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Compound 48/80 (trimer) is a trimer of Compound 48/80 (HY-115768). Compound 48/80 is widely used in animal and tissue models as a "selective" mast cell activator .
UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13 nM .
Cu(II)GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3β. Cu(II)GTSM inhibits Amyloid-β oligomers (AβOs) and decreases tau phosphorylation. Cu(II)GTSM also decreases the abundance of Amyloid-β trimers. Cu(II)GTSM is a potential anticancer and antimicrobial agent .
PRL-IN-1 (compound 43) is a phosphatase of regenerating liver (PRL) inhibitor that directly binds the PRL1 trimer interface and obstructs PRL1 trimerization. PRL-IN-1 shows potent anticancer activities .
TRIM24/BRPF1-IN-2 (compound 20l) is a potent TRIM24/BRPF1 dual inhibitor, with IC50 values of 0.98 and 1.16 μM, respectively. TRIM24/BRPF1-IN-2 shows TRIM24/BRPF1 bromodomain binding affinity. TRIM24/BRPF1-IN-2 can be used for prostate cancer research .
IACS-9571 (trifluoroacetate) is a potent and selective inhibitor of TRIM24 and BRPF1, with IC50 of 8 nM for TRIM24, and Kd of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.
IACS-9571 is a potent and selective inhibitor of TRIM24 and BRPF1, with IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.
IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively .
BRPF1B/TRIM24-IN-1 (compound 34) is a potent TRIM24/BRPF1/BRPF2 inhibitor, with IC50 values of 0.43, 0.34, 1.75 μM, respectively. BRPF1B/TRIM24-IN-1 binds the TRIM24 bromodomain with a KD of 222 nM and has a KD for the BRPF1 bromodomain of 137 nM and for BRD1 of 1130 nM .
2-2(t) aptamer sodium is a 42-nucleotide trimeric complex of aptamer (2-2) targeting ErbB-2. 2-2(t) aptamer sodium inhibits the growth of gastric cancer cells in vitro and in vivo .
TRIM10 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM11 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM13 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM14 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM15 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM16 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM16 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM2 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM21 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM21 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM22 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM22 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM23 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM23 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM24 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM24 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM25 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM25 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM26 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM26 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM27 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM27 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM28 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM28 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM29 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM29 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM3 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM31 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM31 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM32 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM32 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM33 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM33 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM35 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM35 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM36 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM36 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM37 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM37 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM38 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM38 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM39 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM39 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM4 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM40 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM40 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM41 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM41 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM43 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM43 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM44 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM44 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM45 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM45 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM46 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM46 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM47 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM47 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM48 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM48 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM5 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM52 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM52 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM54 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM54 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM55 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM55 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM56 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM56 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM58 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM58 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM59 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM59 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM6 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM60 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM60 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM62 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM62 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM63 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM63 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM64 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM64 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM65 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM65 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM66 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM66 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM67 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM67 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM69 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM69 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM7 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM71 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM71 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM72 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM72 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM8 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM9 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects .
TNF-α-IN-2 is a potent and orally active inhibitor of tumor necrosis factor alpha (TNFα), with an IC50 of 25 nM in the HTRF assay. TNF-α-IN-2 distorts the TNFα trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-α-IN-2 can be used for the research of rheumatoid arthritis .
N6F11 is a selective ferroptosis inducer, and can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. N6F11 initiates HMGB1-dependent antitumor immunity mediated by CD8 + T cells .
Gnetifolin E is a resveratrol trimer derivative that can be isolated from Gnetum brunonianum. Gnetifolin E has anti-inflammatory activity, and inhibits TNF-α .
BRD5529 is an effective dose-dependent CARD9-TRIM62 protein–protein interaction (PPI) inhibitor with an IC50 value of 8.6 μM. BRD5529 has potency and complete inhibition of CARD9 ubiquitinylation in vitro, also has favorable solubility. BRD5529 can be used for the research of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC) .
