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Results for "

linkage

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Amylases (2) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (2) Bacterial (2) Biochemical Assay Reagents (54) C-type Lectin-like Receptors (CTLRs) (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (1) Drug-Linker Conjugates for ADC (2) EGFR (2) Endogenous Metabolite (12) Fluorescent Dye (9) Glycosidase (1) Glycosyltransferase (2) Isotope-Labeled Compounds (1) Liposome (6) Microtubule/Tubulin (1) NO Synthase (1) Nucleoside Antimetabolite/Analog (1) p38 MAPK (1) PD-1/PD-L1 (1) PERK (1) PROTACs (1) Reactive Oxygen Species (1) Sialyltransferase (1) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (14) Infection (2) Inflammation/Immunology (4) Metabolic Disease (15) Neurological Disease (1)
Click Chemistry:	TCO (1) Azide (8) Tetrazine (1) Alkynes (1)
Oligonucleotides:	Pegylated Lipids (3) Nucleoside Phosphoramidites (2) Phospholipids (2) Cationic Lipids (1)

107

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70136

Endo-β-Galactosidase	Others	Metabolic Disease
Endo-β-Galactosidase catalyzes the hydrolysis of internal β1-4 galactose linkages in unbranched, repeating poly-N-acetyllactosamine ([GlcNAc- (1-3)Gal- (1-4)]_n) structures .

HY-W016413

4-(Hydroxymethyl)phenoxyacetic acid	Biochemical Assay Reagents	Others
4-(Hydroxymethyl)phenoxyacetic acid is an acid-labile resin linkage agent for use in solid phase peptide synthesis .

HY-P2968

Bacterial α-Amylase	Amylases	Others
Bacterial α-Amylase catalyses the hydrolysis of internal α-1,4-glycosidic linkages in starch in low molecular weight products, such glucose, maltose and maltotriose units. Bacterial α-Amylase is often used in biochemical studies .

HY-101160

SG2057 DRG16	DNA Alkylator/Crosslinker ADC Cytotoxin	Cancer
SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent .

HY-P2988

Neuraminidase, Microorganism Exo-α-sialidase	Endogenous Metabolite	Infection
Neuraminidase, Microorganism (Exo-α-sialidase) is an exosialidase, is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase, derived from mucosal pathogens, is a virulence factor that modifies the host's response to infection .

HY-D2219

Sulfo-Cy7 tetrazine	Fluorescent Dye	Others
Sulfo-Cy7 tetrazine is a near-infrared water-soluble fluorophore. Sulfo-Cy7 tetrazine contains the methyltetrazine group for rapid, efficient, and metal-free conjugation to cycloolefin in a reaction called TCO linkage .

HY-D1510

4-Nitrophenyl 2-O-(β-L-Fucopyranosyl)-β-D-Galactopyranoside	Biochemical Assay Reagents	Others
4-Nitrophenyl 2-O-(β-L-Fucopyranosyl)-β-D-Galactopyranoside is a synthetic chromogenic substrate and can be used in the assay of α-fucosidases which hydrolyze the glycosidic linkage Fuc α1-2Gal. The assay is based on the sequential action of α-fucosidase and an exogenously added exo-β-d-galactosidase to release the easily measurable p-nitrophenol moiety .

HY-145823

EGFR-IN-42	EGFR	Cancer
EGFR-IN-42 (Compound 17b) is a potent inhibitor of EGFR with single-digit nanomolar activity. EGFR-IN-42 connects tamoxifen or endoxifen with the EGFR-inhibitor gefitinib via a covalent linkage. EGFR-IN-42 retains both ER antagonist activity and EGFR inhibition. EGFR-IN-42 has superior anti-cancer activity .

HY-145824

EGFR-IN-43	EGFR	Cancer
EGFR-IN-43 (Compound 17c) is a potent inhibitor of EGFR with single-digit nanomolar activity. EGFR-IN-43 connects tamoxifen or endoxifen with the EGFR-inhibitor gefitinib via a covalent linkage. EGFR-IN-43 retains both ER antagonist activity and EGFR inhibition. EGFR-IN-43 has superior anti-cancer activity .

HY-E70011

Levanase	Biochemical Assay Reagents	Others
Levanase is a slime-dissolving enzyme of Rhodotorula species. Levanase performs random hydrolysis of β-2,6 fructofuranosyl linkages in β-2,6 fructans containing more than 3 fructose units .

