Search Result
Results for "
charge
" in MedChemExpress (MCE) Product Catalog:
16
Biochemical Assay Reagents
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-130463
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PG(16:0/18:1); 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)
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Liposome
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Others
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POPG sodium salt is a phospholipid molecule having one negative charge, which can interact with the positive charges of peptides .
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- HY-D0948
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Fluorescent Dye
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Infection
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Celestine Blue is a electroactive indicator in DNA biosensors. Celestine Blue is strongly adsorbed on the spinel phases and CNT (carbon nanotubes), facilitates dispersion, acts as a capping agent and allows for the fabrication of spinel decorated CNT. Celestine Blue is an efficient charge transfer mediator, which allows for significant improvement of capacitive behavior. TiO2 nanoparticles doped with Celestine Blue can be used as a label in a sandwich immunoassay for the hepatitis C virus (HCV) core antigen .
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- HY-Y0316B
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Sodium lauryl sulfate for electrophoresis; Laurylsulfuric acid sodium salt for electrophoresis
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Biochemical Assay Reagents
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Others
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Sodium dodecyl sulfate for electrophoresis is a high purity sodium dodecyl sulfate (SDS) with a minimum purity of 98.5%. It is an anionic detergent commonly used in electrophoretic procedures to denature and impart a negative charge to proteins, allowing separation based on size and charge. Sodium dodecyl sulfate for electrophoresis has unique chemical properties that make it an effective ingredient in many laboratory applications, helping to improve the resolution and sensitivity of protein analysis.
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- HY-W102545
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Biochemical Assay Reagents
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Others
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Diaza-15-crown-5 extends the lifetime of M intermediates in BR membranes. Diaza-15-crown-5 is a crown ether compound that alters the surface charge of BR membranes. Diaza-15-crown-5 changes the surface charge of the BR film. and overall membrane stability. Diaza-15-crown-5 allows the M state to be maintained for a longer period of time .
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- HY-D1259
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VDP-green (NEP)
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Fluorescent Dye
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Neurological Disease
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NEP (VDP-green (NEP)) is a turn-on fluorescent probe based on the intramolecular charge transfer (ICT) mechanism for sensing vicinal dithiol-containing proteins (VDPs). NEP exhibits high selectivity toward VDPs in live cells and in vivo and displays a strong green fluorescence signal (λex/λem=430/535 nm). NEP has the potential for parkinsonism .
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- HY-111303
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Sirtuin
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Neurological Disease
Inflammation/Immunology
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CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 µM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC50=2.8 µM) or SIRT3 (IC50>100 µM) . CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research .
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- HY-164283
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2-((2,3-Bis(oleoyloxy)propyl)dimethylammonio)ethyl hydrogen phosphate
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Others
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Others
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DOCP (2-((2,3-Bis(oleoyloxy)propyl)dimethylammonio)ethyl hydrogen phosphate), characterized by their inverted charge orientation compared to traditional phosphocholine (PC) lipids, feature a quaternary amine positioned near the bilayer interface and a phosphate group that protrudes into the aqueous environment. This unique configuration of iPC lipids provides an exceptional opportunity to explore the biophysical properties and bioactivity implications resulting from the charge inversion at the bilayer surface.
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- HY-124357
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S-Norfluoxetine hydrochloride; LY 215229 hydrochloride
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Others
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Neurological Disease
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Seproxetine (S-Norfluoxetine) hydrochloride is a selective serotonin reuptake inhibitor (SSRI) that enhances serotonin levels in the brain by specifically inhibiting the serotonin uptake carrier. Seproxetine hydrochloride exhibits strong charge transfer interactions with π-electron acceptors, forming stable complexes that enhance its binding affinity to multiple receptors, including serotonin and dopamine receptors. Seproxetine hydrochloride demonstrates improved biological activity when interacting with charge transfer complexes, leading to increased stability and efficacy in therapeutic applications.
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- HY-17567
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- HY-Y0316BR
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Biochemical Assay Reagents
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Others
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Sodium dodecyl sulfate for electrophoresis (Standard) is the analytical standard of Sodium dodecyl sulfate for electrophoresis. This product is intended for research and analytical applications. Sodium dodecyl sulfate for electrophoresis is a high purity sodium dodecyl sulfate (SDS) with a minimum purity of 98.5%. It is an anionic detergent commonly used in electrophoretic procedures to denature and impart a negative charge to proteins, allowing separation based on size and charge. Sodium dodecyl sulfate for electrophoresis has unique chemical properties that make it an effective ingredient in many laboratory applications, helping to improve the resolution and sensitivity of protein analysis.
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- HY-W409806
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Liposome
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Inflammation/Immunology
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Cholesterylamine is a cationic lipid. Cholesterylamine can be added to the PLGA to prepare PLGA particle having surface charge. Cholesterylamine can be used for drug delivery. Cholesterylamine can be used for autoimmune diseases and allergy research .
