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Results for "

indoleamine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Indoleamine 2,3-Dioxygenase (IDO) (43) Apoptosis (5) Aryl Hydrocarbon Receptor (1) Aurora Kinase (4) Bacterial (4) mAChR (4) Methionine Adenosyltransferase (MAT) (1) Parasite (4) PROTACs (2) Sirtuin (1) Virus Protease (4)
By Research Areas:	Cancer (37) Infection (5) Inflammation/Immunology (12) Metabolic Disease (4) Neurological Disease (7)

Inhibitors & Agonists

Peptides

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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Indoleamine 2,3-Dioxygenase (IDO)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0033

Roxyl-9	Indoleamine 2,3-Dioxygenase (IDO)	Others
Roxyl-9 is a IDO1 (Indoleamine 2,3-dioxygenase 1) inhibitor .

HY-N0707

(S)-Indoximod 1-Methyl-L-tryptophan; (S)-NLG-8189	Indoleamine 2,3-Dioxygenase (IDO)	Neurological Disease Cancer
(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO) (K_i: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease .

HY-18770B

Navoximod 5+ Cited Publications GDC-0919; NLG-919	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Navoximod (GDC-0919; NLG-?919) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with K_i/EC₅₀ of 7 nM/75 nM.

HY-139204

BMS-986242 1 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used for the research of cancer .

HY-151093

IDO2-IN-1 1 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology
IDO2-IN-1 is an orally active and potent Indoleamine 2,3-dioxygenase 2 (IDO2) inhibitor with an IC₅₀ value of 112 nM. IDO2-IN-1 can be used for inflammatory autoimmunity research .

HY-128355

IDO/TDO-IN-1	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC₅₀s of 9.7 and 47 nM, respectively .

HY-15683

IDO5L 3 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC₅₀ of 67 nM.

HY-16987

IDO-IN-3	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC₅₀ of 290 nM.

HY-111234

IDO-IN-11	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC₅₀s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 13.

HY-110387

IDO-IN-9	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC₅₀s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 6.

HY-79531

IDO-IN-1	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC₅₀ of 59 nM.

HY-145346

NLG802	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
NLG802 is a proagent of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.

HY-134583

IDO1-IN-7	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC₅₀ of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer .

HY-151425

TDO-IN-1	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
TDO-IN-1 is an orally active and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), shows excellent selectivity over *indoleamine-2,3-dioxygenase* (IDO), with an IC₅₀ value of 0.62 μM (IDO). TDO-IN-1 reverse the local immune tolerance of tumor tissue to inhibit tumor growth in vivo .

HY-115122

IDO-IN-12	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-12 is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO 2017181849 A1.

HY-128355A

(R)-IDO/TDO-IN-1	Indoleamine 2,3-Dioxygenase (IDO)	Others Cancer
(R)-IDO/TDO-IN-1 (compound 25) is an indoleamine-2,3-dioxygenase (IDO) inhibitor, with good pharmacokinetic properties. (R)-IDO/TDO-IN-1 exhibits anti-tumor activity in MC38 xenograft model. (R)-IDO/TDO-IN-1 shows synergistic effect with anti-PD-1 monoclonal antibody (SHR-1210) .

HY-15689

Epacadostat 15+ Cited Publications INCB 024360	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology Cancer
Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC₅₀ of 71.8 nM .

HY-163520

IDO1-IN-24	Indoleamine 2,3-Dioxygenase (IDO)	Others
IDO1-IN-24 (compound 2c) inhibits IDO1 production in cell-based assay with an IC₅₀ value of 17 μM .

HY-151886

NU223612	PROTACs Indoleamine 2,3-Dioxygenase (IDO)	Neurological Disease Cancer
NU223612 is a potent PROTAC (PROTACs) that degrades indoleamine 2,3-dioxygenase 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO)) with a K_d of 640 nM. NU223612 potently degrades the IDO1 protein through CRBN-mediated proteasomal degradation. NU223612 is bound to CRBN with an affinity of 290 nM. NU223612 can cross the blood-brain barrier (BBB) .

HY-129749

IDO-IN-13	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology
IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an EC₅₀ of 17 nM, extracted from patent WO2019040102A1, example 43 .

HY-148383

DP00477	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
DP00477 is a potent *IDO1 (indoleamine* 2,3-dioxygenase 1) inhibitor with an IC₅₀** value of 7.0 µM. DP00477 has the potential for the research of cancer .

