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Results for "

branched-chain

" in MedChemExpress (MCE) Product Catalog:

62

Inhibitors & Agonists

3

Biochemical Assay Reagents

11

Peptides

14

Natural
Products

8

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17

Isotope-Labeled Compounds

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-131503

    13-MTD; 13-Methylmyristic acid

    Apoptosis Cancer
    13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .
    13-Methyltetradecanoic acid
  • HY-W193545A
    ERG240
    2 Publications Verification

    Others Inflammation/Immunology Cancer
    ERG240 is an oral active branched-chain amino acid aminotransferase 1 (BCAT1) inhibitor. ERG240 can be used for the research of cancer, rheumatoid arthritis, and bone disease .
    ERG240
  • HY-148242A

    Fluorescent Dye Cancer
    BAY-252 is a potent branched-chain amino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC50s of 2 μM and 2 μM, respectively. BAY-069 also can be used as a chemical probe. BAY-069 can be used for the research of cancer .
    BAY-252
  • HY-N0486
    L-Leucine
    Maximum Cited Publications
    9 Publications Verification

    Leucine

    mTOR Endogenous Metabolite Metabolic Disease Cancer
    L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .
    L-Leucine
  • HY-W127484

    14-Methylpentadecanoic acid

    Biochemical Assay Reagents Others
    14-Methylpentadecanoic acid is a branched-chain fatty acid that has been found in soil bacteria. 1,2
    Isopalmitic acid
  • HY-B1122
    L-Cycloserine
    1 Publications Verification

    (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone

    GABA Receptor HIV Neurological Disease Cancer
    L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains .
    L-Cycloserine
  • HY-113063
    3-Methyl-2-oxovaleric acid
    2 Publications Verification

    Endogenous Metabolite Others
    3-Methyl-2-oxovaleric acid is a neurotoxin, an acidogen, and a metabotoxin, and also an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids.
    3-Methyl-2-oxovaleric acid
  • HY-160569

    Liposome Inflammation/Immunology
    C14-SPM is a polyamine branched-chain lipidoid that can be used for the delivery of siRNA .
    C14-SPM
  • HY-121950

    Biochemical Assay Reagents Others
    18-Methyleicosanoic acid is a branched-chain fatty acid. 18-Methyleicosanoic acid has a hydrophobic surface and can act as a boundary lubricant .
    18-Methyleicosanoic acid
  • HY-N0486S13

    mTOR Endogenous Metabolite Metabolic Disease
    L-Leucine- 15N,d10 is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
    L-Leucine-15N,d10
  • HY-N0486S11

    mTOR Endogenous Metabolite Metabolic Disease
    L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
    L-Leucine-d1
  • HY-111487

    Endogenous Metabolite Metabolic Disease Cancer
    α-methylacyl-CoA racemase 1 is an enzyme that catalyzes a key chiral inversion step in the metabolism of branched-chain fatty acids, and used as a maker in prostate and other cancer.
    α-Methylacyl-CoA racemase 1
  • HY-N0486S

    mTOR Endogenous Metabolite Metabolic Disease
    L-Leucine-d10 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
    L-Leucine-d10
  • HY-N0486S4

    Isotope-Labeled Compounds mTOR Endogenous Metabolite Metabolic Disease
    L-Leucine-d7 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
    L-Leucine-d7
  • HY-N0486S9

    mTOR Endogenous Metabolite Metabolic Disease
    L-Leucine-d3 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
    L-Leucine-d3
  • HY-N0486S12

    mTOR Endogenous Metabolite Metabolic Disease
    L-Leucine-d2 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
    L-Leucine-d2
  • HY-N0486S2

    mTOR Endogenous Metabolite Metabolic Disease
    Leucine- 13C6 is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
    L-Leucine-13C6
  • HY-N0486S1

    mTOR Endogenous Metabolite Metabolic Disease
    L-Leucine- 13C is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
    L-Leucine-13C
  • HY-N0486S3

    mTOR Endogenous Metabolite Metabolic Disease
    L-Leucine- 15N is the 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1][2].
    L-Leucine-15N
  • HY-N0486S10

    Isotope-Labeled Compounds mTOR Endogenous Metabolite Metabolic Disease
    L-Leucine- 18O2 is the 18O-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
    L-Leucine-18O2
  • HY-N0486R

    mTOR Endogenous Metabolite Metabolic Disease
    L-Leucine (Standard) is the analytical standard of L-Leucine. This product is intended for research and analytical applications. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .
    L-Leucine (Standard)
  • HY-N0486S5

    Isotope-Labeled Compounds mTOR Endogenous Metabolite Metabolic Disease
    L-Leucine-2- 13C is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
    L-Leucine-2-13C
  • HY-121727