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- HY-W142596
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Liposome
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Others
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1,2-DImyristoyl-rac-glycero-3-phosphocholine (DMPC), a zwitterionic phospholipid, is chosen as a simple eukaryotic cell membrane, mimicking the neutral charge of the surface membrane of eukaryotic plasma membranes .
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- HY-W007509
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5-Aminoindole
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Biochemical Assay Reagents
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Others
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1H-Indol-5-amine (5-Aminoindole) can be utilized as absorbent for hydrophobic charge induction chromatography (HCIC), or synthesis of tetracyclic heterocycles through the three-component reaction .
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- HY-I0259
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Biochemical Assay Reagents
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Others
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8-Amino-2-naphthol is a photoactive charge transfer compounds, which can be used as fluorescent probe. 8-Amino-2-naphthol is also utilized as chiral organocatalyst .
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- HY-W250110
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Biochemical Assay Reagents
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Infection
Others
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Polyethylenimine (PEI) branched is a organic macromolecule with high cationic-charge-density potential. PEI can ensnare DNA as well as attach to cell membrane, PEI also retains a substantial buffering capacity at virtually any pH. PEI is widely used as transfection reagent .
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- HY-D0045
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5-ROX, SE
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Fluorescent Dye
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Others
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5-Carboxy-X-rhodamin N-succinimidyl ester (5-ROX, SE) is a labeling reagent. 5-Carboxy-X-rhodamin N-succinimidyl ester can be used in the preparation of charge-modified dye-labeled Dideoxynucleotide Triphosphates (ddNTP) to "direct-load" DNA sequencing .
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- HY-D0835
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Hydroxyapatite (25-45μm)
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Biochemical Assay Reagents
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Others
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Hydroxylapatite (Hydroxyapatite) is a naturally occurring calcium phosphate which is a major mineral component of bone and teeth bones. Nano-scale Hydroxylapatite particles are increasingly being used as carriers for controlled and targeted delivery of bioactive agents like agents, proteins, and nucleic acids due to their high porosity, negative charge, and biodegradability .
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- HY-D0047
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5-CFDA
3 Publications Verification
5-Carboxyfluorescein diacetate
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Fluorescent Dye
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Others
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5-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .
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- HY-D0721
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6-Carboxyfluorescein diacetate
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Fluorescent Dye
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Others
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6-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .
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- HY-D0722
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5-(6)-Carboxyfluorescein diacetate; CFDA
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Fluorescent Dye
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Others
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5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .
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- HY-D0215
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Safranine T
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Fluorescent Dye
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Others
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Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. It can readily intercalate into biological macromolecules, including DNA and proteins. Safranin can be used as a redox indicator in the determination of metal ion concentration .
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- HY-N12540
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MGDG
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Others
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Others
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Monogalactosyldiacylglycerol (MGDG) is a polar lipid that does not form a bilayer and is found, for example, in the chloroplast thylakoid of aerobic photosynthetic organisms. Monogalactosyldiacylglycerol lacks charge and is highly unsaturated, which provides a fluid environment that facilitates the diffusion process of electron transfer in photosynthesis and may be used in the packaging of natural proteins. The galactolipid Monogalactosyldiacylglycerol has anti-inflammatory effects in vivo ..
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- HY-Y0850U6
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Polyvinyl alcohol (Mw 205000); Poly(Ethenol) (Mw 205000)
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Biochemical Assay Reagents
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Others
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PVA (Polyvinyl alcohol) (Mw 205000) is a polyvinyl alcohol with a molecular weight of 205000, which is used as a biological excipient. PVA (Mw 205000) has excellent optical properties, high dielectric strength and excellent charge storage, and can be used as an embedded pad and substrate for metal/inorganic nanofillers for sensing, optoelectronic devices and many other applications .
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- HY-107202A
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Toll-like Receptor (TLR)
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Infection
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Poly (I:C):Kanamycin (1:1) is a mixture of poly (I:C) and kanamycin. Poly(I:C) is a synthetic double-stranded RNA (dsRNA), which is a Toll-like receptor 3 (TLR3) agonist. Kanamycin is positively charged (poly-NH3) and can thus neutralize the negative charge of Poly I:C and thereby stabilized the molecule.
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- HY-W250110R
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Biochemical Assay Reagents
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Infection
Others
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Polyethylenimine (branched) (Standard) is the analytical standard of Polyethylenimine (branched). This product is intended for research and analytical applications. Polyethylenimine (PEI) branched is a organic macromolecule with high cationic-charge-density potential. PEI can ensnare DNA as well as attach to cell membrane, PEI also retains a substantial buffering capacity at virtually any pH. PEI is widely used as transfection reagent .
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- HY-131131
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Fluorescent Dye
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Others
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5-CFDA-AM is a cell-permeable esterase substrate that can be used as an active probe to measure enzyme activity and cell membrane integrity. 5-CFDA-AM is electroneutral and can enter the cell at a lower concentration than CFDA, where it is hydrolysed by intracellular esterases to produce carboxyfluorescein. Carboxyfluorescein contains an additional negative charge and can be better retained in the cell .
