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Results for "

mTORC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminoacyl-tRNA Synthetase (2) AMPK (4) Antibiotic (2) Antifolate (1) Apoptosis (15) Autophagy (32) Bacterial (5) c-Fms (1) c-Met/HGFR (2) DNA-PK (6) DNA/RNA Synthesis (2) Drug Metabolite (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (3) FKBP (2) Fungal (2) Glutaminase (2) HIV (1) iGluR (2) Influenza Virus (4) Isotope-Labeled Compounds (1) Kinesin (1) Mitophagy (2) mTOR (69) Phosphatase (1) PI3K (13) Pim (1) PKC (1) Prolyl Endopeptidase (PREP) (3) RABV (1) Ribosomal S6 Kinase (RSK) (1) ROR (1) Small Interfering RNA (siRNA) (2) Tyrosinase (2) ULK (1)
By Research Areas:	Cancer (79) Cardiovascular Disease (1) Infection (5) Inflammation/Immunology (6) Metabolic Disease (7) Neurological Disease (8)
Oligonucleotides:	siRNAs (2)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114384B

NV-5138 hydrochloride 5 Publications Verification	mTOR	Neurological Disease
NV-5138 hydrochloride, a leucine analog, is the first selective and orally active brain *mTORC1* activator, binding to Sestrin2. NV-5138 hydrochloride is used for antidepressant studies .

HY-14581

Palomid 529 5 Publications Verification P529	mTOR Apoptosis	Cancer
Palomid 529 is a potent inhibitor of *mTORC1* and *mTORC2* complexes.

HY-132168

RMC-5552 1 Publications Verification	mTOR	Cancer
RMC-5552 is a potent and selective *mTORC1* inhibitor. RMC-5552 inhibits phosphorylation of mTORC1 pS6K and p4EBP1 with IC₅₀s of 0.14 nM and 0.48 nM, respectively. RMC-5552 shows much lower pAKT inhibition (IC₅₀ of 19 nM), resulting in mTORC1/mTORC2 selectivity approaching 40-fold. RMC-5552 has anti-cancer activity .

HY-134904

RMC-6272 1 Publications Verification RM-006	mTOR	Cancer
RMC-6272 (RM-006) is a bi-steric *mTORC1*-selective inhibitor. RMC-6272 exhibits potent and selective (> 10-fold) inhibition of mTORC1 over mTORC2. RMC-6272 shows improved inhibition of mTORC1 in comparison to Rapamycin, and induces more cell death in TSC2 null tumors .

HY-100026

PQR620 4 Publications Verification	mTOR	Cancer
PQR620 is an orally bioavailable and selective brain penetrant inhibitor of *mTORC1/2* .

HY-N2517

Dihydroevocarpine	mTOR	Cancer
Dihydroevocarpine induces cytotoxicity in acute myeloid leukemia via suppressing the *mTORC1/2* activity .

HY-107363

FT-1518	mTOR	Cancer
FT-1518 is a new generation selective, potent and oral bioavailable *mTORC1* and *mTORC2* inhibitor, and exhibits antitumor activity.

HY-155475

mTORC1-IN-2	mTOR	Cardiovascular Disease
mTORC1-IN-2 (compound H3) is a NO donor compound that alleviates vasodilation and attenuates myocardial hypoxic injury. *mTORC1*-IN-2 upregulates TSC2-P expression and inhibits mTORC1 expression .

HY-15281

QL-IX-55	mTOR	Cancer
QL-IX-55 is a selective ATP-competitive inhibitor of *mTORC1/2* with IC₅₀s of 50/50/10-50 nM for Human mTORC1/Yeast mTORC1/Yeast mTORC2, respectively.

HY-111065

OXA-01	mTOR	Cancer
OXA-01 is a potent *mTORC1* and *mTORC2* inhibitor, with IC₅₀ values of 29 nM and 7 nM, respectively .