    AE 1887196; BCS-BX60309

    Acetolactate Synthase (ALS) Others
    Triafamone (AE 1887196) is a paddy field pre-emergence and post-emergence sulfonamide herbicide. Triafamone weeds by inhibiting the acetolactate synthase (ALS) enzyme, thereby blocking the biosynthesis of branched-chain amino acids .
    Triafamone
  • HY-N0486S8

    mTOR Endogenous Metabolite Metabolic Disease
    L-Leucine- 13C6, 15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
    L-Leucine-13C6,15N
  • HY-N9417

    2,3-Dihydroxy-3-methylbutanoic acid

    Others Others
    2,3-Dihydroxyisovaleric acid (2,3-Dihydroxy-3-methylbutanoic acid) is a natural metabolite of the branched-chain amino acid leucine that has been found present in the urine of a patient with 2-hydroxyglutaric aciduria .
    2,3-Dihydroxyisovaleric acid
  • HY-N0486S6

    mTOR Endogenous Metabolite Metabolic Disease
    L-Leucine-2- 13C, 15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
    L-Leucine-2-13C,15N
  • HY-N0486S7

    mTOR Endogenous Metabolite Metabolic Disease
    L-Leucine-1- 13C, 15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
    L-Leucine-1-13C,15N
  • HY-148242
    BAY-069
    2 Publications Verification

    Fluorescent Dye Cancer
    BAY-069 is a potent branched-chain amino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC50 values of 31 nM and 153 nM, respectively. BAY-069 also can be used as a chemical probe. BAY-069 can be used tor research anticancer .
    BAY-069
  • HY-155156

    Endogenous Metabolite Cardiovascular Disease
    PF-07238025 is a BCKDC kinase (BDK) inhibitor (EC50=19 nM). PF-07238025 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07238025 improved cardiometabolic endpoints and improves glucose tolerance in mice .
    PF-07238025
  • HY-155157

    Endogenous Metabolite Cardiovascular Disease
    PF-07247685 is a BCKDC kinase (BDK) inhibitor (EC50=2.2 nM). PF-07247685 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07247685 improved cardiometabolic endpoints and improves glucose tolerance in mice .
    PF-07247685
  • HY-122950

    Fungal Infection
    Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide .
    Harzianic acid
  • HY-131503S

    13-MTD-d6; 13-Methylmyristic acid-d6

    Isotope-Labeled Compounds Apoptosis Cancer
    13-Methyltetradecanoic acid-d6 is a deuterated labeled 13-Methyltetradecanoic acid . 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .
    13-Methyltetradecanoic acid-d6
  • HY-141669
    BCAT-IN-2
    2 Publications Verification

    Others Metabolic Disease
    BCAT-IN-2 is a potent, selective and orally active inhibitor of mitochondrial branched-chain aminotransferase (BCATm), with a pIC50 of 7.3. BCAT-IN-2 shows selectivity for BCATm over BCATc (pIC50=6.6). BCAT-IN-2 can be used for the research of obesity and dislipidema .
    BCAT-IN-2
  • HY-W654264

    Endogenous Metabolite Integrin Cardiovascular Disease
    2-Methylbutyrylcarnitine (chloride) is a gut microbial metabolite which binds to integrin α2β1 in platelets, potentiating cytosolic phospholipase A2 (cPLA2) activation and platelet hyperresponsiveness. 2-Methylbutyrylcarnitine (chloride) enhances platelet hyperreactivity and thrombus formation in mice. 2-Methylbutyrylcarnitine (chloride) is a branched-chain acylcarnitine .
    2-Methylbutyrylcarnitine chloride
  • HY-B1845

    Herbicide Others
    Florasulam is a targeted post-emergent herbicide belonging to the triazolopyrimidine sulfonanilide class, which functions by inhibiting acetolactate synthase (ALS) in plants. Located in the chloroplasts, ALS plays a crucial role in the biosynthesis of branched-chain amino acids. When Florasulam inhibits ALS, it disrupts plant cell division, reduces growth, and ultimately leads to plant death.
    Florasulam
  • HY-W017386S

    Isotope-Labeled Compounds Neurological Disease
    3-Methyl-2-oxovaleric acid-d8 (sodium) is the deuterium labeled 3-Methyl-2-oxovaleric acid. 3-Methyl-2-oxovaleric acid is a neurotoxin, an acidogen, and a metabotoxin, and also an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids[1].
    3-Methyl-2-oxovaleric acid-d8 sodium
  • HY-113063R

    Endogenous Metabolite Others
    3-Methyl-2-oxovaleric acid (Standard) is the analytical standard of 3-Methyl-2-oxovaleric acid. This product is intended for research and analytical applications. 3-Methyl-2-oxovaleric acid is a neurotoxin, an acidogen, and a metabotoxin, and also an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids.
    3-Methyl-2-oxovaleric acid (Standard)
  • HY-116044
    BCATc Inhibitor 2
    4 Publications Verification

    Others Neurological Disease
    BCATc Inhibitor 2 is a selective branched-chain aminotransferase (BCAT) inhibitor for research of neurodegenerative diseases. The IC50s of 0.2 μM, 0.8 μM and 3.0 μM for rat cytosolic isoenzyme rBCATc, human cytosolic isoenzyme hBCATc and rat mitochondrial isoenzyme rBCATm, respectively. BCATc, also called BCAT1, is in the cytoplasm .
    BCATc Inhibitor 2
  • HY-W110242A

