Search Result

Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

Virus Protease

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dengue Virus (11) HCV Protease (18) HIV Protease (15) Influenza Virus (2) Ser/Thr Protease (2) Virus Protease (30) Apoptosis (4) Aurora Kinase (4) Bacterial (4) Ceramidase (2) Cytochrome P450 (2) DNA/RNA Synthesis (4) EBV (3) Endogenous Metabolite (1) FAAH (2) Flavivirus (10) Glucocorticoid Receptor (2) Glutathione Peroxidase (2) HCV (12) HIV (10) HSV (5) Indoleamine 2,3-Dioxygenase (IDO) (4) Isotope-Labeled Compounds (1) mAChR (4) Nucleoside Antimetabolite/Analog (2) Parasite (4) Proteasome (1) SARS-CoV (22) TRP Channel (1)
By Research Areas:	Cancer (12) Infection (81) Inflammation/Immunology (17) Metabolic Disease (4) Neurological Disease (4)

By Targets:

Dengue Virus (11)

HCV Protease (18)

HIV Protease (15)

Influenza Virus (2)

Ser/Thr Protease (2)

Virus Protease (30)

Apoptosis (4)

Aurora Kinase (4)

Bacterial (4)

Ceramidase (2)

Cytochrome P450 (2)

DNA/RNA Synthesis (4)

EBV (3)

Endogenous Metabolite (1)

FAAH (2)

Flavivirus (10)

Glucocorticoid Receptor (2)

Glutathione Peroxidase (2)

HCV (12)

HIV (10)

HSV (5)

Indoleamine 2,3-Dioxygenase (IDO) (4)

Isotope-Labeled Compounds (1)

mAChR (4)

Nucleoside Antimetabolite/Analog (2)

Parasite (4)

Proteasome (1)

SARS-CoV (22)

TRP Channel (1)

By Research Areas:

Cancer (12)

Infection (81)

Inflammation/Immunology (17)

Metabolic Disease (4)

Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Virus Protease HCV Protease HIV Protease Protease Activated Receptor (PAR) Ser/Thr Protease Influenza Virus Dengue Virus ClpP Serpin Enteropeptidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108462

ML-SA1 3 Publications Verification	Dengue Virus TRP Channel Flavivirus	Infection
ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC₅₀ value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral .

HY-15256

Faldaprevir BI 201335	HCV Protease	Infection
Faldaprevir (BI 201335) is a potent, orally active and selective noncovalent inhibitor of NS3/4A protease of HCV (hepatitis C virus) genotypes 1a and 1b, with K_i values of 2.6 and 2.0 nM, respectively. Faldaprevir inhibits HCV RNA replication, with EC₅₀ values of 6.5 and 3.1 nM, respectively. Faldaprevir has potent antiviral activity against chronic HCV infection .

HY-144646

SP-471	Flavivirus Dengue Virus Virus Protease	Infection
SP-471 is a potent dengue virus (DENV) protease inhibitor with IC₅₀ value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV .

HY-P2502

*Hepatitis Virus* C NS3 Protease Inhibitor 2**	HCV Protease HCV	Infection
Hepatitis Virus C NS3 Protease Inhibitor 2 is a product-based peptide inhibitor of hepatitis C virus (HCV) NS3 protease, with a K_i of 41 nM .

HY-19232

R-87366	HIV Protease	Inflammation/Immunology
R-87366 is a water-soluble human immunodeficiency virus (HIV) protease inhibitor. R-87366 has potent inhibitory for HIV protease with a K_i value of 11 nM. R-87366 can be used for the research of anti-human immunodeficiency virus (HIV) .

HY-P4018

HIV Protease Substrate IV	HIV Protease	Infection
HIV Protease Substrate IV is a substrate of HIV protease. HIV Protease Substrate IV can be used to measure the activity of HIV (human immunodeficiency virus) -1 protease .

