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expansion

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49

Inhibitors & Agonists

2

Fluorescent Dye

4

Biochemical Assay Reagents

9

Peptides

1

MCE Kits

9

Natural
Products

1

Isotope-Labeled Compounds

1

Click Chemistry

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134669
    CypK

    N-Cyclopropene-L-Lysine

    		 Amino Acid Derivatives Cancer
    CypK (N-Cyclopropene-L-Lysine), a cyclopropene derivative of lysine, is efficiently incorporated into antibodies through genetic-code expansion. CypK is a minimal bioorthogonal handle for the creation of stable therapeutic protein conjugates .
    CypK
  • HY-10593
    IQ 1

    		Wnt Others
    IQ 1 is a Wnt/β-catenin/CBP signalling sustainer. IQ 1 maintains long-term expansion of Wnt/β-catenin-driven mouse embryonic stem cells (ESCs) and prevents spontaneous differentiation by enhancing β-catenin/CBP-mediated transcription and preventing conversion to β-catenin/p300-mediated transcription. IQ-1 regulates Wnt signalling by interacting with PR72/130. IQ 1 can be used in study of ESCs expansion .
    IQ 1
  • HY-109086
    Edicotinib
    2 Publications Verification

    JNJ-40346527; JNJ-527

    		 c-Fms Neurological Disease Inflammation/Immunology
    Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC50 of 3.2 nM. Edicotinib exhibits less inhibitory effects on KIT and FLT3 with IC50 values of 20 nM and 190 nM, respectively . Edicotinib limits microglial expansion and attenuates microglial proliferation and neurodegeneration in mice. Edicotinib has the potential for Alzheimer’s disease and rheumatoid arthritis research .
    Edicotinib
  • HY-P2260
    Tat-beclin 1
    2 Publications Verification

    		 Autophagy HIV Infection
    Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) .
    Tat-beclin 1
  • HY-N0293
    Paeoniflorin
    Maximum Cited Publications
    21 Publications Verification

    Peoniflorin

    		 HSP Infection Neurological Disease Cancer
    Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .
    Paeoniflorin
  • HY-163941
    GSK_WRN2

    		DNA/RNA Synthesis Cancer
    GSK_WRN2 is a potent and selective covalent WRN helicase inhibitor that suppresses replication stress caused by DNA (TA)n dinucleotide repeat expansions. GSK_WRN2 can be used to study microsatellite instability (MSI) cancers .
    GSK_WRN2
  • HY-109086A
    Edicotinib hydrochloride

    JNJ-40346527 hydrochloride; JNJ-527 hydrochloride

    		 c-Fms Neurological Disease Inflammation/Immunology Cancer
    Edicotinib hydrochloride is a potent, selective, brain penetrant and orally active?colony-stimulating factor-1 receptor (CSF-1R)?inhibitor with an IC50 of 3.2 nM. Edicotinib hydrochloride exhibits less inhibitory effects on KIT and FLT3 with IC50 values of 20 nM and 190 nM, respectively . Edicotinib hydrochloride limits microglial expansion and attenuates microglial proliferation and neurodegeneration?in mice. Edicotinib hydrochloride has the potential for Alzheimer’s disease and rheumatoid arthritis research .
    Edicotinib hydrochloride
  • HY-P2260A
    Tat-beclin 1 TFA

    		Autophagy HIV Infection
    Tat-beclin 1 TFA, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 TFA decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) .
    Tat-beclin 1 TFA
  • HY-N0293R
    Paeoniflorin (Standard)

    		HSP Infection Neurological Disease Cancer
    Paeoniflorin (Standard) is the analytical standard of Paeoniflorin. This product is intended for research and analytical applications. Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .
    Paeoniflorin (Standard)
  • HY-N11274
    T-MAS

    4,4-Dimethylzymosterol; 14-Norlanosterol

    		 Others Others
    T-MAS (4,4-Dimethylzymosterol) serves as an intermediate in cholesterol biosynthesis, stimulating oocytes for meiosis and modulating cumulus expansion.
    T-MAS
  • HY-132581A
    Tadnersen sodium

