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Results for "

breaks

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Akt (2) Antibiotic (7) Antifolate (3) Apoptosis (30) ATM/ATR (2) Aurora Kinase (2) Bacterial (4) Bcl-2 Family (6) Biochemical Assay Reagents (4) Calcium Channel (2) Caspase (6) CRISPR/Cas9 (1) Cuproptosis (1) DNA Alkylator/Crosslinker (3) DNA Stain (1) DNA-PK (3) DNA/RNA Synthesis (31) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (8) Endonuclease (2) Fungal (1) Hedgehog (1) HSV (2) Interleukin Related (1) Isotope-Labeled Compounds (2) Keap1-Nrf2 (1) MDM-2/p53 (1) Mitochondrial Metabolism (2) MMP (2) Na+/K+ ATPase (2) NF-κB (1) P-glycoprotein (1) PARP (7) PI3K (2) RAD51 (3) Reactive Oxygen Species (6) Ribosomal S6 Kinase (RSK) (1) Thyroid Hormone Receptor (1) TNF Receptor (1) Topoisomerase (8) VEGFR (1) YB-1 (1) α-synuclein (1)
By Research Areas:	Cancer (84) Cardiovascular Disease (3) Endocrinology (1) Infection (7) Inflammation/Immunology (3) Metabolic Disease (9) Neurological Disease (1)
Oligonucleotides:	mRNA (1)

109

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110111

T2AA	DNA/RNA Synthesis	Cancer
T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase .

HY-160096

M3541	ATM/ATR	Cancer
M3541 is a potent, ATP-competitive and selective ATM inhibitor with an IC₅₀ of 0.25 nM. M3541 shows remarkable selectivity against other protein kinases. M3541 suppresses double-strand breaks (DSB) repair and has antitumor activities .

HY-111183

Neocarzinostatin Zinostatin; Vinostatin	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic	Infection Cancer
Neocarzinostatin, a potent DNA-damaging, anti-tumor antibiotic, recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin induces apoptosis. Neocarzinostatin has potential for EpCAM-positive cancers treatment .

HY-110185

NSC 617145	DNA/RNA Synthesis	Cancer
NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC₅₀ value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases .

HY-W159870

N-Nitrosodibenzylamine	DNA/RNA Synthesis	Others
N-Nitrosodibenzylamine is a potent and orally activity DNA damage inducer. N-Nitrosodibenzylamine induces DNA single-strand breaks (SSBs) .

HY-119892

Batracylin NSC 320846; BAY-H 2049	Topoisomerase	Cancer
Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks .

HY-13550

Ametantrone NSC 196473; NSC 290813	DNA/RNA Synthesis	Cancer
Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break .

HY-16401

Zalypsis PM00104	Apoptosis	Cancer
Zalypsis (PM00104) has anti-tumor activity. Zalypsis binds to DNA and shows cytotoxicity. Zalypsis inhibits cell cycle and transcription, and leads to double stranded DNA breaks .

HY-W159870R

N-Nitrosodibenzylamine (Standard)	DNA/RNA Synthesis	Others
N-Nitrosodibenzylamine (Standard) is the analytical standard of N-Nitrosodibenzylamine. This product is intended for research and analytical applications. N-Nitrosodibenzylamine is a potent and orally activity DNA damage inducer. N-Nitrosodibenzylamine induces DNA single-strand breaks (SSBs) .

HY-117249

Sanazole AK-2123	Apoptosis Caspase	Cancer
Sanazole (AK-2123) is a hypoxic cell radiosensitizer. Sanazole enhances radiation-induced DNA strand breaks. In mouse fibroblast tumors, Sanazole increases nuclear condensation and fragmentation, as well as elevates caspase-3 activity, thereby enhancing radiation-induced apoptosis. These characteristics make Sanazole a promising candidate for research in tumor therapy .

HY-126972

RI(dl)-2	RAD51	Cancer
RI(dl)-2 blocks RAD51’s D-loop activity in biochemical systems with an IC₅₀ value of 11.1 µM and inhibits homologous recombination (HR) activity with an IC₅₀ value of 3.0 µM. RI(dl)-2 inhibits HR-mediated repair of DNA double strand breaks and sensitizes different cancer cell lines .

HY-126020

Bractoppin 2 Publications Verification	DNA/RNA Synthesis RAD51	Cancer
Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC₅₀: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response .

HY-115531

UNC-2170	Others	Cancer
UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC₅₀=29 µM; K_d=22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB) .

HY-135218

AV-153	DNA/RNA Synthesis	Cancer
AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity .

HY-135218A

AV-153 free base 1 Publications Verification	DNA/RNA Synthesis	Cancer
AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity .

HY-O0004

Collagenase I, from Clostridium histolyticum	MMP	Metabolic Disease
Collagenases are enzymes that break the peptide bonds in collagen. Collagenases are derived from the Clostridium histolyticum. Collagenases (Type I) are proteolytic enzymes that break peptide bonds in collagen and can be used for tissue digestion and dissociation.

HY-146095

p53 Activator 2	MDM-2/p53 DNA/RNA Synthesis Apoptosis	Cancer
p53 Activator 2 (compound 10ah) intercalats into DNA and results in significant DNA double-strand break.p53 Activator 2 increases the expression of p53, p-p53, CDK4, p21 to cause cell cycle arrest at G2/M phase.p53 Activator 2 induce apoptosis and significantly down-regulates the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1.p53 Activator 2 has anti-proliferation activity against MGC-803 cells, with an IC₅₀ of 1.73 µM. p53 Activator 2 displays potent anticancer efficiency against MGC-803 xenograft tumors models .

HY-D1023

5-BrdUTP sodium salt 5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt	DNA/RNA Synthesis	Others
5-BrdUTP sodium salt is a TdT substrate which can be used to label the DNA double-strand breaks.

HY-B0504S

Creatinine-d3 3 Publications Verification NSC13123-d₃	Endogenous Metabolite	Metabolic Disease Cancer
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle[1].

HY-13567S

Bendamustine-d4 SDX-105-d₄ free base	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

HY-148078

PFM03	Endonuclease	Others
PFM03 is a MRE11 Endonuclease inhibitor. PFM03 regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) .

HY-160424

DEANO sodium Diethylamine NONOate sodium; Diethylamine nitric oxide sodium	Others	Others
DEANO sodium is notric oxide donor. DEANO sodium potentiates the abilitv of hypoxanthine/xanthine oxidase to induce lipid peroxidation as well as DNA single- and double-strand breaks .

HY-B0504S2

Creatinine-d5 NSC13123-d₅	Endogenous Metabolite	Metabolic Disease
Creatinine-d₅ is the deuterium labeled Creatinine. Creatinine (NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.

HY-W414321

Fructosamine hydrochloride D-Isoglucosamine hydrochloride	Endogenous Metabolite	Others
Fructosamine hydrochloride (D-Isoglucosamine hydrochloride) is a metabolic intermediate and component of cell membranes and cartilage. Fructosamine hydrochloride induces site-specific breaks in DNA chains, especially in the presence of Cu ²⁺ .

HY-B0504S1

Creatinine-13C NSC13123-¹³C	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Creatinine- ¹³C is the ¹³C-labeled Creatinine. Creatinine (NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.

HY-138645A

5-Iminodaunorubicin hydrochloride	DNA/RNA Synthesis	Cancer
5-Iminodaunorubicin hydrochloride is a quinone-modified anthracycline that retains antitumor activity . 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells .

HY-138645

5-Iminodaunorubicin	DNA/RNA Synthesis	Cancer
5-Iminodaunorubicin is a quinone-modified anthracycline that retains antitumor activity . 5-Iminodaunorubicin produces protein-concealed DNA strand breaks in cancer cells .

HY-N7147

Irisquinone	Others	Cancer
Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks .

HY-129715

MPI-0441138	Apoptosis	Cancer
MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death .

HY-15620

Methylproamine 1 Publications Verification	DNA/RNA Synthesis	Others
Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks .

HY-P2373

Nattokinase, Natto fermentation 1 Publications Verification	Others	Cardiovascular Disease
Nattokinase, Natto fermentation is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases .

HY-E70005A

Collagenase, Type I 1 Publications Verification EC 3.4.24.3	MMP	Others
Collagenase, Type I is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type I breaks down collagens 1, 3, 7, 8, 10, gelatin, proteoglycans, aggrecan .

HY-123232

KU-0058684	PARP	Cancer
KU-0058684 is a potent PARP inhibitor, with an IC₅₀ of 3.2 nM for PARP-1. KU-0058684 significantly reduces DNA double strand break (DSB) repair .

HY-N8533

Sodium Camptothecin	DNA/RNA Synthesis	Infection Cancer
Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA .

HY-108860

Oncaspar PEG-L-asparaginase; Pegasparaginase	Others	Cancer
Oncaspar (PEG-L-asparaginase; Pegasparaginase), a pegylated form of native Escherichia coli-derived L-asparaginase, breaks down the amino acid asparagine that are circulating in the bloodstream. Oncaspar plays an important role in acute lymphoblastic leukemia (ALL) .

