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excretion

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Amylases (1) Antibiotic (1) Apoptosis (1) Biochemical Assay Reagents (1) Cytochrome P450 (1) Endogenous Metabolite (18) FABP (1) Glucosidase (1) HBV (1) Histone Methyltransferase (1) Isotope-Labeled Compounds (2) Na+/Ca2+ Exchanger (3) NO Synthase (1) P-glycoprotein (2) Parasite (3) Potassium Channel (1) Prostaglandin Receptor (1) Reactive Oxygen Species (1) SGLT (5) Small Interfering RNA (siRNA) (1) Src (1) URAT1 (1) Xanthine Oxidase (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (8) Endocrinology (1) Infection (5) Inflammation/Immunology (6) Metabolic Disease (37) Neurological Disease (4)
Oligonucleotides:	siRNAs (1)

Inhibitors & Agonists

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0324

Cholic acid 5+ Cited Publications	Endogenous Metabolite	Metabolic Disease
Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active .

HY-N0324A

Cholic acid sodium 5+ Cited Publications Sodium cholate	Endogenous Metabolite	Metabolic Disease
Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid sodium is orally active .

HY-113409

3-Hydroxyisovaleric acid	Endogenous Metabolite	Metabolic Disease
3-Hydroxyisovaleric acid is a normal endogenous metabolite excreted in the urine. The urinary excretion of 3-hydroxyisovaleric acid is early and sensitive indicator of biotin deficiency .

HY-153972

URAT1&XO inhibitor 2	URAT1 Xanthine Oxidase	Metabolic Disease Inflammation/Immunology
URAT1&XO inhibitor 2 (Compound BDEO) is a dual inhibitor of xanthine oxidase and URAT1, with IC₅₀ of 3.3 μM for xanthine oxidase. URAT1&XO inhibitor 2 blocks uptake of uric acid in HEK293 cells expressing URAT1, with a K_i value of 0.145 μM. URAT1&XO inhibitor 2 decreases serum urate level and uric acid excretion in hyperuricemic mice. URAT1&XO inhibitor 2 can be used for research of hyperuricemia .

HY-137339

Amitriptyline N-β-D-glucuronide	Others	Others
Amitriptyline N-β-D-glucuronide is an ammonium glucuronide and an urinary excretion metabolite of amitriptyline .

HY-111054

N-methyl-N-dithiocarboxyglucamine MDCG	Endogenous Metabolite	Inflammation/Immunology
N-methyl-N-dithiocarboxyglucamine (MDCG) mobilizes and promotes excretion of metallothione-bound ¹⁰⁹Cd. N-methyl-N-dithiocarboxyglucamine shows effects on acute and chronic Cd intoxication .

HY-N0324B

Cholic acid sodium hydrate	Endogenous Metabolite	Metabolic Disease
Cholic acid sodium hydrate is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid sodium hydrate facilitates fat absorption and cholesterol excretion. Cholic acid sodium hydrate is orally active .

HY-B2153

Tetraethylenepentamine pentahydrochloride	Others	Metabolic Disease
Tetraethylenepentamine pentahydrochloride is an effective chelator in increasing the urinary excretion of copper .

HY-106300

AA 193	Others	Cardiovascular Disease
AA 193 is a uricosuric agent. AA 193 increases urate excretion in hyperuricemic rats .

HY-101000

Clazuril R62690	Parasite	Infection
Clazuril (R62690) has a coccidiocidal effect on the asexual and sexual developmental stages of both Eimeria species, resulting in a complete interruption of the life cycle .

HY-101000R

Clazuril (Standard)	Parasite	Infection
Clazuril (Standard) is the analytical standard of Clazuril. This product is intended for research and analytical applications. Clazuril (R62690) has a coccidiocidal effect on the asexual and sexual developmental stages of both Eimeria species, resulting in a complete interruption of the life cycle .