PCNA-I1 is a potent PCNA (proliferating cell nuclear antigen) inhibitor. PCNA-I1 directly binds PCNA trimers with a Kd of 0.41 μM and exhibits antitumor activity both in vitro and in vivo .
AB-729 sodium is a siRNA specifically designed to inhibit viral replication and reduces HBV antigens . AB-729 conjugates to a trimer of N-acetylgalactosamine (GalNAc) ligand that promotes uptake into hepatocytes via the asialoglycoprotein receptor (ASGR).
SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .
SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .
SB24011 is a STING-TRIM29 interaction inhibitor with a IC50 value of 3.85 μM. SB24011 enhances STING immunity by upregating STING protein levels, thereby enhancing the immunotherapy effect of STING agonists and anti-PD-1 antibodies through systemic anticancer immunity .
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC50s of 5.9 μM and 12.1 μM, respectively .
5M038 is an inhibitor of HIV envelope-mediated fusion with potent inhibitory activity against gp41-mediated membrane fusion. 5M038 prevents the formation of the gp41 post-fusion conformation and inhibits envelope-mediated membrane fusion in cell-cell fusion and viral infectivity assays. 5M038 has shown broad fusion inhibition in tests against multiple HIV-1 subtypes, including M and T strains. 5M038 targets a highly conserved hydrophobic pocket and binds to the gp41 trimer, thereby exerting its inhibitory effect .
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC50s of 5.9 μM and 12.1 μM, respectively .
Gnetifolin E is a resveratrol trimer derivative that can be isolated from Gnetum brunonianum. Gnetifolin E has anti-inflammatory activity, and inhibits TNF-α .
SARS-CoV-2 S1 Protein, in its Spike protein S1 form, initiates infection by attaching the virion to the cell membrane through host receptor interaction. Simultaneously, Spike protein S2' acts as a viral fusion peptide, revealing itself after S2 cleavage during virus endocytosis. SARS-COV-2 S Trimer Protein (HEK293, Fc) is the recombinant Virus-derived SARS-COV-2 S Trimer protein, expressed by HEK293 , with C-hFc labeled tag.
AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1). AITRL/TNFSF18 Trimer Protein, Human (HEK293, His-Flag) is a recombinant human AITRL (Q72-S199) trimer with N-terminal His and Flag tag, which is expressed in HEK293.
SARS-CoV-2 S1 Protein, in its Spike protein S1 form, initiates infection by attaching the virion to the cell membrane through host receptor interaction. Simultaneously, Spike protein S2' acts as a viral fusion peptide, revealing itself after S2 cleavage during virus endocytosis. SARS-CoV-2 S Trimer Protein (Biotinylated, HEK293, His-Avi) is the recombinant Virus-derived SARS-CoV-2 S Trimer protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1). AITRL/TNFSF18 Protein, Human (Biotinylated, HEK293, His-Flag) is a recombinant biotinylated human AITRL (Q72-S199) with N-terminal His and Flag tag, which is expressed in HEK293.
B Cell Maturation Antigen (BCMA) also referred to as TNFRSF17 or CD269, is a transmembrane glycoprotein member of the tumor necrosis factor receptor (TNFR) superfamily. BCMA is used as a biomarker for Multiple myeloma (MM). BCMA mainly plays an important role in B cells for their proliferation, survival and also differentiates them into plasma cells. BCMA/TNFRSF17 Trimer Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant protein with a C-Terminal Avi label and a C-Terminal His label, It consists of 54 amino acids (M1-A54) and is produced in HEK293 cells.
