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bridge

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59

Inhibitors & Agonists

4

Screening Libraries

3

Fluorescent Dye

9

Biochemical Assay Reagents

23

Peptides

1

Inhibitory Antibodies

8

Natural
Products

5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P10587
    Icotrokinra

    JNJ-77242113; JNJ-2113; PN-235

    		 Interleukin Related STAT Inflammation/Immunology
    Icotrokinra (JNJ-77242113) is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (IC50=5.6 pM) and inhibits IL-23-induced interferon IFN-γ production in NK cells with an IC50 of 18.4 pM. In addition, Icotrokinra exhibits anti-inflammatory activity in a rat TNBS-induced colitis model. Icotrokinra can be used in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease .
    Icotrokinra
  • HY-121083
    Aerugidiol

    		Others Others
    Aerugidiol is a bridge-head oxygenated sesquiterpene isolated from the rhizomes of Curcuma aeruginosa .
    Aerugidiol
  • HY-W101954
    (Fmoc-Cys-OtBu)2 (disulfide bridge)

    		Biochemical Assay Reagents Others
    (Fmoc-Cys-OtBu)2 (Disulfide bond) is a cystine dipeptide which is linked through an oxidized disulfide bond. (Fmoc-Cys-OtBu)2 (disulfide bridge) can be used in the synthesis of cleavable disulfide linkers.
    (Fmoc-Cys-OtBu)2 (disulfide bridge)
  • HY-P10654
    RhTx

    		TRP Channel Neurological Disease
    RhTx is a transient receptor potential vanillin-1 (TRPV1) activator. RhTx can be used to study pain perception .
    RhTx
  • HY-P10819
    S9-CMC1 TFA

    		Histone Demethylase Apoptosis Cancer
    S9-CMC1 TFA is a covalent peptide lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 value of 2.53 μM. S9-CMC1 TFA specifically recognizes Cys360 in the enzyme-active region. S9-CMC1 TFA inhibits LSD1 activity, increasing H3K4me1 and H3K4me2 levels, leading to G1 cell cycle arrest and apoptosis and inhibiting cell proliferation. S9-CMC1 TFA significantly inhibits tumor growth in A549 xenograft animal models .
    S9-CMC1 TFA
  • HY-P4320
    Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge:cys1-cys10)

    		Integrin Cancer
    Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge:cys1-cys10), a decapeptide containing a cyclic RGD active sequence, is an Integrin αIIbβ3 antagonist that inhibits platelet and Adhesion of proMMP-13 .
    Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge:cys1-cys10)
  • HY-163331
    Cresomycin

    		Antibiotic Bacterial Infection
    Cresomycin is a bridged macrobicyclic antibiotic that can bind to the bacterial ribosome. Cresomycin exhibits efficacy against both Gram-positive and Gram-negative bacteria, including multidrug-resistant strains of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa .
    Cresomycin
  • HY-W543137
    PT-ttpy

    		G-quadruplex DNA/RNA Synthesis Cancer
    Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).
    PT-ttpy
  • HY-N7534A
    (-)-Epipinoresinol

    		Drug Isomer Others
    (-)-Epipinoresinol is an isomer of the lignan (+)-Epipinoresinol. CYP81Q3 specifically catalyzes the formation of the methylenedioxy bridge (MDB) in (+)-Epipinoresinol to produce (+)-Pluviatilol.
    (-)-Epipinoresinol
  • HY-N7534
    (+)-Epipinoresinol

    		Others Others
    (+)-Epipinoresinol is a lignan compound. CYP81Q3 specifically catalyzes methylenedioxy bridge (MDB) formation in (+)-Epipinoresinol to produce (+)-Pluviatilol .
    (+)-Epipinoresinol
  • HY-111999A
    E7766 diammonium salt
    1 Publications Verification

    		 STING Cancer
    E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities .
    E7766 diammonium salt
  • HY-N10766
    Ampelopsin F

    		Others Others
    Ampelopsins F is a bridged plant oligostilbene that can be isolated from Ampelopsis brevipedunculata var. hancei roots. Ampelopsins F is a resveratrol dimer .
    Ampelopsin F
  • HY-111999B
    E7766 disodium

    		STING Cancer
    E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities .
    E7766 disodium
  • HY-119526
    Bismaleimide

    		Biochemical Assay Reagents Others
    Bismaleimide is a compound used to prepare aerogels with excellent heat resistance. By optimizing its use as a bridging moiety and the polarity of the solvent, aerogels with good properties can be produced.
    Bismaleimide
  • HY-P3215
    Oxytocin parallel dimer

