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Results for "

antihistaminic (H1)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (8) Adrenergic Receptor (6) Antibiotic (1) Apoptosis (7) Bacterial (1) Calcium Channel (4) Cytochrome P450 (1) Drug Metabolite (4) Endogenous Metabolite (10) Fungal (1) HBV (2) Histamine Receptor (115) Influenza Virus (1) Isotope-Labeled Compounds (14) mAChR (8) mGluR (3) P-glycoprotein (1) P2X Receptor (2) Parasite (2) Potassium Channel (7) SARS-CoV (7) Sodium Channel (4)
By Research Areas:	Cancer (13) Cardiovascular Disease (2) Endocrinology (65) Infection (9) Inflammation/Immunology (93) Metabolic Disease (6) Neurological Disease (35)

124

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0781

Promethazine hydrochloride 1 Publications Verification	Histamine Receptor mAChR Adrenergic Receptor	Neurological Disease Endocrinology
Promethazine hydrochloride is an orally active phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. Promethazine hydrochloride is a potent H1 receptor antagonist and a mAChR antagonist. It also has a certain affinity for 5-HT2A and 5-HT2C receptors .

HY-B0781R

Promethazine (hydrochloride) (Standard)	Histamine Receptor mAChR Adrenergic Receptor	Neurological Disease Endocrinology
Promethazine (hydrochloride) (Standard) is the analytical standard of Promethazine (hydrochloride). This product is intended for research and analytical applications. Promethazine hydrochloride is an orally active phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. Promethazine hydrochloride is a potent H1 receptor antagonist and a mAChR antagonist. It also has a certain affinity for 5-HT2A and 5-HT2C receptors .

HY-W683872

Talastine	Histamine Receptor	Inflammation/Immunology
Talastine is a potent *H1-antihistamine*. Talastine can induce allergic exanthema .

HY-W281862

Sequifenadine	Histamine Receptor	Inflammation/Immunology
Sequifenadine is a H1-antihistamine. Sequifenadine has the potential for the research of inflammatory eye disease with allergic symptoms .

HY-101745

Rocastine AHR-11325	Histamine Receptor	Inflammation/Immunology
Rocastine is a selective, nonsedating H1 antagonist, acting as an antihistamine.

HY-B0539S

Desloratadine-d4 Sch34117-d₄	Histamine Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Desloratadine-d₄ is the deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

HY-B0539S3

Desloratadine-d5 Sch34117-d₅	Isotope-Labeled Compounds Histamine Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Desloratadine-d₅ is deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

HY-B0539S1

Desloratadine-d9 Sch34117-d₉	Histamine Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Desloratadine-d₉ is the deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

HY-118910

AHR-14310C	Histamine Receptor	Inflammation/Immunology
AHR-14310C is a potent, long-acting, nonsedating *H1-antihistamine* that prevents antigen-induced mucus formation in sensitive rats .

HY-129783

Phenindamine tartrate	Histamine Receptor	Inflammation/Immunology
Phenindamine tartrate is a Histamine H1-receptor antagonist. Phenindamine tartrate is an antihistamine .

HY-B0539R

Desloratadine (Standard) Sch34117 (Standard)	Histamine Receptor Endogenous Metabolite Drug Metabolite	Inflammation/Immunology Endocrinology Cancer
Desloratadine (Standard) is the analytical standard of Desloratadine. This product is intended for research and analytical applications. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating *H1-antihistamine* Loratadine. Desloratadine is a selective *H1-receptor* antagonist that has anti-allergic and anti-inflammatory activities .

HY-100238

Antihistamine-1	Histamine Receptor Cytochrome P450 Potassium Channel	Neurological Disease Endocrinology
Antihistamine-1 is a *H1-antihistamine* (K_i=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC₅₀s of 5.4 and 0.8 μM, respectively.

HY-107647A

(R)-(+)-Dimethindene maleate	Histamine Receptor	Inflammation/Immunology
(R)-(+)-Dimethindene maleate is an orally active *H₁-receptor* blocker with antihistaminic properties in pigs .

HY-B0539S4

Desloratadine-d4 hydrobromide Sch34117-d₄ hydrobromide	Histamine Receptor Endogenous Metabolite Drug Metabolite Isotope-Labeled Compounds	Inflammation/Immunology Endocrinology Cancer
Desloratadine-d₄ hydrobromide is deuterated labeled Desloratadine (HY-B0539). Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating *H1-antihistamine* Loratadine. Desloratadine is a selective *H1-receptor* antagonist that has anti-allergic and anti-inflammatory activities .