HY-B2220

Cellulase	Biochemical Assay Reagents	Others
Cellulase is an enzyme catalyzing the hydrolysis of certain linkages in cellulose and other carbohydrates.

HY-158000

Bile acid probe 1	Fluorescent Dye	Metabolic Disease
Bile acid probe 1, a clickable and photoreactive probe for Bile acid, contains ester linkage .

HY-E70110

Endo-1,4-β-mannanase	Others	Others
Endo-1,4-β-mannanase is an important catalytic agent that randomly cleave the β-1,4-linkage in the mannan backbone and release short β-1,4-mannooligosaccharides and mannose .

HY-B0445

NAD+ Maximum Cited Publications 27 Publications Verification β-DPN; β-NAD; β-Nicotinamide Adenine Dinucleotide	Endogenous Metabolite	Metabolic Disease
NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

HY-107824

D-Melibiose	Endogenous Metabolite	Inflammation/Immunology
D-Melibiose is a disaccharide which is composed of one galactose and one glucose moiety in an alpha (1-6) glycosidic linkage.

HY-W347315

6-(Biotinamido)hexylazide	Biochemical Assay Reagents	Others
6-(Biotinamido)hexylazide is a click chemistry biotinylation reagent that can react with alkyne molecule to form a stable triazole linkage.

HY-N10998

Chamaejasmenin A	Others	Others
Chamaejasmenin A is a C-3/C-3’’ linkage biflavanone that can be isolated from Stellera chamaejasme L. .

HY-169799

Cholylglycylamidofluorescein CGamF	Endogenous Metabolite Fluorescent Dye	Metabolic Disease
Cholylglycylamidofluorescein (CGamF) is a fluorescent probe for hepatic bile acid transport. Cholylglycylamidofluorescein is composed of Cholic acid conjugated via a glycylamino linkage to fluorescein. (Ex/Em = 492/515 nM in Aqueous)

HY-135717

Norbiotinamine	Biochemical Assay Reagents	Cancer
Norbiotinamine is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction .

HY-135717A

Norbiotinamine hydrochloride	Biochemical Assay Reagents	Cancer
Norbiotinamine hydrochloride is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction .

HY-W800689

Tri(propargyl-NHCO-ethyloxyethyl)amine	Biochemical Assay Reagents	Others
Tri(propargyl-NHCO-ethyloxyethyl)amine is a crosslinker that can react with azide compounds or biomolecules via copper catalyzed Click Chemistry to form a stable triazole linkage.

HY-N7592

Arjunetin	Others	Others
Arjunetin, isolated from Terminalia arjuna, is an insect feeding-deterrent and growth inhibitor .

HY-N7592R

Arjunetin (Standard)	Others	Others
Arjunetin (Standard) is the analytical standard of Arjunetin. This product is intended for research and analytical applications. Arjunetin, isolated from Terminalia arjuna, is an insect feeding-deterrent and growth inhibitor .

HY-P99493

Cantuzumab ravtansine IMGN242; huC242-DM4	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Cantuzumab ravtansine (IMGN242; huC242-DM4), an ADC, is a humanized monoclonal antibody, huC242, covalently linked via a disulfide bond to DM4 (DM4 (HY-12454)). Cantuzumab ravtansine has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts .

HY-B2193

α-Amylase 1 Publications Verification	Amylases	Others
α-Amylase is a hydrolase enzyme that catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose.

HY-E70023

Sphingolipid ceramide N-deacylase (SCDase)	Endogenous Metabolite	Metabolic Disease
Sphingolipid ceramide N-deacylase (SCDase) cleaves the N-acyl linkage between fatty acids and sphingosine bases in various glycosphingolipids. Sphingolipid ceramide N-deacylase catalyzes glycosphingolipids to lysoglycosphingolipids .

HY-D2748

5-JOE azide	Fluorescent Dye	Others
5-JOE azide is a fluorescent dye with the emission in yellow region of the spectrum. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-W800807

R6G azide, 5-isomer	Fluorescent Dye	Others
R6G azide, 5-isomer is a xanthene dye with a terminal azide. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-W800671

1,5-Diazidopentane 1,5-Pentane diazide	Biochemical Assay Reagents	Others
1,5-Diazidopentane (1,5-Pentane diazide) is a linker with two azide groups which can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-P2988B

Neuraminidase, arthrobacter ureafaciens	Endogenous Metabolite	Infection
Neuraminidase, arthrobacter ureafaciens is an exosialidase which cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase can facilitate virus release from infected cells .