HY-148310

Flaviviruses-IN-2	Virus Protease	Infection
Flaviviruses-IN-2 (compound 78) is a potent flaviviruses inhibitor. Flaviviruses-IN-2 reduces the WNV (West Nile virus) *protease* activity, with inhibition of 56% .

HY-15256A

Faldaprevir sodium BI 201335 sodium	HCV Protease	Infection
Faldaprevir sodium is a potent, orally active and selective noncovalent inhibitor of NS3/4A protease of HCV (hepatitis C virus) genotypes 1a and 1b, with K_i values of 2.6 and 2.0 nM, respectively. Faldaprevir sodium inhibits HCV RNA replication, with EC₅₀ values of 6.5 and 3.1 nM, respectively. Faldaprevir sodium has potent antiviral activity against chronic HCV infection .

HY-153921

DEPN-8	Dengue Virus	Infection
DEPN-8 is a WNV protease substrate. DEPN-8 is used for dengue virus protease inhibitor development .

HY-P10871

cTEV6-2	Virus Protease	Infection
cTEV6-2 binds to the cysteine residue (C151) of tobacco etch virus protease (TEV protease), and covalently inhibits TEV protease with an IC₅₀ of 81.7 nM .

HY-19194

A-80987	HIV Protease	Infection
A-80987 is an inhibitor of human immunodeficiency virus type 1 (HIV-1) protease .

HY-129678

UK-88947 hydrochloride	HIV Protease HIV	Infection
UK-88947 hydrochloride is a protease inhibitor with activity in inhibiting the replication of human immunodeficiency virus HIV-1. UK-88947 hydrochloride can be added to cells before infection to block the early steps of HIV-1 replication. The use of UK-88947 hydrochloride shows its specific inhibitory effect on HIV-1. At the same time, when the virus infects cells, it inhibits the action of viral protease and affects the virus replication process .

HY-N5068

Isorhamnetin 7-O-α-L-rhamnoside	SARS-CoV	Infection
Isorhamnetin 7-O-α-L-rhamnoside shows binding affinity with COVID-19 virus main protease .

HY-I0179

ITMN 4077	HCV Protease	Infection
ITMN 4077 is a macrocyclic inhibitor against Hepatitis C Virus (HCV) NS3 protease (EC₅₀: 2131 nM) .

HY-P3794

Glu-Ala-Leu-Phe-Gln-pNA	Virus Protease	Infection
Glu-Ala-Leu-Phe-Gln-pNA is a Chiba virus 3C-like protease (CVP) substrate .

HY-169102

CHIKV nsP2 protease-IN-1	Virus Protease	Infection
CHIKV nsP2 protease-IN-1(compound J13) is an oral active non-structural protein 2 protease inhibitor with the EC₅₀ of 0.39 μM aganist of CHIKV S27. CHIKV nsP2 protease-IN-1 can be used for study of Chikungunya virus .

HY-P2054

Mvt-101	HIV Protease	Infection
Mvt-101 is a hexapeptide-based inhibitor of HIV-1 protease. Mvt-101 is also reduced-peptide-bond inhibitor. Mvt-101 inhibits reproduction of the HIV virus by blocking protease action .

HY-106920

Kynostatin 272 KNI 272; Kynostatin; NSC 651714	HIV Protease	Infection
Kynostatin 272 (KNI 272) is a potent HIV protease inhibitor. Kynostatin 272 inhibits the activity of the HIV protease by simulating the substrate transition state of the HIV protease, thus preventing a key step in the replication of the HIV virus. Kynostatin 272 provides an important research foundation for the development of drugs for HIV and AIDS .

HY-139794

SDZ283-910	HIV	Infection
SDZ283-910 is a potent *human immunodeficiency virus* type-1 (HIV-1)** protease inhibitor .

HY-P4773

HSV-1 Protease substrate	HSV	Infection
HSV-1 Protease substrate is a peptide substrate for HSV-1 (Herpes Simplex Virus Type 1) protease, and the specificity constant (k_cat/K_m) at pH 7.5 for cleavage is 5.2 M ^-1 s ^-1 .

