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Results for "

SYK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Syk (60) 5-HT Receptor (5) Adrenergic Receptor (2) Akt (1) Apoptosis (13) Aurora Kinase (1) Autophagy (2) Btk (2) c-Kit (3) Endogenous Metabolite (2) ERK (3) FAK (2) FLT3 (10) GSK-3 (1) Histamine Receptor (1) Isotope-Labeled Compounds (1) JAK (6) LRRK2 (1) Mixed Lineage Kinase (2) NO Synthase (2) p38 MAPK (1) PAK (2) Phosphatase (1) PI3K (1) PKA (1) PKC (3) Pyk2 (2) RET (1) Small Interfering RNA (siRNA) (3) Src (6) STAT (1) VEGFR (3)
By Research Areas:	Cancer (39) Cardiovascular Disease (4) Endocrinology (3) Inflammation/Immunology (43) Metabolic Disease (2)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Syk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131341

Syk-IN-4	Syk	Inflammation/Immunology Cancer
Syk-IN-4 is a potent, selective and orally bioavailable *SYK* inhibitor with an IC₅₀ of 0.31 nM. SYK has emerged as a potential target for autoimmunity and hematological cancers .

HY-12657

Syk-IN-1 1 Publications Verification	Syk	Inflammation/Immunology
Syk-IN-1 (compound 4) is a potent *Syk* inhibitor, with an IC₅₀ of 35 nM .

HY-112390A

Syk Inhibitor II 2 Publications Verification	Syk 5-HT Receptor	Inflammation/Immunology
Syk Inhibitor II is a potent, high selective and ATP-competitive *Syk* inhibitor with an IC₅₀ of 41 nM. Syk Inhibitor II inhibits 5-HT release from RBL-cells with an IC₅₀ of 460 nM. Syk Inhibitor II shows less potent against other kinases and has anti-allergic effect .

HY-120533

Syk-IN-11	Syk	Inflammation/Immunology
Syk-IN-11 (BIIB-057) is a selective *Syk* inhibitor with an IC₅₀ Of 13 nM. Syk-IN-11 can be used in the study of arthritis and chronic lymphocytic leukemia .

HY-149895

Syk-IN-7	Syk	Cancer
Syk-IN-7 (compound 17) is an inhibitor of spleen tyrosine kinase (SYK) .

HY-145029

SYK/JAK-IN-1	Syk JAK	Inflammation/Immunology Cancer
SYK/JAK-IN-1 is dual *SYK/JAK* inhibitor with IC₅₀s of <5 nM for SYK and JAK2, respectively .

HY-112390

Syk Inhibitor II dihydrochloride	5-HT Receptor Syk	Inflammation/Immunology
Syk Inhibitor II dihydrochloride is a potent, high selective and ATP-competitive *Syk* inhibitor with an IC₅₀ of 41 nM. Syk Inhibitor II dihydrochloride inhibits 5-HT release from RBL-cells with an IC₅₀ of 460 nM. Syk Inhibitor II dihydrochloride shows less potent against other kinases and has anti-allergic effect .

HY-112390C

Syk Inhibitor II hydrochloride	5-HT Receptor Syk	Inflammation/Immunology
Syk Inhibitor II hydrochloride is a potent, high selective and ATP-competitive *Syk* inhibitor with an IC₅₀ of 41 nM. Syk Inhibitor II hydrochloride inhibits 5-HT release from RBL-cells with an IC₅₀ of 460 nM. Syk Inhibitor II hydrochloride shows less potent against other kinases and has anti-allergic effect .

HY-P2505

Syk Kinase Peptide Substrate	Syk	Others
Syk Kinase Peptide Substrate is a Syk kinase peptide substrate.

HY-155513

Syk-IN-8	Syk	Cancer
Syk-IN-8 (compound 19q) is a Syk inhibitor, with antiproliferative activity against multiple hematological tumour cells. Syk-IN-8 inhibits PLCγ2 phosphorylation, can be used for research in blood cancers .

