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Pathways Recommended:	Vitamin D Related/Nuclear Receptor

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Vitamin D3-26,26,26,27,27,27-d<sub>6</sub>

" in MedChemExpress (MCE) Product Catalog:

By Targets:	VD/VDR (11) Apoptosis (5) Autophagy (3) Bacterial (5) Calcium Channel (2) COX (1) DNA/RNA Synthesis (10) Drug Metabolite (1) Endogenous Metabolite (50) Ferroptosis (3) HBV (3) Influenza Virus (3) Isotope-Labeled Compounds (39) Keap1-Nrf2 (4) NF-κB (2) Nucleoside Antimetabolite/Analog (1) PPAR (2) RAR/RXR (2) Reactive Oxygen Species (5)
By Research Areas:	Cancer (22) Cardiovascular Disease (5) Endocrinology (1) Infection (4) Inflammation/Immunology (3) Metabolic Disease (22) Neurological Disease (9)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: VD/VDR P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W011474

Geranylgeraniol	NF-κB	Inflammation/Immunology
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-B0511S

Biotin-d2-1 Vitamin B7 d<sub>2sub>-1; Vitamin H d<sub>2sub>-1; D-Biotin d<sub>2sub>-1	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Biotin-d₂-1 is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.

HY-B0511S1

rel-Biotin-d4 rel-Vitamin B7-d<sub>4sub>; rel-Vitamin H-d<sub>4sub>; rel-D-Biotin-d<sub>4sub>	Endogenous Metabolite	Metabolic Disease
rel-Biotin-d₄ is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.

HY-B1008S

4-Aminobenzoic acid-d4 PABA-d<sub>4sub>; Vitamin Bx-d<sub>4sub>; Vitamin H1-d<sub>4sub>; p-Aminobenzoic acid-d<sub>4sub>	Isotope-Labeled Compounds Endogenous Metabolite	Others
4-Aminobenzoic acid-d₄ is the deuterium labeled 4-Aminobenzoic acid. 4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.

HY-112499S1

Menaquinone-7-13C6 Vitamin K2-7-¹³C<sub>6sub>; Vitamin K2(35)-¹³C<sub>6sub>; Vitamin MK-7-¹³C<sub>6sub>	Isotope-Labeled Compounds	Cardiovascular Disease
Menaquinone-7- ¹³C₆ is the ¹³C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].

HY-112499S

Menaquinone-7-d7 Vitamin K2-7-d<sub>7sub>; Vitamin K2(35)-d<sub>7sub>; Vitamin MK-7-d<sub>7sub>	Isotope-Labeled Compounds	Cardiovascular Disease
Menaquinone-7-d₇ is the deuterium labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].

HY-16637S1

Folic acid-d4 Vitamin B9-d<sub>4sub>; Vitamin M-d<sub>4sub>	Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite	Cancer
Folic acid-d₄ is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-16637S

Folic acid-d2 Vitamin B9-d<sub>2sub>; Vitamin M-d<sub>2sub>	Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite	Cancer
Folic acid-d₂ (Vitamin B9-d₂) is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-B0511S2

Biotin-d2 Vitamin B7-d<sub>2sub>; Vitamin H-d<sub>2sub>; D-Biotin-d<sub>2sub>	Endogenous Metabolite	Metabolic Disease
Biotin-d₂ is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.

HY-W011474R

Geranylgeraniol (Standard)	NF-κB	Inflammation/Immunology
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model [4].

HY-B0332S

Menadione-d3 Vitamin K3-d<sub>3sub>	Endogenous Metabolite	Others
Menadione-d₃ is the deuterium labeled Menadione. Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo.

HY-16637S3

Folic acid-13C5 Vitamin B9-¹³C<sub>5sub>; Vitamin M-¹³C<sub>5sub>	Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite	Cancer
Folic acid- ¹³C₅ is the ¹³C-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-16637S5

Folic acid-13C6 Vitamin B9-¹³C<sub>6sub>; Vitamin M-¹³C<sub>6sub>	Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite	Cancer
Folic acid-13C6 is a deuterated labeled Folic acid . Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency .

HY-N0684S4

Vitamin K1-d3 Phylloquinone-d<sub>3sub>; Phytomenadione-d<sub>3sub>	Endogenous Metabolite Isotope-Labeled Compounds	Cardiovascular Disease
Vitamin K1-d₃ (Phylloquinone-d₃; Phytomenadione-d₃) is deuterium-labeled Vitamin K1 (HY-N0684) .

