2)

VEGFR (3)

By Research Areas:

Cancer (34)

Cardiovascular Disease (6)

Endocrinology (1)

Infection (12)

Inflammation/Immunology (44)

Metabolic Disease (4)

Neurological Disease (9)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: NF-κB Dan family AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138537

*NF-κB-IN-1* 2 Publications Verification	IKK	Cancer
NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells .

HY-N5048

Galloylpaeoniflorin 6'-O-Galloyl paeoniflorIN	NF-κB	Others
Galloylpaeoniflorin is a *NF-κB* inhibitor . And Galloylpaeoniflorin is a inhibitor of DNA cleavage .

HY-N1380

Guaiacol 2-Methoxyphenol	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and *NF-κB* activation . Anti-inflammatory activity .

HY-15122

Sinomenine 10+ Cited Publications	NF-κB Opioid Receptor Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the *NF-κB* activation . Sinomenine also is an activator of μ-opioid receptor .

HY-10172

IMD-0354 Maximum Cited Publications 19 Publications Verification IKK2 INhibitor V	IKK	Cancer
IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity . IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC₅₀ of 1.2 uM .

HY-15122A

Sinomenine hydrochloride 10+ Cited Publications CucolINe hydrochloride	NF-κB Opioid Receptor Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the *NF-κB* activation . Sinomenine also is an activator of μ-opioid receptor .

HY-168710

TLR4/NF-κB-IN-1	Toll-like Receptor (TLR) NF-κB IKK	Inflammation/Immunology
TLR4/NF-κB-IN-1 (Compound 7x) is an orally available inhibitor that specifically targets the *TLR4/NF-κB* signaling pathway, offering anti-inflammatory effects and the ability to cross the blood-brain barrier. TLR4/NF-κB-IN-1 can reduce acute neuroinflammation in mice caused by LPS (HY-D1056) and downregulate the expression of TLR4, *P-NF-κB* and P-IκB-α proteins .

HY-146058

*NF-κB/PON1-IN-1*	NF-κB Reactive Oxygen Species	Cancer
NF-κB/PON1-IN-1 (Compound 16) is a *NF-κB/PON1* pathway inhibitor. NF-κB/PON1-IN-1 has antioxidant (IC₅₀ = 45.76 µM) and hepatoprotective activities .

HY-161520

Glucocorticoid receptor/NF-κB modulator-1	Glucocorticoid Receptor NF-κB	Inflammation/Immunology
Glucocorticoid receptor/NF-κB modulator-1 (Compound 20) is a derivative of ocotillol. Glucocorticoid receptor/NF-κB modulator-1 suppresses the degradation of glucocorticoid receptor (GR) mRNA and GR protein, inhibits the activation of NF-κB signaling pathway. Glucocorticoid receptor/NF-κB modulator-1 downregulates levels of NO, interleukin-6 and tumor necrosis factor-alpha (TNF-α). Glucocorticoid receptor/NF-κB modulator-1 ameliorates sepsis in mouse model .

HY-N12527

Hyperelamine A	NF-κB	Others
Hyperelamine A (compound 5) is a polycyclic polyprenylated acylphloroglucinols (PPAPs). Hyperelamine A exhibits inhibitory activity against LPS-activated NO production in BV-2 cells via TLR-4/NF κB signaling .

HY-B0167

Salicylic acid 5+ Cited Publications 2-Hydroxybenzoic acid	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-B0289

Erdosteine 1 Publications Verification RV 144	NF-κB Bacterial	Infection Metabolic Disease Inflammation/Immunology
Erdosteine inhibits lipopolysaccharide (LPS)-induced *NF-κB* activation . Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects .

HY-B0167A

Sodium Salicylate 5+ Cited Publications Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt	COX NF-κB Ribosomal S6 Kinase (RSK) Autophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation . Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a *NF-κB* inhibitor that decreases inflammatory gene expression and improves repair in aged muscle .

HY-N6065

Praeruptorin A 2 Publications Verification	NF-κB	Inflammation/Immunology
Praeruptorin A is a main bioactive constituent of Peucedanum praeruptorum (also known as Bai-Hua Qian Hu). Praeruptorin A exerts anti-inflammatory effects in vitro through inhibition of *NF-κB* activation .

HY-N8551

(5E)-7-Oxozeaenol	Others	Infection Cancer
(5E)-7-Oxozeaenol is an active fungal extract that is cytotoxic. (5E)-7-Oxozeaenol exhibits antibacterial, mitochondrial transmembrane potential, and NF-κB effects .

HY-W067427

BAY32-5915	IKK	Cancer
BAY32-5915 is a potent IKKα inhibitor with an IC₅₀ value of 60 nM. BAY32-5915 has not affect Doxorubicin (HY-15142A)-induced NF-κB activation .

HY-N2682B

Dehydrodiconiferyl alcohol	Estrogen Receptor/ERR	Metabolic Disease Inflammation/Immunology
Dehydrodiconiferyl alcohol is an estrogen receptor agonist that can promote BMP-2-induced osteoblastogenesis. Dehydrodiconiferyl alcohol also exerts anti-inflammatory activity through inactivation of NF-κB pathways .