HY-B1281

Mepyramine maleate 2 Publications Verification Pyrilamine maleate	Histamine Receptor	Neurological Disease Endocrinology
Mepyramine maleate, a first generation antihistamine, is an antagonist of histamine H1 receptor, with K_ds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pK_d of 9.4 for H1 receptor.

HY-B0539S2

Desloratadine-3,3,5,5-d4	Histamine Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Desloratadine-3,3,5,5-d₄ is the deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

HY-B0286

Chlorpheniramine 2 Publications Verification Chlorphenamine	Histamine Receptor	Inflammation/Immunology
Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases research .

HY-B1215

Dimenhydrinate	Histamine Receptor	Neurological Disease Endocrinology
Dimenhydrinate is an orally active *H1-antihistamine* consisting of Diphenhydramine (HY-B0303) and 8-Chlorotheophylline. Dimenhydrinate is used to prevent nausea, vomiting, dizziness, and vertigo associated with motion sickness .

HY-167850

Noberastine maleate R 64947 maleate	Histamine Receptor	Neurological Disease
Noberastine maleate is a potent Histamine H1 antagonist. Noberastine maleate has specific peripheral antihistamine activity .

HY-106334

Noberastine R 64947	Histamine Receptor	Neurological Disease
Noberastine is a potent Histamine H1 antagonist. Noberastine has specific peripheral antihistamine activity .

HY-B0157AS

Ketotifen-d3 fumarate	Histamine Receptor SARS-CoV Influenza Virus	Inflammation/Immunology Endocrinology
Ketotifen-d₃ (fumarate) is the deuterium labeled Ketotifen fumarate. Ketotifen (HC 20511) fumarate is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks[1][2].

HY-105542

Niaprazine	Histamine Receptor	Neurological Disease
Niaprazine is a histamine H1-receptor antagonist. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research .

HY-106957

Efletirizine	Histamine Receptor	Inflammation/Immunology
Efletirizine (EFZ) is an orally active antihistamine with high selectivity and affinity to the *H₁-receptor*. Efletirizine can be used for allergic disease research .

HY-B1281R

Mepyramine maleate (Standard)	Histamine Receptor	Neurological Disease Endocrinology
Mepyramine maleate (Standard) is the analytical standard of Mepyramine maleate. This product is intended for research and analytical applications. Mepyramine maleate, a first generation antihistamine, is an antagonist of histamine H1 receptor, with Kds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pKd of 9.4 for H1 receptor.

HY-B0298A

Clemastine fumarate 5+ Cited Publications HS-592 fumarate; Meclastine fumarate	Histamine Receptor	Neurological Disease Endocrinology
Clemastine (HS-592) fumarate is a selective histamine H1 receptor antagonist. Clemastine fumarate is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects .

HY-13710A

Dimethindene maleate	Histamine Receptor Endogenous Metabolite	Inflammation/Immunology
Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions .

HY-B0298

Clemastine HS-592; Meclastine	Histamine Receptor	Neurological Disease
Clemastine (HS-592) is a potent and orally active histamine receptor H1 antagonist. Clemastine is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects .

HY-W010841

Levocetirizine dihydrochloride 2 Publications Verification (R)-Cetirizine dihydrochloride	Histamine Receptor	Inflammation/Immunology Endocrinology Cancer
Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria .

HY-B0814

Levocetirizine 2 Publications Verification (R)-Cetirizine	Histamine Receptor	Inflammation/Immunology Endocrinology Cancer
Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria .

HY-B1215R

Dimenhydrinate (Standard)	Histamine Receptor	Neurological Disease Endocrinology
Dimenhydrinate (Standard) is the analytical standard of Dimenhydrinate. This product is intended for research and analytical applications. Dimenhydrinate is an orally active *H1-antihistamine* consisting of Diphenhydramine (HY-B0303) and 8-Chlorotheophylline. Dimenhydrinate is used to prevent nausea, vomiting, dizziness, and vertigo associated with motion sickness .

HY-131256A

Cetirizine Impurity C dihydrochloride	Histamine Receptor	Inflammation/Immunology Endocrinology
Cetirizine Impurity C dihydrochloride is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist ^{[1] ^{^{[2] ^.}}}

HY-131256

Cetirizine Impurity C	Histamine Receptor	Inflammation/Immunology Endocrinology
Cetirizine Impurity C is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist ^{[1] ^{^{[2] ^.}}}

HY-N0054

Osthole Maximum Cited Publications 12 Publications Verification Osthol; NSC 31868	Histamine Receptor Apoptosis Parasite HBV	Infection Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H₁ receptor activity. Osthole also suppresses the secretion of HBV in cells.