HY-N0682S

Pyridoxine-d3 hydrochloride Pyridoxol-d<sub>3sub> hydrochloride; Vitamin B6-d<sub>3sub> hydrochloride	Endogenous Metabolite Keap1-Nrf2	Neurological Disease
Pyridoxine-d₃ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-N0684S1

Vitamin K1-d4 Phylloquinone-d<sub>4sub>; Phytomenadione-d<sub>4sub>	Endogenous Metabolite	Cardiovascular Disease
Vitamin K1-d₄ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1].

HY-15398S3

Vitamin D3-d3 Cholecalciferol-d<sub>3sub>; Colecalciferol-d<sub>3sub>	Bacterial Endogenous Metabolite VD/VDR	Metabolic Disease Cancer
Vitamin D3-d₃ is the deuterium labeled Vitamin D3. Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

HY-N0682S2

Pyridoxine-d5 hydrochloride Pyridoxol-d<sub>5sub> hydrochloride; Vitamin B6-d<sub>5sub> hydrochloride	Keap1-Nrf2 Endogenous Metabolite	Neurological Disease
Pyridoxine-d₅ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride[1]. Pyridoxine hydrochloride (Pyridoxol;Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol;Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway[2].

HY-75958S1

Vitamin D4-d5 22-Dihydroergocalciferol-d<sub>5sub>	VD/VDR	Metabolic Disease
Vitamin D4-d₅ is the deuterium labeled Vitamin D4. Vitamin D4 (22-Dihydroergocalciferol) is a Vitamin D derived from fungi. The precursor of Vitamin D4 is 22,23-dihydroergosterol[1].

HY-B0152S

Adenine-d1 6-Aminopurine-d<sub>1sub>; Vitamin B4-d<sub>1sub>	DNA/RNA Synthesis Endogenous Metabolite	Cancer
Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].

HY-B0143S2

Niacin-d4 Nicotinic acid-d<sub>4sub>; Vitamin B3-d<sub>4sub>	Autophagy Endogenous Metabolite	Metabolic Disease
Niacin-d₄ is the deuterium labeled Niacin. Niacin (Nicotinic acid) is a vitamin and is part of the vitamin B group.

HY-N0680S1

Thiamine-d3 hydrochloride Thiamine chloride-d<sub>3sub> hydrochloride; Vitamin B1-d<sub>3sub> hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis HBV	Neurological Disease
Thiamine-d₃ (hydrochloride) is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.

HY-B0456S3

Riboflavin-d3 Vitamin B2-d<sub>3sub>; E101-d<sub>3sub>	Isotope-Labeled Compounds Endogenous Metabolite	Others
Riboflavin-d₃ is the deuterium labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.

HY-N0680S2

Thiamine-d4 hydrochloride Thiamine chloride-d<sub>4sub> hydrochloride; Vitamin B1-d<sub>4sub> hydrochloride	Endogenous Metabolite Apoptosis HBV	Neurological Disease
Thiamine-d₄ (hydrochloride) is deuterium labeled Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.

HY-13332

Calcifediol-d6 25-hydroxy Vitamin D3-d<sub>6sub>	VD/VDR	Metabolic Disease
Calcifediol-d₆ is the deuterium labeled Calcifediol. Calcifediol, a major circulating metabolite of vitamin D3, is a potent VDR ligand .

HY-32351S

Calcifediol-d3 25-hydroxy Vitamin D3-d<sub>3sub>	VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol-d₃ is a deuterium labeled Calcifediol. Calcifediol, is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-32349S

Ercalcidiol-d3 25-Hydroxy Vitamin D2-d<sub>3sub>	Endogenous Metabolite	Metabolic Disease
Ercalcidiol-d₃ is the deuterium labeled Ercalcidiol. Ercalcidiol is a metabolite of Vitamins D2. Ercalcidiol can be used as an indicator of vitamins D status .

HY-32351AS

Calcifediol-d6 monohydrate 25-hydroxy Vitamin D3-d<sub>6sub> monohydrate	Isotope-Labeled Compounds VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol-d₆ monohydrate is the deuterium labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-76542S

Vitamin D2-d6 Ergocalciferol-d<sub>6sub>; Calciferol-d<sub>6sub>; Ercalciol-d<sub>6sub>	VD/VDR Endogenous Metabolite	Metabolic Disease
Vitamin D2-d₆ is the deuterium labeled Vitamin D2. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D[1][2].