HY-50710

KU-0063794 10+ Cited Publications	mTOR	Cancer
KU-0063794 is a potent and specific *mTOR* inhibitor, inhibiting both the *mTORC1* and *mTORC2* complexes with IC₅₀s of 10 nM.

HY-15247

Vistusertib 20+ Cited Publications AZD2014	mTOR Autophagy Apoptosis	Cancer
Vistusertib (AZD2014) is an ATP competitive *mTOR* inhibitor with an IC₅₀ of 2.81 nM. AZD2014 inhibits both *mTORC1* and *mTORC2* complexes.

HY-13806

XL388 3 Publications Verification	mTOR Autophagy	Cancer
XL388 is a highly potent and ATP-competitive *mTOR* inhibitor with an IC₅₀ of 9.9 nM. XL388 simultaneously inhibits both *mTORC1* and *mTORC2*.

HY-100222

CZ415 3 Publications Verification	mTOR	Cancer
CZ415 is a potent and highly selective *mTOR* inhibitor with a pIC₅₀ of 8.07. CZ415 inhibits *mTORC1* and *mTORC2* protein complex.

HY-15248

GDC-0349 2 Publications Verification	mTOR Autophagy	Cancer
GDC-0349 is a potent and selective ATP-competitive *mTOR* inhibitor with a K_i of 3.8 nM. GDC-0349 inhibits of both *mTORC1* and *mTORC2* complexes.

HY-16956

Onatasertib 2 Publications Verification CC-223; ATG-008	mTOR Apoptosis	Cancer
Onatasertib (CC-223) is a potent, selective, and orally bioavailable inhibitor of *mTOR* kinase, with an IC₅₀ value for mTOR kinase of 16 nM. Onatasertib inhibits both *mTORC1* and *mTORC2*.

HY-P5984

Thioether-cyclized helix B peptide, CHBP	mTOR	Others
Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .

HY-10422

AZD-8055 45+ Cited Publications	mTOR Autophagy Apoptosis	Cancer
AZD-8055 is a potent, selective, and orally bioavailable ATP-competitive *mTOR* kinase inhibitor with an IC₅₀ of 0.8 nM. AZD-8055 inhibits both *mTORC1* and *mTORC2* .

HY-10474

Torkinib 15+ Cited Publications PP 242	mTOR Autophagy Mitophagy Apoptosis	Cancer
Torkinib (PP 242) is a selective and ATP-competitive *mTOR* inhibitor with an IC₅₀ of 8 nM . PP242 inhibits both *mTORC1* and *mTORC2* with IC₅₀s of 30 nM and 58 nM, respectively .

HY-13003

Torin 1 75+ Cited Publications	mTOR Autophagy	Cancer
Torin 1 is a potent inhibitor of *mTOR* with an IC₅₀ of 3 nM. Torin 1 inhibits both *mTORC1/2 complexes with IC₅₀* values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy.

HY-18353

mTOR inhibitor-3 3 Publications Verification	mTOR	Cancer
mTOR inhibitor-3 is a remarkably selective *mTOR* inhibitor with a K_i of 1.5 nM. mTOR inhibitor-3 suppresses *mTORC1* and *mTORC2* in cellular and in vivo pharmacokinetic (PK)/pharmacodynamic (PD) experiments.

HY-16962

CC-115 2 Publications Verification	DNA-PK mTOR	Cancer
CC-115 is a potent and dual DNA-PK and *mTOR* kinase inhibitor with IC₅₀s of 13 nM and 21 nM, respectively. CC-115 blocks both *mTORC1* and *mTORC2* signaling.

HY-16962A

CC-115 hydrochloride 2 Publications Verification	DNA-PK mTOR	Cancer
CC-115 hydrochloride is a potent and dual DNA-PK and *mTOR* kinase inhibitor with IC₅₀s of 13 nM and 21 nM, respectively. CC-115 blocks both *mTORC1* and *mTORC2* signaling.

