Search Result
Results for "
antineoplastic activity
" in MedChemExpress (MCE) Product Catalog:
20
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-108610
-
|
(R)-ET-18-OCH3
|
HIV
|
Infection
Cancer
|
|
(R)-Edelfosine ((R)-ET-18-OCH3) is a ether lipid analog with anti-HIV and antineoplastic activity .
|
-
-
- HY-P99498
-
|
CEA-IL2v; RG 7813; RO 6895882
|
Interleukin Related
|
Inflammation/Immunology
Cancer
|
|
Cergutuzumab amunaleukin (CEA-IL2v) is a monomeric carcinoembryonic antigen (CEA)-targeted IL-2 variant-based immunocytokine. Cergutuzumab amunaleukin has immunostimulating and antineoplastic activities .
|
-
-
- HY-119824
-
|
|
Bacterial
|
Cancer
|
|
Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity .
|
-
-
- HY-152852S
-
|
Mifanertinib-d6
|
Isotope-Labeled Compounds
c-Met/HGFR
|
Cancer
|
|
Mefatinib-d6 free base (Mifanertinib-d6) is the deuterium labeled Mefatinib. Mefatinib is a potent tyrosine kinase inhibitor with antineoplastic activity .
|
-
-
- HY-P99628
-
|
|
EGFR
|
Cancer
|
|
Futuximab is a chimeric monoclonal antibody targeting non-overlapping epitopes on EGFR. Futuximab has antineoplastic activity .
|
-
-
- HY-126933
-
|
RS-1541
|
LDLR
|
Cancer
|
|
Palmitoyl rhizoxin (RS-1541), a 13-0-palmitoyl derivative of Rhizoxin, is a potent antineoplastic agent with anti-tumour activity. Palmitoyl rhizoxin binds to the lipoproteins and the low-density lipoprotein (LDL) receptors in M5076 sarcoma .
|
-
-
- HY-P99581
-
|
OTSA101-DTPA; OTSA101-DTPA-90Y; OTSA101-SS01
|
Wnt
|
Cancer
|
|
Tabituximab barzuxetan (exclude Y90) is a radioimmunoconjugate composed of a humanized monoclonal antibody targeting FZD-10 (OTSA-101). Tabituximab barzuxetan shows antineoplastic activity. Tabituximab barzuxetan can be used for synovial sarcoma research .
|
-
-
- HY-120098
-
|
|
Others
|
Cancer
|
|
Vinleurosine is an indole alkaloid with antineoplastic activity .
|
-
-
- HY-120098A
-
|
|
Others
|
Cancer
|
|
Vinleurosine sulfate is an indole alkaloid with antineoplastic activity .
|
-
-
- HY-156646
-
|
|
CDK
|
Cancer
|
|
Tibremciclib is a CDK4 inhibitor with antineoplastic activity .
|
-
-
- HY-152852A
-
|
Mifanertinib dimaleate
|
c-Met/HGFR
|
Cancer
|
|
Mefatinib is a potent tyrosine kinase inhibitor with antineoplastic activity .
|
-
-
- HY-156620
-
-
-
- HY-U00337A
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from Ellipticine (HY-15753). Datelliptium chloride hydrochloride is effective in vivo against a variety of murine solid tumors .
|
-
-
- HY-13768A
-
|
SKF 104864A hydrochloride; NSC 609669 hydrochloride
|
Topoisomerase
Autophagy
Apoptosis
|
Cancer
|
|
Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities.
|
-
-
- HY-152830
-
|
|
c-Met/HGFR
|
Cancer
|
|
Adrixetinib is an inhibitor of protein tyrosine kinase with antineoplastic activity .
|
-
-
- HY-152840
-
|
|
c-Met/HGFR
|
Cancer
|
|
Emzeltrectinib is a potent tyrosine kinase inhibitor with antineoplastic activity .
|
-
-
- HY-156623
-
|
|
PARP
|
Cancer
|
|
Lerzeparib is an (ADP-ribose) polymerase (PARP) inhibitor, with antineoplastic activity .
|
-
-
- HY-10159
-
|
AMN107
|
Bcr-Abl
Autophagy
|
Cancer
|
|
Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
|
-
-
- HY-N6031
-
|
Moscatilin
|
NF-κB
|
Cancer
|
|
Dendrophenol (Moscatilin) acts as a NF-κB inhibitor . Antineoplastic activity .
|
-
-
- HY-147248
-
|
|
Others
|
Cancer
|
|
Opadotina is a small molecule of anvatabart opadotin. Opadotina shows antineoplastic activity .
|
-
-
- HY-119969
-
|
NSC 182986
|
Others
|
Cancer
|
|
Diaziquone (Diaziquone) is a water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity .
|
-
-
- HY-152852
-
|
Mifanertinib
|
c-Met/HGFR
|
Cancer
|
|
Mefatinib free base is a potent tyrosine kinase inhibitor with antineoplastic activity .
|
-
-
- HY-17420
-
|
|
DNA Alkylator/Crosslinker
|
Cancer
|
|
Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.
|
-
-
- HY-17420A
-
|
Cyclophosphamide monohydrate
|
DNA Alkylator/Crosslinker
|
Cancer
|
|
Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
|
-
-
- HY-15753
-
|
NSC 71795
|
Topoisomerase
|
Cancer
|
|
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
|
-
-
- HY-15753A
-
|
NSC 71795 hydrochloride
|
Topoisomerase
|
Cancer
|
|
Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
|
-
-
- HY-147245
-
|
STP1002
|
PARP
|
Cancer
|
|
Basroparib is a potent poly (ADP-ribose) polymerase (PARP) inhibitor, with antineoplastic activity .
|
-
-
- HY-156609
-
|
|
Others
|
Cancer
|
|
FOXM1-IN-2 is a FOXM1 inhibitor, with antineoplastic activity .
|
-
-
- HY-152830A
-
|
|
Others
|
Cancer
|
|
Adrixetinib (TFA) is an inhibitor of protein tyrosine kinase with antineoplastic activity .