HY-N0682S1

Pyridoxine-d2 hydrochloride Pyridoxol-d<sub>2sub> (hydrochloride); Vitamin B6-d<sub>2sub> (hydrochloride)	Endogenous Metabolite Keap1-Nrf2	Neurological Disease
Pyridoxine-d₂ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-B1342S4

Retinol-d5 Vitamin A1-d<sub>5sub>; all-trans-Retinol-d<sub>5sub>	Isotope-Labeled Compounds	Others
Retinol-d₅ is the deuterium labeled Retinol[1].

HY-B1342S1

Retinol-d6 Vitamin A1-d<sub>6sub>; all-trans-Retinol-d<sub>6sub>	Endogenous Metabolite	Metabolic Disease
Retinol-d₆ is the deuterium labeled Vitamin A. Retinol is an endogenous metabolite.

HY-B0166S6

L-Ascorbic acid-d2 L-Ascorbate-d<sub>2sub>; Vitamin C--d<sub>2sub>	Apoptosis Calcium Channel Endogenous Metabolite Reactive Oxygen Species	Neurological Disease Metabolic Disease Cancer
L-Ascorbic acid-d₂ is the deuterium labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a colla

HY-B1342S

Retinol-d8 Vitamin A1-d<sub>8sub>; all-trans-Retinol-d<sub>8sub>	Endogenous Metabolite	Metabolic Disease
Retinol-d₈ is the deuterium labeled Retinol. Retinol is an endogenous metabolite.

HY-N0679S4

Retinyl acetate-d4 Retinol acetate-d<sub>4sub>; Vitamin A acetate-d<sub>4sub>	Isotope-Labeled Compounds	Cancer
Retinyl acetate-d₄ is the deuterium labeled Retinyl acetate[1]. Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities[2].

HY-15330

Vitamin D2-d3 Ergocalciferol-d<sub>3sub>; Calciferol-d<sub>3sub>; VD2-d<sub>3sub>	VD/VDR	Metabolic Disease
Vitamin D2-d₃ (Ergocalciferol-d₃) is the deuterium labeled vitamin D2.

HY-32350S1

Ercalcitriol-d3 1α,25-Dihydroxy Vitamin D2-d<sub>3sub>	Isotope-Labeled Compounds	Others
Ercalcitriol-d₃ is the deuterium labeled Ercalcitriol. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

HY-B2156S

Menaquinone-4-d7 Vitamin K2(MK-4)-d<sub>7sub>; Menaquinone K4-d<sub>7sub>	Endogenous Metabolite	Cancer
Menaquinone-4-d₇ (Vitamin K2(MK-4)-d7) is the deuterium labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.

HY-N7148S

*α-Vitamin* E-d6** (+)-α-Tocopherol-d<sub>6sub>; D-α-Tocopherol-d<sub>6sub>	COX Endogenous Metabolite Isotope-Labeled Compounds	Others
α-Vitamin E-d₆ is the deuterium labeled α-Vitamin E[1].

HY-N0683S6

*α-Vitamin* E-d11** (+)-α-Tocopherol-d<sub>11sub>; D-α-Tocopherol-d<sub>11sub>	Bacterial Endogenous Metabolite Ferroptosis Reactive Oxygen Species Influenza Virus Isotope-Labeled Compounds	Infection Cancer
α-Vitamin E-d11 ((+)-α-Tocopherol-d11) is the deuterium labeled α-Vitamin E (HY-N0683). α-Vitamin E ((+)-α-Tocopherol), a naturally occurring vitamin E form, is a potent antioxidant .

HY-14649S3

Retinoic acid-d6 Vitamin A acid-d<sub>6sub>; all-trans-Retinoic acid-d<sub>6sub>; ATRA-d<sub>6sub>	RAR/RXR PPAR Autophagy Endogenous Metabolite	Cancer
Retinoic acid-d₆ is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].

HY-14649S4

Retinoic acid-d5 Vitamin A acid-d<sub>5sub>; all-trans-Retinoic acid-d<sub>5sub>; ATRA-d<sub>5sub>	Isotope-Labeled Compounds RAR/RXR PPAR	Cancer
Retinoic acid-d₅ is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-16637S4

Folic acid-13C5,15N Vitamin B9-¹³C<sub>5sub>,¹⁵N; Vitamin M-¹³C<sub>5sub>,¹⁵N	Isotope-Labeled Compounds	Others
Folic acid- ¹⁵N, ¹³C₅ is the ¹³C₅ and ¹⁵N labeled Folic acid (HY-16637) .

HY-16760S

9-cis-Retinol acetate-d5 9-cis-Vitamin A acetate-d<sub>5sub>; Zuretinol acetate-d<sub>5sub>	Isotope-Labeled Compounds	Others
9-cis-Retinol acetate-d₅ is the deuterium labeled 9-cis-Retinol acetate. 9-cis-Retinol acetate is a retinal derivative[1][2].