    		Oxytocin Receptor Endocrinology
    Oxytocin parallel dimer is the disulfide-bridged homo peptide dimer. Oxytocin dimer has oxytocin and vasopressin-like activity with less toxic than oxytocin .
    Oxytocin parallel dimer
  • HY-P2331
    Actagardin

    Antibiotic A 3802-IV-3; Gardimycin

    		 Antibiotic Infection
    Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes. It is composed of macrocyclic rings formed by thioether bridges. Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.
    Actagardin
  • HY-P3215A
    Oxytocin parallel dimer TFA

    		Oxytocin Receptor Endocrinology
    Oxytocin parallel dimer TFA is the disulfide-bridged homo peptide dimer. Oxytocin dimer has oxytocin and vasopressin-like activity with less toxic than oxytocin .
    Oxytocin parallel dimer TFA
  • HY-P3314
    Nendratareotide

    		Somatostatin Receptor Metabolic Disease
    Nendratareotide is a somatostatin analogue .
    Nendratareotide
  • HY-P9940
    Emicizumab

    		Factor VIII Cardiovascular Disease
    Emicizumab is a bispecific monoclonal antibody that bridges activated factor IX and factor X to replace the function of missing activated factor VIII, thereby restoring hemostasis. Emicizumab can be used for hemophilia A research .
    Emicizumab
  • HY-P5165
    Maurotoxin

    		Potassium Channel Inflammation/Immunology
    Maurotoxin is a 34-residue and four disulde-bridged toxin that can be isolated from the chactoid scorpion (Scorpio maurus). Maurotoxin inhibits the Shaker potassium channels (ShB) K + current with an IC50 of 2 nM .
    Maurotoxin
  • HY-N11977
    Stenophyllol B

    		Others Others
    Stenophyllol B (compound 4) is a trimeric stilbene with bicyclic and bridged tricyclic skeletons. Stenophyllol B was first discovered in the dipterocarps plant and has been found in many species of Hopea, Neobalanocarpus, Shorea, Stemonoporus and Vateri .
    Stenophyllol B
  • HY-P5816
    BmK-M1

    		Sodium Channel Neurological Disease
    BmK-M1 is a scorpion toxin, and is composed of 64 amino acids cross-linked by four disulfide bridges. BmK-M1 inhibits Na + channel and can be considered both as a cardiotoxin and a neurotoxin .
    BmK-M1
  • HY-W686763
    Triacetylphloroglucinol

    2,4,6-Triacetylphloroglucinol

    		 Drug Intermediate Infection
    Triacetylphloroglucinol (2,4,6-Triacetylphloroglucinol) is a C3-symmetric three-dimensional bridged ligand. It has been used in the synthesis of various compounds including trinuclear vanadium Schiff base complexes, copper complexes and anthelmintics.
    Triacetylphloroglucinol
  • HY-P3026
    Bowman-birk inhibitor

    		Ser/Thr Protease Endogenous Metabolite Cancer
    The Bowman-Birk inhibitor, a highly cross-linked protein featuring seven disulfide bridges, possesses spatially distinct domains specifically designed for the inhibition of both trypsin and chymotrypsin, showcasing its significant role as a plant protease inhibitor with anticarcinogenic properties.
    Bowman-birk inhibitor
  • HY-P1631
    Polyphemusin I

    		Bacterial Infection
    Polyphemusin I is a natural antimicrobial peptide with excellent antimicrobial activity against Gram-negative and Gram-positive bacteria. Polyphemusin I contains 18 amino acids and is stabilized into an amphiphilic, antiparallel β-hairpin by two disulfide bridges .
    Polyphemusin I
  • HY-139371
    3-Desoxy-3,4-methylenedioxy pyrovalerone hydrochloride

    		Drug Derivative Others
    3-Desoxy-3,4-methylenedioxy pyrovalerone hydrochloride is an analog of 3,4-MDPV in which the heterocyclic 3-position oxygen from the 3,4-methylenedioxy ring has been replaced by a methylene bridge.
    3-Desoxy-3,4-methylenedioxy pyrovalerone hydrochloride
  • HY-P5159
    Crotamine

    		Sodium Channel Inflammation/Immunology
    Crotamine is a Na + channel modulator. Crotamine is a 42 amino acid toxin cross-linked by three disulfide bridges. Crotamine has analgesic activity. Crotamine also interacts with lipid membranes and shows myonecrotic activity. Crotamine can be isolated from Crotalus durissus terrificus venom .
    Crotamine
  • HY-P5160
    Phlotoxin-1