HY-10243

Vaniprevir MK-7009	HCV HCV Protease	Infection
Vaniprevir (MK-7009) is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease.

HY-150549

HIV-1 protease-IN-6	HIV Protease HIV	Infection Inflammation/Immunology
HIV-1 protease-IN-6 (compound 17d) is a potent HIV-1 protease inhibitor, with an IC₅₀ of 21 pM and a K_i of 4.7 pM, respectively. HIV-1 protease-IN-6 exhibits potent antiviral activity to DRV (darunavir)-resistant variant, even more than wild type virus .

HY-B0689C

(threo)-Indinavir (threo)-MK-639; (threo)-L735524	HIV	Infection
(Threo)-Indinavir is a protease inhibitor that plays an important role in HIV/AIDS suppression. (Threo)-Indinavir is used as a component of highly active antiretroviral suppression. By inhibiting the viral protease, (threo)-Indinavir ((threo)-MK-639) is able to effectively block the replication of the HIV virus .

HY-153076

Flaviviruses-IN-3	Virus Protease	Infection
Flaviviruses-IN-3 (compound 87) is a potent flaviviruse inhibitor. Flaviviruses-IN-3 reduces the WNV (West Nile virus) protease activity, with a inhibition of 54% .

HY-149034

Influenza A virus-IN-8 S5	Influenza Virus	Infection Cancer
Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent *Influenza A Virus* (IAV)** inhibitor (with sufficient protease stability) with IC₅₀s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a K_d of 1.0 nM .

HY-169012

PSB-21110	SARS-CoV Virus Protease	Infection
PSB-21110 is an irreversible SARS-CoV-2 Mpro inhibitor with EC₅₀ value of 2.68 nM. PSB-21110 has antiviral activity .

HY-136575

4-Hydroxy-2-methylbenzenesulfonic acid ammonium	Virus Protease	Infection
4-Hydroxy-2-methylbenzenesulfonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC₅₀ of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC₅₀ of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability .

HY-136574

2-Hydroxy-4-methylbenzenesulphonic acid ammonium	Virus Protease	Infection
2-Hydroxy-4-methylbenzenesulphonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC₅₀ of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC₅₀ of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability .

HY-161762

RA-0002034	Virus Protease	Infection
RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with an IC₅₀ of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner .

HY-136573

5-Hydroxytoluene-2,4-disulphonic acid diammonium	Virus Protease	Infection
5-Hydroxytoluene-2,4-disulphonic acid diammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC₅₀ of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC₅₀ of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability .

HY-161762A

(E/Z)-RA-0002034	Influenza Virus	Cancer
(E/Z)-RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with IC50 of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner.

HY-P10608

KK4A peptide	HCV	Infection
KK4A peptide is a small peptide derived from nonstructural protein 4A (NS4A) of hepatitis C virus (HCV) that significantly increases the catalytic efficiency of NS3 protease. The KK4A peptide may be used to gain insights into the function and mechanism of the HCV NS3 protease, thereby advancing research into HCV infection .

HY-100212

JE-2147 AG1776; KNI-764	HIV HIV Protease	Infection
JE-2147 (AG1776) is a potent dipeptide protease inhibitor with a K_i of 0.33 nM for HIV-1 protease. JE-2147 has effective activities against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro .

HY-P5313A

Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr acetate	Dengue Virus	Infection
Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr acetate is a DEN protease substrate, which can be used in research related to dengue virus (drug development) .

HY-163318

NS2B/NS3-IN-8	Virus Protease	Infection
NS2B/NS3-IN-8 (compound MH1) is a Zika virus NS2B-NS3 protease inhibitor .

HY-122453

Palinavir	HIV Protease	Infection
Palinavir is a potent human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) *protease* inhibitor with an IC₅₀ of 0.5-30 nM . Palinavir has antiviral activity .