HY-151634

Syk-IN-6	Syk STAT ERK	Cancer
Syk-IN-6 is an inhibitor of the lipid-SH2 domain interaction, control the cellular activity of kinases containing SH2 domain. Syk-IN-6 blocks *Syk* kinase activity, which associated hematopoietic malignancies, including acute myeloid leukemia (AML) .

HY-112390B

Syk Inhibitor II dihydrochloride dihydrate	Syk 5-HT Receptor	Inflammation/Immunology
Syk Inhibitor II dihydrochloride dihydrate is a potent, high selective and ATP-competitive *Syk* inhibitor with an IC₅₀ of 41 nM. Syk Inhibitor II dihydrochloride dihydrate inhibits 5-HT release from RBL-cells with an IC₅₀ of 460 nM. Syk Inhibitor II dihydrochloride dihydrate shows less potent against other kinases and has anti-allergic effect .

HY-130680

Syk-IN-3	Syk	Cancer
Syk-IN-3, a potent spleen tyrosine kinase (Syk) inhibitor, extracted from patent WO2011075515A1, compound example 152, has an IC₅₀ of 1 nM .

HY-P2504

Syk Kinase Peptide Substrate, Biotin labeled	Syk	Others
Syk Kinase Peptide Substrate, Biotin labeled is a biotin-labled Syk kinase peptide substrate.

HY-RS14075

SYK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SYK Human Pre-designed siRNA Set A contains three designed siRNAs for SYK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SYK Human Pre-designed siRNA Set A SYK Human Pre-designed siRNA Set A

HY-RS14076

Syk Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Syk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Syk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Syk Mouse Pre-designed siRNA Set A Syk Mouse Pre-designed siRNA Set A

HY-RS14077

Syk Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Syk Rat Pre-designed siRNA Set A contains three designed siRNAs for Syk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Syk Rat Pre-designed siRNA Set A Syk Rat Pre-designed siRNA Set A

HY-15323

PRT062607 Hydrochloride 3 Publications Verification P505-15 Hydrochloride	Syk Mixed Lineage Kinase PAK Pyk2 FAK Apoptosis Src	Cancer
PRT062607 (P505-15) Hydrochloride is an orally available *Syk* inhibitor (IC₅₀: 1 nM) that inhibits inflammation and induction Apoptosis. PRT062607 Hydrochloride exerts potent antitumor activity in tumor xenograft mouse models .

HY-15324

PRT062607 acetate 3 Publications Verification P505-15 acetate; PRT-2607 acetate; BIIB-057 acetate	Syk Src Mixed Lineage Kinase PAK Pyk2 FAK Apoptosis	Cancer
PRT062607 (P505-15) acetate is an orally available *Syk* inhibitor (IC₅₀: 1 nM) that inhibits inflammation and induction Apoptosis. PRT062607 acetate exerts potent antitumor activity in tumor xenograft mouse models . .

HY-15999A

Cerdulatinib hydrochloride 5 Publications Verification PRT062070 hydrochloride; PRT2070 hydrochloride	Syk JAK	Cancer
Cerdulatinib hydrochloride (PRT062070) is a selective, oral active and reversible ATP-competitive inhibitor of dual *SYK* and JAK, with IC₅₀s of 32 nM, 0.5 nM, 12 nM, 6 nM and 8 nM for *SYK* and Tyk2, JAK1, 2, 3, respectively. Cerdulatinib hydrochloride could be used to research autoimmune disease and B-cell malignancies .

HY-145598

Sovleplenib HMPL-523	Syk	Cancer
Sovleplenib (HMPL-523) is a highly potent, orally available and selective *SYK* inhibitor with an IC₅₀ of 25 nM. Anti-tumor activity. Sovleplenib can be used for the research of immune thrombocytopenia (ITP) .

HY-100867A

Mivavotinib monohydrochloride TAK-659 monohydrochloride; CB-659 monohydrochloride	Syk FLT3	Cancer
TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC₅₀ of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL) .