|
-
-
- HY-10502
-
|
IND 58359; R115777
|
Farnesyl Transferase
|
Infection
Cancer
|
|
Tipifarnib (IND 58359) binds to and inhibits farnesyltransferase (FTase) with an IC50 of 0.86 nM. Antineoplastic activity and antiparasitic activity .
|
-
-
- HY-15459
-
|
XRP6258; RPR-116258A; taxoid XRP6258
|
Microtubule/Tubulin
Autophagy
|
Cancer
|
|
Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.
|
-
-
- HY-N0679
-
|
Retinol acetate; Vitamin A acetate
|
Others
|
Cancer
|
|
Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities .
|
-
-
- HY-12289
-
|
VS-6063; PF-04554878
|
FAK
|
Cancer
|
|
Defactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities.
|
-
-
- HY-W415824A
-
|
|
Others
|
Cancer
|
|
Mannomustine dihydrochloride is an alkylating agent with antineoplastic activity. Mannomustine dihydrochloride causes severe bone marrow depression. Mannomustine dihydrochloride is a powerful vesicant.
|
-
-
- HY-101820
-
|
|
EGFR
|
Cancer
|
|
Simotinib is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities .
|
-
-
- HY-16162
-
|
|
TRP Channel
|
Cancer
|
|
D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.
|
-
-
- HY-101820A
-
|
|
EGFR
|
Cancer
|
|
Simotinib hydrochloride is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities .
|
-
-
- HY-10159S
-
|
AMN107-d6
|
Bcr-Abl
Autophagy
|
Cancer
|
|
Nilotinib-d6 is a deuterium labeled Nilotinib. Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity[1].
|
-
-
- HY-132549S
-
-
-
- HY-13301
-
|
|
HSP
|
Cancer
|
|
MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with potential antineoplastic activity .
|
-
-
- HY-148807
-
|
QC8222 free base; TACH 101 free base
|
Histone Demethylase
|
Cancer
|
|
Zavondemstat (QC8222; TACH 101) is an inhibitor of histone lysine demethylase 4D (KDM4D) with antineoplastic activity .
|
-
-
- HY-138627
-
|
|
Drug Metabolite
EGFR
|
Cancer
|
|
AST5902 is the active metabolite of Firmonertinib (HY-112870) (EGFR inhibitor). AST5902 has antineoplastic activity .
|
-
-
- HY-17420AS
-
|
|
Isotope-Labeled Compounds
DNA Alkylator/Crosslinker
|
Cancer
|
|
Cyclophosphamide-d8 (hydrate) is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities[1][2].
|
-
-
- HY-B0078S
-
-
-
- HY-111789
-
|
TAK-981
|
E1/E2/E3 Enzyme
|
Inflammation/Immunology
Cancer
|
|
Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities .
|
-
-
- HY-N7651
-
|
|
Others
|
Cancer
|
|
Neoanhydropodophyllol is a cyclolignan derivative, with antineoplastic activity. Neoanhydropodophyllol displays cytotoxicity against several cancer cells (leukemia, lung carcinoma and colon carcinoma) .
|
-
-
- HY-17420S1
-
-
-
- HY-147303
-
|
|
Trk Receptor
EGFR
|
Cancer
|
|
Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity .
|
-
-
- HY-120220
-
|
A-20968; Ancyte
|
Others
|
Cancer
|
|
Piposulfan (Ancyte) is a methanesulfonate, alkylating derivative of piperazine. Piposulfan has potential antineoplastic activity. Piposulfan can be used for the research of cancer .
|
-
-
- HY-N12262
-
|
|
Bacterial
|
Infection
Cancer
|
|
(+)-Epieudesmin is an antineoplastic agent. (+)-Epieudesmin has marginal cancer cell line inhibitory activities. (+)-Epieudesmin inhibits the growth of Gram-negative pathogen .
|
-
- HY-15459S
-
|
XRP6258-d6; RPR-116258A-d6; taxoid XRP6258-d6
|
Microtubule/Tubulin
Autophagy
|
Cancer
|
|
Cabazitaxel-d6 is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity[1][2].
|
-
- HY-13768AR
-
|
|
Topoisomerase
Autophagy
Apoptosis
|
Cancer
|
|
Topotecan (hydrochloride) (Standard) is the analytical standard of Topotecan (hydrochloride). This product is intended for research and analytical applications. Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities.
|
-
- HY-117286
-
|
TEN-010
|
Epigenetic Reader Domain
|
Cancer
|
|
(S)-JQ-35 (TEN-010) is an inhibitor of the Bromodomain and Extra-Terminal (BET) family bromodomain-containing proteins with potential antineoplastic activity.
|
-
- HY-112056
-
-
- HY-148807A
-
|
QC8222; TACH 101
|
Histone Demethylase
|
Cancer
|
|
Zavondemstat (QC8222; TACH 101) (L-lysine) is an inhibitor of histone lysine demethylase 4D (KDM4D) with antineoplastic activity .
|
-
- HY-12289S
-
|
VS-6063-d6; PF-04554878-d6
|
FAK
Isotope-Labeled Compounds
|
Cancer
|
|
Defactinib-d6 is a deuterium labeled Defactinib (HY-12289). Defactinib is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities .
|
-
- HY-10159R
-
|
|
Bcr-Abl
Autophagy
|
Cancer
|
|
Nilotinib (Standard) is the analytical standard of Nilotinib. This product is intended for research and analytical applications. Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
|
-
- HY-18632
-
|
|
Histone Demethylase
|
Cancer
|
|
GSK2879552 an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/ KDM1A), with potential antineoplastic activity .
|
-
- HY-15459S1
-
-
- HY-147407
-
|
|
Others
|
Cancer
|
|
Imbotolimod, immunoglobulin G1-kappa, is a humanized monoclonal antibody with anti-ERBB2 and antineoplastic activity. Imbotolimod is a derivative of telratolimod .
|
-
- HY-N0679S4
-
|
Retinol acetate-d4; Vitamin A acetate-d4
|
Isotope-Labeled Compounds
|
Cancer
|
|
Retinyl acetate-d4 is the deuterium labeled Retinyl acetate[1]. Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities[2].