HY-P5313

Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr	Dengue Virus	Infection
Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr is a DEN protease substrate, which can be used in research related to dengue virus (drug development) .

HY-P4038

Hepatitis C Virus S5A/5B	HCV Protease	Infection
Hepatitis C Virus S5A/5B is a synthetic peptide substrate. Hepatitis C Virus S5A/5B mimics the NS5A/5B junction of the nonstructural protein (NS), served as the substrate for the study of HCV NS3 protease activity .

HY-136797

BP13944	Dengue Virus	Infection
BP13944 is a potential small molecule inhibitor discovered by high-throughput screening. It can effectively inhibit the expression of dengue virus (DENV) replicons with an EC50 value of 1.03±0.09 μM. BP13944 can inhibit the replication or viral RNA synthesis of all four serotypes of DENV, but is ineffective against Japanese encephalitis virus. BP13944 may target the DENV NS3 protease, and the E66G amino acid substitution in the NS3 protease region will cause the virus to become resistant to BP13944. BP13944 has no obvious cytotoxicity. As there is currently no effective dengue vaccine and treatment, BP13944, as an effective small molecule inhibitor, may become a potential agent for the treatment of dengue in the future.

HY-161352

NPI52	Virus Protease	Infection
NPI52 (Compound E1) is a foot-and-mouth disease virus 3C protease (FMDV 3Cpro) inhibitor, with IC₅₀ values of 0.05 and 0.11 µM in FRET and cell-based assay, respectively .

HY-B0182

Carmofur 3 Publications Verification HCFU	Nucleoside Antimetabolite/Analog SARS-CoV Virus Protease FAAH Ceramidase Glutathione Peroxidase	Infection Inflammation/Immunology Cancer
Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC₅₀ of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) .

HY-112254

ZINC03129319	Flavivirus Dengue Virus Virus Protease	Infection
ZINC03129319 is a dengue virus (DENV) NS2B-NS3 protease inhibitor extracted from patent US20150141521A1, has inhibition constants (K_i1) of 92 μM and K_i3 of 20 μM.

HY-169419

SARS-CoV-2-IN-108	SARS-CoV Virus Protease	Infection
SARS-CoV-2-IN-108 (Compound 29) is an inhibitor for SARSCoV-2 papain-like protease with an IC₅₀ of 0.14 µM. SARS-CoV-2-IN-108 inhibits the virus replication with an EC₅₀ of 0.21 µM .

HY-14434

Asunaprevir 35+ Cited Publications BMS-650032	HCV HCV Protease SARS-CoV	Infection
Asunaprevir (BMS-650032) is a potent and orally bioavailable hepatitis C virus (HCV) NS3 protease inhibitor, with IC₅₀ of 0.2 nM-3.5 nM . Asunaprevir inhibits SARS-CoV-2 3CL ^pro activity .

HY-B0182R

Carmofur (Standard)	Nucleoside Antimetabolite/Analog SARS-CoV Virus Protease FAAH Ceramidase Glutathione Peroxidase	Infection Inflammation/Immunology Cancer
Carmofur (Standard) is the analytical standard of Carmofur. This product is intended for research and analytical applications. Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC₅₀ of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) .

HY-144644

NS2B/NS3-IN-3	Virus Protease Flavivirus	Infection
NS2B/NS3-IN-3 (Compd 66) is an inhibitor of Flavivirus NS2B-NS3 protease .

HY-N2006

Ganoderic acid B	EBV HIV Protease	Infection Inflammation/Immunology
Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC₅₀: 170 μM) .

HY-138687

Nirmatrelvir Maximum Cited Publications 77 Publications Verification PF-07321332	SARS-CoV	Infection Inflammation/Immunology
Nirmatrelvir (PF-07321332) is a potent and orally active *SARS-CoV 3C-like protease* (3CL ^PRO)** inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research .