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- HY-152073
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Fluorescent Dye
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Others
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BETA-1 is the first twisted intramolecular charge transfer (TICT)-aggregation-induced emission (AIE) integration molecule. BETA-1 emits cyan fluorescence in lipid droplets (LDs) and red fluorescence in mitochondria. BETA-1 can be used for the simultaneous and dual-color imaging of LDs and mitochondria in vivo and in vitro .
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- HY-D1366
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Fluorescent Dye
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Sulfo-Cyanine5.5 carboxylic acidCI Pigment violet 32 is a water-soluble, far-red emitting fluorophore. Due to its four sulfo groups, this dye has a negative charge at neutral pH and is very hydrophilic. As a cyanine dye, sulfo-Cyanine5.5 shows a very low dependence of fluorescence on pH and a very high extinction coefficient.
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- HY-139200
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Liposome
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Others
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DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo .
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- HY-126377
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Biochemical Assay Reagents
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Others
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Sulfobetaine 10, is a zwitterionic surfactant commonly used in biochemistry and biophysics. It is commonly used to dissolve membrane proteins and other hydrophobic molecules in aqueous solutions. Sulfobetaine 10 has both positively and negatively charged groups in its structure, which allows it to maintain a neutral charge in solution and reduces its tendency to denature proteins. It is considered a mild, non-denaturing surfactant and is widely used in protein research.
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- HY-Y0850A2
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PVA, MW 40000 (Excipient)
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Biochemical Assay Reagents
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Others
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Polyvinyl alcohol, MW 40000 (Excipient) (PVA, MW 40000 (Excipient)) is a polyvinyl alcohol (PVA) with a molecular weight of 40000, which is used as a bioexcipient. Polyvinyl alcohol has good optical properties, high dielectric strength and excellent charge storage capacity. Polyvinyl alcohol can be used as an embedding pad and matrix for metal/inorganic nanofillers for sensing, optoelectronic devices and many other applications .
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- HY-Y0850A6
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PVA, MW 164000 (Excipient)
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Biochemical Assay Reagents
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Others
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Polyvinyl alcohol, MW 164000 (Excipient) (PVA, MW 164000 (Excipient)) is a polyvinyl alcohol (PVA) with a molecular weight of 164000, which is used as a bioexcipient. Polyvinyl alcohol has good optical properties, high dielectric strength and excellent charge storage capacity. Polyvinyl alcohol can be used as an embedding pad and matrix for metal/inorganic nanofillers for sensing, optoelectronic devices and many other applications .
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- HY-Y0850A7
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PVA, MW 94000 (Excipient)
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Biochemical Assay Reagents
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Others
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Polyvinyl alcohol, MW 94000 (Excipient) (PVA, MW 94000 (Excipient)) is a polyvinyl alcohol (PVA) with a molecular weight of 94000, which is used as a bioexcipient. Polyvinyl alcohol has good optical properties, high dielectric strength and excellent charge storage capacity. Polyvinyl alcohol can be used as an embedding pad and matrix for metal/inorganic nanofillers for sensing, optoelectronic devices and many other applications .
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- HY-P4086
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RABV
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Infection
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Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R), a chimeric peptide consisting of 29 amino acids, is synthesized by adding nona-arginine motif to the carboxy terminus of RVG (rabies virus glycoprotein). Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) is positively charged and able to bind negatively charged nucleic acids via charge interaction .
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- HY-W250194
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Biochemical Assay Reagents
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Others
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Luviquat FC 550 is a cationic polymer commonly used in a variety of personal care and cosmetics. It is a viscous liquid containing quaternary ammonium groups which give it a positive charge. Luviquat FC 550 has a variety of properties suitable for these applications including its ability to provide conditioning, antistatic and film-forming properties to hair and skin. In addition, it is used as a binder in oral care products and as a flocculant in industrial water treatment.
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- HY-D0041
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Calcein-AM
Maximum Cited Publications
47 Publications Verification
Calcein acetoxymethyl ester
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Fluorescent Dye
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Cancer
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Calcein AM, has cell membrane permeability and can easily enter the cell. Calcein AM has no fluorescence and is hydrolyzed by endogenous esterase in the cell to produce polar molecule Calcein (Calcein), which has strong negative charge and cannot permeate the cell membrane. Calcein can emit strong green fluorescence, so it is often used with Propidium Iodide for cell viability/virulence detection, excitation/emission wavelength: 494/515 nm .
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- HY-W127620
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Biochemical Assay Reagents
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Others
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Sulfobetaine-12is a zwitterionic surfactant, which means it has both positive and negative charges in its molecules. It is used as a detergent in various industries, including pharmaceuticals, cosmetics, and personal care products. Sulfobetaine-12Often used as a mild surfactant due to its non-irritating properties and ability to stabilize emulsions. Plus, it has antistatic properties that can be used to clean electronics and other static-prone surfaces.
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- HY-W127621
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Biochemical Assay Reagents
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Others
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Sulfobetaine-8is a zwitterionic surfactant, which means it has both positive and negative charges in its molecules. It is used as a detergent in various industries, including pharmaceuticals, cosmetics, and personal care products. Sulfobetaine-8Often used as a mild surfactant because of its non-irritating and ability to stabilize emulsions. Plus, it has antistatic properties that can be used to clean electronics and other static-prone surfaces.
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- HY-Y1738
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Tetrakis(triphenylphosphine)palladium(0)
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Biochemical Assay Reagents
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Others
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Tetrakis(triphenylphosphine)palladium (Pd(PPhs)) series of cross-coupling catalysts can be used to construct an organic heterojunction solar cell model. Adding different amounts of Pd(PPhs) significantly affected free carrier generation, non-twin trap and surface trap-assisted recombination as well as bimolecular recombination and charge extraction, but the impact on the non-duplex recombination process was limited because the catalyst could not promote efficient Trap-assisted reorganization. The studied system is highly robust with the addition of a small amount of Pd(PPha) .
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- HY-121746
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PPAR
Calcium Channel
Apoptosis
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Cardiovascular Disease
Metabolic Disease
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GW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPARγ agonist. GW7845 is effective at inhibiting voltage-dependent calcium channels (VDCC) and relaxing pressurized arteries with IC50 of 3 μM by using Ba 2+ as the charge carrier through VDCC. GW7845-induced apoptosis is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells .
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- HY-Y0850A2R
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Biochemical Assay Reagents
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Others
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Polyvinyl alcohol, MW 40000 (Excipient) (Standard) is the analytical standard of Polyvinyl alcohol, MW 40000 (Excipient). This product is intended for research and analytical applications. Polyvinyl alcohol, MW 40000 (Excipient) (PVA, MW 40000 (Excipient)) is a polyvinyl alcohol (PVA) with a molecular weight of 40000, which is used as a bioexcipient. Polyvinyl alcohol has good optical properties, high dielectric strength and excellent charge storage capacity. Polyvinyl alcohol can be used as an embedding pad and matrix for metal/inorganic nanofillers for sensing, optoelectronic devices and many other applications .
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- HY-W099581
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SB3-14; DMAPS
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Biochemical Assay Reagents
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Others
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Zwittergent 3-14 (DMAPS) is a zwitterionic detergent commonly used in biochemistry and molecular biology for the solubilization and purification of membrane-bound proteins and other hydrophobic biomolecules, which have both hydrophilic and hydrophobic moieties , so that it has good detergency properties, making it suitable for stabilizing membrane proteins in aqueous solutions. In addition, DMAPS has been used in various techniques such as electrophoresis and chromatography for the separation and analysis of biomolecules. The long The hydrocarbon chains provide it with good membrane penetration and solubilization capabilities, while the sulfonate and quaternary ammonium groups ensure water solubility and charge neutrality.
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- HY-149203A
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Fluorescent Dye
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Others
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MQA-P is a multifunctional near-infrared (NIR) fluorescent probe that simultaneously detects ONOO -, viscosity, and polarity within mitochondria. MQA-P exhibits significant response to ONOO -, λem=645 nm; and NIR channel at λem>704 nm Medium is highly sensitive to viscosity/polarity. MQA-P possesses excited-state intramolecular charge transfer (ESICT) properties that are highly sensitive to polarity by designing the N,N-dimethylamino group as the electron donor and the quinoline cation unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images .
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- HY-123035
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HSP
Akt
EGFR
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Endocrinology
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Gamendazole, an indazole carboxylic acid (ICA), is an orally active, selective HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A) inhibitor. Gamendazole binds to the C-terminal nucleotide binding pocket of HSP90 and cause downregulation of clients AKT1 and ERBB2, but stabilizes the HSP90 heterocomplex. Gamendazole specifically inhibits the actin bundling function of EEF1A1, but does not bind to the nucleotide docking pocket nor inhibits the ribosome charging or protein translation functions of EEF1A1. Gamendazole, an antispermatogenic compound with antifertility effects, has the potential for reversible non-hormonal male contraceptive agent research .
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- HY-W099581R
-
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Biochemical Assay Reagents
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Others
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Sulfobetaine-14 (Standard) is the analytical standard of Sulfobetaine-14. This product is intended for research and analytical applications. Zwittergent 3-14 (DMAPS) is a zwitterionic detergent commonly used in biochemistry and molecular biology for the solubilization and purification of membrane-bound proteins and other hydrophobic biomolecules, which have both hydrophilic and hydrophobic moieties , so that it has good detergency properties, making it suitable for stabilizing membrane proteins in aqueous solutions. In addition, DMAPS has been used in various techniques such as electrophoresis and chromatography for the separation and analysis of biomolecules. The long The hydrocarbon chains provide it with good membrane penetration and solubilization capabilities, while the sulfonate and quaternary ammonium groups ensure water solubility and charge neutrality.
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- HY-D0093
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EthD-1
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DNA Stain
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Others
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Ethidium homodimer (EthD-1) is a high-affinity fluorescent nucleic acid dye commonly used to stain mammals, bacteria, yeast, and fungi. Ethidium homodimer binds to DNA or RNA, enhancing fluorescence more than 30 times. The Ethidium homodimer has a strong positive charge, so it cannot cross cell membranes and stain living cells; But the Ethidium homodimer can cross the disordered region of the dead cell membrane to reach the nucleus and embed the DNA double strand to produce red fluorescence. Therefore, Ethidium homodimer is a relatively sensitive nucleic acid stain that can accurately detect nucleic acids in solution or in decomposing cells. Ethidium homodimer binds DNA, Ex/Em=528/617 nm .
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- HY-W391671
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Others
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Others
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Poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine], a type of poly(triaryl amine), serves as an organic p-type semiconductor exhibiting hole mobilities ranging from 10?3 to 10?2 cm2 V?1 s?1, which significantly enhances carrier mobility. This stable glassy polymer possesses a favorable ionization potential for thick film diodes. Committed to providing Greener Alternative Products that comply with one or more of The 12 Principles of Greener Chemistry, this material falls under the Enabling category of greener alternatives, aligning with the principle of "Design for energy efficiency." Additionally, while hole transport organic materials like this ensure optimal energy level alignment with the absorber layer for efficient charge collection, they may be susceptible to degradation under ambient conditions.
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- HY-121690
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SD-3211
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Others
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Others
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Semotiadil is a novel calcium antagonist whose stereochemical structure was investigated by X-ray crystallography and circular dichroism spectroscopy. X-ray structural analysis was performed using its enantiomeric salts with (S)-(+)-mandelic acid (2); 1 (mandelate salt). The R absolute configuration of 1, which was previously determined by chemical transformation of an optically active synthetic precursor, was directly confirmed by this analysis. Hydrogen bonding, charge repulsion, and hydrophobic interactions that stabilize the crystal structure were observed in the crystals. Circular dichroism spectra of 1 (mandelate salt) and 1 (hydrofuranate salt) in ethanolic solution showed similar spectral patterns. The CD bands of each chromophore were unambiguously assigned, and the conformation of the benzothiazole ring was determined using the optical rotation rule. The X-ray and CD data confirmed the P conformation of the benzothiazole ring and the equatorial position of the 2-phenyl ring in both the crystal and ethanolic solution states. These findings are in good agreement with our previous results on the conformational analysis of 2-arylbenzothiazole derivatives.
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Cat. No. |
Product Name |
Type |
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- HY-D0948
-
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Dyes
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Celestine Blue is a electroactive indicator in DNA biosensors. Celestine Blue is strongly adsorbed on the spinel phases and CNT (carbon nanotubes), facilitates dispersion, acts as a capping agent and allows for the fabrication of spinel decorated CNT. Celestine Blue is an efficient charge transfer mediator, which allows for significant improvement of capacitive behavior. TiO2 nanoparticles doped with Celestine Blue can be used as a label in a sandwich immunoassay for the hepatitis C virus (HCV) core antigen .
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- HY-D0047
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5-CFDA
3 Publications Verification
5-Carboxyfluorescein diacetate
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Fluorescent Dyes/Probes
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5-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .
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- HY-D0721
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6-Carboxyfluorescein diacetate
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Fluorescent Dyes/Probes
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6-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .
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- HY-D0722
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5-(6)-Carboxyfluorescein diacetate; CFDA
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Fluorescent Dyes/Probes
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5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .
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- HY-D0215
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Safranine T
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Dyes
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Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. It can readily intercalate into biological macromolecules, including DNA and proteins. Safranin can be used as a redox indicator in the determination of metal ion concentration .
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- HY-131131
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Fluorescent Dyes/Probes
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5-CFDA-AM is a cell-permeable esterase substrate that can be used as an active probe to measure enzyme activity and cell membrane integrity. 5-CFDA-AM is electroneutral and can enter the cell at a lower concentration than CFDA, where it is hydrolysed by intracellular esterases to produce carboxyfluorescein. Carboxyfluorescein contains an additional negative charge and can be better retained in the cell .
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- HY-D1259
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VDP-green (NEP)
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Fluorescent Dyes/Probes
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NEP (VDP-green (NEP)) is a turn-on fluorescent probe based on the intramolecular charge transfer (ICT) mechanism for sensing vicinal dithiol-containing proteins (VDPs). NEP exhibits high selectivity toward VDPs in live cells and in vivo and displays a strong green fluorescence signal (λex/λem=430/535 nm). NEP has the potential for parkinsonism .
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- HY-149203
-
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Fluorescent Dyes/Probes
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MQA-P is a multifunctional near-infrared (NIR) fluorescent probe for simultaneously detecting ONOO -, viscosity, and polarity within mitochondria. MQA-P exhibits a remarkable turn-on response to ONOO - (λem=645 nm) and is highly sensitive to viscosity/polarity in the NIR channel with λem>704 nm. MQA-P exhibits excited-state intramolecular charge transfer (ESICT) feature that is highly polarity-sensitive by engineering N,N-dimethylamino as the electron donor and a quinoline cationic unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images .
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- HY-W923198
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Methacryloyloxy fluorescein
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Fluorescent Dyes/Probes
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Fluorescein O-methacrylate (Methacryloyloxy fluorescein) is a pH-sensitive dye featuring a fluorescent monomer, characterized by an excitation spectrum at 490 nm and an emission spectrum at 520 nm. With fluorescein serving as an indicator that possesses minimal negative charges, it exhibits properties such as biocompatibility, non-toxicity, and excellent dispersion in aqueous solutions.
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- HY-D1366
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Fluorescent Dyes/Probes
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Sulfo-Cyanine5.5 carboxylic acidCI Pigment violet 32 is a water-soluble, far-red emitting fluorophore. Due to its four sulfo groups, this dye has a negative charge at neutral pH and is very hydrophilic. As a cyanine dye, sulfo-Cyanine5.5 shows a very low dependence of fluorescence on pH and a very high extinction coefficient.
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- HY-D0041
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Calcein-AM
Maximum Cited Publications
47 Publications Verification
Calcein acetoxymethyl ester
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Fluorescent Dyes/Probes
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Calcein AM, has cell membrane permeability and can easily enter the cell. Calcein AM has no fluorescence and is hydrolyzed by endogenous esterase in the cell to produce polar molecule Calcein (Calcein), which has strong negative charge and cannot permeate the cell membrane. Calcein can emit strong green fluorescence, so it is often used with Propidium Iodide for cell viability/virulence detection, excitation/emission wavelength: 494/515 nm .
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- HY-D0093
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EthD-1
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DNA Stain
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Ethidium homodimer (EthD-1) is a high-affinity fluorescent nucleic acid dye commonly used to stain mammals, bacteria, yeast, and fungi. Ethidium homodimer binds to DNA or RNA, enhancing fluorescence more than 30 times. The Ethidium homodimer has a strong positive charge, so it cannot cross cell membranes and stain living cells; But the Ethidium homodimer can cross the disordered region of the dead cell membrane to reach the nucleus and embed the DNA double strand to produce red fluorescence. Therefore, Ethidium homodimer is a relatively sensitive nucleic acid stain that can accurately detect nucleic acids in solution or in decomposing cells. Ethidium homodimer binds DNA, Ex/Em=528/617 nm .
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Cat. No. |
Product Name |
Type |
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- HY-Y0316B
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Sodium lauryl sulfate for electrophoresis; Laurylsulfuric acid sodium salt for electrophoresis
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Surfactants
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Sodium dodecyl sulfate for electrophoresis is a high purity sodium dodecyl sulfate (SDS) with a minimum purity of 98.5%. It is an anionic detergent commonly used in electrophoretic procedures to denature and impart a negative charge to proteins, allowing separation based on size and charge. Sodium dodecyl sulfate for electrophoresis has unique chemical properties that make it an effective ingredient in many laboratory applications, helping to improve the resolution and sensitivity of protein analysis.
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- HY-W007509
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5-Aminoindole
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Biochemical Assay Reagents
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1H-Indol-5-amine (5-Aminoindole) can be utilized as absorbent for hydrophobic charge induction chromatography (HCIC), or synthesis of tetracyclic heterocycles through the three-component reaction .
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- HY-I0259
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Biochemical Assay Reagents
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8-Amino-2-naphthol is a photoactive charge transfer compounds, which can be used as fluorescent probe. 8-Amino-2-naphthol is also utilized as chiral organocatalyst .
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- HY-139200
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Drug Delivery
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DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo .
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- HY-126377
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Surfactants
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Sulfobetaine 10, is a zwitterionic surfactant commonly used in biochemistry and biophysics. It is commonly used to dissolve membrane proteins and other hydrophobic molecules in aqueous solutions. Sulfobetaine 10 has both positively and negatively charged groups in its structure, which allows it to maintain a neutral charge in solution and reduces its tendency to denature proteins. It is considered a mild, non-denaturing surfactant and is widely used in protein research.
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- HY-W102545
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Chelators
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Diaza-15-crown-5 extends the lifetime of M intermediates in BR membranes. Diaza-15-crown-5 is a crown ether compound that alters the surface charge of BR membranes. Diaza-15-crown-5 changes the surface charge of the BR film. and overall membrane stability. Diaza-15-crown-5 allows the M state to be maintained for a longer period of time .