HY-N11562

Aristololactam II	Others	Others
Aristololactam II, a metabolite of Aristolochic acid II (AAII), is an excretion product found in the urine, which is considered to be detoxification metabolite of AAII .

HY-143712

Allolithocholic acid	Endogenous Metabolite	Metabolic Disease
Allolithocholic acid is a steroid acid could found in normal serum and feces. Allolithocholic acid facilitates excretion, absorption, and transport of fats and sterols in the intestine and liver .

HY-76199

trans-4-Hydroxycyclohexanecarboxylic acid	Others	Metabolic Disease
trans-4-Hydroxycyclohexanecarboxylic acid is a substrate for cyclohexanecarboxylic acid production. trans-4-Hydroxycyclohexanecarboxylic acid is the by-product of intestinal bacterial metabolism via urinary excretion .

HY-126816

Atrazine mercapturate	Endogenous Metabolite	Others
Atrazine mercapturate is a metabolite of herbicide Atrazine (HY-N7091), which is detectable in urinary excretion. Atrazine mercapturate serve as an unambiguous confirmation of human exposure to Atrazine .

HY-N0324S

Cholic acid-d4	Endogenous Metabolite	Metabolic Disease
Cholic acid-d₄ is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

HY-N0324S1

Cholic acid-d5	Endogenous Metabolite	Metabolic Disease
Cholic acid-d₅ is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

HY-N0324S2

Cholic acid-13C	Endogenous Metabolite	Metabolic Disease
Cholic acid- ¹³C is the ¹³C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

HY-B0373

Tiopronin	Others	Metabolic Disease
Tiopronin is a diffusible antioxidant, an antidote to heavy metal poisoning and a radioprotective agent. Tiopronin can control the rate of cystine precipitation and excretion and has the potential for cystinuria, rheumatoid arthritis and hepatic disorders .

HY-161702

RO6806051	FABP	Metabolic Disease
RO6806051 (compound12) is a potent dual fatty acid binding protein 4 and 5 (FABP4 and FABP5) inhibitor with good selectivity and absorption, distribution, metabolism and excretion (eADME) properties .

HY-120147

Ethiazide	Others	Cardiovascular Disease
Ethiazide is a thiazole diuretic which inhibits renal reabsorption of sodium and water, thereby increasing urine excretion, reducing fluid retention, and lowering blood volume and blood pressure. Ethiazide can be used for cardiovascular research .

HY-122988A

Namoxyrate Xenbucin (2-dimethylaminoethanol)	Others	Others
Namoxyrate (Xenbucin (2-dimethylaminoethanol)) is a compound with analgesic activity. It can be dissociated into different components in rats. Its absorption and excretion vary depending on the components, and it has different affinities in human and rat plasma proteins.

HY-131060

CN128 hydrochloride CN328	Others	Others
CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia .

HY-B0235

Trichlormethiazide	Others	Metabolic Disease
Trichlormethiazide is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model .

HY-B0235A

Trichlormethiazide sodium	Others	Metabolic Disease
Trichlormethiazide sodium is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide sodium increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model .

HY-B1300A

Cefonicid	Others	Others
Pharmacokinetic studies of Cefonicid have shown that high blood concentrations can be achieved rapidly after intravenous and intramuscular injection, and that concomitant use of albendazole prolongs its half-life in the body and reduces the rate of renal excretion .

HY-136630

Felotaxel SHR110008	Others	Others
Felotaxel (SHR110008) is a compound with antitumor activity that has specific pharmacokinetic properties in rats and is rapidly distributed to normal tissues. The kidney is the major excretion organ, and its plasma protein binding capacity is nearly linearly related to concentration.

HY-W721656

Triclacetamol	Others	Inflammation/Immunology
Triclacetamol is the trichloroacetyl derivative of Acetaminophen (HY-66005), exhibiting weak cyclooxygenase inhibition and possessing analgesic and antipyretic activities as a nonsteroidal anti-inflammatory drug (NSAID). Triclacetamol acts as an anti-inflammatory agent and promotes the excretion of uric acid .