    Others Cardiovascular Disease
    (S)-CPP sodium serves as an inhibitor of the branched-chain α-ketoacid dehydrogenase complex (BCKDC) kinase, commonly referred to as BDK or keto acid dehydrogenase kinase. As a negative regulator of BCKDC activity, the inhibition of BDK by (S)-CPP (with an IC50 of 6.3 μM) results in the activation of the complex and a notable decrease in plasma levels of leucine/isoleucine and valine in wild-type mice.
    (S)-CPP sodium
  • HY-159648

    Endogenous Metabolite Cardiovascular Disease
    PF-07328948 is an orally effective BDK (branch chain ketoacid dehydrogenase kinase) inhibitor. PF-07328948 acts as a BCKDH (branch chain ketoacid dehydrogenase) enzyme complex degrader to enhance BCAA (branch chain amino acid) catabolism and has potential inhibitory effects on heart failure .
    PF-07328948
  • HY-114855
    BT2
    4 Publications Verification

    Bcl-2 Family Metabolic Disease
    BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC) . BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM .
    BT2
  • HY-W014206

    Biochemical Assay Reagents Others
    Isopentyl octanoate is a class of esters formed by the esterification of branched-chain isoamyl alcohol, also known as isoamyl alcohol, with octanoylate. The compound has a fruity smell and is commonly used as a flavoring in foods such as baked goods, candy and beverages. It can also be used as a fragrance ingredient in personal care products, and as a solvent or plasticizer in various industrial applications. In addition, Isopentyl octanoate can be used as a starting material for the synthesis of other organic compounds.
    Isopentyl octanoate
  • HY-B1845R

    Endogenous Metabolite Others
    Florasulam (Standard) is the analytical standard of Florasulam. This product is intended for research and analytical applications. Florasulam is a targeted post-emergent herbicide belonging to the triazolopyrimidine sulfonanilide class, which functions by inhibiting acetolactate synthase (ALS) in plants. Located in the chloroplasts, ALS plays a crucial role in the biosynthesis of branched-chain amino acids. When Florasulam inhibits ALS, it disrupts plant cell division, reduces growth, and ultimately leads to plant death.
    Florasulam (Standard)
  • HY-W015667

    Ethyl 2-methylvalerate

    Biochemical Assay Reagents Others
    Ethyl 2-methylpentanoate is a class of esters consisting of branched-chain isovaleric acid esterified with ethanol. The compound has a fruity, pungent smell and is commonly used as a flavoring in foods such as baked goods, dairy products and beverages. It can also be used as a fragrance ingredient in personal care products, and as a solvent or plasticizer in various industrial applications. In addition, Ethyl 2-methylpentanoate can be used as a starting material for the synthesis of other organic compounds.
    Ethyl 2-methylpentanoate
  • HY-B1876

    Acetolactate Synthase (ALS) Photosystem II Fungal Others
    Nicosulfuron is efficient, harmless, antifungal and selective herbicide belonging to the sulfonylurea family. Nicosulfuron is also a photosynthetic system inhibitor and inhibits acetolactate synthase (ALS) enzyme activity. Nicosulfuron degradation by Plectosphaerella cucumerina AR1 is glucose concentration dependent in planktonic lifestyle. Nicosulfuron enhances the glycolysis pathway and tricarboxylic acid cycle to improve the adaptability of sweet maize. Nicosulfuron reduces the synthesis of branched-chain amino acids (BCAAs), which is proming for maize cultivation .
    Nicosulfuron
  • HY-157270

    Others Others
    2-Heptylundecanol is a branched chain aliphatic alcohol which can be used in the synthesis of nano lipid particles .
    2-Heptylundecanol
  • HY-I1060
    L-Alloisoleucine
    1 Publications Verification

    (3R)-LS-Isoleucine; L-Allo-isoleucine

    Endogenous Metabolite Others
    L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).
    L-Alloisoleucine
  • HY-I1060S

    Isotope-Labeled Compounds Endogenous Metabolite Others
    L-Alloisoleucine-d10 is the deuterium labeled L-Alloisoleucine. L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).
    L-Alloisoleucine-d10
  • HY-W422402

    Acetolactate Synthase (ALS) Others
    Foramsulfuron is a postemergence herbicide used for selective control of grass and some broadleaved weeds in maize (Zea mays L.). Foramsulfuron is a sulfonylurea herbicide that exerts its herbicidal activity by inhibiting acetolactate synthase (ALS), a key enzyme in the biosynthesis of branched chain amino acids .
    Foramsulfuron
  • HY-N0771
    L-Isoleucine
    4 Publications Verification

    Endogenous Metabolite Cardiovascular Disease Metabolic Disease Inflammation/Immunology
    L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .
    L-Isoleucine

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