|
-
- HY-17420S
-
|
|
DNA Alkylator/Crosslinker
|
Cancer
|
|
Cyclophosphamide-d4 is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant[1][2].
|
-
- HY-138627A
-
|
|
EGFR
Drug Metabolite
|
Cancer
|
|
AST5902 trimesylate is the principal metabolite of Alflutinib (AST2818) both in vitro and in vivo. AST5902 trimesylate exerts antineoplastic activity. Alflutinib is an EGFR inhibitor .
|
-
- HY-147280
-
|
GP-2250
|
Apoptosis
|
Cancer
|
|
Misetionamide is an orally oxathiazin-like compound. Misetionamide is a glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with antineoplastic activity. Misetionamide can be used for the research of cancer .
|
-
- HY-10159B
-
|
AMN107 hydrochloride
|
Bcr-Abl
Autophagy
|
Cancer
|
Nilotinib (AMN107) hydrochloride is an orally active Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity and can be used in studies of chronic myelogenous leukaemia .
|
-
- HY-17420AR
-
|
|
DNA Alkylator/Crosslinker
|
Cancer
|
|
Cyclophosphamide (hydrate) (Standard) is the analytical standard of Cyclophosphamide (hydrate). This product is intended for research and analytical applications. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
|
-
- HY-17420R
-
|
|
DNA Alkylator/Crosslinker
|
Cancer
|
|
Cyclophosphamide (Standard) is the analytical standard of Cyclophosphamide. This product is intended for research and analytical applications. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.
|
-
- HY-10159S1
-
-
- HY-15459R
-
|
|
Microtubule/Tubulin
Autophagy
|
Cancer
|
|
Cabazitaxel (Standard) is the analytical standard of Cabazitaxel. This product is intended for research and analytical applications. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.
|
-
- HY-17617
-
|
Z-360
|
Cholecystokinin Receptor
|
Endocrinology
Cancer
|
|
Nastorazepide (Z-360) is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity.
|
-
- HY-B2082
-
-
- HY-N3154
-
|
|
Others
|
Cancer
|
|
Odorinol is a natural product isolated from branches and leaves of Aglaia odorata. Odorinol has potential antineoplastic activity and can inhibit both the initiation and promotion stages of skin cancer .
|
-
- HY-N0679R
-
|
|
Others
|
Cancer
|
|
Retinyl acetate (Standard) is the analytical standard of Retinyl acetate. This product is intended for research and analytical applications. Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities .
|
-
- HY-147877
-
|
|
Topoisomerase
|
Cancer
|
|
Topoisomerase II inhibitor 12 (Compound 8c) is a topoisomerase II (topo II) inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity .
|
-
- HY-18632A
-
|
|
Histone Demethylase
|
Cancer
|
|
GSK2879552 dihydrochloride an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), with potential antineoplastic activity .
|
-
- HY-112314
-
|
|
Src
Bcr-Abl
Apoptosis
|
Cancer
|
|
AZD0424 is an orally active, and dual selective Src/Abl kinase inhibitor with potential antineoplastic activity . AZD0424 induces apoptosis and cell cycle arrest in lymphoma cells .
|
-
- HY-108250
-
|
|
Androgen Receptor
|
Cancer
|
|
(R)-Bicalutamide is the (R)-enantiomer of Bicalutamide (HY-14249). (R)-Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R)-Bicalutamide is widely used for the research of prostate cancer .
|
-
- HY-N3155
-
|
Roxburghiline
|
Others
|
Cancer
|
|
Odorine (Roxburghiline) is a natural product isolated from branches and leaves of Aglaia odorata. Odorine has potential antineoplastic activity and can inhibit both the initiation and promotion stages of skin cancer .
|
-
- HY-13324
-
|
RTA 402; NSC 713200; CDDO Methyl ester
|
Keap1-Nrf2
Autophagy
Apoptosis
Ferroptosis
|
Cancer
|
|
Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway.
|
-
- HY-N0876
-
|
|
Others
|
Cancer
|
|
Arenobufagin is a natural bufadienolide from toad venom; has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells.
|
-
- HY-N11110
-
|
|
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Inuviscolide is an apoptosis inducer. Inuviscolide can induce of G2/M arrest in human melanoma cell lines. Inuviscolide exhibits antineoplastic and anti-inflammatory activities .
|
-
- HY-152861
-
|
TAK-676 free base
|
STING
|
Cancer
|
|
Dazostinag (TAK-676 free base) is an agonist of stimulator of interferon genes (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis antibody-drug conjugates (ADCs) .
|
-
- HY-N2812
-
|
4-O-Epipodophyllotoxinyl acetate
|
HSV
VSV
|
Infection
Cancer
|
|
Epipodophyllotoxin acetate (4-O-Epipodophyllotoxinyl acetate; compound 4) is a cyclolignan that exhibits antineoplastic and antiviral activities. Epipodophyllotoxin acetate inhibits HSV and VSV, with IC50s of 0.2 and 0.1 μg/mL, respectively .
|
-
- HY-B1468
-
|
|
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Cancer
|
|
8-Azaguanine is a purine analogue that shows antineoplastic activity. 8-Azaguanine functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth .
|
-
- HY-N3883
-
|
|
Autophagy
|
Neurological Disease
Cancer
|
|
Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities .
|
-
- HY-148793
-
|
|
c-Met/HGFR
|
Cancer
|
|
Resencatinib is a potent tyrosine kinase inhibitor with antineoplastic activity . Resencatinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-106825
-
|
|
Microtubule/Tubulin
|
Cancer
|
|
Clanfenur is a substituted benzoylphenylurea, an analogue of the pesticide fenfluramide, with potential antineoplastic activity. Clanfenur can bind to the colchicine-binding site on β-tubulin, inhibit microtubule polymerization, and thus prevent tumor cell replication .
|
-
- HY-19437
-
|
AT-1727
|
Topoisomerase
|
Cancer
|
|
Bimolane (AT-1727), a human topoisomerase II inhibitor, can be used as an anti-neoplastic agent and for the research of psoriasis. Bimolane shows leukemogenic activity and induces multiple types of chromosomal aberrations in human lymphocytes .