HY-P4209A

Boc-GRR-AMC TFA	Virus Protease	Others
Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .

HY-161371

VD5123	Ser/Thr Protease	Cancer
VD5123 is a serine protease inhibitor. VD5123 inhibits TMPRS2, HGFA, matriptase, hepsin with IC₅₀s of 15, 3980, 140, 37 nM respectively. VD5123 can be used for antiviral research, such as SARS-CoV-2 and broad panel of coronaviruses and influenza viruses .

Cat. No.	Product Name

HY-L147

Protease Inhibitor Library

702 compounds

A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the formation of new protein products. Proteases play important roles in regulating multiple biological processes in all living organisms, such as regulating the fate, localization, and activity of many proteins, modulating protein-protein interactions, creating new bioactive molecules, contributing to the processing of cellular information, and generating, transducing, and amplifying molecular signals.

Proteases are important targets in drug discovery. Some protease inhibitors are often used as anti-virus drugs and anti-cancer drugs. MCE offers a unique collection of 702 protease inhibitors. MCE Protease Inhibitor Library is critical for drug discovery and development.

Cat. No.	Product Name	Type

HY-B0961

Merbromin Mercury dibromofluorescein disodium salt; ZP1	Dyes
Merbromin is a mixed inhibitor of the 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2, with an IC₅₀ of 2.7 μM. Merbromin effectively inhibits the replication of the Zika virus (ZIKV) and shows anti-ZIKV activity by inhibiting ZIKVpro. Merbromin can also be used as a topical disinfectant for cuts and scrapes, and it serves as a biological dye .

Cat. No.	Product Name	Target	Research Area

HY-P5313A

Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr acetate	Dengue Virus	Infection
Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr acetate is a DEN protease substrate, which can be used in research related to dengue virus (drug development) .

HY-P2502

*Hepatitis Virus* C NS3 Protease Inhibitor 2**	HCV Protease HCV	Infection
Hepatitis Virus C NS3 Protease Inhibitor 2 is a product-based peptide inhibitor of hepatitis C virus (HCV) NS3 protease, with a K_i of 41 nM .

HY-P4018

HIV Protease Substrate IV	HIV Protease	Infection
HIV Protease Substrate IV is a substrate of HIV protease. HIV Protease Substrate IV can be used to measure the activity of HIV (human immunodeficiency virus) -1 protease .

HY-P10871

cTEV6-2	Virus Protease	Infection
cTEV6-2 binds to the cysteine residue (C151) of tobacco etch virus protease (TEV protease), and covalently inhibits TEV protease with an IC₅₀ of 81.7 nM .

HY-P3794

Glu-Ala-Leu-Phe-Gln-pNA	Virus Protease	Infection
Glu-Ala-Leu-Phe-Gln-pNA is a Chiba virus 3C-like protease (CVP) substrate .

HY-P2054

Mvt-101	HIV Protease	Infection
Mvt-101 is a hexapeptide-based inhibitor of HIV-1 protease. Mvt-101 is also reduced-peptide-bond inhibitor. Mvt-101 inhibits reproduction of the HIV virus by blocking protease action .

HY-P4773

HSV-1 Protease substrate	HSV	Infection
HSV-1 Protease substrate is a peptide substrate for HSV-1 (Herpes Simplex Virus Type 1) protease, and the specificity constant (k_cat/K_m) at pH 7.5 for cleavage is 5.2 M ^-1 s ^-1 .

HY-149034

Influenza A virus-IN-8 S5	Influenza Virus	Infection Cancer
Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent *Influenza A Virus* (IAV)** inhibitor (with sufficient protease stability) with IC₅₀s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a K_d of 1.0 nM .

HY-P10608

KK4A peptide	HCV	Infection
KK4A peptide is a small peptide derived from nonstructural protein 4A (NS4A) of hepatitis C virus (HCV) that significantly increases the catalytic efficiency of NS3 protease. The KK4A peptide may be used to gain insights into the function and mechanism of the HCV NS3 protease, thereby advancing research into HCV infection .