HY-13703A

Nimustine hydrochloride 1 Publications Verification ACNU	DNA/RNA Synthesis DNA Alkylator/Crosslinker Apoptosis	Cancer
Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas .

HY-116770

PFM01 1 Publications Verification	Endonuclease	Cancer
PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) .

HY-13744

Rubitecan RFS 2000; 9-Nitrocamptothecin	Topoisomerase	Cancer
Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells .

HY-W004520

Phenazine methylsulfate 1 Publications Verification 5-Methylphenazinium methylsulfate	Bacterial Antibiotic Apoptosis	Others
Phenazine methylsulfate is a free radical generator, can be used as an electron transfer reactant in cell viability assays. Phenazine methylsulfate induces ssDNA break formation in the presence of the reducing agent NADPH. Phenazine methylsulfate also induces oxidative DNA damage and apoptosis .

HY-18626

NK 314	Topoisomerase	Cancer
NK 314 is an inhibitor for topoisomerase IIα, which generates the break of DNA double-strand. NK 314 arrests the cell cycle at G2 phase in human acute myeloid leukemia cells, inhibits the proliferation of CEM with IC₉₀ of 55 nM .

HY-164279

YTR107	DNA/RNA Synthesis	Cancer
YTR107 is a radiation sensitizer. YTR107 binds to nucleophosmin1 (NPM1) and inhibits pentamer formation. YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppresses repair of DNA double strand breaks, and enhances radiosensitization .

HY-124899

Hh-Ag1.5 1 Publications Verification SAg1.5	Hedgehog	Metabolic Disease
Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC₅₀ of 1 nM . Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure .

HY-113064

Selenocystine 1 Publications Verification	Endogenous Metabolite	Cancer
Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

HY-E70369

Collagenase H (Recombinant)	Biochemical Assay Reagents	Others
Collagenase H Recombinant is able to digest and break down collagen (especially collagen III) in the extracellular matrix (ECM). Collagenase H Recombinant is important in the isolation and function of rat pancreatic islets. Collagenase H Recombinant can be used in tissue engineering and cell culture .

HY-19609

Calicheamicin 5+ Cited Publications Calicheamicin γ1	DNA Alkylator/Crosslinker ADC Cytotoxin Bacterial Apoptosis Antibiotic	Infection Cancer
Calicheamicin, an antitumor antibiotic, is a cytotoxic agent that causes double-strand DNA breaks. Calicheamicin is a DNA synthesis inhibitor . Calicheamicin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-163519

α-Synuclein inhibitor 13	α-synuclein	Neurological Disease
α-Synuclein inhibitor 13 is an inhibitor of α-synuclein (α-Syn). α-Synuclein inhibitor 13 inhibits the aggregation of α-Syn proteins and is able to break down formed fibers. It is mainly used in Parkinson's disease research .

HY-19137

Pibrozelesin KW 2189 free base	Antibiotic	Infection Cancer
Pibrozelesin (KW 2189 free base) is the derivative of antibiotic Duocarmycin B2. Pibrozelesin exhibits antitumor activity, inhibits proliferation of cell H69 with an IC₅₀ of 1.9 μM. Pibrozelesin induces the DNA strand breaks upon activation via carboxyl esterase .

HY-149348

DiPT-4	Topoisomerase PARP Apoptosis	Cancer
DiPT-4 is a dual TOP1/PARP1 inhibitor that induces massive DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells. DiPT-4 has the potential to overcome cancer drug resistance .

HY-126940

Furanodiene	Reactive Oxygen Species P-glycoprotein Apoptosis	Cancer
Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level .

HY-W018326

Temozolomide acid	DNA/RNA Synthesis	Cancer
Temozolomide acid is a carboxylic acid derivative of Temozolomide (HY-17364) with anticancer activity. Temozolomide is a DNA alkylating agent, methylating the guanine and adenine bases of DNA, causing breaks in DNA double strand, cell cycle arrest, and eventually cell death. Temozolomide acid is promising for research of glioblastoma and brain cancer .

Cat. No.	Product Name

HY-L098

Drug Metabolite Library

222 compounds

A drug metabolite is a byproduct of the body breaking down, or “metabolizing” a drug into a different substance. Most drugs undergo chemical alteration by various bodily systems as a way to create compounds that are more easily excreted from the body. Drugs can be metabolized by oxidation, reduction, hydrolysis, hydration, conjugation, condensation, or isomerization. Drug metabolism can produce metabolites with physicochemical and pharmacological properties that differ substantially from those of the parent drug, and consequently have important implications for both drug safety and efficacy.