    BIIB078 sodium; IONIS-C9Rx sodium

    		 Others Ras Neurological Disease
    Tadnersen sodium, an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion .
    Tadnersen sodium
  • HY-132869
    MEIS-IN-1

    		HOXA Others
    MEIS-IN-1 is a potent myeloid ecotropic viral integration site (MEIS) inhibitor to induce murine and human hematopoietic stem-cell expansion.
    MEIS-IN-1
  • HY-136607
    DiAzK

    		Others Others
    DiAzK is a bifunctional amino acid. DiAzK can be inserted into almost any protein interface with minimal structural perturbation using genetic code expansion .
    DiAzK
  • HY-132581
    Tadnersen

    BIIB078; IONIS-C9Rx

    		 Ras Others Neurological Disease
    Tadnersen (BIIB078), an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion .
    Tadnersen
  • HY-18569
    3-Indoleacetic acid
    4 Publications Verification

    Indole-3-acetic acid; 3-IAA

    		 Molecular Glues Endogenous Metabolite Others
    3-Indoleacetic acid is is an IAA hormone and growth regulator that can promote plant nutritional growth through processes such as cell expansion, differentiation, morphogenesis, and organogenesis .
    3-Indoleacetic acid
  • HY-B1347
    Clorprenaline hydrochloride

    		Adrenergic Receptor Inflammation/Immunology Endocrinology
    Clorprenaline hydrochloride is a β2-adrenergic receptor agonist that is implicated in bronchial expansion. Clorprenaline has the potential for asthma research .
    Clorprenaline hydrochloride
  • HY-100791
    NSC23005 sodium
    1 Publications Verification

    		 Others Cancer
    NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.
    NSC23005 sodium
  • HY-P4047
    Cyclo(RGDfK(Mal))

    		Drug Derivative Others
    Cyclo(RGDfK(Mal)) is a pentapeptide. Cyclo(RGDfK(Mal)) improves the attachment and infiltration of human pluripotent stem cells. Cyclo(RGDfK(Mal)) can be used for 3D stem cell culture and expansion .
    Cyclo(RGDfK(Mal))
  • HY-131106S
    Clorprenaline-d7

    		Isotope-Labeled Compounds Adrenergic Receptor Inflammation/Immunology Endocrinology
    Clorprenaline-d7 is a deuterium labeled Clorprenaline. Clorprenaline is a β2-adrenergic receptor agonist that is implicated in bronchial expansion. Clorprenaline has the potential for asthma research[1].
    Clorprenaline-d7
  • HY-120942
    XIE18-6

    		Others Cancer
    XIE18-6 is a potent INK4C (p18) inhibitor. XIE18-6 shows potent bioactivity in hematopoietic stem cells (HSCs) expansion with an ED50 of 105.5 nM .
    XIE18-6
  • HY-B1347R
    Clorprenaline hydrochloride (Standard)

    		Adrenergic Receptor Inflammation/Immunology Endocrinology
    Clorprenaline hydrochloride (Standard) is the analytical standard of Clorprenaline hydrochloride. This product is intended for research and analytical applications. Clorprenaline hydrochloride is a β2-adrenergic receptor agonist that is implicated in bronchial expansion. Clorprenaline has the potential for asthma research .
    Clorprenaline hydrochloride (Standard)
  • HY-103244
    CITCO
    2 Publications Verification

    		 Apoptosis Cancer
    CITCO, an imidazothiazole derivative, is a selective Constitutive androstane receptor (CAR) agonist. CITCO inhibits growth and expansion of brain tumour stem cells (BTSCs) and has an EC50 of 49 nM over pregnane X receptor (PXR), and no activity on other nuclear receptors .
    CITCO
  • HY-141878
    di-Ellipticine-RIBOTAC