HY-W590544

1-Azidodecane	Biochemical Assay Reagents	Others
1-Azidodecane is a compound with an azide head and a 10-carbon tail. The azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-W441002

DSPE-succinic acid	Liposome	Others
DSPE-succinic acid is a phophalipid capped with a carboxylic acid moiety. The carboxylic acid moiety is reactive with amine to from a stable amide linkage. DSPE-succinic acid can be used to prepare nanoparticles or liposomes for agent nanocarrier to deliver therapeutics .

HY-B0445S1

NAD+-13C5 β-DPN-¹³C₅; β-NAD-¹³C₅; β-Nicotinamide Adenine Dinucleotide-¹³C₅	Endogenous Metabolite	Metabolic Disease
NAD+- ¹³C₅-1 is the ¹³C labeled NAD+[1]. NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

HY-W654288

NAD+-d4 β-DPN-d₄; β-NAD-d₄; β-Nicotinamide Adenine Dinucleotide-d₄	Isotope-Labeled Compounds	Others
NAD+-d₄ is the deuterium-labeled NAD+ (HY-B0445). NAD+-d₄ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

HY-E70191

β-1,4-Galactosyltransferase 2 EC:2.4.1.22; B4GALT2	Glycosyltransferase	Others
β-1,4-Galactosyltransferase 2 catal exclusive specificity for the donor substrate UDP-galactose and all transfer galactosein a beta1,4 linkage .

HY-W590592

Azido-PEG12-azide	Biochemical Assay Reagents	Others
Azido-PEG12-azide is a monodisperse PEG linker containing two azide groups. The azide group can react with alkyne, BCN, or DBCO via Click Chemistry to yield a stable triazole linkage.

HY-E70038

Endoglycoceramidase II (EGCase II)	Endogenous Metabolite	Metabolic Disease
Endoglycoceramidase II (EGCase II) is an endo-β-glucosidase releasing the complete glycan from ceramide in glycosphingolipids. Endoglycoceramidase II Catalyzes the hydrolysis of the β-glycosidic linkage between oligosaccharides and ceramides in various glycosphingolipids .

HY-W590545

Octyl azide 1-Azidooctane	Biochemical Assay Reagents	Others
Octyl azide (1-Azidooctane) is a compound with an azide head and a 8-carbon tail. The azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-P2802B

α-Glucosidase, rice	Endogenous Metabolite	Metabolic Disease
α-Glucosidase, rice is a carbohydrase enzyme that catalyzes the release of α-glucose molecules. α-Glucosidase, rice retains exoglycosidases, which hydrolyze α-glucosidic linkage at the nonreducing end of a substrate .

HY-E70116

Isoamylase Glycogen α-1,6-glucanohydrolase	Glycosidase	Others
Isoamylase (Glycogen α-1,6-glucanohydrolase) catalyzes the hydrolysis of α-1,6-glycosidic linkages in glycogen, amylopectin and α/β-limit dextrins .

HY-W800808

ROX azide, 5-isomer	Fluorescent Dye	Others
ROX azide, 5-isomer is a red-emitting rhodamine dye possessing high brightness and fluorescence quantum yield. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-E70281

Recombinant endoglycoceramidase II rEGCase II	Biochemical Assay Reagents	Metabolic Disease
Recombinant endoglycoceramidase II (rEGCase II) is an endo-β-glucosidase releasing the complete glycan from ceramide in glycosphingolipids. Recombinant endoglycoceramidase II catalyzes the hydrolysis of the β-glycosidic linkage between oligosaccharides and ceramides in various glycosphingolipids .

HY-P2802A

α-Glucosidase, bacillus stearothermophilus	Endogenous Metabolite	Metabolic Disease
α-Glucosidase, bacillus stearothermophilus is a carbohydrase enzyme that catalyzes the release of α-glucose molecules. α-Glucosidase, bacillus stearothermophilus retains exoglycosidases, which hydrolyze α-glucosidic linkage at the nonreducing end of a substrate .