HY-112386

OXSI-2	Syk	Inflammation/Immunology
OXSI-2 is a bioavailable, cell-permeable *Syk* inhibitor with an EC₅₀ of 313 nM and an IC₅₀ of 14 nM .

HY-100338

CNX-500	Btk	Cancer
CNX-500 is a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin. CNX-500 retains inhibitory activity against Btk (IC₅₀ of 0.5 nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn .

HY-13518

Piceatannol 15+ Cited Publications Astringenin; trans-Piceatannol	Syk Autophagy Apoptosis Endogenous Metabolite	Cancer
Piceatannol is a well-known *Syk* inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI) . Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties . Piceatannol induces apoptosis in DLBCL cell lines . Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells .

HY-13518R

Piceatannol (Standard)	Syk Autophagy Apoptosis Endogenous Metabolite	Cancer
Piceatannol (Standard) is the analytical standard of Piceatannol. This product is intended for research and analytical applications. Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI) . Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties . Piceatannol induces apoptosis in DLBCL cell lines . Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells .

HY-162427

NMS-0963	Syk	Endocrinology
NMS-0963 (compound 1) is an inhibitor of spleen tyrosine kinase (SYK) with an oral activity and IC₅₀ value of 3 nM. NMS-0963 inhibits BaF3-TEL/SYK cell line proliferative at 27 nM .

HY-15999

Cerdulatinib 5 Publications Verification PRT062070; PRT2070	JAK Syk	Cancer
Cerdulatinib (PRT062070) is a selective Tyk2 inhibitor with an IC₅₀ of 0.5 nM. Cerdulatinib (PRT062070) also is a dual JAK and *SYK* inhibitor with IC₅₀s of 12, 6, 8 and 32 for JAK1, 2, 3 and SYK, respectively.

HY-136198

SRX3207	Syk PI3K	Cancer
SRX3207 is an orally active and first-in-class dual *Syk/PI3K* inhibitor, with IC₅₀ values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression .

HY-15322

PRT062607 3 Publications Verification P505-15; PRT-2607; BIIB-057	Syk	Inflammation/Immunology
PRT062607(P505-15; PRT-2607; BIIB-057) is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM; >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.

HY-16420

R112	Syk	Inflammation/Immunology
R112 is a fast and reversible inhibitor of spleen tyrosine kinase (Syk) kinase. R112 inhibits Syk kinase activity with an IC₅₀ value of 226 nM and a Ki value of 96 nM. R112 inhibits IgE-FcεRI signaling pathway. R112 can be used for the research of allergic rhinitis .

HY-15968

Entospletinib 5+ Cited Publications GS-9973	Syk	Cancer
Entospletinib (GS-9973) is an orally bioavailable, selective *Syk* inhibitor with an IC₅₀ of 7.7 nM.

HY-138961

ER-27319	Syk	Inflammation/Immunology
ER-27319, an acridone derivative, is a potent and selective *SYK* inhibitor, and inhibits the tyrosine phosphorylation of *SYK* and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC₅₀ of 10 μM and can be used for study in allergic diseases .

HY-16902

RO9021	Syk	Inflammation/Immunology
RO9021 is an orally bioavailable, novel ATP-competitive inhibitor of *SYK, with an average IC₅₀* of 5.6 nM.

HY-12974

PRT-060318 1 Publications Verification PRT318	Syk	Cancer
PRT-060318 (PRT318) is a novel selective inhibitor of the tyrosine kinase *Syk* with an IC₅₀ of 4 nM.

HY-109091

Lanraplenib 2 Publications Verification GS-9876	Syk	Inflammation/Immunology
Lanraplenib (GS-9876) is a highly selective and orally active *SYK* inhibitor (IC₅₀=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib (GS-9876) inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans .

HY-109082A

Cevidoplenib dimesylate SKI-O-703 dimesylate	Syk	Inflammation/Immunology
Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities .

HY-109091B

Lanraplenib succinate 2 Publications Verification GS-9876 succinate	Syk	Inflammation/Immunology
Lanraplenib succinate (GS-9876 succinate) is a highly selective and orally active *SYK* inhibitor (IC₅₀=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib succinate (GS-9876 succinate) inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans .

HY-109091A

Lanraplenib monosuccinate GS-9876 monosuccinate	Syk	Inflammation/Immunology
Lanraplenib monosuccinate (GS-9876 monosuccinate) is a highly selective and orally active *SYK* inhibitor (IC₅₀=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib monosuccinate (GS-9876 monosuccinate) inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans .

HY-112319

MK-8457	Syk	Inflammation/Immunology
MK-8457 is a dual *SYK/ZAP70* inhibitor. MK-8457 can be used for research of rheumatoid arthritis .

HY-12067

R406 Maximum Cited Publications 28 Publications Verification	Syk FLT3 Apoptosis	Inflammation/Immunology Cancer
R406 is an orally available and competitive *Syk/FLT3* inhibitor for ATP binding with a K_i of 30 nM, potently inhibits Syk kinase activity in vitro with an IC₅₀ of 41 nM, measured at an ATP concentration corresponding to its K_m value. R406 reduces immune complex-mediated inflammation . R406 also inhibits Lyn (IC₅₀=63 nM) and Lck (IC₅₀=37 nM) .

HY-100867

Mivavotinib TAK-659; CB-659	Syk FLT3	Cancer
TAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC₅₀ of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL) .

HY-103018

Gusacitinib 1 Publications Verification ASN-002	JAK Syk	Inflammation/Immunology Cancer
Gusacitinib (ASN-002) is an orally active dual *SYK/JAK* kinase inhibitor with IC₅₀ values of 5, 46, 4, 11 and 8 nM for *SYK, JAK1, JAK2, JAK3* and TYK2, respectively. Gusacitinib rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma .

HY-103018A

Gusacitinib hydrochloride ASN-002 hydrochloride	JAK Syk	Inflammation/Immunology Cancer
Gusacitinib (ASN-002) hydrochloride is an orally active dual *SYK/JAK* kinase inhibitor with IC₅₀ values of 5, 46, 4, 11 and 8 nM for *SYK, JAK1, JAK2, JAK3* and TYK2, respectively. Gusacitinib hydrochloride rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib hydrochloride can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma .

HY-120214

TAS05567	Syk RET	Inflammation/Immunology
TAS05567 is a potent, highly selective, ATP-competitive and orally active *Syk* inhibitor with an IC₅₀ of 0.37 nM. In a panel of 192 kinases, TAS05567 only shows >70% inhibition of *Syk* and 4 other kinases (FLT3, JAK2, KDR and RET with IC₅₀s of 10 nM, 4.8 nM, 600 nM and 29 nM, respectively). TAS05567 can be used for humoral immune-mediated inflammatory conditions such as autoimmune and allergic diseases .

HY-76474A

BAY 61-3606 hydrochloride 5+ Cited Publications	Apoptosis Syk	Inflammation/Immunology Cancer
BAY 61-3606 hydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM . BAY 61-3606 hydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 hydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. BAY 61-3606 hydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.

HY-N7314

Asebogenin	Syk	Inflammation/Immunology
Asebogenin has antimalarial activity in vitro . Asebogenin can inhibit the phosphorylation of *Syk*, thereby effectively suppressing platelet activation and the formation of neutrophil extracellular traps .

HY-76474

BAY 61-3606	Syk Apoptosis	Inflammation/Immunology Cancer
BAY 61-3606 is an orally available, ATP-competitive, reversible and highly selective *Syk* inhibitor with a K_i of 7.5 nM and an IC₅₀ of 10 nM . BAY 61-3606 reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell . BAY 61-3606 induces a large decrease of Syk phosphorylation in K-rn cell lysates . Bay 61-3606 sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells .

HY-14985

BAY 61-3606 dihydrochloride 5+ Cited Publications	Syk Apoptosis	Inflammation/Immunology Cancer
BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective *Syk* inhibitor with a K_i of 7.5 nM an IC₅₀ of 10 nM . BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell . BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates . Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells .

HY-11108

R406 free base Maximum Cited Publications 28 Publications Verification	Syk FLT3 Apoptosis	Inflammation/Immunology Cancer
R406 free base is an orally available and competitive *Syk/FLT3* inhibitor for ATP binding with a K_i of 30 nM, potently inhibits Syk kinase activity in vitro with an IC₅₀ of 41 nM, measured at an ATP concentration corresponding to its K_m value. R406 free base reduces immune complex-mediated inflammation . R406 free base also inhibits Lyn (IC₅₀=63 nM) and Lck (IC₅₀=37 nM) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13518

Piceatannol 15+ Cited Publications Astringenin; trans-Piceatannol	Structural Classification Microorganisms Stilbenes Rheum palmatum L. Classification of Application Fields Polygonaceae Source classification Plants Disease Research Fields Cancer	Syk Autophagy Apoptosis Endogenous Metabolite
Piceatannol is a well-known *Syk* inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI) . Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties . Piceatannol induces apoptosis in DLBCL cell lines . Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells .

HY-N10182

Spinacetin	Phyllodium pulchellum (L.) Desv. Structural Classification Flavonols Flavonoids Source classification Plants Compositae	Histamine Receptor
Spinacetin is a natural product that can be isolated from Inula japonica. Spinacetin inhibits the release of histamine. Spinacetin has anti-inflammatory activity .

HY-N7675

Flavanomarein	Cardiovascular Disease Classification of Application Fields Cercis chinensis Bunge Source classification Metabolic Disease Plants Compositae Flavonoids other families Flavonones Phenols Polyphenols Disease Research Fields	Others
Flavanomarein is a predominant flavonoid of Coreopsis tinctoria Nutt with protective effects against diabetic nephropathy. Flavanomarein has good antioxidative, antidiabetic, antihypertensive and anti-hyperlipidemic activities .

HY-13518R

Piceatannol (Standard)	Structural Classification Microorganisms Stilbenes Rheum palmatum L. Polygonaceae Source classification Plants	Syk Autophagy Apoptosis Endogenous Metabolite
Piceatannol (Standard) is the analytical standard of Piceatannol. This product is intended for research and analytical applications. Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI) . Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties . Piceatannol induces apoptosis in DLBCL cell lines . Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells .

HY-N7314

Asebogenin	Structural Classification Populus balsamifera L. Source classification Phenols Polyphenols Plants Salicaceae	Syk
Asebogenin has antimalarial activity in vitro . Asebogenin can inhibit the phosphorylation of *Syk*, thereby effectively suppressing platelet activation and the formation of neutrophil extracellular traps .

HY-N3702

Dehydroabietinol	Structural Classification Terpenoids Verbenaceae Callicarpa bodinieri Levl. Source classification Diterpenoids Plants	Syk
Dehydroabietinol is an abietane diterpenoid. Dehydroabietinol has kinase inhibition activity for spleen tyrosine kinase (SYK) with an IC₅₀ value of 46.4 μM. Dehydroabietinol can be used for the research of immune-mediated disease .

HY-N7675A

(2R)-Flavanomarein	Structural Classification Flavonoids Cercis chinensis Bunge Flavonones Source classification Plants Compositae	Others
(2R)-Flavanomarein is a predominant flavonoid of Coreopsis tinctoria Nutt with protective effects against diabetic nephropathy. (2R)-Flavanomarein has good antioxidative, antidiabetic, antihypertensive and anti-hyperlipidemic activities .