The SARS-Cov-2 S glycoprotein is a SARS-Cov-2 S glycoprotein. The amino acid sequence 1261-1267a.a of the SARS-Cov-2 S glycoprotein is transmembrane. The SARS-Cov-2 S glycoprotein is a highly glycosylated trimer, each of which consists of 1260 amino acids (residues 14-1273), divided into four structural domains: the n-terminal domain (NTD), the c-terminal domain (CTD, also known as the receptor-binding domain, RBD), and two subdomains (SD1 and SD2). SARS-COV-2 S trimer Protein (XBB.1.16, HEK293, His) is the recombinant virus-derived SARS-COV-2 S trimer, expressed by HEK293 , with C-His labeled tag. ,
SARS-CoV-2 S1 Protein, in its Spike protein S1 form, initiates infection by attaching the virion to the cell membrane through host receptor interaction. Simultaneously, Spike protein S2' acts as a viral fusion peptide, revealing itself after S2 cleavage during virus endocytosis. SARS-COV-2 S Trimer Protein (HEK293, His-Avi) is the recombinant Virus-derived SARS-COV-2 S Trimer protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
B Cell Maturation Antigen (BCMA) also referred to as TNFRSF17 or CD269, is a transmembrane glycoprotein member of the tumor necrosis factor receptor (TNFR) superfamily. BCMA is used as a biomarker for Multiple myeloma (MM). BCMA mainly plays an important role in B cells for their proliferation, survival and also differentiates them into plasma cells. BCMA/TNFRSF17 Trimer Protein, Human (HEK293, His-Avi) is a recombinant protein with a C-Terminal Avi label and a C-Terminal His label, It consists of 54 amino acids (M1-A54) and is produced in HEK293 cells.
LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type . LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNγ, triggering tumor apoptosis signal . LIGHT/TNFSF14 is also involved in the dominant LTβR-NIK-p52 NF-κB pathway promoting the expression of inflammatory gene. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection. Human LIGHT/TNFSF14 Protein has 240 amino acids and a transmembrane domain (38-58 a.a.). LIGHT/TNFSF14 Trimer Protein, Human (HEK293, His-Flag) is the extracellular part (S89-V240) of human LIGHT/TNFSF14 Protein, produced by HEK293 cells, with N-terminal His- and Flag-tag.
SARS-CoV-2 S1 Protein, in its Spike protein S1 form, initiates infection by attaching the virion to the cell membrane through host receptor interaction. Simultaneously, Spike protein S2' acts as a viral fusion peptide, revealing itself after S2 cleavage during virus endocytosis. SARS-COV-2 S Trimer Protein (D614G, HEK293, His-Avi) is the recombinant Virus-derived SARS-COV-2 S Trimer protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
As a ligand of CD27, CD70 protein is an indispensable part of T cell immune coordination and is of particular importance in antiviral responses. The CD70-CD27 pathway emerged as a key player that contributes to the generation and maintenance of T cell-mediated immune responses. FITC-Labeled CD70 Trimer Protein, Human (HEK293, His-Flag) is the recombinant human-derived FITC-Labeled CD70 Trimer protein, expressed by HEK293 , with His labeled tag. The total length of FITC-Labeled CD70 Trimer Protein, Human (HEK293, His-Flag) is 142 a.a., with molecular weight (glycosylation form) of 50-55 kDa.
The TL1A protein (VEGI protein), belongs to the tumor necrosis factor (TNF) family and is a receptor for TNFRSF25 and TNFRSF6B. TL1A is involved in the activation of NF-κB and C-Jun pathways, which can be used as a regulator of mucosal immunity and participate in the immune pathway of inflammatory bowel disease (IBD) pathogenesis. TL1A originates from endothelial cells and inhibits the proliferation of breast cancer, epithelial and myeloid tumor cells. The human TL1A protein has a transmembrane domain (36-56 a.a.) that can be cleaved into membrane-type and soluble peptide fragments. TL1A/TNFSF15 Trimer Protein, Human (HEK293, His-Flag) is the extracullar part of TL1A protein (D91-L251), produced in HEK293 cells with N-terminal His- and Flag-tag.