HY-12652

AZD3147	mTOR	Cancer
AZD3147 is a potent, orally active, selective dual inhibitor of *mTORC1* and *mTORC2* with an IC₅₀ value of 1.5 nM. AZD3147 also has a selective effect on PI3K .

HY-12513

Samotolisib 5+ Cited Publications LY3023414	PI3K DNA-PK mTOR Autophagy	Cancer
Samotolisib (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and *mTORC1/2* with IC₅₀s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively. Samotolisib potently inhibits *mTORC1*/2 at low nanomolar concentrations .

HY-15272

WAY-600 5+ Cited Publications	mTOR	Inflammation/Immunology Cancer
WAY-600 is a potent, ATP-competitive, and selective *mTOR* inhibitor with an IC₅₀ of 9 nM for recombinant mTOR enzyme. WAY-600 blocks mTOR complex 1/2 (mTORC1/2) assemble and activation.

HY-137175

TMBIM6 antagonist-1	mTOR	Cancer
TMBIM6 antagonist-1, a potential TMBIM6 antagonist, prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, and also regulates TMBIM6-leaky Ca ²⁺ .

HY-124798

Rheb inhibitor NR1 2 Publications Verification	mTOR	Neurological Disease Inflammation/Immunology Cancer
Rheb inhibitor NR1 is a Rheb inhibitor with an IC₅₀ of 2.1 µM in the Rheb-IVK assay. Rheb inhibitor NR1 can directly bind Rheb in the switch II domain and selectively inhibit the activation of mechanistic target of rapamycin complex 1 (mTORC1). Rheb inhibitor NR1 inhibits the phosphorylation of mTORC1 driven ^T389pS6K1 and increases the phosphorylation of ^S473pAKT in a dose-dependent manner. Rheb inhibitor NR1 does not influence mTORC2 activity . ^{(Rheb-IVK: Rheb-dependent mTORC1 kinase activity)}

HY-120904

AMPK-IN-1	AMPK	Metabolic Disease
AMPK-IN-1 is an activator of AMPK (EC₅₀: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way .

HY-14530

Pelitrexol 1 Publications Verification AG 2037	Antifolate	Cancer
Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), a purine biosynthetic enzyme. Pelitrexol also inhibits *mTORC1* by reducing GTP-bound Rheb level, a *mTORC1* obligate activator. Pelitrexol shows robust tumor growth suppression in mice .

HY-10423

OSI-027 10+ Cited Publications ASP7486	mTOR Autophagy	Cancer
OSI-027 (ASP7486) is a potent, selective, orally active and ATP-competitive *mTOR* kinase activity inhibitor with an IC₅₀ of 4 nM. OSI-027 targets both *mTORC1* and *mTORC2* with IC₅₀s of 22 nM and 65 nM, respectively .

HY-15174

Dactolisib Tosylate 55+ Cited Publications BEZ235 Tosylate; NVP-BEZ 235 Tosylate	PI3K mTOR Autophagy	Cancer
Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and *mTOR* kinase inhibitor with IC₅₀ values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits *mTORC1* and *mTORC2*.

HY-N0112

Dihydromyricetin 10+ Cited Publications Ampelopsin; Ampeloptin	mTOR Influenza Virus DNA/RNA Synthesis Autophagy	Infection Cancer
Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting *mTOR* signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 22 μM.

HY-111370

mTOR inhibitor-2	mTOR	Cancer
mTOR inhibitor-2 is a highlt potent, selective and oral *mTOR* inhibitor with an IC₅₀ of 7 nM. mTOR inhibitor-2 inhibits cellular phosphorylation of mTORC1 (pS6 and p4E-BP1) and mTORC2 (pAKT (S473)) substrates .

HY-10044

WYE-132 5+ Cited Publications WYE-125132	mTOR Apoptosis	Cancer
WYE-132 (WYE-125132) is a highly potent, ATP-competitive, and specific *mTOR* kinase inhibitor (IC₅₀: 0.19±0.07 nM; >5,000-fold selective versus PI3Ks). WYE-132 (WYE-125132) inhibits *mTORC1* and *mTORC2*.