HY-W440896

DSPE-PEG-SH, MW 2000	Liposome	Others
DSPE-PEG-SH, MW 2000 is a pegylated phospholipid with thiol group which is reactive with maleimide to form a covalent thioether linkage. The amphiphatic polymer can form lipid bilayer in aqueous solution and be used to encapsulate agents for drug delivery system, such as mRNA vaccine.

HY-W251756

3-(2-Iodoethoxy)prop-1-yne	Biochemical Assay Reagents	Others
3-(2-Iodoethoxy)prop-1-yne is a crosslinker that can be used in copper catalyzed azide-alkyne Click Chemistry to form a stable triazole linkage with azides. The iodine (I) acts as a good leaving group for nucleophilic substitution reactions.

HY-W800777

6-(3-Hydroxypropylamino)hexyl 2-hexyldecanoate	Liposome	Cancer
6-(3-Hydroxypropylamino)hexyl 2-hexyldecanoate is an ionizable lipid which can be used to make ALC-0315. The lipid has an ester bond adjacent to C6 relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver.

HY-W591969

Benzyl (6-oxohexyl)carbamate	Biochemical Assay Reagents	Others
Benzyl (6-oxohexyl)carbamate is a linker containing an aldehyde group and a benzyl (Cbz) protecting group. The aldehyde can react with hydrazine or hydrazide to form a hydrolytic acyl hydrozone linkage. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.

HY-E70138

β-1,4-Galactosyltransferase 7 EC:2.4.1.133; B4GALT7	Glycosyltransferase	Others
β-1,4-Galactosyltransferase 7 has exclusive specificity for the donor substrate UDP-galactose and all transfer galactose in a β-1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. .

HY-34643

6-Heptynoic acid Hept-6-ynoic acid	Biochemical Assay Reagents	Others
6-Heptynoic acid (Hept-6-ynoic acid) is a reagent with an alkyne group and a carboxylic acid. The terminal carboxylic acid can form amide bond with primary amines (activation is needed). The alkyne can form triazole linkage with azide containing molecules via copper catalyzed reactions.

HY-P3173

Pullulanase R-enzyme	Endogenous Metabolite	Others
Pullulanase (R-enzyme) is a starch debranching enzyme, is often used in biochemical studies. Pullulanase hydrolyses the α-1,6 glucosidic linkages in starch, amylopectin, pullulan, and related oligosaccharides. Pullulanase converts polysaccharide into small fermentative sugars during saccharification .

Cat. No.	Product Name	Type

HY-114351

BODIPY FL hydrazide	Fluorescent Dyes/Probes
BODIPY FL Hydrazide is a green-fluorescent dye, BODIPY FL Hydrazide is reactive with aldehyde/ketone on polysaccharides and glycoproteins, yielding a reversible Schiff base product that can be transformed to a stable linkage using a reducing agent like sodium borohydride or sodium cyanoborohydride. (λ_ex=495 nm, λ_em=516 nm) .

HY-D2219

Sulfo-Cy7 tetrazine	Fluorescent Dyes/Probes
Sulfo-Cy7 tetrazine is a near-infrared water-soluble fluorophore. Sulfo-Cy7 tetrazine contains the methyltetrazine group for rapid, efficient, and metal-free conjugation to cycloolefin in a reaction called TCO linkage .

HY-D2748

5-JOE azide	Fluorescent Dyes/Probes
5-JOE azide is a fluorescent dye with the emission in yellow region of the spectrum. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-W800807

R6G azide, 5-isomer	Fluorescent Dyes/Probes
R6G azide, 5-isomer is a xanthene dye with a terminal azide. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-W800808

ROX azide, 5-isomer	Fluorescent Dyes/Probes
ROX azide, 5-isomer is a red-emitting rhodamine dye possessing high brightness and fluorescence quantum yield. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-W591393

Biotin Azide Plus	Fluorescent Dyes/Probes
Biotin Azide Plus is a biotinylation reagent used for labeing glycoproteins, carbohydrate-containing compounds that have oxidizable sugars or aldehydes. Biotin Azide Plus is a complete copper-chelating system that acts simultaneously as both reactant and catalyst in CuAAC reactions. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-D2744

BP Fluor 488 TCO

Fluorescent Dyes/Probes

BP Fluor 488 TCO reacts with tetrazines to produce a stable, covalent linkage, also referred to as the inverse-electron demand Diels-Alder cycloaddition reaction. This reaction is extremely fast (k > 800 M-1 s-1), selective, biocompatible, and does not require Cu-catalyst or elevated temperatures. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date.