|
-
- HY-16271S
-
|
|
Isotope-Labeled Compounds
MDM-2/p53
|
Cancer
|
|
Kevetrin (hydrochloride)- 13C2, 15N3 is the 13C-labeled and 15N-labeled Kevetrin (hydrochloride). Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
|
-
- HY-103711
-
|
|
Microtubule/Tubulin
|
Cancer
|
|
Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts .
|
-
- HY-100498A
-
|
|
Others
|
Cancer
|
|
GSK-2256098 hydrochloride is a focal adhesion kinase (FAK) inhibitor that exhibits potential antiangiogenic and antineoplastic activities. GSK-2256098 hydrochloride targets FAK to inhibit tumor cell growth by regulating cell adhesion, migration, proliferation, and survival.
|
-
- HY-19983
-
|
|
FGFR
|
Cancer
|
|
ASP5878 is an oral active inhibitor of FGFR 1, 2, 3, and 4, with IC50 values of 0.47 nM, 0.6 nM, 0.74 nM and 3.5 nM for FGFR 1, 2, 3, and 4 kinase activity. ASP5878 has potential antineoplastic activity .
|
-
- HY-114570
-
|
NSC 286193; Riboxamide
|
Nucleoside Antimetabolite/Analog
Orthopoxvirus
|
Infection
Cancer
|
|
Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH) . Tiazofurin also has anti-orthopoxvirus and anti-variola activities .
|
-
- HY-111789A
-
|
(S)-TAK-981
|
Others
|
Inflammation/Immunology
Cancer
|
|
(S)-Subasumstat is the isomer of Subasumstat (HY-111789), and can be used as an experimental control. Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities .
|
-
- HY-14776
-
|
CX-3543
|
DNA/RNA Synthesis
|
Cancer
|
|
Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template .
|
-
- HY-129768
-
|
|
Eukaryotic Initiation Factor (eIF)
|
Cancer
|
|
CMLD012072 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012072 can induce RNA clamping of eIF4A1 and eIF4A2 and possess potent anti-neoplastic activity .
|
-
- HY-130812
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
Gemcitabine-O-Si(di-iso)-O-Mc is a agent-linker conjugate for ADC with potent antitumor activity by using Gemcitabine (a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent; HY-17026), linked via the ADC linker .
|
-
- HY-19897
-
|
|
FLT3
VEGFR
|
Cancer
|
|
4SC-203 is a potent multikinase inhibitor with potential antineoplastic activity. 4SC-203 selectively FLT3/STK1, FLT3 mutated forms, and VEGFRs .
|
-
- HY-P990072
-
|
|
PD-1/PD-L1
|
Cancer
|
|
Lipustobart is an IgG4-kappa, anti-PDCD1 (programmed cell death 1, PD1, PD-1, CD279) humanized monoclonal antibody. Lipustobart shows immunostimulant and antineoplastic activity .
|
-
- HY-114335
-
|
|
NF-κB
Fungal
|
Infection
Inflammation/Immunology
Cancer
|
|
Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica . Triphala inhibits NF-κB activation. Triphala exerts antifungal action . Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities.
|
-
- HY-P990037
-
|
|
CD38
|
Cancer
|
|
Erzotabart is an IgG1-kappa, anti-CD38 (ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, cADPR1) Homo sapiens monoclonal antibody. Erzotabart shows antineoplastic activity .
|
-
- HY-13550A
-
|
NSC 196473 acetate; NSC 290813 acetate
|
DNA/RNA Synthesis
|
Cancer
|
|
Ametantrone acetate (NSC 196473 acetate) is an antineoplastic drug with topoisomerase II inhibitory activity. Ametantrone acetate causes covalent cross-linking of DNA. The pharmacokinetic profile of Ametantrone acetate has been confirmed in clinical trials, and its elimination pathway in the body indicates the existence of a major metabolic pathway .
|
-
- HY-114177
-
|
PF-06873600
|
CDK
|
Cancer
|
|
PF-06873600 is a selective and orally bioavailable inhibitor of cyclin-dependent kinase (CDK), with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively. PF-06873600 has potential antineoplastic activity .
|
-
- HY-13624A
-
|
4'-Epidoxorubicin hydrochloride
|
DNA/RNA Synthesis
Topoisomerase
Apoptosis
Antibiotic
|
Cancer
|
|
Epirubicin hydrochloride (4'-Epidoxorubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase . Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity .
|
-
- HY-B0069
-
|
F-ara-A; NSC 118218
|
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
STAT
Apoptosis
|
Cancer
|
|
Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes .
|
-
- HY-13624
-
|
4'-Epidoxorubicin
|
DNA/RNA Synthesis
Topoisomerase
Apoptosis
Antibiotic
|
Cancer
|
|
Epirubicin (4'-Epidoxorubicin), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase . Epirubicin inhibits DNA and RNA synthesis. Epirubicin is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity .
|
-
- HY-114577
-
|
Isophosphoramide mustard tromethamine; IPM tromethamine; ZIO-201 tromethamine
|
DNA Alkylator/Crosslinker
|
Cancer
|
|
Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.
|
-
- HY-132822
-
|
SBP-101
|
Others
|
Cancer
|
|
Ivospemin (SBP-101) is an antineoplastic spermine analog. Ivospemin has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin is promising for research of cancers .
|
-
- HY-P4144
-
|
Phor18-LHRH (338613)
|
GnRH Receptor
|
Endocrinology
Cancer
|
|
Onvitrelin ucalontide ([Phor18-LHRH (338613)]) is an analogue of luteinizing hormone releasing hormone (LHRH) with antineoplastic activity. Onvitrelin ucalontide is a peptide with sequences of KFAKFAKKFAKFAKKFAKQHWSYGLRPG. Onvitrelin ucalontide effectively inhibits breast cancer, ovarian cancer and prostate cancer xenografts in mouse model .