HY-10681

Gedatolisib 4 Publications Verification PKI-587; PF-05212384	PI3K mTOR	Cancer
Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and *mTOR* with IC₅₀s of 0.4 nM, 5.4 nM and 1.6 nM, respectively . Gedatolisib is equally effective in both complexes of mTOR, *mTORC1* and *mTORC2* .

HY-143510

RMC-4627	mTOR	Cancer
RMC-4627 is a selective *mTORC1* inhibitor that activates 4EBP1 and inhibits tumor growth.

HY-15271

WYE-687 3 Publications Verification	mTOR PI3K	Cancer
WYE-687 is an ATP-competitive *mTOR* inhibitor with an IC₅₀ of 7 nM. WYE-687 concurrently inhibits activation of *mTORC1* and *mTORC2. WYE-687 also inhibits PI3Kα* and PI3Kγ with IC₅₀s of 81 nM and 3.11 μM, respectively.

HY-P5984A

Thioether-cyclized helix B peptide, CHBP TFA	mTOR	Others
Thioether-cyclized helix B peptide, CHBP (TFA) is the TFA form of Thioether-cyclized helix B peptide, CHBP (HY-P5984). Thioether-cyclized helix B peptide, CHBP (TFA) can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .

HY-13002

Torin 2 10+ Cited Publications	mTOR DNA-PK Autophagy Apoptosis	Cancer
Torin 2 is an *mTOR* inhibitor with EC₅₀ of 0.25 nM for inhibiting cellular mTOR activity, and exhibits 800-fold selectivity over PI3K (EC₅₀: 200 nM). Torin 2 also inhibits DNA-PK with an IC₅₀ of 0.5 nM in the cell free assay. Torin 2 can suppress both *mTORC1* and *mTORC2*.

HY-15271A

WYE-687 dihydrochloride	mTOR PI3K	Cancer
WYE-687 dihydrochloride is an ATP-competitive *mTOR* inhibitor with an IC₅₀ of 7 nM . WYE-687 dihydrochloride concurrently inhibits activation of *mTORC1* and *mTORC2* . WYE-687 also inhibits PI3Kα and PI3Kγ with IC₅₀s of 81 nM and 3.11 μM, respectively .

HY-N0112R

Dihydromyricetin (Standard)	mTOR Influenza Virus DNA/RNA Synthesis Autophagy	Infection Cancer
Dihydromyricetin (Standard) is the analytical standard of Dihydromyricetin. This product is intended for research and analytical applications. Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 22 μM.

HY-12034

WYE-354 5+ Cited Publications	mTOR Autophagy Apoptosis	Cancer
WYE-354 is an ATP-competitive *mTOR* inhibitor with an IC₅₀ of 5 nM. WYE-354 also inhibits PI3Kα and PI3Kγ with IC₅₀s of 1.89 μM and 7.37 μM, respectively. WYE-354 inhibits both *mTORC1* and *mTORC2*. WYE-354 induces autophagy activation in vitro .

HY-16585

VS-5584 5 Publications Verification SB2343	PI3K mTOR	Cancer
VS-5584 is a *pan-PI3K/mTOR* kinase inhibitor with IC₅₀s of 16 nM, 68 nM, 42 nM, 25 nM, and 37 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively. VS-5584 simultaneously blocks *mTORC2* as well as *mTORC1*.

HY-161509

PT-88	mTOR	Cancer
PT-88 is a highly selective inhibitor of *mTOR* (Mammalian target of rapamycin) (IC₅₀=1.2 nM). PT-88 inhibits both *mTORC1* and *mTORC2* complexes, both of which are active forms of *mTOR* protein kinases and are closely associated with cell growth, proliferation, and survival. PT-88 can be used to study the role of *mTOR* in tumorigenesis and development, especially in the treatment of breast cancer .