Cat. No.	Product Name	Type

HY-W441002

DSPE-succinic acid	Drug Delivery
DSPE-succinic acid is a phophalipid capped with a carboxylic acid moiety. The carboxylic acid moiety is reactive with amine to from a stable amide linkage. DSPE-succinic acid can be used to prepare nanoparticles or liposomes for agent nanocarrier to deliver therapeutics .

HY-W440896

DSPE-PEG-SH, MW 2000	Drug Delivery
DSPE-PEG-SH, MW 2000 is a pegylated phospholipid with thiol group which is reactive with maleimide to form a covalent thioether linkage. The amphiphatic polymer can form lipid bilayer in aqueous solution and be used to encapsulate agents for drug delivery system, such as mRNA vaccine.

HY-W441011

DSPE-NHS	Drug Delivery
DSPE-NHS is a bioconjugation phospholipid molecule with two hydrophobic lipid tails. DSPE-NHS is a self-assembling reagent which forms lipid bilayer in aqueous solution. The NHS-ester is reactive with N-terminal of protein/peptide or other amine molecule to form a stable amide linkage. DSPE-NHS labels antibodies. DSPE-NHS can be used to prepare liposomes as agent nanocarrier .

HY-E70153

Fucosyltransferase 2 EC:2.4.1.69; FUT2	Enzyme Substrates
Fucosyltransferase 2 (EC:2.4.1.69; FUT2) adds a fucose to the terminal galactose of a type I chain in an α1-2 linkage .

HY-E70191

β-1,4-Galactosyltransferase 2 EC:2.4.1.22; B4GALT2	Enzyme Substrates
β-1,4-Galactosyltransferase 2 catal exclusive specificity for the donor substrate UDP-galactose and all transfer galactosein a beta1,4 linkage .

HY-E70185

Lysosomal α-mannosidase EC:3.2.1.24; MAN2B1; LAMAN	Enzyme Substrates
Lysosomal α-mannosidase (EC:3.2.1.24; MAN2B1; LAMAN) is an exoglycosidase that hydrolyzes α-mannosidic linkages of mannoglycans. Lysosomal α-mannosidase can be used in the study of α-mannosidosis .

HY-E70138

β-1,4-Galactosyltransferase 7 EC:2.4.1.133; B4GALT7	Enzyme Substrates
β-1,4-Galactosyltransferase 7 has exclusive specificity for the donor substrate UDP-galactose and all transfer galactose in a β-1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. .

HY-W441003

DSPE-PEG-IA (MW 2000)	Drug Delivery
DSPE-PEG-IA, MW 2000 is a thiol reactive phospholipid polyPEG. The iodoacetyll group is reactive with thiol to produce a thioether linkage. The polymer can self-assemble in water to form lipid bilayer and can be used to encapsulate drugs in targeted delivery application, such as liposomal doxorubicin as an anti cancer drug or mRNA vaccine. Reagent grade, for research use only.

HY-E70156

Fucosyltransferase 7 EC:2.4.1.-; FUT7	Enzyme Substrates
Fucosyltransferase 7 (FUT7) is a golgi stack membrane protein. Fucosyltransferase 7catalyzes the final fucosylation step in the synthesis of Lewis antigens and generates a unique glycosylated product sialyl Lewis X (sLeX). Fucosyltransferase 7 catalyzes alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens .

HY-W440884

DSPE-PEG-Ald (MW 3400)	Drug Delivery
DSPE-PEG-Ald, MW 3400 is a self-assemble polyPEG which spontaneously forms lipid bilayer in water. The polymer can be used to prepare nanoparticles or liposomse as a targeted drug carrier, such as mRNA vaccine. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond. Reagent grade, for research use only.