HY-A0069A

Doxylamine	Histamine Receptor	Inflammation/Immunology
Doxylamine, a first generation antihistamine, is a histamine (H1) receptor antagonist. Doxylamine is also a local analgesic agent and effective hypnotic agent .

HY-B1296S1

Promethazine-d4 (±)-Promethazine-d₄; N,N-dimethyl-1-phenothiazin-10-yl-propan-2-amine-d₄	Isotope-Labeled Compounds Adrenergic Receptor mAChR Histamine Receptor	Neurological Disease
Promethazine-d4 is a deuterated-labeled promethazine (HY-B0781). Promethazine is an orally active H1 receptor and mAChR antagonist with antihistamine (H1), sedative, antiemetic, anticholinergic, and anti-motion sickness properties .

HY-12966

Cetirizine methyl ester	Histamine Receptor	Inflammation/Immunology Endocrinology
Cetirizine methyl ester is an impurity of Cetirizine (HY-17042). Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist .

HY-B1483

Methapyrilene hydrochloride Thenylpyramine hydrochloride	Histamine Receptor	Inflammation/Immunology
Methapyrilene (Thenylpyramine) hydrochloride is an orally active H1-receptor antihistamine and an anticholinergic agent of the pyridine chemical class. Methapyrilene hydrochloride has hepatotoxicity and can be used as a hepatotoxin that cause periportal hepatic necrosis in vivo

HY-B0286R

Chlorpheniramine (Standard)	Histamine Receptor	Inflammation/Immunology
Chlorpheniramine (Standard) is the analytical standard of Chlorpheniramine. This product is intended for research and analytical applications. Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases research .

HY-A0069

Doxylamine succinate	Histamine Receptor	Inflammation/Immunology Endocrinology
Doxylamine (succinate), a first generation antihistamine, is a histamine (H1) receptor antagonist. Doxylamine is also a local analgesic agent and effective hypnotic agent .

HY-A0191

Dexbrompheniramine (+)-Brompheniramine; (S)-Brompheniramine	Endogenous Metabolite Histamine Receptor	Inflammation/Immunology
Dexbrompheniramine is an orally active H1 receptor antagonist. Dexbrompheniramine is an antihistamine that reduces the effects of natural chemical histamine. Dexbrompheniramine can be used for the research of hay fever and urticaria .

HY-A0191A

Dexbrompheniramine maleate (+)-Brompheniramine maleate; (S)-Brompheniramine maleate	Endogenous Metabolite Histamine Receptor	Inflammation/Immunology
Dexbrompheniramine maleate is an orally active H1 receptor antagonist. Dexbrompheniramine maleate is an antihistamine that reduces the effects of natural chemical histamine. Dexbrompheniramine maleate can be used for the research of hay fever and urticaria .

HY-B0814S

Levocetirizine-d4 dihydrochloride (R)-Cetirizine-d₄(dihydrochloride)	Isotope-Labeled Compounds Histamine Receptor	Inflammation/Immunology Endocrinology
Levocetirizine-d₄ (dihydrochloride) is the deuterium labeled Levocetirizine. Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1].

HY-B0298AR

Clemastine (fumarate) (Standard) HS-592 (fumarate) (Standard); Meclastine (fumarate) (Standard)	Histamine Receptor	Neurological Disease Endocrinology
Clemastine (fumarate) (Standard) is the analytical standard of Clemastine (fumarate). This product is intended for research and analytical applications. Clemastine (HS-592) fumarate is a selective histamine H1 receptor antagonist. Clemastine fumarate is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects .

HY-131579

Deschloro Cetirizine dihydrochloride	Drug Metabolite	Inflammation/Immunology
Deschloro Cetirizine Dihydrochloride is a Cetirizine impurity. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting *histamine H1-receptor* antagonist.

HY-W010841R

Levocetirizine (dihydrochloride) (Standard) (R)-Cetirizine (dihydrochloride) (Standard)	Histamine Receptor	Inflammation/Immunology Endocrinology
Levocetirizine (dihydrochloride) (Standard) is the analytical standard of Levocetirizine (dihydrochloride). This product is intended for research and analytical applications. Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria .

HY-105542R

Niaprazine (Standard)	Histamine Receptor	Neurological Disease
Niaprazine (Standard) is the analytical standard of Niaprazine. This product is intended for research and analytical applications. Niaprazine is a histamine H1-receptor antagonist. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research .

HY-17042A

Cetirizine dihydrochloride 2 Publications Verification P071	Histamine Receptor	Inflammation/Immunology Endocrinology Cancer
Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine *H1-receptor* antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .

HY-17042

Cetirizine 2 Publications Verification	Histamine Receptor	Inflammation/Immunology Endocrinology
Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine *H1-receptor* antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .

HY-B0970

Diphenylpyraline hydrochloride 4-Diphenylmethoxy-1-methylpiperidine hydrochloride	Histamine Receptor	Neurological Disease Endocrinology
Diphenylpyraline hydrochloride is a potent histamine H₁?receptor antagonist. Diphenylpyraline hydrochloride acts as an orally active antihistamine agent?with antimuscarinic and antiallergic effects. Diphenylpyraline hydrochloride can be used for the relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders in vivo.

HY-B0462A

Azelastine	Histamine Receptor SARS-CoV	Infection Metabolic Disease Inflammation/Immunology Endocrinology
Azelastine, an antihistamine, is a potent and selective histamine 1 (H₁) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0054

Osthole Maximum Cited Publications 12 Publications Verification Osthol; NSC 31868	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Coumarins Plants Biological Pesticide Research Agricultural Research Infection other families Phenylpropanoids Inflammation/Immunology Disease Research Fields Endocrinology	Histamine Receptor Apoptosis Parasite HBV
Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H₁ receptor activity. Osthole also suppresses the secretion of HBV in cells.

HY-A0191

Dexbrompheniramine (+)-Brompheniramine; (S)-Brompheniramine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Histamine Receptor
Dexbrompheniramine is an orally active H1 receptor antagonist. Dexbrompheniramine is an antihistamine that reduces the effects of natural chemical histamine. Dexbrompheniramine can be used for the research of hay fever and urticaria .

HY-17042

Cetirizine 2 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Endocrinology	Histamine Receptor
Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine *H1-receptor* antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .

HY-B0539R

Desloratadine (Standard) Sch34117 (Standard)	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Histamine Receptor Endogenous Metabolite Drug Metabolite
Desloratadine (Standard) is the analytical standard of Desloratadine. This product is intended for research and analytical applications. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating *H1-antihistamine* Loratadine. Desloratadine is a selective *H1-receptor* antagonist that has anti-allergic and anti-inflammatory activities .

HY-N0054R

Osthole (Standard)	Structural Classification other families Source classification Coumarins Phenylpropanoids Plants	Histamine Receptor Apoptosis Parasite HBV
Osthole (Standard) is the analytical standard of Osthole. This product is intended for research and analytical applications. Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells.

HY-129482

Detoxin D1	Structural Classification Natural Products Microorganisms Source classification	Others
Detoxin D1 is a compound with antihistamine activity and a new type of H1 antagonist. In the suppression of seasonal allergic rhinitis, a daily dose of 10-30 mg has an equivalent and highly effective inhibitory effect compared with placebo and has good safety.

HY-N1514R

Ganoderenic acid B (Standard)	Triterpenes Structural Classification Human Gut Microbiota Metabolites Microorganisms Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Endogenous metabolite	P-glycoprotein
Doxylamine (succinate) (Standard) is the analytical standard of Doxylamine (succinate). This product is intended for research and analytical applications. Doxylamine (succinate), a first generation antihistamine, is a histamine (H1) receptor antagonist. Doxylamine is also a local analgesic agent and effective hypnotic agent .

HY-17042R

Cetirizine (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Histamine Receptor
Cetirizine (Standard) is the analytical standard of Cetirizine. This product is intended for research and analytical applications. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine *H1-receptor* antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .

HY-W040129R

Chromomycin A3 (Standard)	Microorganisms Source classification	Bacterial Fungal Apoptosis Antibiotic
Meclizine (dihydrochloride) (Standard) is the analytical standard of Meclizine (dihydrochloride). This product is intended for research and analytical applications. Meclizine (Meclozine) dihydrochloride, an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine dihydrochloride is a member of the piperazine class of H1 antagonists. Meclizine dihydrochloride is an effective anti-motion sickness agent. Meclizine dihydrochloride crosses the blood-brain barrier. Meclizine dihydrochloride can be used for the research of polyQ toxicity disorders, such as Huntington's disease. Meclizine dihydrochloride is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR .

Cat. No.	Product Name	Chemical Structure

HY-B0157AS

Ketotifen-d3 fumarate
Ketotifen-d₃ (fumarate) is the deuterium labeled Ketotifen fumarate. Ketotifen (HC 20511) fumarate is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks[1][2].

HY-B0814S1

Levocetirizine-d4

Levocetirizine-d₄ ((R)-Cetirizine-d₄) is the deuterium-labeled Levocetirizine (HY-B0814) . Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria .

HY-B0539S

Desloratadine-d4
Desloratadine-d₄ is the deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

HY-B0539S3

Desloratadine-d5
Desloratadine-d₅ is deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

HY-B0539S1

Desloratadine-d9
Desloratadine-d₉ is the deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

HY-B0539S4

Desloratadine-d4 hydrobromide
Desloratadine-d₄ hydrobromide is deuterated labeled Desloratadine (HY-B0539). Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating *H1-antihistamine* Loratadine. Desloratadine is a selective *H1-receptor* antagonist that has anti-allergic and anti-inflammatory activities .

HY-B0539S2

Desloratadine-3,3,5,5-d4
Desloratadine-3,3,5,5-d₄ is the deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

HY-B1296S1

Promethazine-d4
Promethazine-d4 is a deuterated-labeled promethazine (HY-B0781). Promethazine is an orally active H1 receptor and mAChR antagonist with antihistamine (H1), sedative, antiemetic, anticholinergic, and anti-motion sickness properties .

HY-B0814S

Levocetirizine-d4 dihydrochloride

Levocetirizine-d₄ (dihydrochloride) is the deuterium labeled Levocetirizine. Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1].

HY-B0781S1

Promethazine-d3 hydrochloride

Promethazine-d₃ (hydrochloride) is deuterium labeled Promethazine (hydrochloride). Promethazine hydrochloride is an orally active phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. Promethazine hydrochloride is a potent H1 receptor antagonist and a mAChR antagonist. It also has a certain affinity for 5-HT2A and 5-HT2C receptors .

HY-17042AS

Cetirizine-d4 dihydrochloride
Cetirizine-d₄ (dihydrochloride) is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

HY-17042S

Cetirizine-d4
Cetirizine-d₄ is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

HY-17042S1

Cetirizine-d8
Cetirizine-d₈ is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

HY-17042AS1

Cetirizine-d8 dihydrochloride
Cetirizine-d₈ (dihydrochloride) is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

HY-B0548AS2

Hydroxyzine-d8 dihydrochloride
Hydroxyzine-d₈ (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder[1][2].

HY-B0548AS1

Hydroxyzine-d4' dihydrochloride
Hydroxyzine-d₄ (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder[1][2].

HY-B0462AS

Azelastine-13C,d3
Azelastine- ¹³C,d₃ is deuterium labeled Azelastine. Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2[1][2][3][4].

HY-B0781S

Promethazine-d4 hydrochloride
Promethazine-d₄ (hydrochloride) is the deuterium labeled Promethazine hydrochloride. Promethazine hydrochloride is the first-generation antihistamine; strong antagonist of the H1 receptor and moderate mACh receptor antagonist, moderate affinity for 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors.

HY-B0640S

Epinastine-13C,d3 hydrobromide
Epinastine- ¹³C,d₃ (hydrobromide) is the ¹³C- and deuterium labeled Epinastine. Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action[1][2][3][4].

HY-B0462S

Azelastine-13C,d3 hydrochloride
Azelastine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Azelastine hydrochloride. Azelastine- ¹³C,d₃ (hydrochloride), an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine- ¹³C,d₃ (hydrochloride) can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2[1][2][3][4].

HY-124356AS

Alcaftadine carboxylic acid-d3 sodium

Alcaftadine carboxylic acid-d₃ (sodium) is deuterium labeled Alcaftadine carboxylic acid. Alcaftadine carboxylic acid is a broad-spectrum antihistamine compound with high affinity for histamine H1 and H2 receptors and low affinity for H4 receptors. Alcaftadine carboxylic acid has also demonstrated effects on modulating immune cell recruitment and stabilizing mast cells. Alcaftadine carboxylic acid is more effective than placebo in preventing ocular itching associated with allergic conjunctivitis and is at least as effective as olopatadine 0.01% .

HY-32329S

Setiptiline-d3

Setiptiline-d₃ is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine[1][2].

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