HY-N0682S3

Pyridoxine-13C4 hydrochloride Pyridoxol-¹³C<sub>4sub> hydrochloride; Vitamin B6-¹³C<sub>4sub> hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite Keap1-Nrf2	Neurological Disease
Pyridoxine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Pyridoxine (hydrochloride). Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-N0684S3

Vitamin K1-13C6 Phylloquinone-¹³C<sub>6sub>; Phytomenadione-¹³C<sub>6sub>	Endogenous Metabolite	Cardiovascular Disease
Vitamin K1- ¹³C₆ is the ¹³C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-15398S4

Vitamin D3-13C5 Cholecalciferol-¹³C<sub>5sub>; Colecalciferol-¹³C<sub>5sub>	Bacterial VD/VDR	Infection Endocrinology
Vitamin D3- ¹³C₅ is the deuterium labeled Vitamin D3 (HY-15398). Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells[1][2].

HY-32351AS1

Calcifediol-13C5 monohydrate 25-Hydroxy Vitamin D3-¹³C<sub>5sub> monohydrate	Isotope-Labeled Compounds VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol- ¹³C₅ monohydrate is the ¹³C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-150660S

Ercalcidiol-13C5 25-Hydroxy Vitamin D2-¹³C<sub>5sub>	Isotope-Labeled Compounds	Others
25-Hydroxyvitamin D2-(20,21,22,26,27- ¹³C₅) solution is the ¹³C labeled 25-Hydroxyvitamin D2[1].

HY-16637S2

(Rac)-Folic acid-13C5,15N (Rac)-Vitamin B9-¹³C<sub>5sub>,¹⁵N; (Rac)-Vitamin M-¹³C<sub>5sub>,¹⁵N	Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite	Cancer
(Rac)-Folic acid- ¹³C₅, ¹⁵N is the ¹³C-labeled and ¹⁵N-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model [4].

Cat. No.	Product Name	Chemical Structure

HY-B0511S

Biotin-d2-1
Biotin-d₂-1 is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.

HY-B0511S1

rel-Biotin-d4
rel-Biotin-d₄ is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.

HY-B1008S

4-Aminobenzoic acid-d4
4-Aminobenzoic acid-d₄ is the deuterium labeled 4-Aminobenzoic acid. 4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.

HY-112499S1

Menaquinone-7-13C6

Menaquinone-7- ¹³C₆ is the ¹³C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].

HY-B0332S

Menadione-d3
Menadione-d₃ is the deuterium labeled Menadione. Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo.

HY-16637S3

Folic acid-13C5
Folic acid- ¹³C₅ is the ¹³C-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-112499S

Menaquinone-7-d7

Menaquinone-7-d₇ is the deuterium labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].

HY-16637S1

Folic acid-d4
Folic acid-d₄ is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-16637S

Folic acid-d2
Folic acid-d₂ (Vitamin B9-d₂) is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-B0511S2

Biotin-d2
Biotin-d₂ is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.

HY-16637S5

Folic acid-13C6
Folic acid-13C6 is a deuterated labeled Folic acid . Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency .

HY-B1342S5

Gildeuretinolum
Gildeuretinolum (Retinol-d3; Vitamin A1-d3) is a vitamin A analogue .

HY-N0684S4

Vitamin K1-d3
Vitamin K1-d₃ (Phylloquinone-d₃; Phytomenadione-d₃) is deuterium-labeled Vitamin K1 (HY-N0684) .

HY-N0682S

Pyridoxine-d3 hydrochloride
Pyridoxine-d₃ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-N0684S1

Vitamin K1-d4
Vitamin K1-d₄ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1].

HY-15398S3

Vitamin D3-d3
Vitamin D3-d₃ is the deuterium labeled Vitamin D3. Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

HY-N0682S2

Pyridoxine-d5 hydrochloride
Pyridoxine-d₅ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride[1]. Pyridoxine hydrochloride (Pyridoxol;Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol;Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway[2].

HY-75958S1

Vitamin D4-d5
Vitamin D4-d₅ is the deuterium labeled Vitamin D4. Vitamin D4 (22-Dihydroergocalciferol) is a Vitamin D derived from fungi. The precursor of Vitamin D4 is 22,23-dihydroergosterol[1].

HY-B0152S

Adenine-d1
Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].

HY-B0143S2

Niacin-d4
Niacin-d₄ is the deuterium labeled Niacin. Niacin (Nicotinic acid) is a vitamin and is part of the vitamin B group.