    		PROTACs Neurological Disease
    di-Ellipticine-RIBOTAC is a dual-function small molecule that reduces c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo amyotrophic lateral sclerosis (ALS ) models.
    di-Ellipticine-RIBOTAC
  • HY-116057
    Stemazole

    		Apoptosis Others
    Stemazole is a protective agent that promotes stem cell survival. Stemazole has the protective effect of human embryonic stem cells (hESCs). Stemazole enhances clonal expansion of single cells and decreases apoptosis. Stemazole for the study of stem cell survival in starvation culture .
    Stemazole
  • HY-123535
    P18IN003

    		Others Inflammation/Immunology
    P18IN003 is a potent p18(INK4C) inhibitor andspecifically block the activity of p18 protein. P18IN003 has the potential to be aneffective chemical agent for therapeutic expansion of HSC .
    P18IN003
  • HY-107661
    Arundic Acid
    1 Publications Verification

    ONO-2506; (R)-2-Propyloctanoic acid

    		 Others Neurological Disease
    Arundic acid (ONO-2506) is an astrocyte-modulating agent, which delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis. Arundic acid has the potential for stroke and Alzheimer’s disease research .
    Arundic Acid
  • HY-18569R
    3-Indoleacetic acid (standard)

    Indole-3-acetic acid (standard); 3-IAA (standard)

    		 Molecular Glues Endogenous Metabolite Others
    3-Indoleacetic acid (Standard) is the analytical standard of 3-Indoleacetic acid. This product is intended for research and analytical applications. 3-Indoleacetic acid is is an IAA hormone and growth regulator that can promote plant nutritional growth through processes such as cell expansion, differentiation, morphogenesis, and organogenesis .
    3-Indoleacetic acid (standard)
  • HY-145686
    AV023

    		Wnt Nuclear Factor of activated T Cells (NFAT) Inflammation/Immunology
    AV023 is a potent inhibitor of ANKRD22. AV023 promotes the expansion of gastrointestinal mucosal epithelial stem cells and indirectly activates the Wnt classical pathway, which helps the recovery of damaged gastrointestinal mucosal tissues in the body (extracted from patent CN111205231B) .
    AV023
  • HY-155363
    AMPK activator 13

    		AMPK Metabolic Disease
    AMPK activator 13 is a potent activator of AMPK. AMPK activator 13 inhibits mitotic clonal expansion of 3T3-L1 cells by activating AMPK pathway and enhances cell mitochondrial oxygen consumption rate. AMPK activator 13 can be used in study obesity .
    AMPK activator 13
  • HY-162658
    Leuxinostat

    		HDAC Apoptosis Cancer
    Leuxinostat is an inhibitor for HDAC with IC50 of 30 nM for hHDAC6. Leuxinostat inhibits the proliferation of cells THP1, K562, U937 and MEK1, induces apoptosis in leukemia cells NB4 and MOLT-4. Leuxinostat inhibits the expansion of hematopoietic stem cells and exhibits antileukemic activity in zebrafish models .
    Leuxinostat
  • HY-167934
    Isomer-CM 352

    		Others Neurological Disease
    Isomer-CM 352 is a new antifibrinolytic agent with inhibitory activity against matrix metalloproteinases. Isomer-CM 352 effectively reduced hematoma expansion and promoted functional and neurological recovery in a model of intracerebral hemorrhage. Isomer-CM 352 improved neurological function by preventing hematoma growth and showed potential in the suppression of acute neurological diseases .
    Isomer-CM 352
  • HY-159621
    Endosidine 5

    ES5

    		 Others Endocrinology
    Endosidine 5 (ES5) inhibits EPS (extracellular polymeric substance) secretion and cell wall expansion. Endosidine 5 alters secretion of ECM (extracellular matrix) material in Penium margaritaceum by affecting the Golgi apparatus. Endosidine 5 interferes with recycling endosomes through Annexin A6, thereby promoting the release and expression of mRNA into the cytoplasm .
    Endosidine 5
  • HY-W259767
    3-Iodo-L-phenylalanine