Species:	Human (4)
Tag:	His (2) Tag Free (1) Avi (1) GST (1)
Source:	Sf9 insect cells (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P702728

	SYK Protein, Human (Biotinylated, sf9, Avi) SYK; spleen tyrosine kinase; tyrosine-protein kinase SYK; p72-SYK; FLJ25043; FLJ37489; DKFZp313N1010	Human	Sf9 insect cells
	SYK protein is a non-receptor tyrosine kinase that mediates signal transduction across different receptors, including B-cell receptors (BCR), affecting innate and adaptive immunity, cell adhesion, and osteoclast maturation , platelet activation and vascular development. SYK forms complexes with activated receptors, phosphorylates downstream effectors, and is critical in BCR and T cell receptor signaling. SYK Protein, Human (Biotinylated, sf9, Avi) is the recombinant human-derived SYK, expressed by Sf9 insect cells , with N-Avi labeled tag. ,

HY-P701638

	SYK Protein, Human (Sf9) SYK; Tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-SYK	Human	Sf9 insect cells
	SYK protein is a non-receptor tyrosine kinase that mediates signal transduction across different receptors, including B-cell receptors (BCR), affecting innate and adaptive immunity, cell adhesion, and osteoclast maturation , platelet activation and vascular development. SYK forms complexes with activated receptors, phosphorylates downstream effectors, and is critical in BCR and T cell receptor signaling. SYK Protein, Human (Sf9) is the recombinant human-derived SYK protein, expressed by Sf9 insect cells , with tag free. The total length of SYK Protein, Human (Sf9) is 280 a.a., .

HY-P701637

	SYK Protein, Human (Sf9, His) SYK; Tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-SYK	Human	Sf9 insect cells
	SYK protein is a non-receptor tyrosine kinase that mediates signal transduction across different receptors, including B-cell receptors (BCR), affecting innate and adaptive immunity, cell adhesion, and osteoclast maturation , platelet activation and vascular development. SYK forms complexes with activated receptors, phosphorylates downstream effectors, and is critical in BCR and T cell receptor signaling. SYK Protein, Human (Sf9, His) is the recombinant human-derived SYK protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of SYK Protein, Human (Sf9, His) is 280 a.a., .

HY-P702729

	ZAP70 Protein, Human (sf9, His, GST) ZAP70; zeta-chain (TCR) associated protein kinase 70kDa; SRK, zeta chain (TCR) associated protein kinase (70 kD); tyrosine-protein kinase ZAP-70; STD; ZAP 70; SYK-related tyrosine kinase; 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; zeta-chain associated protein kinase, 70kD; SRK; TZK; ZAP-70; FLJ17670; FLJ17679	Human	Sf9 insect cells
	ZAP70 Protein, Human (sf9, His, GST) is the recombinant human-derived ZAP70, expressed by Sf9 insect cells , with His, GST labeled tag. ,

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HY-10230S

Midostaurin-d5
Midostaurin-d₅ is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80937

	ZAP70 Antibody (YA651) ZAP70; SRK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; SYK-related tyrosine kinase	WB, IP	Human
	ZAP70 Antibody (YA651) is a non-conjugated and Mouse origined monoclonal antibody about 70 kDa, targeting to ZAP70 (4B2). It can be used for WB,IP assays with tag free, in the background of Human.

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Cat. No.	Product Name		Classification

HY-125387

TOP1210		Alkynes
TOP1210 is a narrow-spectrum tyrosine kinase inhibitor with potent inhibitory activity against P38α, Src, and Syk kinases. TOP1210 effectively reduced proinflammatory cytokines released by peripheral blood monocytes, primary macrophages, HT29 cells, inflammatory cells in ulcerative colitis (UC) biopsies, and myofibroblasts isolated from inflamed colonic UC mucosa. TOP1210 showed significant anti-inflammatory effects in cell experiments and UC biopsies, superior to some selective kinase inhibitors. The multi-kinase inhibition of TOP1210 provides the possibility of obtaining a wider range of therapeutic effects, especially in the regulation of autoimmune responses .

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