HY-P5313

Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr	Dengue Virus	Infection
Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr is a DEN protease substrate, which can be used in research related to dengue virus (drug development) .

HY-P4038

Hepatitis C Virus S5A/5B	HCV Protease	Infection
Hepatitis C Virus S5A/5B is a synthetic peptide substrate. Hepatitis C Virus S5A/5B mimics the NS5A/5B junction of the nonstructural protein (NS), served as the substrate for the study of HCV NS3 protease activity .

HY-P4209

Boc-GRR-AMC	Peptides	Others
Boc-GRR-AMC is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .

HY-P4209A

Boc-GRR-AMC TFA	Virus Protease	Others
Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .

HY-P5415

DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS	HIV	Others
DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a biological active peptide. (DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is also called HIV protease substrate I in some literature. It is widely used for the continuous assay for HIV protease activity. The 11-kD protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore a target for the design of selective acquired immunodeficiency syndrome (AIDS) therapeutics. The FRET-based fluorogenic substrate is derived from a natural processing site for HIV-1 PR. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that is linearly related to the extent of substrate hydrolysis. The fluorescence quantum yields of the HIV-1 PR substrate in the FRET assay increased by 40.0- and 34.4-fold, respectively, per mole of substrate cleaved. Because of its simplicity and precision in the determination of reaction rates required for kinetic analysis, this substrate offers many advantages over the commonly used HPLC or electrophoresis-based assays for peptide substrate hydrolysis by retroviral PRs. Abs/Em = 340nm/490nm.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2006

Ganoderic acid B	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields	EBV HIV Protease
Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC₅₀: 170 μM) .

HY-N1992

Theaflavin 3,3'-digallate 5 Publications Verification TF-3; ZP10	Infection Structural Classification Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae	Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (K_d=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N4155

2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid	Rosaceae Rosa cymosa (L.) Tratt. Plants	EBV HIV Protease HSV
2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of *Epstein-Barr virus* early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides**)-activated RAW 264.7 cells .

HY-N0110

Palmatine chloride Maximum Cited Publications 6 Publications Verification	Structural Classification Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Cancer	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N0110B

Palmatine hydroxide Maximum Cited Publications 6 Publications Verification	Alkaloids Phellodendron amurense Rupr. Other Alkaloids Source classification Rutaceae Plants	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N5068

Isorhamnetin 7-O-α-L-rhamnoside	Infection Flavonols Structural Classification Flavonoids Classification of Application Fields Elaeagnaceae Source classification Phenols Polyphenols Hippophae rhamnoides subsp. sinensis Rousi Plants Disease Research Fields	SARS-CoV
Isorhamnetin 7-O-α-L-rhamnoside shows binding affinity with COVID-19 virus main protease .

HY-N2006R

Ganoderic acid B (Standard)	Triterpenes Structural Classification Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants	EBV HIV Protease
Ganoderic acid B (Standard) is the analytical standard of Ganoderic acid B. This product is intended for research and analytical applications. Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC₅₀: 170 μM) .

HY-N144101

SARS-CoV MPro-IN-2	Infection Quinones Classification of Application Fields Source classification Plants Lithospermum canescens Lehm. Naphthalene Quinones Disease Research Fields Boraginaceae	SARS-CoV
SARS-CoV MPro-IN-2 (compound 15) is a potent inhibitor of SARS-CoV-2 M ^pro with an IC₅₀ value of 72.07 nM. The main protease (M ^pro) of the virus as the major enzyme processing viral polyproteins contributes to the replication and transcription of SARS-CoV-2 in host cells, and has been characterized as an attractive target in agent discovery. SARS-CoV MPro-IN-2 has the potential for the research of COVID-19 .