MCE offers a unique collection of 222 drug metabolites which is a useful tool for drug safety and efficacy study and drug repurposing.

HY-L147

Protease Inhibitor Library

617 compounds

A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the formation of new protein products. Proteases play important roles in regulating multiple biological processes in all living organisms, such as regulating the fate, localization, and activity of many proteins, modulating protein-protein interactions, creating new bioactive molecules, contributing to the processing of cellular information, and generating, transducing, and amplifying molecular signals.

Proteases are important targets in drug discovery. Some protease inhibitors are often used as anti-virus drugs and anti-cancer drugs. MCE offers a unique collection of 617 protease inhibitors. MCE Protease Inhibitor Library is critical for drug discovery and development.

Cat. No.	Product Name	Type

HY-D2353

Biotin-PEG3-benzophenone

Dyes

Biotin-PEG3-benzophenone is biotin-labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite and a photosensitizer that has been implicated in photosensitive damage to DNA. Benzophenone causes nucleobase oxidation, formation of cyclobutane-pyrimidine dimers, single-strand breaks, DNA-protein cross-links or abasic sites, different pathologies that may occur in nucleosides, oligonucleotides or DNA .

Cat. No.	Product Name	Type

HY-15620

Methylproamine 1 Publications Verification	Gene Sequencing and Synthesis
Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks .

HY-15917A

L-Dithiothreitol

Carbohydrates

L-Dithiothreitol (DTT) is a reducing agent commonly used in various biochemical applications to break disulfide bonds in proteins, thereby denaturing proteins or preventing the formation of unwanted aggregates. DTT has a unique chemical property that cleaves the sulfur-sulfur bond in the disulfide bond to form a sulfhydryl group. This makes it a useful tool for protein purification, enzyme assays, and protein structure studies.

HY-D1023

5-BrdUTP sodium salt 5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt	Biochemical Assay Reagents
5-BrdUTP sodium salt is a TdT substrate which can be used to label the DNA double-strand breaks.

HY-W076740

8-Bromoadenine 8-Bromo-9H-purin-6-amine	Gene Sequencing and Synthesis
8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells. 8-Bromoadenine is a brominated derivative of adenine, and radioactive adenine can be prepared by replacing bromine with deuterium .

HY-W543137

PT-ttpy	Biochemical Assay Reagents
Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).

Cat. No.	Product Name	Target	Research Area

HY-113064

Selenocystine 1 Publications Verification	Endogenous Metabolite	Cancer
Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

HY-P4523

FA-Ala-Arg	Endogenous Metabolite	Endocrinology
FA-Ala-Arg is a dipeptide with furylacryloyl group. FA-Ala-Arg breaks down to produce arginine. While cell-surface Carboxypeptidase-D (CPD) also increases intracellular Arg, which is converted to nitric oxide (NO). FA-Ala-Arg enhances NO production in MCF-7 cells. FA-Ala-Arg also increases the cell survival of prolactin (PRL)-treated cells, PRL regulates CPD mRNA levels in cells .

HY-P5429

DNA-PK Substrate	Peptides	Others
DNA-PK Substrate is a biological active peptide. (A substrate for DNA-dependent protein kinase (DNA-PK), phosphorylation. DNA-PK is essential for the repair of DNA double-strand breaks. This peptide corresponding to 11–24 amino acids of human p53 with threonine 18 and serine 20 changed to alanine is used as a substrate for the assay of DNA-PK activityPyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0504S

Creatinine-d3 3 Publications Verification NSC13123-d₃	Classification of Application Fields Metabolic Disease Disease Research Fields	Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle[1].

HY-N8533

Sodium Camptothecin	Infection Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields	DNA/RNA Synthesis
Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA .

HY-13744

Rubitecan RFS 2000; 9-Nitrocamptothecin	Alkaloids Structural Classification Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Cancer	Topoisomerase
Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells .

HY-113064

Selenocystine 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

HY-126940

Furanodiene	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Curcuma longa Disease Research Fields Cancer Zingiberaceae	Reactive Oxygen Species P-glycoprotein Apoptosis
Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level .

HY-B1357

Digitoxin Maximum Cited Publications 6 Publications Verification	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Source classification Scrophulariaceae Plants Disease Research Fields Steroids	Bcl-2 Family Caspase Apoptosis HSV Na+/K+ ATPase Calcium Channel
Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .

HY-N4170

Chebulic acid 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Combretaceae Source classification Phenols Polyphenols Metabolic Disease Terminalia chebula Retz. Plants Disease Research Fields	Keap1-Nrf2 Reactive Oxygen Species
Chebulic acid is a phenolic acid compound isolated from Terminalia chebula with strong antioxidant activity, which breaks protein cross-links induced by advanced glycation end products (AGEs) and inhibits the formation of AGEs. Chebulic acid is effective in controlling elevated metabolic parameters, oxidative stress, and liver damage, supporting its beneficial role in asthma, diabetes, and liver protection .

HY-N7147

Irisquinone	Structural Classification Natural Products Iridaceae Source classification Plants Iris latea pallasii	Others
Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks .

HY-125918

Bleomycin A5 hydrochloride Pingyangmycin hydrochloride	Structural Classification Microorganisms Antibiotics Source classification	Apoptosis Antibiotic
Bleomycin A5 (Pingyangmycin) hydrochloride is an anti-neoplastic glycoprotein antibiotic. Bleomycin A5 suppresses Drp1-mediated mitochondrial fission and induces apoptosis in human nasal polyp-derived fibroblasts. Bleomycin A5 hydrochloride has anticancer activities relying on its ability to produce RNA and DNA breaks, thus, leading to cell death ..

HY-117818

Sapurimycin Antibiotic DC 116	Structural Classification Microorganisms Antibiotics Source classification Disease Research Anticancer	Antibiotic
Sapurimycin is an antitumor antibiotic isolated from Streptomyces DO-116 and belongs to the capramycin family. Sapurimycin exhibits potent activity against Gram-positive bacteria and exhibits significant antitumor effects against leukemia P388 and sarcoma 180 in mouse models. In vitro studies have shown that Sapurimycin can induce single-strand breaks in supercoiled plasmid DNA .

HY-B1357R

Digitoxin (Standard)	Digitalis purpurea Linn. Structural Classification Microorganisms Source classification Scrophulariaceae Plants Steroids	Bcl-2 Family Caspase Apoptosis HSV Na+/K+ ATPase Calcium Channel
Digitoxin (Standard) is the analytical standard of Digitoxin. This product is intended for research and analytical applications. Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .

HY-N6739

Beauvericin	Cardiovascular Disease Structural Classification Human Gut Microbiota Metabolites Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Endogenous metabolite Disease Research Fields	Bacterial Apoptosis Fungal PI3K Akt TNF Receptor Interleukin Related
Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis, thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages .

HY-119109

Laminaran	Structural Classification Polysaccharides Microorganisms other families Classification of Application Fields Source classification Plants Disease Research Fields Saccharides Cancer	Others
Laminaran is an β-1-3-glucan and a typical ligand for Dectin-1 from Eisenia Bicyclis, has potent immunomodulating, radioprotective, and anticancer activities . Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds . Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy .

HY-100978

(±)-Hexanoylcarnitine chloride DL-Hexanoylcarnitine chloride	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into energy that can be used by the body. (±)-Hexanoylcarnitine chloride also serves as a specific and easily detectable biomarker for rat skeletal muscle toxicity. Cerivastatin (HY-129458) and TMPD (HY-W012145) induce an increase in Hexanoylcarnitine in rats in a metabolomic analysis of the rectus femoris muscle. In type 2 diabetes, Hexanoylcarnitine is also significantly associated with and improves prediction of all-cause mortality. Hexanoylcarnitine is a biomarker for the identification of novel pathogenic pathways .

HY-N4327

Eurycomalactone	Structural Classification other families Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields	NF-κB Apoptosis Akt Bcl-2 Family
Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC₅₀ value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394) .

Cat. No.	Product Name	Chemical Structure

HY-B0504S

Creatinine-d3 3 Publications Verification
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle[1].

HY-B0504S2

Creatinine-d5
Creatinine-d₅ is the deuterium labeled Creatinine. Creatinine (NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.

HY-B0504S1

Creatinine-13C
Creatinine- ¹³C is the ¹³C-labeled Creatinine. Creatinine (NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.

HY-19939S

VX-984 4 Publications Verification
VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium .

HY-13567S

Bendamustine-d4
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

Cat. No.	Product Name		Classification

HY-164062

LZCap AG(3'Acm) Cas9 mRNA		mRNA
The Cas9 protein, guided by sgRNA, induces DNA double-strand breaks (DSBs) at specific genomic locations, activating the cell's endogenous DNA repair mechanisms, non-homologous end joining (NHEJ), or homology-directed repair (HDR), for repairing the targeted DSBs, enabling genome DNA target recognition and cleavage. LZCap AG(3'Acm) Cas9 mRNA can be used together with purified sgRNA for CRISPR/Cas genome editing, where the expressed Cas9 protein acts in conjunction with sgRNA to perform cleavage.

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