HY-N1098

Velutin	HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology
Velutin is an aglycone extracted from Flammulina velutipes, with inhibitory activity against melanin biosynthesis. Velutin reduces osteoclast differentiation and down-regulates HIF-1α through the NF-κB pathway .

HY-N1380R

Guaiacol (Standard) 2-Methoxyphenol (Standard)	COX Endogenous Metabolite NF-κB	Inflammation/Immunology
Guaiacol (Standard) is the analytical standard of Guaiacol. This product is intended for research and analytical applications. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and *NF-κB* activation . Anti-inflammatory activity .

HY-N1380S

Guaiacol-d7 2-Methoxyphenol-d₇	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol-d₇ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-100538

DTP3 1 Publications Verification	DNA/RNA Synthesis JAK	Cancer
DTP3 TFA is a potent and selective GADD45β/MKK7 inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway .

HY-15122R

Sinomenine (Standard)	NF-κB Opioid Receptor Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Sinomenine (Standard) is the analytical standard of Sinomenine. This product is intended for research and analytical applications. Sinomenine, an alkaloid extracted from?Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of μ-opioid receptor .

HY-B0167S

Salicylic acid-d6 2-Hydroxybenzoic acid-d₆	Isotope-Labeled Compounds COX Autophagy Mitophagy Apoptosis	Inflammation/Immunology Cancer
Salicylic acid-d₆ is a deuterium labeled Salicylic acid (HY-B0167). Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-N1380S3

Guaiacol-d4 2-Methoxyphenol-d₄	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol-d₄ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N3617R

Coniferin (Standard)	Fungal	Infection
Sinomenine (Standard) is the analytical standard of Sinomenine. This product is intended for research and analytical applications. Sinomenine, an alkaloid extracted from?Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of μ-opioid receptor .

HY-B0167AR

Sodium Salicylate (Standard)	COX NF-κB Ribosomal S6 Kinase (RSK) Autophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Sodium Salicylate (Standard) is the analytical standard of Sodium Salicylate. This product is intended for research and analytical applications. Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation . Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a *NF-κB* inhibitor that decreases inflammatory gene expression and improves repair in aged muscle .

HY-N1380S4

Guaiacol-d4-1 2-Methoxyphenol-d₄-1	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol-d₄-1 is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-B0167R

Salicylic acid (Standard) 5+ Cited Publications 2-Hydroxybenzoic acid (Standard)	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Salicylic acid (Standard) is the analytical standard of Salicylic acid. This product is intended for research and analytical applications. Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-N1380S2

Guaiacol-13C6 2-Methoxyphenol-¹³C₆	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol- ¹³C₆ is the ¹³C labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-15122AR

Sinomenine hydrochloride (Standard)	NF-κB Opioid Receptor Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Sinomenine hydrochloride (Standard) is the analytical standard of Sinomenine hydrochloride. This product is intended for research and analytical applications. Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of μ-opioid receptor .

HY-B0289R

Erdosteine (Standard)	NF-κB Bacterial	Infection Metabolic Disease Inflammation/Immunology
Erdosteine (Standard) is the analytical standard of Erdosteine. This product is intended for research and analytical applications. Erdosteine inhibits lipopolysaccharide (LPS)-induced *NF-κB* activation . Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects .

HY-111172

Inotilone	MMP NF-κB	Cancer
Inotilone is an inhibitor of matrix metalloproteinase MMP-2 and MMP-9, to against metastatic in lung cancer cells. Inotilone enhances the activity of the antioxidant enzymes to support its anti-metastatic activity. Inotilone also inhibits IκBα phosphorylation and NFκB p65 nuclear translocation, involving in FAK, PI3K/AKT, MAPKs and NFκB pathways .

HY-N6065R

Praeruptorin A (Standard)	NF-κB	Inflammation/Immunology
Praeruptorin A (Standard) is the analytical standard of Praeruptorin A. This product is intended for research and analytical applications. Praeruptorin A is a main bioactive constituent of Peucedanum praeruptorum (also known as Bai-Hua Qian Hu). Praeruptorin A exerts anti-inflammatory effects in vitro through inhibition of NF-κB activation .

HY-156340

Anti-inflammatory agent 58	Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 58 is an anti-inflammatory agent. Anti-inflammatory agent 58 inhibits IL-1β with an IC₅₀ of 1.08 μM. Anti-inflammatory agent 58 decreases pro-inflammatory gene expression, protein secretion, and *NF-κB* phosphorylation .

HY-156342

Anti-inflammatory agent 59	Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 59 is an anti-inflammatory agent. Anti-inflammatory agent 58 inhibits IL-1β with an IC₅₀ of 2.28 μM. Anti-inflammatory agent 58 decreases pro-inflammatory gene expression, protein secretion, and *NF-κB* phosphorylation .

