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Results for "

naphthoquinone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) Autophagy (1) Bacterial (6) Biochemical Assay Reagents (1) CXCR (2) Dihydroorotate Dehydrogenase (2) DNA/RNA Synthesis (2) Endogenous Metabolite (3) Fungal (4) GnRH Receptor (2) HIF/HIF Prolyl-Hydroxylase (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Isotope-Labeled Compounds (1) Monoamine Oxidase (2) NF-κB (2) Parasite (9) PI3K (1) Somatostatin Receptor (1) Tau Protein (1) Topoisomerase (3) Urotensin Receptor (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (2) Endocrinology (4) Infection (15) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (4)

By Targets:

Apoptosis (5)

Autophagy (1)

Bacterial (6)

Biochemical Assay Reagents (1)

CXCR (2)

Dihydroorotate Dehydrogenase (2)

DNA/RNA Synthesis (2)

Endogenous Metabolite (3)

Fungal (4)

GnRH Receptor (2)

HIF/HIF Prolyl-Hydroxylase (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Isotope-Labeled Compounds (1)

Monoamine Oxidase (2)

NF-κB (2)

Parasite (9)

PI3K (1)

Somatostatin Receptor (1)

Tau Protein (1)

Topoisomerase (3)

Urotensin Receptor (1)

By Research Areas:

Cancer (20)

Cardiovascular Disease (2)

Endocrinology (4)

Infection (15)

Inflammation/Immunology (4)

Metabolic Disease (1)

Neurological Disease (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W015490

1,4-Naphthoquinone 3 Publications Verification	Monoamine Oxidase	Cancer
1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity .

HY-115243

2-Chloro-1,4-naphthoquinone	Others	Others
2-Chloro-1,4-naphthoquinone is an reactive intermediate. 2-Chloro-1,4-naphthoquinone can be used for the research of various biochemical studies .

HY-N8139

2-Amino-3-carboxy-1,4-naphthoquinone	Others	Metabolic Disease
2-Amino-3-carboxy-1,4-naphthoquinone is the electron transfer mediator. 2-Amino-3-carboxy-1,4-naphthoquinone changes glucose metabolism of the homofermentative lactic acid bacteria .

HY-N7116

Lawsone methyl ether 2-Methoxy-1,4-naphthoquinone	Fungal Bacterial	Infection
Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities .

HY-121632

Quinoclamine 2 Publications Verification	NF-κB	Cancer
Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity .

HY-W015490S

*1,4-Naphthoquinone-d6*	Monoamine Oxidase	Cancer
1,4-Naphthoquinone-d₆ is the deuterium labeled 1,4-Naphthoquinone[1]. 1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity[2].

HY-W585943

6-Methyl-1,4-naphthoquinone	Biochemical Assay Reagents
6-Methyl-1,4-naphthoquinone is a kind of biochemical reagent.

HY-N3036

(Rac)-Isovalerylshikonin	Others	Others
(Rac)-Isovalerylshikonin (compound 372) is a naphthoquinone pigment present in hexane extracts of safflower roots .

HY-121632R

Quinoclamine (Standard)	NF-κB	Cancer
Quinoclamine (Standard) is the analytical standard of Quinoclamine. This product is intended for research and analytical applications. Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity .

HY-N10200

2,7-Dimethoxy-6-(1-acetoxyethyl)juglone	Others	Others
2,7-Dimethoxy-6-(1-acetoxyethyl)juglone is a naphthoquinone derivative found in the fungus Kirschsteiniothelia species .

HY-B0332

Menadione Maximum Cited Publications 17 Publications Verification Vitamin K3	Endogenous Metabolite	Cancer
Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer .

HY-B0332R

Menadione (Standard)	Endogenous Metabolite	Others
Menadione (Standard) is the analytical standard of Menadione. This product is intended for research and analytical applications. Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer .

HY-108011

Naftazone	Others	Cardiovascular Disease
Naftazone is a naphthoquinone derivative, it can be used for the research of venous insufciency. Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation .

HY-N3488

Isodiospyrin	Topoisomerase Bacterial Fungal	Infection Cancer
Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities .

HY-N6961

Lapachol 2 Publications Verification	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite	Infection Inflammation/Immunology Cancer
Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .

HY-U00094

INO5042	Others	Inflammation/Immunology
INO5042, a thiazole fused 1,4-naphthoquinone compound, and exhibits anti-inflammation activity .

HY-N6961R

Lapachol (Standard)	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite	Infection Inflammation/Immunology Cancer
Lapachol (Standard) is the analytical standard of Lapachol. This product is intended for research and analytical applications. Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .

HY-149938

Antimalarial agent 25	Parasite	Infection
Antimalarial agent 25 is an orally active 1,4-naphthoquinones derivative with antimalarial activity. