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cruzi

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Apoptosis (1) Autophagy (1) Bacterial (3) Biochemical Assay Reagents (1) Casein Kinase (1) Cathepsin (2) CCR (2) CDK (1) Cytochrome P450 (6) Filovirus (2) Fungal (2) Glycosidase (1) GSK-3 (1) HBV (1) Isotope-Labeled Compounds (1) Lactate Dehydrogenase (3) Necroptosis (2) NTPDase (1) Parasite (66) Proteasome (1) Reactive Oxygen Species (1) SARS-CoV (2) Ser/Thr Protease (1)
By Research Areas:	Cancer (7) Infection (73) Inflammation/Immunology (5) Metabolic Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103033

T.cruzi-IN-1	Parasite	Infection
T.cruzi-IN-1 is a potent Trypanosoma cruzi inhibitor with an IC₅₀ of 8 nM. T.cruzi-IN-1, a 4-trifluoromethyl substituted analog, has the potential for both the acute and chronic stages of Chagas disease .

HY-159097

T.cruzi-IN-4	Parasite	Infection
T.cruzi-IN-4 (Compound 21) is an anti-parasitic agent. T.cruzi-IN-4 inhibits the trypomastigote and amastigote form of Trypanosoma cruzi with IC₅₀ of 0.033 μM (120 h), T.cruzi-IN-4 inhibits the promastigote and amastigote form of Leishmania infantum with IC₅₀ of 28.74 and 61.82 μM. T.cruzi-IN-4 inhibits Leishmania amazonensis promastigote form with IC₅₀ of 18.38 μM .

HY-168342

*Anti-Trypanosoma cruzi* agent-6**	Parasite	Infection
Anti-Trypanosoma cruzi agent-6 (Compound 8) exhibits inhibitory activity against Trypanosoma cruzi, that inhibits the epimastigote, trypomastigote and amastigote form of T. cruzi with IC₅₀s of 24.7 µM, 1.8 µM and 1.6 µM, respectively .

HY-147765

*Anti-Trypanosoma cruzi* agent-3**	Parasite	Infection
Anti-Trypanosoma cruzi agent-3 (Compound 7c) is an antiprotozoal agent .

HY-115972

*Anti-Trypanosoma cruzi* agent-2**	Parasite	Infection Inflammation/Immunology
Anti-Trypanosoma cruzi agent-1 (Compd 3b), selective compound against NINOA trypomastigote (IC₅₀ = 0.51 µM) and INC-5 epimastigote form (IC₅₀ = 3.06 µM), posseses anti-T. gondii activity .

HY-148323

*Anti-Trypanosoma cruzi* agent-4**	Parasite	Infection
Anti-Trypanosoma cruzi agent-4 (compound 5c) is an inhibitor of Trypanosoma cruzi. Anti-Trypanosoma cruzi agent-4 can be used for the research of infection .

HY-116004

*Anti-Trypanosoma cruzi* agent-5**	Parasite	Infection
Anti-Trypanosoma cruzi agent-5 (compoung 8) is a potent inhibitor of Trypanosoma cruzi proliferation .

HY-115971

*Anti-Trypanosoma cruzi* agent-1**	Parasite	Infection Inflammation/Immunology
Anti-Trypanosoma cruzi agent-1 (Compd E5) posseses anti-T. gondii activity .

HY-130752

VNI	Cytochrome P450 Parasite	Infection
VNI is an effective inhibitor of CYP51. VNI can inhibit sterol synthesis in Trypanosoma cruzi, exhibiting anti-Trypanosoma cruzi activity .

HY-107034

Moxipraquine 349C59	Parasite	Infection
Moxipraquine is a potent insecticide against Trypanosoma cruzi. Moxipraquine effectively inhibits Leishmania major, L. mexicana mexicana and L. brasiliensis panamensis but not L.b. brasiliensis .

HY-151943

Antitrypanosomal agent 11	Parasite	Infection
Antitrypanosomal agent 11 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC₅₀ of 0.23 μM .

HY-172207

POPTc80-IN-1	Ser/Thr Protease Parasite	Infection
POPTc80-IN-1 (Compound LC-45) is a competitive inhibitor for prolyl oligopeptidase of Trypanosoma cruzi POPTc80 with an IC₅₀ of 0.23 μM and a K_i of 0.054 μM. POPTc80-IN-1 inhibits the invasion of T. cruzi into host cell with an IC₅₀ of 46.71 μM .

HY-172206

TSO-13	Parasite	Infection
TSO-13 is the inhibitor for the main cysteine protease of Trypanosoma cruzi Cruzipain with an IC₅₀ of 2.2 μM. TSO-13 inhibits T. cruzi in Vero cell with an IC₅₀ of 1.9 μM .

HY-N10443

Mammea A/BA	Parasite Apoptosis Autophagy Reactive Oxygen Species	Infection
Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease .

HY-12607

ML251	Parasite	Infection
ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC₅₀=0.37 μM) and T. cruzi PFK (IC₅₀=0.13 μM). ML251 can be used for the research of parasite .

HY-149079

Antiparasitic agent-15	Parasite Necroptosis	Infection
Antiparasitic agent-15, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-15 has IC₅₀s of 0.9 μM and 0.64 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-15 has IC₅₀s of 42.2 μM and 9.58 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-15 induces parasite cell death through necrosis induction. Antiparasitic agent-15 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes .

HY-149080

Antiparasitic agent-16	Parasite Necroptosis	Infection
Antiparasitic agent-16, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-16 has IC₅₀s of 1.0 μM and 0.6 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-16 has IC₅₀s of 150.2 μM and 16.75 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-16 induces parasite cell death through necrosis induction. Antiparasitic agent-16 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes .

HY-151942

Antitrypanosomal agent 10	Parasite	Infection
Antitrypanosomal agent 10 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC₅₀ of 0.28 μM .

HY-W010538

trans-4-Methylcyclohexanamine	Parasite	Infection
trans-4-Methylcyclohexanamine is an intermediate and can be used for the development of T. cruzi enzyme inhibitor .

HY-N2656

5,7,8-Trimethoxycoumarin	Parasite	Infection
5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC₅₀s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively .

HY-161299

LAPTc-IN-1	Parasite	Infection
LAPTc-IN-1 (compound 4) is a competitive inhibitor targeting acidic M17 leucinopeptidase (LAPTc) with K_i=0.27 μM. LAPTc-IN-1 is a potential antagonist of the parasite Trypanosoma cruzi .

HY-124623

DNDI-8219	Parasite	Infection
DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.

HY-146042

Antiparasitic agent-4	Parasite	Infection
Antiparasitic agent-4 (compound 4q) has highly antiparasitic activity against Leishmania infantum (L. infantum) and *Trypanosoma cruzi* (T. cruzi) with IC₅₀**s of 8.51 μM and 2.20 μM, respectively. Antiparasitic agent-4 also has certain cytotoxicity against HepG2 (CC₅₀ = 18.97 μM) .

HY-146041

Antiparasitic agent-2	Parasite	Infection
Antiparasitic agent-2 (compound 8a) has highly antiparasitic activity against Leishmania infantum (L. infantum) and *Trypanosoma cruzi* (T. cruzi) with IC₅₀**s of 7.28 μM and 2.30 μM, respectively. Antiparasitic agent-2 also has certain cytotoxicity against HepG2 (CC₅₀ = 26.79 μM) .

HY-N11173

cis-Melilotoside	Others	Metabolic Disease
cis-Melilotoside, an o-Coumaric acid derivative, shows potent antioxidant activity. cis-Melilotoside has antiprotozoal activity moderately against T. cruzi with an IC₅₀ of 78.2 ug/mL .

HY-129228

Lychnopholide	Parasite	Infection
Lychnopholide is a sesquiterpene lactone derived from the Asteraceae, Lychnopholide exhibits anti-trypanosomal activity against Trypanosoma cruzi. lychnopholide encapsulated in nanocapsules reduces its toxicity to mammalian cells. Lychnopholide ameliorates Chagas disease in mouse models .

HY-N10441

3β-Hydroxy-hop-22(29)-ene	Parasite	Infection
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana .

HY-155281

Antiparasitic agent-18	Parasite	Infection
Antiparasitic agent-18 (compound 3a) is active and selective against the T. brucei (EC₅₀=0.4 μM), T. cruzi (EC₅₀=0.21 μM), and L. donovani (EC₅₀=0.26 μM). Antiparasitic agent-18 has potent antiprotozoal activity .

HY-124112

PAM 1392	Parasite	Infection
PAM 1392 is active orally against *Plasmodium berghei* in mice, *P. cynofologi* and *P. knowlesi* in monkeys and Trypanosoma cruzi in tissue cultures of mice, and *hemolytic streptococci* in vitro. PAM 1392 has antimalarial and antitrypanosomal activities, which is proming for rasearch of drug-resistant malaria .

HY-113907

SDZ-285604 VNF	Cytochrome P450 Parasite	Infection
SDZ-285604 (VNF) is a T. cruzi CYP51 inhibitor and can be used for study of Trypanosoma cruzi infection .

HY-N2970

Burchellin	Parasite	Infection
Burchellin is a neolignan that can inhibit Trypanosoma cruzi .

HY-153238

AN15368	Parasite	Infection
AN15368 is an orally active small-molecule precursor that can be activated by parasite carboxypeptidase to produce a compound that targets the messenger RNA processing pathway in T. cruzi. cruzi. AN15368 has the potential to prevent and research Chagas disease potential .

HY-121187

BiPNQ	Parasite	Infection
BiPNQ is a potent inhibitor of Trypanosoma cruzi, the causative agent of Chagas disease .

HY-155103

Antitrypanosomal agent 15	Proteasome Parasite	Infection
Antitrypanosomal agent 15 (compound 26) is an orally active, brain-penetrant, selective inhibitor against *Trypanosoma cruzi* proteasome, with an _pIC₅₀** of 7.4 and <4 for T. cruzi and human proteasome, respectively. Antitrypanosomal agent 15 has favorable ADME properties and can be used for Chagas disease study .

HY-123562

GNF7686	Cytochrome P450	Others
GNF7686 is a cytochrome b inhibitor. GNF7686 exhibits inhibitory activity against complex III in the extracts of L. donovani and T. cruzi .

HY-118338

WRR-483	Parasite	Infection
WRR-483 is an analog of K11777, an inhibitor of cruzain, used to inhibit the proliferation of Trypanosoma cruzi in cell culture. WRR-483 can eradicate parasitic infection in an acute Chagas disease mouse model. WRR-483 is an irreversible cysteine protease inhibitor that shows pH-dependent high affinity and potent trypanocidal activity against cruzain and T. cruzi infection, and is expected to inhibit Chagas disease.

HY-146049

Antitrypanosomal agent 4	Parasite	Infection
Antitrypanosomal agent 4 (compound 19) is a potent and blood-brain barrier permeable antitrypanosomal agent. Antitrypanosomal agent 4 has good activity against *Trypanosoma cruzi* (T. cruzi)** and Trypanosoma brucei brucei (T. b. brucei) with IC₅₀s of 1.2 μM and 70 nM, respectively . Antitrypanosomal agent 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B1548

Benznidazole 3 Publications Verification Benznidazol; Ro 07-1051; Ro 71051	Parasite Antibiotic	Infection
Benznidazole (Ro 07-1051) is an antiparasitic medication, with an IC₅₀ of 20.35 μM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease .

HY-W040073

Nifurtimox	Parasite Lactate Dehydrogenase	Infection Cancer
Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

HY-123251

DB-766	Parasite	Infection
DB-766 is an anti-parasite and antileishmanial agent, and is active against T. cruzi. DB-766 effectively reduces the parasite load in the blood and cardiac tissue .

HY-157028

Antiparasitic agent-19	Others	Infection
Antiparasitic agent-19 (compound 40) is a compound with broad-spectrum antiparasitic activity. Antiparasitic agent-19 has minimal toxicity against Trypanosoma brucei, Leishmania Infantum, and Trypanosoma cruzi .

HY-168732

MCG-02	Parasite	Infection
MCG-02 is the inhibitor for cruzain (CRZ) and cathepsin L-like protease (CATL), that inhibits the CRZ in Trypanosoma cruzi and CATL in Trypanosoma brucei with the IC₅₀ 0.2 μM and 0.02 μM .

HY-129130

Canthin-6-one N-oxide Canthin-6-one 3-oxide	Parasite	Infection
Canthin-6-one N-oxide (Canthin-6-one 3-oxide) is an orally active antiparasitic agent with limited activity .

HY-117129

MK 436 MK-0436	Parasite	Infection
MK 436 (MK-0436) is a metabolite with anti-trypanosomal activity that can be isolated from dog urine, particularly effective against Trypanosoma cruzi, the pathogen responsible for Chagas disease in South America .

HY-146745

Antileishmanial agent-5	Parasite	Inflammation/Immunology
Antileishmanial agent-4 is a ribonucleoside analogue and acts as an antileishmanial agent. Antileishmanial agent-4 is against L.infantum and T.cruzi with EC₅₀ values of 0.68 μM and 0.83 μM, respectively .

HY-N7632

5-Desmethylsinensetin	Bacterial	Infection Inflammation/Immunology
5-desmethylsinensetin, isolated from Artemisia princeps , possesses antiprotozoal activity. 5-desmethylsinensetin shows IC₅₀ values of 0.4 μg/mL on T. cruzi* epimastigotes* and 75.1 μg/mL on trypomastigotes, respectively .

HY-N4033

Horminone 7α-Hydroxyroyleanone	Bacterial	Infection
Horminone is an abietan diterpene quinone that can be isolated from Labiatae family. Horminone increases of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum levels in vivo. Horminone inhibits the growth of Trypanosoma cruzi and shows antibacterial activity .

HY-W040073S

Nifurtimox-d4	Isotope-Labeled Compounds Parasite Lactate Dehydrogenase	Infection Cancer
Nifurtimox-d₄ is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

HY-170782

CZP-IN-1	Casein Kinase	Infection
CZP-IN-1 (compound SH-1) is an inhibitor targeting the pathogen Trypanosoma cruzi cruzipain (CZP) and does not inhibit cathepsin L (IC₅₀=28 nM). CZP-IN-1 can be used for the research of Chagas disease .

HY-173051

Antiparasitic agent-24	Parasite	Infection
Antiparasitic agent-24 (Compound 14a) is an antiparasitic agent, with EC₅₀s of 0.005 μM (L. maj), 0.069 μM (L. don), 0.82 μM (T. brucei), 4.1 μM (T. cruzi) respectively .

Cat. No.	Product Name	Type

HY-W127497

Methyl 12-Methyltetradecanoate	Drug Delivery
Methyl 12-Methyltetradecanoate is a methylated fatty acid methyl ester that has been found in vermicompost of cow dung, papaya leaves, and cuticle wax of K. africana. It is a volatile compound in lipid-reducing granule tea. The levels of methyl 12-methylmyristate were reduced in T. cruzi treated with nifurtimox compared to untreated controls.

Cat. No.	Product Name	Target	Research Area

HY-P10795

NK-2 Antibiotic NK 2	Parasite Bacterial Fungal	Infection
NK-2 (Antibiotic NK 2), a shortened linear amphipathic NK-Lysin analog (comprising residues 39 to 65 of NK-lysin), is an antimicrobial peptide that exhibits potent activities against trypanosoma cruzi, Candida albicans, gram-positive and gram-negative bacteria. NK-2 can kill trypanosomes residing inside the human glioblastoma cell line 86HG39, left the host cells apparently unharmed .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7632

5-Desmethylsinensetin	Classification of Application Fields Flavones Source classification Plants Compositae Infection Monophenols Flavonoids other families Erythrina eriotriocha Phenols Inflammation/Immunology Disease Research Fields	Bacterial
5-desmethylsinensetin, isolated from Artemisia princeps , possesses antiprotozoal activity. 5-desmethylsinensetin shows IC₅₀ values of 0.4 μg/mL on T. cruzi* epimastigotes* and 75.1 μg/mL on trypomastigotes, respectively .