HY-N0680S1

Thiamine-d3 hydrochloride
Thiamine-d₃ (hydrochloride) is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.

HY-B0456S3

Riboflavin-d3
Riboflavin-d₃ is the deuterium labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.

HY-N0680S2

Thiamine-d4 hydrochloride
Thiamine-d₄ (hydrochloride) is deuterium labeled Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.

HY-13332

Calcifediol-d6
Calcifediol-d₆ is the deuterium labeled Calcifediol. Calcifediol, a major circulating metabolite of vitamin D3, is a potent VDR ligand .

HY-32351S

Calcifediol-d3
Calcifediol-d₃ is a deuterium labeled Calcifediol. Calcifediol, is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-32349S

Ercalcidiol-d3
Ercalcidiol-d₃ is the deuterium labeled Ercalcidiol. Ercalcidiol is a metabolite of Vitamins D2. Ercalcidiol can be used as an indicator of vitamins D status .

HY-32351AS

Calcifediol-d6 monohydrate
Calcifediol-d₆ monohydrate is the deuterium labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-76542S

Vitamin D2-d6
Vitamin D2-d₆ is the deuterium labeled Vitamin D2. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D[1][2].

HY-N0682S1

Pyridoxine-d2 hydrochloride
Pyridoxine-d₂ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-B1342S4

Retinol-d5
Retinol-d₅ is the deuterium labeled Retinol[1].

HY-B1342S1

Retinol-d6
Retinol-d₆ is the deuterium labeled Vitamin A. Retinol is an endogenous metabolite.

HY-B0166S6

L-Ascorbic acid-d2
L-Ascorbic acid-d₂ is the deuterium labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a colla

HY-B1342S

Retinol-d8
Retinol-d₈ is the deuterium labeled Retinol. Retinol is an endogenous metabolite.

HY-N0679S4

Retinyl acetate-d4
Retinyl acetate-d₄ is the deuterium labeled Retinyl acetate[1]. Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities[2].

HY-15330

Vitamin D2-d3
Vitamin D2-d₃ (Ergocalciferol-d₃) is the deuterium labeled vitamin D2.

HY-32350S1

Ercalcitriol-d3
Ercalcitriol-d₃ is the deuterium labeled Ercalcitriol. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

HY-B2156S

Menaquinone-4-d7
Menaquinone-4-d₇ (Vitamin K2(MK-4)-d7) is the deuterium labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.

HY-N7148S

*α-Vitamin* E-d6**
α-Vitamin E-d₆ is the deuterium labeled α-Vitamin E[1].

HY-N0683S6

*α-Vitamin* E-d11**
α-Vitamin E-d11 ((+)-α-Tocopherol-d11) is the deuterium labeled α-Vitamin E (HY-N0683). α-Vitamin E ((+)-α-Tocopherol), a naturally occurring vitamin E form, is a potent antioxidant .

HY-14649S3

Retinoic acid-d6

Retinoic acid-d₆ is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].

HY-14649S4

Retinoic acid-d5

Retinoic acid-d₅ is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-16637S4

Folic acid-13C5,15N
Folic acid- ¹⁵N, ¹³C₅ is the ¹³C₅ and ¹⁵N labeled Folic acid (HY-16637) .

HY-16760S

9-cis-Retinol acetate-d5
9-cis-Retinol acetate-d₅ is the deuterium labeled 9-cis-Retinol acetate. 9-cis-Retinol acetate is a retinal derivative[1][2].

HY-N0682S3

Pyridoxine-13C4 hydrochloride
Pyridoxine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Pyridoxine (hydrochloride). Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-N0684S3

Vitamin K1-13C6
Vitamin K1- ¹³C₆ is the ¹³C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-15398S4

Vitamin D3-13C5
Vitamin D3- ¹³C₅ is the deuterium labeled Vitamin D3 (HY-15398). Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells[1][2].

HY-32351AS1

Calcifediol-13C5 monohydrate
Calcifediol- ¹³C₅ monohydrate is the ¹³C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-150660S

Ercalcidiol-13C5
25-Hydroxyvitamin D2-(20,21,22,26,27- ¹³C₅) solution is the ¹³C labeled 25-Hydroxyvitamin D2[1].

HY-16637S2

(Rac)-Folic acid-13C5,15N
(Rac)-Folic acid- ¹³C₅, ¹⁵N is the ¹³C-labeled and ¹⁵N-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-B0456S2

Riboflavin-13C5
Riboflavin- ¹³C₅ is the ¹³C-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.

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Vitamin D3-26,26,26,27,27,27-d<sub>6</sub>

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