|
-
- HY-P990086
-
|
|
Interleukin Related
|
Cancer
|
|
Vopikitug is an IgG1-kappa, anti-IL2RA (interleukin 2 receptor alpha subunit, IL-2RA, TAC, p55, CD25) homo sapiens monoclonal antibody. Vopikitug shows antineoplastic activity .
|
-
- HY-W011434
-
|
TGIC
|
MDM-2/p53
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via?p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research .
|
-
- HY-138627B
-
|
|
Others
|
Cancer
|
|
AST5902 mesylate is a principal metabolite of Alflutinib, exhibiting significant antineoplastic activity. AST5902 mesylate contributes to the overall pharmacological effects in the treatment of non-small cell lung cancer. AST5902 mesylate is involved in the response to activating EGFR mutations and can help overcome EGFR T790M drug-resistant mutations.
|
-
- HY-17602
-
|
BBI503
|
Others
|
Cancer
|
|
Amcasertib (BBI503) is an orally active and small-molecule multi-kinase inhibitor. Amcasertib exhibits inhibitory activity against the NANOG and CD133 expression and cell viability in PC-9/GR cells. As an orally available cancer cell stemness kinase inhibitor with potential antineoplastic activity, it is currently being studied in phase I clinical trials in a number of cancers.
|
-
- HY-130149
-
|
MRTX849
|
Ras
|
Cancer
|
|
Adagrasib (MRTX849) is a potent, orally-available, and mutation-selective covalent inhibitor of KRAS G12C with potential antineoplastic activity. Adagrasib covalently binds to KRAS G12C at the cysteine at residue 12, locks the protein in its inactive GDP-bound conformation, and inhibits KRAS-dependent signal transduction .
|
-
- HY-B0497S1
-
|
BAY2353-13C6
|
Isotope-Labeled Compounds
STAT
Parasite
Antibiotic
|
Infection
Cancer
|
|
Niclosamide- 13C6 is the 13C6 labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.
|
-
- HY-10224A
-
|
LBH589 lactate; NVP-LBH589 lactate
|
HDAC
HIV
Autophagy
Apoptosis
|
Infection
Cancer
|
|
Panobinostat lactate is a potent and orally active non-selective HDAC inhibitor. Panobinostat lactate has antineoplastic activities. Panobinostat lactate effectively disrupts HIV latency. Panobinostat lactate induces cell apoptosis and autophagy. Panobinostat lactate can be used for the study of refractory or relapsed multiple myeloma .
|
-
- HY-10206
-
|
MP470; HPK 56
|
c-Kit
PDGFR
RAD51
FLT3
c-Met/HGFR
RET
Apoptosis
|
Cancer
|
|
Amuvatinib (MP470) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib (MP470) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair . Antineoplastic activity .
|
-
- HY-16560
-
|
Campathecin; (S)-(+)-Camptothecin; CPT
|
Topoisomerase
ADC Cytotoxin
MicroRNA
Influenza Virus
Apoptosis
Fungal
Antibiotic
|
Infection
Cancer
|
|
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM . Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells .
|
-
- HY-10206A
-
|
MP470 hydrochloride; HPK 56 hydrochloride
|
c-Kit
PDGFR
RAD51
FLT3
c-Met/HGFR
RET
|
Cancer
|
|
Amuvatinib hydrochloride (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib hydrochloride (MP470 hydrochloride) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair . Antineoplastic activity .
|
-
- HY-129390
-
|
ICP-022
|
Btk
|
Cancer
|
|
Orelabrutinib (ICP-022) is a potent, orally active, and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. Orelabrutinib prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK .
|
-
- HY-15244A
-
|
BYL-719 hydrochloride
|
PI3K
|
Cancer
|
|
Alpelisib hydrochloride (BYL-719 hydrochloride) is a potent, orally active, and selective PI3Kα inhibitor with IC50s of 5 nM, 250 nM, 290 nM and 1200 nM for p110α, p110γ, p110δ, and p110β, respectively. Alpelisib hydrochloride (BYL-719 hydrochloride) shows antineoplastic activity .
|
-
- HY-10293
-
|
INCB007839; INCB7839
|
MMP
|
Cancer
|
|
Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2 + breast cancer, gliomas, et al .
|
-
- HY-148789
-
|
OP-1250
|
Estrogen Receptor/ERR
|
Inflammation/Immunology
Cancer
|
|
Palazestrant is an antiestrogen and antineoplastic agent. Palazestrant can completely inhibit the activity of 17b-estradiol (E2) with IC50 value of 6.4 nM, and inhibit the proliferation of MCF7 and CAMA-1 cells with IC50 value of 1.4-1.6 nM. Palazestrant can inhibit ER +/HER2 + cancer .
|
-
- HY-134008
-
|
|
Others
|
Cancer
|
|
Protoapigenone is an antineoplastic agent isolated from ferns. Protoapigenone has significant inhibitory activity against Hep G2, Hep 3B, MCF-7, A549 and MDAMB-231, with IC50s values of 1.60, 0.23, 0.78, 3.88 and 0.27 μg/mL respectively .
|
-
- HY-15959
-
|
Volitinib; HMPL-504; AZD-6094
|
c-Met/HGFR
|
Cancer
|
|
Savolitinib (AZD-6094) is a potent, highly selective, and orally bioavailable c-Met inhibitor with IC50 s of 5 nM and 3 nM for c-Met and p-Met, respectively. Savolitinib (AZD-6094) selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. Antineoplastic activity .
|
-
- HY-147419
-
|
|
PI3K
|
Cancer
|
|
Vulolisib is a potent and orally active phosphatidylinositol 3-kinase (PI3K) inhibitor, with IC50 values of 0.2 nM, 168 nM, 90 nM and 49 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. Antiproliferative and antineoplastic activity .
|
-
- HY-152774
-
|
|
Akt
PI3K
|
Cancer
|
|
Antitumor agent-86 (compound 5a) inhibits MCF-7 breast cancer cells with an IC50 value of 2.62 µM. Antitumor agent-86 induces cell apoptosis and cell cycle arrest, and shows antineoplastic activity by targeting RAS/PI3K/Akt/JNK signaling cascades .