HY-10297

Omipalisib 15+ Cited Publications GSK2126458; GSK458	PI3K mTOR Autophagy	Cancer
Omipalisib (GSK2126458) is an orally active and highly selective inhibitor of PI3K with K_is of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively. Omipalisib has anti-cancer activity .

HY-10115

PI-103 20+ Cited Publications	PI3K mTOR DNA-PK Autophagy Apoptosis	Cancer
PI-103 is a potent PI3K and *mTOR* inhibitor with IC₅₀s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, *mTORC1, and mTORC2. PI-103 also inhibits DNA-PK* with an IC50 of 2 nM. PI-103 induces autophagy .

HY-10115A

PI-103 Hydrochloride 20+ Cited Publications	PI3K mTOR DNA-PK Autophagy Apoptosis	Cancer
PI-103 Hydrochloride is a dual PI3K and *mTOR* inhibitor with IC₅₀s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, *mTORC1, and mTORC2. PI-103 Hydrochloride also inhibits DNA-PK* with an IC50 of 2 nM. PI-103 Hydrochloride induces autophagy .

HY-12868

Bimiralisib 3 Publications Verification PQR309	PI3K mTOR	Cancer
Bimiralisib (PQR309) is a potent, brain-penetrant, orally bioavailable, pan-class I *PI3K/mTOR* inhibitor with IC₅₀s of 33 nM, 451 nM, 661 nM, 708 nM and 89 nM for PI3Kα, PI3Kδ, PI3Kβ, PI3Kγ and *mTOR, respectively. Bimiralisib is an mTORC1* and *mTORC2* inhibitor.

HY-N0656A

(+)-Usnic acid 2 Publications Verification	mTOR Bacterial Autophagy	Cancer
(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of *mTOR, and inhibits mTORC1/2* activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity . (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .

Cat. No.	Product Name	Target	Research Area

HY-P5984

Thioether-cyclized helix B peptide, CHBP	mTOR	Others
Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .

HY-P5984A

Thioether-cyclized helix B peptide, CHBP TFA	mTOR	Others
Thioether-cyclized helix B peptide, CHBP (TFA) is the TFA form of Thioether-cyclized helix B peptide, CHBP (HY-P5984). Thioether-cyclized helix B peptide, CHBP (TFA) can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2517

Dihydroevocarpine	Alkaloids Classification of Application Fields Source classification Evodia rutaecarpa (Juss.) Benth. Rutaceae Quinoline Alkaloids Plants Disease Research Fields Cancer	mTOR
Dihydroevocarpine induces cytotoxicity in acute myeloid leukemia via suppressing the *mTORC1/2* activity .

HY-N0112

Dihydromyricetin 10+ Cited Publications Ampelopsin; Ampeloptin	Infection Flavanonols Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	mTOR Influenza Virus DNA/RNA Synthesis Autophagy
Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting *mTOR* signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 22 μM.

HY-N0656A

(+)-Usnic acid 2 Publications Verification	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Plants Lichen Disease Research Fields Cancer	mTOR Bacterial Autophagy
(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of *mTOR, and inhibits mTORC1/2* activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity . (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .

HY-10219

Rapamycin Maximum Cited Publications 875 Publications Verification Sirolimus; AY-22989	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Classification of Application Fields Antibiotics Anti-aging Source classification Disease Research Disease Research Fields Cancer	mTOR FKBP Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial
Rapamycin (Sirolimus; AY 22989) is a potent and specific *mTOR* inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of *mTORC1* . Rapamycin is an autophagy activator, an immunosuppressant .

HY-N3628

Coronarin A	Hedychium coronarium Koen. Structural Classification Natural Products Plants Zingiberaceae	mTOR Ribosomal S6 Kinase (RSK)
Coronarin A is an orally active natural compound that inhibits *mTORC1* and S6K1 to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research .