HY-18769

BMS-978587 1 Publications Verification IDO-IN-4	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
BMS-978587 (IDO-IN-4) is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1.

HY-18770A

IDO-IN-6 NLG-1486	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-6 (NLG-1486) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, Compound 1486, has an IC₅₀ of <1 μM.

HY-18770

IDO-IN-5 NLG-1489	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-5 (NLG-1489) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1489, has an IC₅₀ of 1-10 μM.

HY-100687

GNF-PF-3777 8-Nitrotryptanthrin	Indoleamine 2,3-Dioxygenase (IDO)	Neurological Disease
GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with K_i of 0.97 μM.

HY-18770C

IDO-IN-8 NLG-1487	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-8 (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1487, has an IC₅₀ of 1-10 μM.

HY-N12125

Entadamide A	Others	Infection
Entadamide A (compound 1) is a tryptophan derivative. Entadamide A prevents tryptophan depletion by inhibiting indoleamine 2, 3-dioxygenase (IDO), thereby inhibiting HIV replication. Entadamide A can be used in drug and neuropsychiatric studies of redesivir [1].

HY-15689R

Epacadostat (Standard)	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology Cancer
Epacadostat (Standard) is the analytical standard of Epacadostat. This product is intended for research and analytical applications. Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC₅₀ of 71.8 nM .

HY-P4149

Imsamotide IDO194-214	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology Cancer
Imsamotide (IDO194-214) is a Indoleamine 2,3-Dioxygenase (IDO) peptide with sequences of DTLLKALLEIASCLEKALQVF, the IDO194-214. Imsamotide is also an immunological agent for active immunization, as well as an antineoplastic agent .

HY-16724

Indoximod 5+ Cited Publications 1-Methyl-D-tryptophan; NLG-8189	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer .

HY-N2463

Kushenol E	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC₅₀ of 7.7 µM and a K_i of 9.5 µM, has anti-tumor activity .

HY-N0707S

(S)-Indoximod-d3 1-Methyl-L-tryptophan-d₃; (S)-NLG-8189-d₃	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
(S)-Indoximod-d₃ is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2][3].

HY-136301

Acid secretion-IN-1	Others	Inflammation/Immunology
Acid secretion-IN-1 is a polycyclic compound extracted from patent WO2018024188A1, Compound Example 17.4. Acid secretion-IN-1 is synthesized and used in the IDO inhibitor synthetic experiment .

HY-101560

Linrodostat 4 Publications Verification BMS-986205; ONO-7701	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Linrodostat (BMS-986205) is a selective and irreversible indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC₅₀ value of 1.1 nM in IDO1-HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers .

HY-108331

3-TYP Maximum Cited Publications 62 Publications Verification	Sirtuin Methionine Adenosyltransferase (MAT) Indoleamine 2,3-Dioxygenase (IDO)	Others
3-TYP is an inhibitor of SIRT3 (IC₅₀: ~377 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases .

HY-101560A

Linrodostat mesylate BMS-986205 mesylate; ONO-7701 mesylate	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Linrodostat (BMS-986205) mesylate is a selective irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), which effectively inhibits IDO1-HEK293 mesylate cells with an IC₅₀ value of 1.1 nM. Linrodostat mesylate demonstrates good pharmacological activity in advanced cancer .

HY-133897

(Rac)-Indoximod 1 Publications Verification 1-Methyl-DL-tryptophan; (Rac)-NLG-8189	Indoleamine 2,3-Dioxygenase (IDO) Apoptosis	Inflammation/Immunology Cancer
(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes .

HY-134217

KYN-101	Aryl Hydrocarbon Receptor	Cancer
KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity .

HY-160025

IDO antagonist-1	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO antagonist-1 (compound 163) is an antagonist of IDO . IDO antagonist-1 inhibits pancreatic adenocarcinoma cells growth in C57BL/6 mice .

HY-111540A

(Rac)-LY-3381916 (Rac)-IDO1-IN-5	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
(Rac)-LY-3381916 ((Rac)-IDO1-IN-5; Example 1) is a racemate of LY-3381916 . LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .

HY-131911

PROTAC IDO1 Degrader-1	PROTACs Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology
PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC₅₀=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells .

HY-111540B

(S)-LY-3381916 1 Publications Verification (S)-IDO1-IN-5	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
(S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC₅₀ value less than 1.5 µΜ . LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .

HY-N0110

Palmatine chloride 5+ Cited Publications	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N0110A

Palmatine	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N0110B

Palmatine hydroxide 5+ Cited Publications	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N0110R

Palmatine chloride (Standard)	Apoptosis Virus Protease Indoleamine 2,3-Dioxygenase (IDO) Parasite Bacterial Aurora Kinase mAChR	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine (chloride) (Standard) is the analytical standard of Palmatine (chloride). This product is intended for research and analytical applications. Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

Cat. No.	Product Name	Target	Research Area

HY-P4149

Imsamotide IDO194-214	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology Cancer
Imsamotide (IDO194-214) is a Indoleamine 2,3-Dioxygenase (IDO) peptide with sequences of DTLLKALLEIASCLEKALQVF, the IDO194-214. Imsamotide is also an immunological agent for active immunization, as well as an antineoplastic agent .

Species:	Human (4) Mouse (1)
Tag:	His (4) Tag Free (1)
Source:	P. pastoris (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P72616

	IDO-1 Protein, Mouse (His) indoleamine 2,3-dioxygenase 1; IDO-1; indoleamine-pyrrole 2,3-dioxygenase; IDO; INDO	Mouse	E. coli
	IDO Protein, an enzyme, is involved in the metabolism of tryptophan. Dysregulation of IDO Protein has been linked to immune escape mechanisms and tumor progression. Targeting IDO Protein may provide potential therapeutic interventions in cancer by modulating tryptophan metabolism, enhancing immune responses, and inhibiting tumor growth. IDO-1 Protein, Mouse (His) is the recombinant mouse-derived IDO protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70863

	IDO-2 Protein, Human (His) indoleamine 2,3-dioxygenase 2; indoleamine 2,3-dioxygenase-like protein 1; indoleamine pyrrole 2,3-dioxygenase-like protein 1; IDO2; INDOL1	Human	E. coli
	The IDO-2 protein plays a key role in cellular processes, catalyzing the initial and rate-limiting steps in the catabolism of the essential amino acid tryptophan in the kynurenine pathway. This enzymatic activity has been confirmed in multiple studies, establishing IDO-2 as a key regulator of tryptophan metabolism with important implications for immune regulation. IDO-2 Protein, Human (His) is the recombinant human-derived IDO-2 protein, expressed by E. coli , with C-6*His labeled tag. The total length of IDO-2 Protein, Human (His) is 407 a.a., with molecular weight of ~41.43 kDa.

HY-P70679

	IDO-1 Protein, Human (His) Indole 2; 3-dioxygenase; indoleamine 2; 3-dioxygenase 1; IDO-1; IDO1; IDO; INDO	Human	E. coli
	IDO proteins catalyze the first step in tryptophan catabolism via the kynurenine pathway, which is critical for immune tolerance and homeostasis maintenance. IDO-1 Protein, Human (His) is the recombinant human-derived IDO protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71743

	IDO-2 Protein, Human (P.pastoris, His) 3-dioxygenase 2; indoleamine-pyrrole 2	Human	P. pastoris
	The IDO-2 protein plays a key role in cellular processes, catalyzing the initial and rate-limiting steps in the catabolism of the essential amino acid tryptophan in the kynurenine pathway. This enzymatic activity has been confirmed in multiple studies, establishing IDO-2 as a key regulator of tryptophan metabolism with important implications for immune regulation. IDO-2 Protein, Human (P.pastoris, His) is the recombinant human-derived IDO-2 protein, expressed by P. pastoris , with N-His labeled tag. The total length of IDO-2 Protein, Human (P.pastoris, His) is 407 a.a., with molecular weight of ~50.4 kDa.

HY-P73121

	IDO-1 Protein, Human indoleamine 2; 3-dioxygenase 1; IDO-1; IDO1; IDO; INDO	Human	E. coli
	IDO proteins catalyze the first step in tryptophan catabolism via the kynurenine pathway, which is critical for immune tolerance and homeostasis maintenance. IDO-1 Protein, Human is the recombinant human-derived IDO protein, expressed by E. coli , with tag free.

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HY-P83355

	Indoleamine 2,3-dioxygenase Antibody (YA3100) 3-dioxygenase; IDO 1; IDO; IDO1; INDO; indolamine 2; 3 dioxygenase; Indole 2 3 dioxygenase	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Indoleamine 2,3-dioxygenase Antibody (YA3100) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3100), targeting Indoleamine 2,3-dioxygenase, with a predicted molecular weight of 45 kDa (observed band size: 45 kDa). Indoleamine 2,3-dioxygenase Antibody (YA3100) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human background.

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indoleamine

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