    		Amino Acid Derivatives
    3-Iodo-L-phenylalanine is an unnatural amino acid that can be used for partial codon redistribution. 3-Iodo-L-phenylalanine has a high efficiency in Ser AGU codon reassignment, and also has a certain effect in Ser UCG codon reassignment. 3-Iodo-L-phenylalanine can be used in the study of genetic code expansion and protein engineering .
    3-Iodo-L-phenylalanine
  • HY-N7661
    4β-Hydroxywithanolide E

    		PPAR Metabolic Disease
    4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression .
    4β-Hydroxywithanolide E
  • HY-W009004B
    Trilysine TFA

    		Biochemical Assay Reagents Others
    Trilysine (TFA) is derived from lysine and rapidly undergoes polymerization with PEG esters to form a three-dimensional absorbable hydrogel. This process is mild to tissues, exothermic reaction-free, and causes minimal tissue response. Trilysine (TFA) and PEG esters form a hydrogel with strong mechanical adhesion, high cohesive strength, and flexibility, which adapts to the natural expansion and contraction of lung tissues .
    Trilysine TFA
  • HY-148835
    AzGGK

    		Fluorescent Dye Others
    AzGGK is an unnatural amino acid. AzGGK is site-specifically incorporated into proteins via genetic-code expansion. AzGGK can be used as site-specific probe for ubiquitylation and SUMOylation . AzGGK is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    AzGGK
  • HY-115893A
    P18IN005 hydrochloride

    		Others Cancer
    P18IN005 hydrochloride is a novel inhibitor of p18, exhibiting potent activity in negatively regulating haematopoietic stem cell (HSC) self-renewal. P18IN005 hydrochloride has been shown to be more effective than p27 in inhibiting HSC self-renewal in mouse models. P18IN005 hydrochloride promotes the expansion of functional HSCs in short-term cultures. P18IN005 hydrochloride serves as a valuable tool for dissecting the signaling pathways involved in stem cell self-renewal.
    P18IN005 hydrochloride
  • HY-148835A
    AzGGK TFA

    		Fluorescent Dye Others
    AzGGK TFA is an unnatural amino acid. AzGGK TFA is site-specifically incorporated into proteins via genetic-code expansion. AzGGK TFA can be used as a site-specific probe for ubiquitylation and SUMOylation. AzGGK TFA is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .
    AzGGK TFA
  • HY-N0007
    (E,E)-Bisdemethoxycurcumin
    4 Publications Verification

    (E,E)-Curcumin III; (E,E)-Didemethoxycurcumin

    		 Apoptosis Autophagy Cancer
    (E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities .
    (E,E)-Bisdemethoxycurcumin
  • HY-N0007R
    (E,E)-Bisdemethoxycurcumin (Standard)

    		Apoptosis Autophagy Cancer
    (E,E)-Bisdemethoxycurcumin (Standard) is the analytical standard of (E,E)-Bisdemethoxycurcumin. This product is intended for research and analytical applications. (E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities .
    (E,E)-Bisdemethoxycurcumin (Standard)
  • HY-102022G
    α-Galactosylceramide

    α-GalCer; KRN7000

    		 Interleukin Related Transmembrane Glycoprotein Inflammation/Immunology Cancer
    α-Galactosylceramide (α-GalCer) (GMP) is a GMP-grade α-Galactosylceramide (HY-102022). Small molecules of GMP grade can be used as adjuvant reagents in cell therapy. α-Galactosylceramide (GMP) can activate iNKT cells in vitro, characterized by rapid secretion of IL-4 and IFN-γ, transient downregulation of cell-surface TCR, clonal expansion and homeostatic contraction. α-Galactosylceramide is a very potent NKT cell agonist and binds effectively to CD1d .
    α-Galactosylceramide
  • HY-D1546
    Biotin-C2-maleimide