|
-
- HY-B0069R
-
|
|
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
STAT
Apoptosis
|
Cancer
|
|
Fludarabine (Standard) is the analytical standard of Fludarabine. This product is intended for research and analytical applications. Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes .
|
-
- HY-13624AR
-
|
|
DNA/RNA Synthesis
Topoisomerase
Apoptosis
Antibiotic
|
Cancer
|
|
Epirubicin (hydrochloride) (Standard) is the analytical standard of Epirubicin (hydrochloride). This product is intended for research and analytical applications. Epirubicin hydrochloride (4'-Epidoxorubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase . Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity .
|
-
- HY-16933
-
|
NSC-153353; SDX-102
|
Antibiotic
|
Infection
Cancer
|
|
L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine (NSC-153353) blocks the common de novo purine biosynthesis pathway and, thereby, inhibits tumor cells with MTAP deficiency .
|
-
- HY-125918
-
|
Pingyangmycin hydrochloride
|
Apoptosis
Antibiotic
|
Infection
Cancer
|
|
Bleomycin A5 (Pingyangmycin) hydrochloride is an anti-neoplastic glycoprotein antibiotic. Bleomycin A5 suppresses Drp1-mediated mitochondrial fission and induces apoptosis in human nasal polyp-derived fibroblasts. Bleomycin A5 hydrochloride has anticancer activities relying on its ability to produce RNA and DNA breaks, thus, leading to cell death ..
|
-
- HY-16560S
-
|
Campathecin-d5; (S)-(+)-Camptothecin-d5; CPT-d5
|
Topoisomerase
ADC Cytotoxin
MicroRNA
Influenza Virus
Apoptosis
Fungal
Antibiotic
|
Infection
Cancer
|
|
Camptothecin-d5 is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].
|
-
- HY-N1976
-
|
(3R,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol
|
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
|
(+)-(3R,8S)-Falcarindiol is a polyacetylene found in carrots, has antimycobacterial activity, with an IC50 of 6 μM and MIC of 24 μM against Mycobacterium tuberculosis H37Ra . Antineoplastic and anti-inflammatory activity . (+)-(3R,8S)-Falcarindiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-15670
-
|
|
γ-secretase
Notch
|
Cancer
|
|
BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC50s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity .
|
-
- HY-P99386
-
|
MNRP-1685A
|
Complement System
|
Cancer
|
|
Vesencumab (MNRP-1685A) is IG1 antibody against neuropilin-1 (NRP-1). Vesencumab binds to NRP-1 and prevents the subsequent coupling of NRP-1 to VEGFR-2. Vesencumab has anti-angiogenic and anti-neoplastic activities. Vesencumab can be used in the research of metastatic solid tumors, including ovarian cancer .
|
-
- HY-W011434R
-
|
|
MDM-2/p53
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Triglycidyl isocyanurate (Standard) is the analytical standard of Triglycidyl isocyanurate. This product is intended for research and analytical applications. Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via?p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research .
|
-
- HY-106634
-
|
Methylglyoxal-bis(guanylhydrazone); MGBG; Methyl-GAG
|
HIV
Apoptosis
|
Infection
Cancer
|
|
Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment .
|
-
- HY-129767
-
|
|
Eukaryotic Initiation Factor (eIF)
|
Cancer
|
|
CMLD012612 is an amidino-rocaglate containing a hydroxamate group and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012612 inhibits cell translation and is cytotoxic to NIH/3T3 cells with an IC50 value of 2 nM. CMLD012612 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A) and possesses potent anti-neoplastic activity .
|
-
- HY-128979
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
Deruxtecan analog 2 (example 9 P3) is a Deruxtecan (HY-13631E) analog. Deruxtecan analog 2 is a agent-linker conjugate composed of Camptothecin (HY-16560) and a linker. Camptothecin (CPT) is a Topo I inhibitor with antineoplastic activity against colorectal, breast, lung and ovarian cancers. Deruxtecan analog 2 can be used for the preparation anti-FGFR2 ADC .
|
-
- HY-10224
-
|
LBH589; NVP-LBH589
|
HDAC
Autophagy
HIV
Apoptosis
|
Cancer
|
|
Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities . Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells . Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma .
|
-
- HY-122502
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
Pyrazofurin, a pyrimidine nucleoside analogue with antineoplastic activity, inhibits cell proliferation and DNA synthesis in cells by inhibiting uridine 5'-phosphate (UMP) synthase . Pyrazofurin is an active, sensitive orotate-phosphoribosyltransferase inhibitor with IC50s between 0.06-0.37 µM in the three squamous cell carcinoma (SCC) cell lines Hep-2, HNSCC-14B and HNSCC-14C .
|
-
- HY-139611
-
|
|
Histone Methyltransferase
|
Cancer
|
|
MRTX-1719 is a potent, orally active, selective PRMT5•MTA complex inhibitor, with IC50 of 3.6 and 20.5 nM for PRMT5•MTA and PRMT5. MRTX-1719 binds to the PRMT5•MTA complex, with KD value of 0.14 pM. MRTX-1719 shows antineoplastic activity in vitro and in vivo, and can be used for cancer study .
|
-
- HY-156618
-
|
ABSK011
|
FGFR
|
Cancer
|
|
Irpagratinib (ABSK011) is an orally active inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinase, targeting to FGFR4 (IC50<10 nM). Irpagratinib inhibits the auto-phosphorylation of FGFR4 and blocks signal transduction from FGFR4 to downstream pathway activation. Irpagratinib exhibits high exposure in PK study in mouse, rat and dog, and also shows antineoplastic/anti-tumor activity in subcutaneous xenograft tumor models .
|
-
- HY-10224S
-
|
LBH589-d4; NVP-LBH589-d4
|
HDAC
Autophagy
HIV
Apoptosis
|
Cancer
|
|
Panobinostat-d4 is the deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].
|
-
- HY-10224S1
-
|
LBH589-d4 hydrochloride; NVP-LBH589-d4 hydrochloride
|
Isotope-Labeled Compounds
HDAC
Autophagy
HIV
Apoptosis
|
Cancer
|
|
Panobinostat-d4 (hydrochloride) is deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].