HY-B1300B

Cefonicid monosodium	Others	Others
Pharmacokinetic studies of Cefonicid monosodium have shown that high blood concentrations can be achieved rapidly after intravenous and intramuscular injection, and that concomitant use of albendazole prolongs its half-life in the body and reduces the rate of renal excretion .

HY-132613

Lumasiran sodium	Small Interfering RNA (siRNA)	Metabolic Disease
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .

HY-N10616

Pseudobaptigenin	Others	Metabolic Disease
Pseudobaptigenin is a flavonoid. Pseudobaptigenin shows very good anticataract activity. Pseudobaptigenin has good binding affinity for the inhibition of glycation against γ-crystallin protein. Pseudobaptigenin also has good ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) property .

HY-B1724R

Perflubron (Standard)	Others	Metabolic Disease Cancer
Perflubron (Standard) is the analytical standard of Perflubron. This product is intended for research and analytical applications. Perflubron (Perfluorooctyl bromide) is a contrast medium for magnetic resonance imaging and sonography. Perflubron can be emulsified with egg phospholipids (EYP) and shows exceptionally fast excretion characteristics .

HY-106570

Tripamide	Potassium Channel	Metabolic Disease
Tripamide is an orally active sulfonamide-derived diuretic antihypertensive agent .

HY-B0373S1

Tiopronin-d3	Isotope-Labeled Compounds	Metabolic Disease
Tiopronin-d₃ is the deuterium labeled Tiopronin. Tiopronin is a diffusible antioxidant, an antidote to heavy metal poisoning and a radioprotective agent. Tiopronin can control the rate of cystine precipitation and excretion and has the potential for cystinuria, rheumatoid arthritis and hepatic disorders[1][2].

HY-111054A

N-methyl-N-dithiocarboxyglucamine sodium MDCG sodium	Endogenous Metabolite	Others
N-methyl-N-dithiocarboxyglucamine (MDCG) sodium mobilizes and promotes excretion of metallothionein-bound ¹⁰⁹Cd in mouse model. N-methyl-N-dithiocarboxyglucamine significantly lowers the Cd content of both the liver and kidney, which is organs most susceptible to Cd-induced toxicity .

HY-113420

11-Dehydro-thromboxane B2	Endogenous Metabolite	Metabolic Disease
11-Dehydro-thromboxane B2 is a platelet hemagglutinin. Thromboxane inhibition was assessed by urinary excretion levels of 11-Dehydro-thromboxane B2. 11-Dehydro-thromboxane B2 can be used in the study of atherosclerotic thrombosis .

HY-113377

L-Glyceric acid	Endogenous Metabolite	Metabolic Disease
L-Glyceric acid is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid excretion to distinguish PH1 from PH2 .

HY-113377A

L-Glyceric acid sodium	Endogenous Metabolite	Metabolic Disease
L-Glyceric acid sodium is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid sodium can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid sodium excretion to distinguish PH1 from PH2 .

HY-W035520

HBED dihydrochloride	Biochemical Assay Reagents	Others
HBED dihydrochloride is an orally active and hexadentate phenolic aminocarboxylate iron chelator. HBED refers to N, N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, inducing iron excretion in primates. HBED dihydrochloride has the potential to be used as an alternative to desferriamine for iron chelation therapy .

HY-163301

Antitumor agent-139	Reactive Oxygen Species	Cancer
Antitumor agent-139 (compound 9b) is a liver - and mitochondria-targeting gold(I) complexe, and produces reactive oxygen species (ROS) and facilitates DNA excretion. Antitumor agent-139 inhibits tumor growth in a patient-derived xenograft model of hepatocellular carcinoma .

HY-10450

Dapagliflozin Maximum Cited Publications 38 Publications Verification BMS-512148	SGLT	Metabolic Disease Cancer
Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .

HY-113329

Guanidinoethyl sulfonate Taurocyamine	Endogenous Metabolite	Metabolic Disease
Guanidinoethyl sulfonate (Taurocyamine), a transport antagonist of taurine, induces much urinary taurine excretion with a resulting decrease in the tissue taurine content and readily produces taurine-deficient fetal rats in pregnant rats . Guanidinoethyl sulfonate, a structural analogue of taurine, acts as a competitive inhibitor of taurine transport .

HY-113465

Leukotriene E4 LTE4	Endogenous Metabolite	Inflammation/Immunology
Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4. Leukotriene E4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). Leukotriene E4 accumulates in both plasma and urine and urinary excretion of Leukotriene E4 is most often used as an indicator of asthma.

HY-B0235R

Trichlormethiazide (Standard)	Others	Metabolic Disease
Trichlormethiazide (Standard) is the analytical standard of Trichlormethiazide. This product is intended for research and analytical applications. Trichlormethiazide is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model .

HY-W339484

1-Ethyl-2-methyl-3-hydroxypyrid-4-one	Others	Others
1-Ethyl-2-methyl-3-hydroxypyrid-4-one is an α-ketohydroxypyridinium iron chelator that increases iron excretion in iron-overloaded rabbits after oral or parenteral administration and is highly specific for iron, with no specific activity for copper, zinc, calcium, and magnesium.

HY-B0357B

Diclazuril sodium R-64433 sodium	Parasite Antibiotic	Infection
Diclazuril sodium (R-64433 sodium) is an anticoccidial agent active in preventing parasitic contamination of livestock and poultry feed. Evaluation of the efficacy of Diclazuril sodium in the treatment of Eimeria infection showed poor performance in sustained levels of oocyst excretion compared with controls. Diclazuril sodium has a significant impact on the pathological effects of young animals in clinical applications .

HY-122613

YM543 free base	SGLT	Metabolic Disease
YM543 free base is a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor. YM543 free base reduces blood glucose levels. YM543 free base can be used in research of diabetes .

HY-123298

Chrysotoxine	Src Akt Apoptosis	Cancer
Chrysotoxine is a dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research .

HY-10450R

Dapagliflozin (Standard)	SGLT	Metabolic Disease Cancer
Dapagliflozin (Standard) is the analytical standard of Dapagliflozin. This product is intended for research and analytical applications. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .

HY-113465S

Leukotriene E4-d5 LTE4-d₅	Endogenous Metabolite	Inflammation/Immunology
Leukotriene E4-d₅ is the deuterium labeled Leukotriene E4. Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4. Leukotriene E4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). Leukotriene E4 accumulates in both plasma and urine and urinary excretion of Leukotriene E4 is most often used as an indicator of asthma.

Cat. No.	Product Name

HY-L0086V

Specs HTS Compounds Library	200,382 compounds
A unique collection contains 200,382 diverse chemical compounds to pharmaceutical and biotechnology scientists for drug discovery.

HY-L145

Antihypertensive Compound Library

633 compounds

The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death.

Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs).

MCE offers a unique collection of 633 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

HY-L047

Endocrinology Compound Library

906 compounds

The endocrine system is a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. Hormones are chemicals that serve to communicate between organs and tissues for physiological regulation and behavioral activities. Hormones affect distant cells by binding to specific receptor proteins in the target cell, resulting in a change in cell function.

The endocrine system is concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Irregulated hormone release, inappropriate response to signaling or lack of a gland can lead to endocrine disease.

MCE offers a unique collection of 906 endocrinology related compounds targeting varieties of hormone receptors such as thyroid hormone receptor, TSH receptor, GNRH receptor, adrenergic receptor, etc. MCE Endocrinology Compound Library is a useful tool for the discovery of endocrinology drugs.

Cat. No.	Product Name	Type

HY-N0324F

Cholic acid-Biotin	Dyes
Cholic acid-Biotin is a biotin-labeled Cholic acid (HY-N0324). Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid has orally activity .

Cat. No.	Product Name	Type