    PhlTx1

    		 Sodium Channel Inflammation/Immunology
    Phlotoxin-1 (PhlTx1) is a 34-amino acid and 3-disulfide bridge peptide. Phlotoxin-1 can be isolated from Phlogiellus genus spider. Phlotoxin-1 is an antinociceptive agent by inhibiting NaV1.7 channel .
    Phlotoxin-1
  • HY-B2227
    Lactate
    Maximum Cited Publications
    17 Publications Verification

    Lactic acid

    		 Endogenous Metabolite Metabolic Disease Inflammation/Immunology Cancer
    Lactate (Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactate is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactate is an oncometabolite and has immune protective role of lactate in anti-tumor immunity .
    Lactate
  • HY-P5159A
    Crotamine TFA

    		Sodium Channel Inflammation/Immunology
    Crotamine TFA is a Na + channel modulator. Crotamine is a 42 amino acid toxin cross-linked by three disulfide bridges. Crotamine has analgesic activity. Crotamine also interacts with lipid membranes and shows myonecrotic activity. Crotamine can be isolated from Crotalus durissus terrificus venom .
    Crotamine TFA
  • HY-145843
    c-Myc inhibitor 5

    		c-Myc Cancer
    c-Myc inhibitor 5 (DA3) is a fluorescent, long chain-bridged bispurine that selectively targets the c-MYC G-quadruplex (KD of 16 μM). c-Myc inhibitor 5 shows inhibition on c-MYC expression rather than other G4-driven oncogenes .
    c-Myc inhibitor 5
  • HY-D0020
    2,2'-Bipyridine
    1 Publications Verification

    		 Biochemical Assay Reagents Infection Endocrinology
    2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity .
    2,2'-Bipyridine
  • HY-P5931
    Spinoxin

    Potassium channel toxin alpha-KTx 6.13; SPX; α-KTx6.13

    		 Potassium Channel Inflammation/Immunology Cancer
    Spinoxin isolated from the venom of scorpion Heterometrus spinifer, is a 34-residue peptide neurotoxin cross-linked by four disulfide bridges. Spinoxin is a potent inhibitor of Kv1.3 potassium channel (IC50 = 63 nM), considering to be valid molecular targets in the diagnostics and therapy of various autoimmune disorders and cancers .
    Spinoxin
  • HY-P5182
    HsTX1

    		Potassium Channel Inflammation/Immunology
    HsTX1, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1, an the inhibitor of potassium channel, with IC50 for Kv1.3 of 12 pM inhibits TEM cell activation and attenuates inflammation in autoimmunity .
    HsTX1
  • HY-W075836
    Ferrocenylmethyltrimethylammonium iodide

    		Biochemical Assay Reagents Others
    Ferrocenylmethyltrimethylammonium (iodide) is an organometallic salt consisting of a ferrocenyl group attached to a quaternary ammonium cation via a methylene bridge. Ferrocenylmethyltrimethylammonium (iodide) has been used as a catalyst and reagent in various organic reactions, including oxidation, reduction, and CH bond activation. In addition, it is also used as a precursor for the synthesis of other organometallic compounds and as a potential material for electrochemical applications.
    Ferrocenylmethyltrimethylammonium iodide
  • HY-147207D
    Phospholipid-PEG-Biotin (MW 10000)

    		Liposome Others
    Phospholipid-PEG-Biotin (MW 10000) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
    Phospholipid-PEG-Biotin (MW 10000)
  • HY-P5182A
    HsTX1 TFA

    		Potassium Channel Inflammation/Immunology
    HsTX1 (TFA) toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1 (TFA) is an the inhibitor of potassium channel, with IC50 for Kv1.3 of 12 pM and inhibits TEM cell activation and attenuates inflammation in autoimmunity .
    HsTX1 TFA
  • HY-147207B
    Phospholipid-PEG-Biotin (MW 3400)

    		Liposome Others
    Phospholipid-PEG-Biotin (MW 3400) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
    Phospholipid-PEG-Biotin (MW 3400)
  • HY-B1349
    Mepiroxol

    		Biochemical Assay Reagents Others
    Mepiroxol can form various interactions with key residues of specific proteins. It establishes salt bridges with Arg-153 and Arg-74, and forms two hydrogen bonds with Asp-50 and Gly-96 through its terminal hydroxyl group, these interactions help enhance its binding affinity and lead to a higher docking score .
    Mepiroxol
  • HY-147207E
    Phospholipid-PEG-Biotin (MW 20000)