|
-
- HY-13233A
-
|
Val-boroPro mesylate; PT100 mesylate
|
Dipeptidyl Peptidase
|
Inflammation/Immunology
Cancer
|
|
Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 < 4 nM; Ki = 0.18 nM) and the inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM), inhibits DPP8/9 (IC50 = 4/11 nM; Ki = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC50 = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities .
|
-
- HY-N1746
-
|
2'-O-Methylkurarinone
|
RANKL/RANK
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
(2S)-2'-Methoxykurarinone, a compound isolated from the roots of Sophora flavescens, has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2'-Methoxykurarinone (MK) displays cytotoxic activity against human myeloid leukemia HL-60 cells .
|
-
- HY-W002585
-
|
|
DNA/RNA Synthesis
Apoptosis
|
Cancer
|
|
O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity .
|
-
- HY-106634R
-
|
|
HIV
Apoptosis
|
Infection
Cancer
|
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Mitoguazone (Standard) is the analytical standard of Mitoguazone. This product is intended for research and analytical applications. Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment .
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- HY-12033
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2-ME2; NSC-659853
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Microtubule/Tubulin
Reactive Oxygen Species
Apoptosis
Autophagy
Endogenous Metabolite
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Cancer
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2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .
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- HY-13233
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Val-boroPro; PT100
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Dipeptidyl Peptidase
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Inflammation/Immunology
Cancer
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Talabostat (Val-boroPro; PT100) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 < 4 nM; Ki = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM), inhibits DPP8/9 (IC50 = 4/11 nM; Ki = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC50 = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities .
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- HY-100001
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TRP Channel
CRAC Channel
Potassium Channel
Autophagy
Apoptosis
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Cardiovascular Disease
Cancer
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SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca 2+ entry (SOCE) inhibitor. SKF-96365 hydrochloride significantly inhibits hERG, hKCNQ1/hKCNE1, hKir2.1 and hKv4.3 current, and significantly prolongs the QTc interval in isolated guinea pig hearts. SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells .
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- HY-15244
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Alpelisib
Maximum Cited Publications
91 Publications Verification
BYL-719
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PI3K
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Cancer
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Alpelisib (BYL-719) is a potent, selective, and orally active PI3Kα inhibitor. Alpelisib (BYL-719) shows efficacy in targeting PIK3CA-mutated cancer. Alpelisib (BYL-719) also inhibits p110α/p110γ/p110δ/p110β with IC50s of 5/250/290/1200 nM, respectively. Antineoplastic activity .
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- HY-12033S2
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2-ME2-d5; NSC-659853-d5
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Isotope-Labeled Compounds
Microtubule/Tubulin
Reactive Oxygen Species
Apoptosis
Autophagy
Endogenous Metabolite
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Cancer
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2-Methoxyestradiol-d5 is the deuterium labeled 2-Hydroxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6][7].
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- HY-12033S
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Microtubule/Tubulin
Reactive Oxygen Species
Apoptosis
Autophagy
Endogenous Metabolite
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Cancer
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2-Methoxyestradiol- 13C,d3 is the 13C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].
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- HY-12033S1
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2-ME2-13C6; NSC-659853-13C6
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Isotope-Labeled Compounds
Microtubule/Tubulin
Reactive Oxygen Species
Apoptosis
Autophagy
Endogenous Metabolite
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Cancer
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2-Methoxyestradiol- 13C6 is the 13C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].
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- HY-155736
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p38 MAPK
EGFR
Raf
CDK
c-Met/HGFR
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Cancer
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MAPK-IN-2 (compound 3h) is a potent MAPK inhibitor with antineoplastic activity. MAPK-IN-2 inhibits cancer cell proliferation among serval cancer cell lines, and suppresses MAPK pathway with potant efficacy (EGFR WT IC50=281 nM, c-MET IC50=205 nM, B-RAF WT IC50=112 nM, and CDK4/6 IC50=95 and 184 nM, respectively). MAPK-IN-2 even shows a remarkable potency against mutated EGFR and B-RAF (EGFR T790M IC50=69 nM and B-RAF V600E IC50=83 nM) .
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- HY-167854
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Others
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Cancer
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KW-2450 Free base is a potent multikinase inhibitor targeting Aurora A and B kinases, demonstrating significant antitumor activity against triple-negative breast cancer (TNBC). KW-2450 Free base effectively reduces cell viability, promotes apoptosis, and inhibits colony formation and mammosphere formation in TNBC cells. KW-2450 Free base significantly suppresses the growth of TNBC xenografts, leading to tetraploid accumulation followed by apoptosis or the survival of octaploid cells. KW-2450 Free base enhances the efficacy of combination therapy with the MEK inhibitor selumetinib, resulting in a synergistic antitumor effect in TNBC models. KW-2450 Free base also acts as an orally bioavailable inhibitor of IGF-1R and IR tyrosine kinases, contributing to its potential antineoplastic activity by inhibiting tumor cell proliferation and inducing apoptosis.
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P1959A
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BIM 23014 acetate
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Peptides
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Endocrinology
Cancer
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Lanreotide (BIM 23014) acetate is a somatostatin analogue with antineoplastic activity. Lanreotide acetate can be used for the research of carcinoid syndrome .
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- HY-P3315
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RV001
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Peptides
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Inflammation/Immunology
Cancer
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Onilcamotide (RV001) is a C-terminal peptide of RhoC protein. Onilcamotide is a cancer vaccine and has potential immunomodulating and antineoplastic activities .
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- HY-P1959
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BIM 23014
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Peptides
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Endocrinology
Cancer
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Lanreotide (BIM 23014) is a somatostatin analogue with antineoplastic activity. Lanreotide can be used for the research of carcinoid syndrome .
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- HY-P1959B
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BIM 23014 diTFA
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Peptides
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Endocrinology
Cancer
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Lanreotide (BIM 23014) diTFA is a somatostatin analogue with antineoplastic activity. Lanreotide diTFA can be used for the research of carcinoid syndrome .