HY-149816

Anti-inflammatory agent 41	Interleukin Related TNF Receptor NF-κB	Inflammation/Immunology
Anti-inflammatory agent 41 (13a) significantly inhibit lipopolysaccharide (LPS)-induced expression of the proinflammatory cytokines IL-6 and TNF-α on J774A.1, THP-1 and LX-2 cells, and inhibits the activation of the *NF-κB* pathway .

HY-N2098

Obtusifolin	NF-κB	Cancer
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting *NF-kB* pathway . Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein .

HY-126390

(E/Z)-BCI NSC 150117	Phosphatase Apoptosis	Inflammation/Immunology Cancer
(E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway .

HY-123503

Salicortin	JNK NF-κB	Neurological Disease Inflammation/Immunology
Salicortin, a phenolic glycoside, has been isolated from many plants such as Populus and Salix species. Salicortin inhibits osteoclast differentiation and bone resorption by down-regulating JNK and *NF-κB/NFATc1* signaling pathways. Salicortin has anti-amnesic, anti-adipogenic, and immune-modulatory activity .

HY-136477

Pentagamavunon-1 PGV-1	Apoptosis COX VEGFR NF-κB	Cancer
Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits *NF-κB* activation .

HY-128423A

Tylvalosin AcetylisovaleryltylosIN	Antibiotic Bacterial NF-κB Apoptosis	Infection Inflammation/Immunology Cancer
Tylvalosin (Acetylisovaleryltylo?sin) is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin is an antiviral agent used to study PRRSV infection. Tylvalosin induces apoptosis. Tylvalosin also has anti-inflammatory activity, alleviates oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation .

HY-N10638

N-Acetyldopamine dimer-2	Reactive Oxygen Species NF-κB	Inflammation/Immunology
N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity .

HY-160706

HHQ16	Drug Derivative	Cardiovascular Disease
HHQ16 is an orally active derivative of Astragaloside IV (HY-N0431). HHQ16 effectively reverses infarction-induced hypertrophy and heart failure by targeted degrading lnc4012/lnc9456 and antagonizing their effects on G3BP2/NF-κB signaling .

HY-121893

p53-MDM2-IN-3	MDM-2/p53 NF-κB	Cancer
p53-MDM2-IN-3 (Compound 5s) is an orally active p53-MDM2 inhibitor with a K_i value of 0.25 μM. p53-MDM2-IN-3 exerts antitumor activity by inhibiting *NF-κB* pathway .

HY-100538A

DTP3 TFA 1 Publications Verification	DNA/RNA Synthesis JNK	Cancer
DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway .

HY-116052

p53-MDM2-IN-2	MDM-2/p53 NF-κB	Cancer
p53-MDM2-IN-2 (Compound 5q) is an orally active p53-MDM2 inhibitor with a K_i value of 0.25 μM. p53-MDM2-IN-2 exerts antitumor activity by inhibiting *NF-κB* pathway .

HY-N9587

Tricin 7-O-β-D-glucopyranoside	Apoptosis	Neurological Disease
Tricin 7-O-β-D-glucopyranoside is a potent and orally active neuroprotective agent. Tricin 7-O-β-D-glucopyranoside induces Apoptosis. Tricin 7-O-β-D-glucopyranoside decreases the expression of TNF-α induced phosphor-κB-α, phosphor-NF-κB, HMGB1 .

HY-128423

Tylvalosin tartrate AcetylisovaleryltylosIN tartrate	Antibiotic Bacterial NF-κB Apoptosis	Infection Inflammation/Immunology
Tylvalosin (Acetylisovaleryltylosin) tartrate is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin tartrate is an antiviral agent useful in studying PRRSV infection. Tylvalosin tartrate induces apoptosis. Tylvalosin tartrate also has anti-inflammatory activity, relieves oxidative stress, and alleviates acute lung injury by inhibiting *NF-κB* activation .

HY-147561

ALPK1-IN-1	NF-κB	Infection Inflammation/Immunology
ALPK1-IN-1 (Compound A001) is a potent inhibitor of alpha-kinase 1 (ALPK1). ALPK1 is an intracytoplasmic serine threonine protein kinase that plays an important role in activating the innate immune response to bacteria via TRAF-interacting protein with forkhead-associated domain (TIFA) dependent proinflammatory NF-κB signaling .

HY-Y1832

o-Vanillin 3-Methoxysalicylaldehyde	Fungal	Infection Cancer
o-Vanillin (2-Vanillin) is a nature product, could be extracted from Vanilla planifolia, Pinus koraiensis fruit. o-Vanillin is a potent antifungal agent. o-Vanillin inhibits the growth of mycelia by disrupting the integrity of cell walls and cell membranes. o-Vanillin inhibits Doxorubicin (HY-15142A)- and 4-hydroperoxycyclophosphamide-induced NF-κB activation .

Cat. No.	Product Name	Type

HY-W016412

Coenzyme Q0

2 Publications Verification

CoQ0

Enzyme Substrates

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling .

Cat. No.	Product Name	Target	Research Area