HY-N0189

Aloe emodin 2 Publications Verification Rhabarberone; 3-Hydroxymethylchrysazine	Quinones Structural Classification Liliaceae Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Disease Research Fields Cancer	mTOR Influenza Virus Apoptosis Autophagy
Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities. aloe-emodin can bind with *mTORC2* and inhibit its kinase activity. Aloe emodin exerts antiproliferation effects and induces cellular apoptosis . Aloe emodin also exhibits antiviral activity that against influenza A virus .

HY-10219R

Rapamycin (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Antibiotics Source classification Disease Research Endogenous metabolite	mTOR FKBP Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial
Rapamycin (Standard) is the analytical standard of Rapamycin. This product is intended for research and analytical applications. Rapamycin (Sirolimus; AY 22989) is a potent and specific *mTOR* inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of *mTORC1* . Rapamycin is an autophagy activator, an immunosuppressant .

HY-W015309

Decanoic acid	Structural Classification Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Biological Pesticide Research Agricultural Research	iGluR Tyrosinase c-Met/HGFR Glutaminase Endogenous Metabolite
Decanoic acid is a key component of the medium-chain triglyceride (MCT) found in coconut oil. Decanoic acid is a brain-penetrant and non-competitive inhibitor of AMPA receptor showing antiseizure activity in rats. Decanoic acid reduces tyrosinase activity and inhibits melanosome maturation. Decanoic acid suppresses the phosphorylation of c-Met and induced apoptosis in hepatocellular carcinoma (HCC) cells by inhibiting the expression of various oncogenic proteins, which is promising for research in the field of mTORC1 signaling, HCC and epilepsy .

HY-N0112R

Dihydromyricetin (Standard)	Flavanonols Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants	mTOR Influenza Virus DNA/RNA Synthesis Autophagy
Dihydromyricetin (Standard) is the analytical standard of Dihydromyricetin. This product is intended for research and analytical applications. Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 22 μM.

HY-N0656AR

(+)-Usnic acid (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Plants Lichen	mTOR Bacterial Autophagy
(+)-Usnic acid (Standard) is the analytical standard of (+)-Usnic acid. This product is intended for research and analytical applications. (+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity . (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .

HY-W015309R

Decanoic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	iGluR Tyrosinase c-Met/HGFR Glutaminase
Decanoic acid (Standard) is the analytical standard of Decanoic acid. This product is intended for research and analytical applications. Decanoic acid is a key component of the medium-chain triglyceride (MCT) found in coconut oil. Decanoic acid is a brain-penetrant and non-competitive inhibitor of AMPA receptor showing antiseizure activity in rats. Decanoic acid reduces tyrosinase activity and inhibits melanosome maturation. Decanoic acid suppresses the phosphorylation of c-Met and induced apoptosis in hepatocellular carcinoma (HCC) cells by inhibiting the expression of various oncogenic proteins, which is promising for research in the field of mTORC1 signaling, HCC and epilepsy .

HY-18980

Rottlerin 5+ Cited Publications Mallotoxin; NSC 56346; NSC 94525	Structural Classification Chalcones Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Mallotus philippensis Cancer	PKC Autophagy Apoptosis HIV RABV
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .

Cat. No.	Product Name	Chemical Structure

HY-10219S1

Rapamycin-13C,d3

Rapamycin- ¹³C,d₃ (Sirolimus- ¹³C,d₃; AY-22989- ¹³C,d₃) is the ¹³C and deuterium labeled Rapamycin (HY-10219) . Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 . Rapamycin is an autophagy activator, an immunosuppressant .

Cat. No.	Product Name		Classification

HY-153493

PF-04523655		siRNAs
PF-04523655 is a siRNA directed against RTP801 gene. RTP801 is an inhibitor of the mammalian target of rampamycin complex 1 (mTORC1) and downstream transcription factor HIF-1.

HY-153493A

PF-04523655 sodium		siRNAs
PF-04523655 sodium is a siRNA directed against RTP801 gene. RTP801 sodium is an inhibitor of the mammalian target of rampamycin complex 1 (mTORC1) and downstream transcription factor HIF-1.

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