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- HY-106374
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Peptides
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Cancer
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Elpamotide is an epitope peptide derived from VEGFR2. Elpamotide induces cytotoxic T lymphocytes (CTLs) to kill VEGFR2-expressing endothelial cells. Elpamotide has potential immunostimulatory and antineoplastic activities. Elpamotide can be used in the research of cancer, such as pancreatic cancer .
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- HY-P4144
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Phor18-LHRH (338613)
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GnRH Receptor
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Endocrinology
Cancer
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Onvitrelin ucalontide ([Phor18-LHRH (338613)]) is an analogue of luteinizing hormone releasing hormone (LHRH) with antineoplastic activity. Onvitrelin ucalontide is a peptide with sequences of KFAKFAKKFAKFAKKFAKQHWSYGLRPG. Onvitrelin ucalontide effectively inhibits breast cancer, ovarian cancer and prostate cancer xenografts in mouse model .
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- HY-115379
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Peptides
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Cancer
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Latromotide is a synthetic peptide with antineoplastic activity. It consists of 10 amino acids corresponding to amino acid residues 66-75 of the human kinesin-like protein KIF20A. Latromotide has a sequence of H-Lys-Val-Tyr-Leu-Arg-Val-Arg-Pro Leu-Leu-OH .
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P99498
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CEA-IL2v; RG 7813; RO 6895882
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Interleukin Related
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Inflammation/Immunology
Cancer
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Cergutuzumab amunaleukin (CEA-IL2v) is a monomeric carcinoembryonic antigen (CEA)-targeted IL-2 variant-based immunocytokine. Cergutuzumab amunaleukin has immunostimulating and antineoplastic activities .
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- HY-P990032
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EOS-448; EOS884448; GSK4428859A
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Inhibitory Antibodies
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Cancer
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Belrestotug (EOS-448) is an antagonistic anti-TIGIT (VSIG9, VSTM3) human immunoglobulin G1 kappa (hIgG1 kappa) antibody. Belrestotug shows antineoplastic activity .
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- HY-P99386
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MNRP-1685A
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Complement System
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Cancer
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Vesencumab (MNRP-1685A) is IG1 antibody against neuropilin-1 (NRP-1). Vesencumab binds to NRP-1 and prevents the subsequent coupling of NRP-1 to VEGFR-2. Vesencumab has anti-angiogenic and anti-neoplastic activities. Vesencumab can be used in the research of metastatic solid tumors, including ovarian cancer .
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- HY-P99628
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EGFR
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Cancer
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Futuximab is a chimeric monoclonal antibody targeting non-overlapping epitopes on EGFR. Futuximab has antineoplastic activity .
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- HY-P99581
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OTSA101-DTPA; OTSA101-DTPA-90Y; OTSA101-SS01
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Wnt
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Cancer
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Tabituximab barzuxetan (exclude Y90) is a radioimmunoconjugate composed of a humanized monoclonal antibody targeting FZD-10 (OTSA-101). Tabituximab barzuxetan shows antineoplastic activity. Tabituximab barzuxetan can be used for synovial sarcoma research .
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- HY-P990072
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PD-1/PD-L1
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Cancer
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Lipustobart is an IgG4-kappa, anti-PDCD1 (programmed cell death 1, PD1, PD-1, CD279) humanized monoclonal antibody. Lipustobart shows immunostimulant and antineoplastic activity .
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- HY-P990037
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CD38
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Cancer
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Erzotabart is an IgG1-kappa, anti-CD38 (ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, cADPR1) Homo sapiens monoclonal antibody. Erzotabart shows antineoplastic activity .
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- HY-P990086
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Interleukin Related
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Cancer
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Vopikitug is an IgG1-kappa, anti-IL2RA (interleukin 2 receptor alpha subunit, IL-2RA, TAC, p55, CD25) homo sapiens monoclonal antibody. Vopikitug shows antineoplastic activity .
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
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- HY-10159S
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Nilotinib-d6 is a deuterium labeled Nilotinib. Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity[1].
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- HY-15459S
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Cabazitaxel-d6 is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity[1][2].
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- HY-15459S1
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Cabazitaxel-d9 is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.
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- HY-152852S
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Mefatinib-d6 free base (Mifanertinib-d6) is the deuterium labeled Mefatinib. Mefatinib is a potent tyrosine kinase inhibitor with antineoplastic activity .
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- HY-132549S
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Nilotinib-d3 is the deuterium labeled Nilotinib. Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity[1][2].
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- HY-17420AS
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Cyclophosphamide-d8 (hydrate) is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities[1][2].
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- HY-B0078S
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Dacarbazine-d6 is the deuterium labeled Dacarbazine. Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas.
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- HY-17420S1
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Cyclophosphamide-d8 is deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.
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- HY-12289S
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Defactinib-d6 is a deuterium labeled Defactinib (HY-12289). Defactinib is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities .
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- HY-N0679S4
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Retinyl acetate-d4 is the deuterium labeled Retinyl acetate[1]. Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities[2].
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- HY-17420S
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Cyclophosphamide-d4 is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant[1][2].
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- HY-10159S1
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Nilotinib-13C,d3 is a deuterated labeled Nilotinib . Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
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-
- HY-16271S
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Kevetrin (hydrochloride)- 13C2, 15N3 is the 13C-labeled and 15N-labeled Kevetrin (hydrochloride). Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
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- HY-B0497S1
-
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Niclosamide- 13C6 is the 13C6 labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.
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- HY-16560S
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Camptothecin-d5 is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].
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-
- HY-10224S
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Panobinostat-d4 is the deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].
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-
- HY-10224S1
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Panobinostat-d4 (hydrochloride) is deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].
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-
- HY-12033S2
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2-Methoxyestradiol-d5 is the deuterium labeled 2-Hydroxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6][7].
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-
-
- HY-12033S
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2-Methoxyestradiol- 13C,d3 is the 13C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].
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-
- HY-12033S1
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2-Methoxyestradiol- 13C6 is the 13C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].
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| Cat. No. |
Product Name |
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Classification |
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- HY-148793
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Alkynes
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Resencatinib is a potent tyrosine kinase inhibitor with antineoplastic activity . Resencatinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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