4-1BBL (4-1BB ligand) is a type II membrane protein of the TNF superfamily, is expressed on antigen-presenting cells. 4-1BB with 4-1BBL can induce T-cell expansion, cytokine induction, differentiation, and upregulation of anti-apoptotic genes as well as protect T cells from activation-induced cell death (AICD). 4-1BBL stimulates T cell proliferation and induces effective anti-tumor immune responses. 4-1BBL is an immunostimulant molecule that interacts with the 4-1BB high-affinity receptor during the antigen presentation, providing costimulatory signals to both CD4+ and CD8+ T cells through the activation of NF-kB, c-Jun, and p38 downstream pathways, triggering pleiotropic effects on the immune system. 4-1BBL/TNFSF9 Trimer Protein, Human (Biotinylated, HEK293, Fc) is a biotinylated recombinant protein with a N-Terminal Fc label, It consists of 184 amino acids (R71-E254) and is produced in HEK293 cells.
CD70 is the ligand of CD27 in activated T and B lymphocytes, is an important cytokine in CD70-CD27 pathway involving with the generation and maintenance of T cell immunity. CD70 is a surface antigen, also shows antiviral activity and regulates viability of tumor cells and regulatory T cells. As for CD70 protein in human contains transmembrane domain and transmembrane helix, belonging to the tumor necrosis factor (TNF) family. CD70 Trimer Protein, Human (Biotinylated, HEK293, His) is a biotinylated CD70 protein trimeric complex, is expressed in the HEK293 cells, with a N terminal His-tag.
APRIL protein (CD256) is a ligand in the tumor necrosis factor (TNF) family that can induce proliferation, regulate tumor cell growth, and may participate in mononuclear/macrophage-mediated immune process. APRIL protein is produced by myeloid cells and their precursors to accelerate cell maturation and peripheral rupture. APRIL protein has been widely used in the study of lymphatic malignancies. APRIL protein is a type II membrane protein with cytoplasmic domain, hydrophobic transmembrane domain and extracellular domain. APRIL/TNFSF13 Trimer Protein, Cynomolgus (HEK293, His-Flag-Avi) is produced by HEK293 cells (K112-L250) with N-terminal His, Avi, and Flag tags.
The TL1A/TNFSF15 trimeric protein is an important member of the tumor necrosis factor family and is critical for immune regulation and cellular responses. Its study enhances our understanding of immune regulation, providing potential applications for immunoassay and therapeutic development. TL1A/TNFSF15 Trimer Protein, Cynomolgus/Rhesus macaque (HEK293, His) is the recombinant Rhesus Macaque, cynomolgus-derived TL1A/TNFSF15 Trimer protein, expressed by HEK293 , with N-His labeled tag. The total length of TL1A/TNFSF15 Trimer Protein, Cynomolgus/Rhesus macaque (HEK293, His) is 180 a.a., with molecular weight of 25-35 kDa.
APRIL/TNFSF13 is a TNF superfamily cytokine that affects tumor cell growth by binding to TNFRSF13B/TACI and TNFRSF17/BCMA receptors. Its homotrimeric structure highlights a potential role in oncogenic processes and immune functions involving monocytes and macrophages. APRIL/TNFSF13 Trimer Protein, Human (Biotinylated, HEK293, Flag, His-Avi) is the recombinant human-derived APRIL/TNFSF13 protein, expressed by HEK293 , with N-Flag, C-Avi, N-His labeled tag. The total length of APRIL/TNFSF13 Trimer Protein, Human (Biotinylated, HEK293, Flag, His-Avi) is 139 a.a., with molecular weight of 55-65 kDa.
BAFF/TNFSF13B protein is a member of the TNF family and regulates immune responses and cell survival. It is also known as B cell activating factor, which plays a vital role in the development, activation and survival of B cells by binding to receptors such as BAFF-R. BAFF/TNFSF13B Trimer Protein, Cynomolgus (HEK293, His-Avi) is the recombinant cynomolgus-derived BAFF/TNFSF13B protein, expressed by HEK293 , with N-His, N-Avi labeled tag.
BAFF/TNFSF13B protein is a cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA, forming a key ligand-receptor pathway together with TNFSF13/APRIL. These interactions play a crucial role in stimulating B-cell and T-cell function and regulating humoral immunity. BAFF/TNFSF13B Trimer Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived BAFF/TNFSF13B protein, expressed by HEK293 , with N-His, N-Avi labeled tag.