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- HY-Y0316BR
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Surfactants
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Sodium dodecyl sulfate for electrophoresis (Standard) is the analytical standard of Sodium dodecyl sulfate for electrophoresis. This product is intended for research and analytical applications. Sodium dodecyl sulfate for electrophoresis is a high purity sodium dodecyl sulfate (SDS) with a minimum purity of 98.5%. It is an anionic detergent commonly used in electrophoretic procedures to denature and impart a negative charge to proteins, allowing separation based on size and charge. Sodium dodecyl sulfate for electrophoresis has unique chemical properties that make it an effective ingredient in many laboratory applications, helping to improve the resolution and sensitivity of protein analysis.
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- HY-W142596
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Drug Delivery
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1,2-DImyristoyl-rac-glycero-3-phosphocholine (DMPC), a zwitterionic phospholipid, is chosen as a simple eukaryotic cell membrane, mimicking the neutral charge of the surface membrane of eukaryotic plasma membranes .
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- HY-Y0850U6
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Polyvinyl alcohol (Mw 205000); Poly(Ethenol) (Mw 205000)
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Drug Delivery
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PVA (Polyvinyl alcohol) (Mw 205000) is a polyvinyl alcohol with a molecular weight of 205000, which is used as a biological excipient. PVA (Mw 205000) has excellent optical properties, high dielectric strength and excellent charge storage, and can be used as an embedded pad and substrate for metal/inorganic nanofillers for sensing, optoelectronic devices and many other applications .
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- HY-W250194
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Surfactants
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Luviquat FC 550 is a cationic polymer commonly used in a variety of personal care and cosmetics. It is a viscous liquid containing quaternary ammonium groups which give it a positive charge. Luviquat FC 550 has a variety of properties suitable for these applications including its ability to provide conditioning, antistatic and film-forming properties to hair and skin. In addition, it is used as a binder in oral care products and as a flocculant in industrial water treatment.
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- HY-W127620
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Surfactants
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Sulfobetaine-12is a zwitterionic surfactant, which means it has both positive and negative charges in its molecules. It is used as a detergent in various industries, including pharmaceuticals, cosmetics, and personal care products. Sulfobetaine-12Often used as a mild surfactant due to its non-irritating properties and ability to stabilize emulsions. Plus, it has antistatic properties that can be used to clean electronics and other static-prone surfaces.
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- HY-W127621
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Surfactants
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Sulfobetaine-8is a zwitterionic surfactant, which means it has both positive and negative charges in its molecules. It is used as a detergent in various industries, including pharmaceuticals, cosmetics, and personal care products. Sulfobetaine-8Often used as a mild surfactant because of its non-irritating and ability to stabilize emulsions. Plus, it has antistatic properties that can be used to clean electronics and other static-prone surfaces.
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- HY-Y1738
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Tetrakis(triphenylphosphine)palladium(0)
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Biochemical Assay Reagents
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Tetrakis(triphenylphosphine)palladium (Pd(PPhs)) series of cross-coupling catalysts can be used to construct an organic heterojunction solar cell model. Adding different amounts of Pd(PPhs) significantly affected free carrier generation, non-twin trap and surface trap-assisted recombination as well as bimolecular recombination and charge extraction, but the impact on the non-duplex recombination process was limited because the catalyst could not promote efficient Trap-assisted reorganization. The studied system is highly robust with the addition of a small amount of Pd(PPha) .
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- HY-W099581
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SB3-14; DMAPS
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Surfactants
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Zwittergent 3-14 (DMAPS) is a zwitterionic detergent commonly used in biochemistry and molecular biology for the solubilization and purification of membrane-bound proteins and other hydrophobic biomolecules, which have both hydrophilic and hydrophobic moieties , so that it has good detergency properties, making it suitable for stabilizing membrane proteins in aqueous solutions. In addition, DMAPS has been used in various techniques such as electrophoresis and chromatography for the separation and analysis of biomolecules. The long The hydrocarbon chains provide it with good membrane penetration and solubilization capabilities, while the sulfonate and quaternary ammonium groups ensure water solubility and charge neutrality.
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- HY-W099581R
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Surfactants
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Sulfobetaine-14 (Standard) is the analytical standard of Sulfobetaine-14. This product is intended for research and analytical applications. Zwittergent 3-14 (DMAPS) is a zwitterionic detergent commonly used in biochemistry and molecular biology for the solubilization and purification of membrane-bound proteins and other hydrophobic biomolecules, which have both hydrophilic and hydrophobic moieties , so that it has good detergency properties, making it suitable for stabilizing membrane proteins in aqueous solutions. In addition, DMAPS has been used in various techniques such as electrophoresis and chromatography for the separation and analysis of biomolecules. The long The hydrocarbon chains provide it with good membrane penetration and solubilization capabilities, while the sulfonate and quaternary ammonium groups ensure water solubility and charge neutrality.