HY-W440902

DSPE-PEG-IA (MW 3400)

Drug Delivery

DSPE-PEG-IA, MW 3400 is an iodoacetyll PEG lipid. The polymer can form lipid bilayer or micelles spontaneoulsy in water. The lipophilic tails can be used to encapsulate hydrophobic therapeutic agents while the hydrophilic head can be used to encapuslate hydrophilic drugs/nutrient, such as antibody, mRNA/DNA. The iodoacetyl group is reactive with thiol to produce a thioether linkage. Reagent grade, for research use only.

HY-W077279

5'-O-DMT-N4-Ac-dC N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine	Gene Sequencing and Synthesis
5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7), a deoxynucleoside, can be used to synthesize of dodecyl phosphoramidite which is the raw material for dod‐DNA (amphiphilic DNA containing an internal hydrophobic region consisting of dodecyl phosphotriester linkages) synthesis .

HY-W440885

DSPE-PEG-Ald (MW 5000)

Drug Delivery

DSPE-PEG-Ald, MW 5000 is a phospholipid PEG polymer which can self-assemble spontaneously in water with their hydrophilic heads oriented toward the water (micelles). The polymer can be used to prepare liposome as a drug nanocarrier for administration of nutrients and therapeutic drugs, such as lipid nanoparticles in mRNA or DNA vaccines. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond. Reagent grade, for research use only.

HY-E70150

ST6 Sialyltransferase 1 EC:2.4.3.3; Alpha-N-Acetylgalactosaminide alpha-2,6-sialyltransferase 1	Enzyme Substrates
ST6 Sialyltransferase 1 (EC:2.4.3.3, ST6GALNAC1, SIAT7A, Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1) transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. ST6 Sialyltransferase 1 plays an important role in cancer .

HY-W145522

Pullulan, Viscosity(10%):15-180mPa.s

Carbohydrates

Pullulan (Pullulan standard 5800) (Mw 362-480 kDa; Mn 100-200 kDa) is a class of orally active and water-soluble linear glucosic polysaccharide. Pullulan can be isolated from the polymorphic fungus Aureobasidium pullulans. Pullulan is composed of maltotriose repeating units linked by α-1,6 linkages and is an amorphous slime matter. Pullulan is widely used in food, environment, pharmaceutical, manufacturing, and electronics .

HY-W440955

Stearic acid-PEG-CH2CO2H (MW 3400)

Drug Delivery

Stearic acid-PEG-CH2CO2H, MW 3400 is a lipophilic thiol-reactive PEG polymer. The stearic acid can be used to encapsulate hydrophobic therapeutic agents while the PEG chain increases overall water solubility and biocompatibilty. Reaction between carboxylic acid (-COOH) and amine (-NH2) vai condensation in the presence of activator, such as HATU or EDC, generates a stable amide linkage. Reagent grade, for research use only.

Cat. No.	Product Name	Target	Research Area

HY-P3752

Gly-Ala-Tyr	Peptides	Others
Gly-Ala-Tyr is a tripeptide composed of L-glycine, alanine and L-tyrosine joined in sequence by peptide linkages. Ala-Gly-Tyr is functionally related to L-alanine, glycine and L-tyrosine.

HY-P4383

H-Leu-Leu-Ala-OH	Peptides	Others
H-Leu-Leu-Ala-OH is a tripeptide composed of two L-leucine units joined to L-alanine by a peptide linkage. H-Leu-Leu-Ala-OH shows antioxidant activities .

HY-P5461

CHRG01	Bacterial	Others
CHRG01 is a biological active peptide. (CHRG01 is derived from human b-defensin 3 (hBD3) C-terminal amino acids 54 to 67, with all Cys residues substituted with Ser. This substitution removes all disulfide bond linkages within the sequence. CHRG01, like hBD3, displays electrostatic-dependent antimicrobial properties.)

Cat. No.	Product Name

HY-K0226

CHO Magnetic Beads (200 nm, 10 mg/mL)
MCE CHO Magnetic Beads (200 nm, 10 mg/mL) contain CHO functional groups, which react with primary amines on proteins or other molecules to form stable amide linkages，can covalently immobilize proteins for the affinity purification of antibodies, antigens and other biomolecules.

HY-K0227

NHS Magnetic Beads (200nm, 10 mg/mL)
MCE NHS Magnetic Beads (200 nm, 10 mg/mL) contain N-hydroxysuccinimide (NHS) functional groups, which react with primary amines on proteins or other molecules to form stable amide linkages，can covalently immobilize proteins for the affinity purification of antibodies, antigens and other biomolecules.