    		Liposome Others
    Phospholipid-PEG-Biotin (MW 20000) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
    Phospholipid-PEG-Biotin (MW 20000)
  • HY-147207
    Phospholipid-PEG-Biotin (MW 1000)

    		Liposome Others
    Phospholipid-PEG-Biotin (MW 1000) is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG-Biotin (MW 3400) can interact with avidinylated antibodies. Phospholipid-PEG-Biotin (MW 3400) can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation .
    Phospholipid-PEG-Biotin (MW 1000)
  • HY-B2227R
    Lactate (Standard)

    		Endogenous Metabolite Metabolic Disease Inflammation/Immunology Cancer
    Lactate (Standard) is the analytical standard of Lactate. This product is intended for research and analytical applications. Lactate (Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactate is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactate is an oncometabolite and has immune protective role of lactate in anti-tumor immunity .
    Lactate (Standard)
  • HY-B2227D
    Calcium 2-hydroxypropanoate pentahydrate

    		Endogenous Metabolite Metabolic Disease Inflammation/Immunology Cancer
    Calcium 2-hydroxypropanoate (pentahydrate) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Calcium 2-hydroxypropanoate (pentahydrate) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Calcium 2-hydroxypropanoate (pentahydrate) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity .
    Calcium 2-hydroxypropanoate pentahydrate
  • HY-118462A
    Coelenteramine 400a hydrochloride

    Coelenterazine 400a hydrochloride; Bisdeoxycoelenterazine hydrochloride

    		 Fluorescent Dye Others
    Coelenteramine (Coelenterazine) 400a hydrochloride, a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a hydrochloride, RLuc can emit blue light at 395 nm . Coelenteramine 400a hydrochloride will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenteramine 400a hydrochloride provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .
    Coelenteramine 400a hydrochloride
  • HY-W615327
    Bis-sulfone NHS ester

    		Biochemical Assay Reagents Others
    Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.
    Bis-sulfone NHS ester
  • HY-D1568
    Sulfo-Cy7.5 NHS ester

    		Fluorescent Dye Others
    Sulfo-Cy7.5 NHS ester is a near infrared water soluble hydrophilic dye, also is an NHS ester for the modification of amine groups. Sulfo-Cy7.5 NHS ester contains a trimeth ylene bridge and has a linker arm for its attachment to proteins, peptides, and other molecules. Sulfo-Cy7.5 NHS ester can be used for the research of NIR imaging applications .
    Sulfo-Cy7.5 NHS ester
  • HY-118462
    Coelenteramine 400a

    Coelenterazine 400a; Bisdeoxycoelenterazine

    		 Fluorescent Dye Others
    Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm . Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .
    Coelenteramine 400a
  • HY-P2833
    Glutathione Peroxidase

    GSH-Px; EC 1.11.1.9

    		 Glutathione Peroxidase Metabolic Disease
    Glutathione Peroxidase (GSH-Px; EC 1.11.1.9) belongs to the peroxidase family and is commonly used in biochemical research. Glutathione Peroxidase can catalyze reduced glutathione (GSH) to form a disulfide bridge with another glutathione molecule, convert it into oxidized glutathione (GSSG), and react with hydrogen peroxide or lipid peroxide reaction, reducing it to H2O. Glutathione Peroxidase is an effective antioxidant against oxidative stress .
    Glutathione Peroxidase
  • HY-D1568A
    Sulfo-Cy7.5 NHS ester tripotassium

    		Fluorescent Dye Others
    Sulfo-Cy7.5 NHS ester tripotassium is a near infrared water soluble hydrophilic dye, also is an NHS ester for the modification of amine groups. Sulfo-Cy7.5 NHS ester tripotassium contains a trimeth ylene bridge and has a linker arm for its attachment to proteins, peptides, and other molecules. Sulfo-Cy7.5 NHS ester tripotassium can be used for the research of NIR imaging applications .
    Sulfo-Cy7.5 NHS ester tripotassium
  • HY-D0020R
    2,2'-Bipyridine (Standard)

    		Biochemical Assay Reagents Infection Endocrinology
    2,2'-Bipyridine (Standard) is the analytical standard of 2,2'-Bipyridine. This product is intended for research and analytical applications. 2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity .
    2,2'-Bipyridine (Standard)

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