    		Fluorescent Dye Cancer
    Biotin-C2-maleimide is an antibody conjugate reagent, can bind to many biomolecules without significantly changing the biological activity of the target molecule .
    Biotin-C2-maleimide
  • HY-160421
    TREM2-IN-1

    		Apoptosis Inflammation/Immunology Cancer
    TREM2-IN-1 (OPA) is a TREM2 inhibitor derived from oxaliplatin and artesunate. TREM2-IN-1 can relieves immunosuppressive tumor microenvironment and enhancing chemical anticancer efficiency. TREM2-IN-1 deters the tumor growth in mice models bearing MC38 colorectal tumor by reducing the number of CD206 + and CX3CR1 + immunosuppressive macrophages. TREM2-IN-1 also promotes the expansion and infiltration of immunostimulatory dendritic, cytotoxic T and natural killer cells .
    TREM2-IN-1
  • HY-P2260B
    Tat-beclin 1 scrambled

    		HIV Infection
    Tat-beclin 1 scrambled is the scrambled part and a scrambled control of Tat-beclin 1 (HY-P2260), which is derived from a region of the autophagy protein, beclin 1. beclin 1 induces autophagy via binding human immunodeficiency virus, HIV-1 Nef and interacting with negative regulator GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens, such as HIV-1. Tat-beclin 1 also reduces mortality in mice infected with chikungunya or West Nile virus .
    Tat-beclin 1 scrambled
  • HY-P2260C
    Tat-beclin 1 scrambled TFA

    		HIV Infection
    Tat-beclin 1 scrambled TFA is the scrambled part and a scrambled control of Tat-beclin 1 (HY-P2260), which is derived from a region of the autophagy protein, beclin 1. beclin 1 induces autophagy via binding human immunodeficiency virus, HIV-1 Nef and interacting with negative regulator GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens, such as HIV-1. Tat-beclin 1 also reduces mortality in mice infected with chikungunya or West Nile virus .
    Tat-beclin 1 scrambled TFA
  • HY-109076
    Tigilanol tiglate

    EBC-46

    		 PKC Cancer
    Tigilanol tiglate (EBC-46) is a protein kinase C (PKC)/C1 domain activator. Tigilanol tiglate is a natural product with antitumor activity used for local administration against a variety of skin malignancies. Tigilanol tiglate is associated with mitochondrial/endoplasmic reticulum (ER) dysfunction, leading to activation of the unfolded protein response (UPRmt/ER) and subsequent induction of ATP depletion, organelles expansion, caspase activation, gasdermin E cleavage, and terminal necrosis. Tigilanol tiglate, as a small anti-tumor molecule with immunomodulatory effects, can be used in the study of head and neck squamous cell carcinoma and soft tissue sarcoma .
    Tigilanol tiglate
  • HY-N4042
    Hirsutenone

    		PI3K ERK Inflammation/Immunology Cancer
    Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity .
    Hirsutenone
  • HY-144088
    ZYF0033

    HPK1-IN-22

    		 MAP4K Inflammation/Immunology Cancer
    ZYF0033 is effective in inhibiting hematopoietic progenitor cells HPK1, basically inhibiting MBP protein oxidation IC50 10 nM . ZYF0033 promotes anti-cancer immune response, lowers SLP76 (acid 376) oxidation. ZYF0033 Suppression 4T-1 Small mouse model with the same underlying cause, medium bulge growth length expansion DC, NK 细细和 CD107a + CD8 + T Cells, PD-1 +CD8 + T Cells, TIM-3 +CD8 + T Cells LAG3< sup>+CD8 + T Cellular immersion decreases.
    ZYF0033
  • HY-N0976
    1,11b-Dihydro-11b-hydroxymedicarpin

    11b-Hydroxy-11b,1-dihydromedicarpin

    		 Interleukin Related Inflammation/Immunology
    1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative . Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways . Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice .
    1,11b-Dihydro-11b-hydroxymedicarpin

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