HY-N1992R

Theaflavin 3,3'-digallate (Standard)	Structural Classification Flavonoids Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Theaceae	Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (Standard) is the analytical standard of Theaflavin 3,3'-digallate. This product is intended for research and analytical applications. Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N0110A

Palmatine	Alkaloids Structural Classification Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N0110R

Palmatine chloride (Standard)	Structural Classification Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Apoptosis Virus Protease Indoleamine 2,3-Dioxygenase (IDO) Parasite Bacterial Aurora Kinase mAChR
Palmatine (chloride) (Standard) is the analytical standard of Palmatine (chloride). This product is intended for research and analytical applications. Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

Species:	Virus (3)
Tag:	His (2) Tag Free (1) GST (1)
Source:	E. coli (4)

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HY-P79151A

	*TEV Protease* Protein, Tobacco etch virus (S2256N, C-His)** Genome polyprotein; Tobacco Etch Virus Protease	Virus	E. coli
	The TEV protease is critical in aphid transmission and has proteolytic activity that cleaves the Gly-Gly dipeptide at its C terminus. In addition to proteolysis, it interacts with virions and aphid stylets, which is critical for aphid transmission. TEV Protease Protein, Tobacco etch virus (S2256N, C-His) is the recombinant Virus-derived TEV Protease protein, expressed by E. coli , with C-6*His labeled tag. The total length of TEV Protease Protein, Tobacco etch virus (S2256N, C-His) is 241 a.a., with molecular weight of approximately 26 kDa.

HY-P74898

	NS3 protease Protein, HCV (GST) Hepatitis C Virus (HCV-1a) NS3 Protease / helicase immunodominant region Protein ( GST)	Virus	E. coli
	NS3 protease Protein is a zinc-dependent serine protease.NS3 needs to bind to the viral protein NS4A to enable additional conformation changes that enhance activity and appropriate intracellular localization.NS3 protein induces Caspase-8-mediated apoptosis independently of its protease or helicase activity.NS3 protease Protein, HCV (GST) is the recombinant Virus-derived NS3 protease protein, expressed by E.coli , with N-GST labeled tag.

HY-P703548

	pp1a Protein, AIBV (His) Replicase polyprotein 1a; ORF1a polyprotein; Avian infectious bronchitis Virus (strain M41); IBV; pp1a; Hydrolase; Lyase; Protease; RNA-binding; Thiol Protease	Virus	E. coli

HY-P703547

	HCVNS5B Protein, HCV Genome polyprotein; Hepatitis C Virus genotype 1b (strain HC-J4); HCV; p23; Helicase; Hydrolase; Ion channel; Multifunctional enzyme; Nucleotidyltransferase; Protease; Ribonucleoprotein; RNA-binding; RNA-directed RNA polymerase; Serine Protease; Thiol Protease; Transferase; Viral ion channel; Viral nucleoprotein	Others	E. coli
	POLG proteins play multiple roles in the viral life cycle, contributing to viral RNA packaging, budding, and particle production. It exhibits RNA-binding and RNA chaperone activities, affecting translation initiation through interactions with viral IRES and ribosomal subunits. HCVNS5B Protein, HCV is the recombinant HCVNS5B, expressed by E. coli , with tag Free labeled tag. ,

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HY-10241S

Simeprevir-13C,d3

Simeprevir- ¹³C,d₃ is the ¹³C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][2][5].

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HY-P80926

	USP7 Antibody (YA657) Deubiquitinating enzyme 7; HAUSP; herpes Virus associated; Herpes Virus associated ubiquitin specific Protease; HerpesVirus-associated ubiquitin-specific Protease; TEF 1; tef-1; TEF1; Ubiquitin carboxyl terminal hydrolase 7; Ubiquitin carboxyl-terminal hy	WB	Human
	USP7 Antibody (YA657) is a non-conjugated and Mouse origined monoclonal antibody about 128 kDa, targeting to USP7 (3E4). It can be used for WB assays with tag free, in the background of Human.