Cat. No.	Product Name	Target	Research Area

HY-P99493

Cantuzumab ravtansine IMGN242; huC242-DM4	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Cantuzumab ravtansine (IMGN242; huC242-DM4), an ADC, is a humanized monoclonal antibody, huC242, covalently linked via a disulfide bond to DM4 (DM4 (HY-12454)). Cantuzumab ravtansine has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B2220

Cellulase	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Biochemical Assay Reagents
Cellulase is an enzyme catalyzing the hydrolysis of certain linkages in cellulose and other carbohydrates.

HY-B0445

NAD+ 25+ Cited Publications β-DPN; β-NAD; β-Nicotinamide Adenine Dinucleotide	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

HY-107824

D-Melibiose	Malvaceae Structural Classification Polysaccharides Classification of Application Fields Malva sinensis Cav. Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	Endogenous Metabolite
D-Melibiose is a disaccharide which is composed of one galactose and one glucose moiety in an alpha (1-6) glycosidic linkage.

HY-N7592

Arjunetin	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Rosaceae Other Diseases Potentilla anserina Linn. Plants Disease Research Fields	Others
Arjunetin, isolated from Terminalia arjuna, is an insect feeding-deterrent and growth inhibitor .

HY-B2193

α-Amylase 1 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Amylases
α-Amylase is a hydrolase enzyme that catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose.

HY-N10998

Chamaejasmenin A	Structural Classification Flavonoids Thymelaeaceae Source classification Stellera chamaejasme Linn. Plants Biflavones	Others
Chamaejasmenin A is a C-3/C-3’’ linkage biflavanone that can be isolated from Stellera chamaejasme L. .

HY-N7592R

Arjunetin (Standard)	Triterpenes Structural Classification Terpenoids Source classification Rosaceae Potentilla anserina Linn. Plants	Others
Arjunetin (Standard) is the analytical standard of Arjunetin. This product is intended for research and analytical applications. Arjunetin, isolated from Terminalia arjuna, is an insect feeding-deterrent and growth inhibitor .

Cat. No.	Product Name	Chemical Structure

HY-W654288

NAD+-d4
NAD+-d₄ is the deuterium-labeled NAD+ (HY-B0445). NAD+-d₄ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

HY-B0445S1

NAD+-13C5
NAD+- ¹³C₅-1 is the ¹³C labeled NAD+[1]. NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

Cat. No.	Product Name		Classification

HY-D2219

Sulfo-Cy7 tetrazine		Tetrazine
Sulfo-Cy7 tetrazine is a near-infrared water-soluble fluorophore. Sulfo-Cy7 tetrazine contains the methyltetrazine group for rapid, efficient, and metal-free conjugation to cycloolefin in a reaction called TCO linkage .

HY-158000

Bile acid probe 1		Alkynes
Bile acid probe 1, a clickable and photoreactive probe for Bile acid, contains ester linkage .

HY-D2748

5-JOE azide		Azide
5-JOE azide is a fluorescent dye with the emission in yellow region of the spectrum. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-W800657

Azido-PEG1-hydrazide hydrochloride		Azide
Azido-PEG1-hydrazide hydrochloride is a bifunctional PEG linker containing an azide group and a hydrazide group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Hydrazine moiety reacts with an aldehyde to form semi-permanent hydrazone bonds.

HY-W457953

tert-Butyl N-(4-azidobutyl)carbamate		Azide
tert-Butyl N-(4-azidobutyl)carbamate is N-Boc protected crosslinker. tert-Butyl N-(4-azidobutyl)carbamate can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W591360

Iodoacetamido-PEG6-azide		Azide
Iodoacetamido-PEG6-azide is an aqueous soluble PEG linker containing an azide and a terminal Iodoacetamido group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.

HY-D2744

BP Fluor 488 TCO		TCO
BP Fluor 488 TCO reacts with tetrazines to produce a stable, covalent linkage, also referred to as the inverse-electron demand Diels-Alder cycloaddition reaction. This reaction is extremely fast (k > 800 M-1 s-1), selective, biocompatible, and does not require Cu-catalyst or elevated temperatures. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date.

HY-W190881

N3-PEG11-CH2CH2Br		Azide
N3-PEG11-CH2CH2Br is a PEG linker containing a bromine and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions.