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- HY-W002004
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4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl
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Biochemical Assay Reagents
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4-Amino-TEMPO can be used as a spin label for detecting radicals and the damage caused by them. 4-Amino-TEMPO possesses superoxide dismutase-mimetic activity, enabling it to easily penetrate cells and protect them from oxidative damage induced by H2O2. Additionally, 4-Amino-TEMPO exhibits significant radiation protective properties, effectively safeguarding DNA from oxidative stress-induced damage caused by UV exposure due to its ability to maintain a positive charge. Furthermore, 4-Amino-TEMPO is a highly selective oxidation catalyst widely used in the research and development of various specialty chemicals, including fragrances, pesticides, and others .
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-W141932
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Stearoylglycine; N-Octadecanoylglycine
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Peptides
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Others
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N-stearoylglycine is a lipid and has a small ionizable polar headgroup whose charge is pH dependent and whose amide moiety can form H-bonded network between adjacent molecules in ordered films .
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- HY-P4086
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RABV
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Infection
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Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R), a chimeric peptide consisting of 29 amino acids, is synthesized by adding nona-arginine motif to the carboxy terminus of RVG (rabies virus glycoprotein). Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) is positively charged and able to bind negatively charged nucleic acids via charge interaction .
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- HY-P3941
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Peptides
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Others
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Ala-Arg-Arg-Pro-Glu-Gly-Arg-Thr-Trp-Ala-Gln-Pro-Gly-Tyr is a peptide. Ala-Arg-Arg-Pro-Glu-Gly-Arg-Thr-Trp-Ala-Gln-Pro-Gly-Tyr can easily be formed with more than one positive charge .
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- HY-P4139
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Peptides
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Others
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activable cell-penetrating peptide (ACCP) consists of a polycationic CPP (typically arg9 or r9) connected via a cleavable linker to a matching polyanion (typically glu9 or e9), which reduces the net charge to nearly zero and thereby inhibits adhesion and uptake into cells .
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- HY-P10300
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IL-8 (54-72)
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Peptides
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Inflammation/Immunology
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CXCL8 (54-72) is a C-terminal peptide based on the chemokine CXCL8. CXCL8 (54-72) has an interaction between a long and highly positively charged C-terminal region and a negative charge on the GAG that binds to the GAG. CXCL8 (54-72) can inhibit the adhesion and migration of neutrophils and adhesion of endothelial cells. CXCL8 (54-72) can be used to study chemokines in inflammatory response .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
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Classification |
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- HY-130463
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PG(16:0/18:1); 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)
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Phospholipids
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POPG sodium salt is a phospholipid molecule having one negative charge, which can interact with the positive charges of peptides .
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- HY-W409806
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Cholesterol
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Cholesterylamine is a cationic lipid. Cholesterylamine can be added to the PLGA to prepare PLGA particle having surface charge. Cholesterylamine can be used for drug delivery. Cholesterylamine can be used for autoimmune diseases and allergy research .
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- HY-139200
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Cationic Lipids
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DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo .
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- HY-W142596
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Phospholipids
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1,2-DImyristoyl-rac-glycero-3-phosphocholine (DMPC), a zwitterionic phospholipid, is chosen as a simple eukaryotic cell membrane, mimicking the neutral charge of the surface membrane of eukaryotic plasma membranes .
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- HY-Y0850A2
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PVA, MW 40000 (Excipient)
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Emulsifiers
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Polyvinyl alcohol, MW 40000 (Excipient) (PVA, MW 40000 (Excipient)) is a polyvinyl alcohol (PVA) with a molecular weight of 40000, which is used as a bioexcipient. Polyvinyl alcohol has good optical properties, high dielectric strength and excellent charge storage capacity. Polyvinyl alcohol can be used as an embedding pad and matrix for metal/inorganic nanofillers for sensing, optoelectronic devices and many other applications .
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- HY-Y0850A6
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PVA, MW 164000 (Excipient)
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Emulsifiers
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Polyvinyl alcohol, MW 164000 (Excipient) (PVA, MW 164000 (Excipient)) is a polyvinyl alcohol (PVA) with a molecular weight of 164000, which is used as a bioexcipient. Polyvinyl alcohol has good optical properties, high dielectric strength and excellent charge storage capacity. Polyvinyl alcohol can be used as an embedding pad and matrix for metal/inorganic nanofillers for sensing, optoelectronic devices and many other applications .
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- HY-Y0850A7
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PVA, MW 94000 (Excipient)
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Emulsifiers
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Polyvinyl alcohol, MW 94000 (Excipient) (PVA, MW 94000 (Excipient)) is a polyvinyl alcohol (PVA) with a molecular weight of 94000, which is used as a bioexcipient. Polyvinyl alcohol has good optical properties, high dielectric strength and excellent charge storage capacity. Polyvinyl alcohol can be used as an embedding pad and matrix for metal/inorganic nanofillers for sensing, optoelectronic devices and many other applications .
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