OX40 Ligand (TNFSF4) is a type II glycoprotein with a cytoplasmic tail of 23 aa and an extracellular domain of 133 aa. OX40 Ligand is a ligand for TNFRSF4 (CD134), belongs to tumor necrosis factor (TNF) family. OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40 Ligand/TNFSF4 Trimer Protein, Human (HEK293, His-Flag) is a recombinant human OX40 Ligand (Q51-L183) with N-terminal His and Flag tag, which is produced in HEK293.
CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5, acts function by generating a costimulatory signal that up-regulates IL-4 synthesis. CD40L is specifically expressed on activated CD4+ T-lymphocytes and involves in activation of NF-κB/MAPK pathway. CD40L also involves in B cell differentiation, maturation, and apoptosis. CD40L in mouse, cleaved into 2 chains of membrane form (1-260 a.a.) and soluble form (112-260 a.a.) which serves as a ligand for integrins (ITGA5:ITGB1 and ITGAV:ITGB3). CD40L/CD154/TRAP Trimer Protein, Mouse (HEK293, Fc) has a total length of 149 amino acids (M112-L260), is expressed in HEK392 cells with N-terminal hFc-tag.
CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5, acts function by generating a costimulatory signal that up-regulates IL-4 synthesis. CD40L is specifically expressed on activated CD4+ T-lymphocytes and involves in activation of NF-κB/MAPK pathway. CD40L also involves in B cell differentiation, maturation, and apoptosis. CD40L in human, cleaved into 2 chains of membrane form (1-261 a.a.) and soluble form (113-261 a.a.) which serves as a ligand for integrins (ITGA5:ITGB1 and ITGAV:ITGB3). CD40L/CD154/TRAP Trimer Protein, Human (HEK293, His-Flag) is composed of a full-length monomer of 149 amino acids (M113-L261), is expressed in HEK392 cells with N-terminal His- and Flag-tag.
APRIL protein (CD256) is a ligand in the tumor necrosis factor (TNF) family that can induce proliferation, regulate tumor cell growth, and may participate in mononuclear/macrophage-mediated immune process. APRIL protein is produced by myeloid cells and their precursors to accelerate cell maturation and peripheral rupture. APRIL protein has been widely used in the study of lymphatic malignancies. Human APRIL protein is a type II membrane protein with cytoplasmic domain, hydrophobic transmembrane domain and extracellular domain. APRIL/TNFSF13 Protein, Human (HEK293, Flag-His) is produced by HEK293 cells (K112-L250) with N-terminal His- and Flag-tags.
2-2(t) aptamer sodium is a 42-nucleotide trimeric complex of aptamer (2-2) targeting ErbB-2. 2-2(t) aptamer sodium inhibits the growth of gastric cancer cells in vitro and in vivo .
TRIM10 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM11 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM13 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM14 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM15 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM16 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM16 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM2 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM21 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM21 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM22 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM22 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM23 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM23 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM24 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM24 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM25 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM25 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM26 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM26 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM27 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM27 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM28 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM28 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM29 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM29 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM3 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM31 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM31 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM32 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM32 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM33 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM33 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM35 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM35 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM36 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM36 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM37 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM37 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM38 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM38 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM39 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM39 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM4 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM40 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM40 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM41 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM41 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM43 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM43 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM44 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM44 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM45 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM45 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM46 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM46 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM47 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM47 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM48 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM48 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM5 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM52 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM52 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM54 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM54 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM55 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM55 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM56 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM56 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM58 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM58 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM59 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM59 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM6 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM60 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM60 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM62 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM62 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM63 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM63 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM64 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM64 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM65 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM65 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM66 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM66 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM67 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM67 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM69 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM69 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM7 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM71 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM71 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM72 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM72 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM8 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TRIM9 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
AB-729 sodium is a siRNA specifically designed to inhibit viral replication and reduces HBV antigens . AB-729 conjugates to a trimer of N-acetylgalactosamine (GalNAc) ligand that promotes uptake into hepatocytes via the asialoglycoprotein receptor (ASGR).
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