HY-W800664

5-(Azido-PEG4)-pent-2-yn-1-ol		Azide
5-(Azido-PEG4)-pent-2-yn-1-Ol is a PEG linker containing an azide group and a terminal hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

HY-151647

3-Azidopropanoic acid-PFP ester		Azide
3-Azidopropanoic acid-PFP ester is an azidopropanoic acid linker that contains an activated PFP ester. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN to form triazole linkages. The activated PFP ester can react with amine groups to form stable amide bonds . 3-Azidopropanoic acid-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W591390

6-Azidohexanoic acid STP ester		Azide
6-Azidohexanoic Acid STP Ester is an amine-reactive, water-soluble labeling reagent with an azide group and a terminal 4-Sulfo-2,3,5,6-tetrafluorophenyl (STP) group. 6-Azidohexanoic Acid STP Ester is used to modify proteins, antibodies, and other amine-containing biopolymers in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. STP esters can react with primary amines, forming covalent amide bonds, and typically display much better stability toward hydrolysis in aqueous media, resulting in more efficiency and better reproducible labeling of biopolymers.

Cat. No.	Product Name		Classification

HY-W441002

DSPE-succinic acid		Phospholipids
DSPE-succinic acid is a phophalipid capped with a carboxylic acid moiety. The carboxylic acid moiety is reactive with amine to from a stable amide linkage. DSPE-succinic acid can be used to prepare nanoparticles or liposomes for agent nanocarrier to deliver therapeutics .

HY-W440896

DSPE-PEG-SH, MW 2000		Pegylated Lipids
DSPE-PEG-SH, MW 2000 is a pegylated phospholipid with thiol group which is reactive with maleimide to form a covalent thioether linkage. The amphiphatic polymer can form lipid bilayer in aqueous solution and be used to encapsulate agents for drug delivery system, such as mRNA vaccine.

HY-W441011

DSPE-NHS		Phospholipids
DSPE-NHS is a bioconjugation phospholipid molecule with two hydrophobic lipid tails. DSPE-NHS is a self-assembling reagent which forms lipid bilayer in aqueous solution. The NHS-ester is reactive with N-terminal of protein/peptide or other amine molecule to form a stable amide linkage. DSPE-NHS labels antibodies. DSPE-NHS can be used to prepare liposomes as agent nanocarrier .

HY-W077279

5'-O-DMT-N4-Ac-dC N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine		Nucleoside Phosphoramidites
5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7), a deoxynucleoside, can be used to synthesize of dodecyl phosphoramidite which is the raw material for dod‐DNA (amphiphilic DNA containing an internal hydrophobic region consisting of dodecyl phosphotriester linkages) synthesis .

HY-W010706

N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine 5'-O-DMT-N4-Bz-dC		Nucleoside Phosphoramidites
N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine (5'-O-DMT-N4-Bz-dC) can be used for synthesis oligodeoxynucleotides containing a 3'-S-phosphorothiolate (3'-PS) linkage. N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine is an useful tool for probing enzyme-catalyzed cleavage processes in DNA .

HY-W800777

6-(3-Hydroxypropylamino)hexyl 2-hexyldecanoate		Cationic Lipids
6-(3-Hydroxypropylamino)hexyl 2-hexyldecanoate is an ionizable lipid which can be used to make ALC-0315. The lipid has an ester bond adjacent to C6 relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver.

HY-W440945

Stearic acid-PEG-amine, MW 2000		Pegylated Lipids
Stearic acid-PEG-amine, MW 2000 is an amphiphilic PEG polymer which forms micelles in an aqueous solution. The terminal amine can react with an NHS ester to form a stable amide linkage. The aliphatic chain of stearic acid can be used to encapsulate or congregate hydrophobic therapeutic agents while the PEG chain enhances overall solubility of the polymer. Reagent grade, for research use only.

HY-W440883

DSPE-PEG-Ald, MW 2000		Pegylated Lipids
DSPE-PEG-Ald, MW 2000 is a phospholipid polyPEG which can self-assemble to form lipid bilayer in aqueous solution. The polymer can be used to prepare liposome as a drug delivery vehicle for administration of drugs or nutrients, such as mRNA vaccines. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond. Reagent grade, for research use only.

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