HY-N10443

Mammea A/BA	other families Source classification Coumarins Phenylpropanoids Plants Calophyllum brasiliense auct. non Camb.	Parasite Apoptosis Autophagy Reactive Oxygen Species
Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease .

HY-N2656

5,7,8-Trimethoxycoumarin	Zanthoxylum dimorphophyllum Hemsl. Structural Classification Rutaceae Coumarins Phenylpropanoids Plants	Parasite
5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC₅₀s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively .

HY-N11173

cis-Melilotoside	Structural Classification Simple Phenylpropanols Orchidaceae Source classification Phenylpropanoids Plants Dendrobium chryseum Z. H. Tsi et S. C. Chen	Others
cis-Melilotoside, an o-Coumaric acid derivative, shows potent antioxidant activity. cis-Melilotoside has antiprotozoal activity moderately against T. cruzi with an IC₅₀ of 78.2 ug/mL .

HY-129228

Lychnopholide	Lychnophora pseudovillosissima Semir & Leitão Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae	Parasite
Lychnopholide is a sesquiterpene lactone derived from the Asteraceae, Lychnopholide exhibits anti-trypanosomal activity against Trypanosoma cruzi. lychnopholide encapsulated in nanocapsules reduces its toxicity to mammalian cells. Lychnopholide ameliorates Chagas disease in mouse models .

HY-N10441

3β-Hydroxy-hop-22(29)-ene	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Source classification Euphorbiaceae Plants	Parasite
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana .

HY-N2970

Burchellin	Structural Classification Source classification Lignans Piperaceae Phenylpropanoids Plants Piper kadsura (Choisy) Ohwi	Parasite
Burchellin is a neolignan that can inhibit Trypanosoma cruzi .

HY-129130

Canthin-6-one N-oxide Canthin-6-one 3-oxide	Structural Classification Alkaloids Simaroubaceae Other Alkaloids Source classification Eurycoma harmandiana Pierre Plants	Parasite
Canthin-6-one N-oxide (Canthin-6-one 3-oxide) is an orally active antiparasitic agent with limited activity .

HY-N4033

Horminone 7α-Hydroxyroyleanone	Quinones Structural Classification Verbenaceae Source classification Verbena officinalis Linn. Plants Phenanthrenequinones	Bacterial
Horminone is an abietan diterpene quinone that can be isolated from Labiatae family. Horminone increases of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum levels in vivo. Horminone inhibits the growth of Trypanosoma cruzi and shows antibacterial activity .

HY-N1985

Acetylastragaloside I	Structural Classification Natural Products Leguminosae Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants	Parasite
Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC₅₀ values of 9.5 and 5.0 μg/mL for *T. brucei rhodesiense* and T. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosome infection .

HY-N1716

2′′-Acetylastragalin	Structural Classification Flavonoids Flavones Ranunculaceae Source classification Plants Delphinium staphisagria L.	Parasite
2’’-Acetylastragalin (Compound 2) is a compound isolated from the aerial parts of Delphinium staphisagria, with an IC₅₀ value of 6.5 μM for Vero cells. 2’’-Acetylastragalin has trypanoidal activity .

HY-N10440

3-Oxo-hop-22(29)-ene	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Source classification Euphorbiaceae Plants	Glycosidase
3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory .

HY-N12788

T-Cadinol	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Casearia sylvestris Sw. Salicaceae	Parasite
T-Cadinol is a sesquiterpene isolated from C. sylvestris that exhibits anti-Trypanosoma cruzi activity, with IC₅₀ values of 18.2 μM and 15.8 μM against trypomastigote and amastigote forms, respectively. T-Cadinol can induce mitochondrial damage in parasites, leading to membrane hyperpolarization and decreased levels of reactive oxygen species. T-Cadinol can be used for the research of Chagas disease .

Cat. No.	Product Name	Chemical Structure

HY-W040073S

Nifurtimox-d4
Nifurtimox-d₄ is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

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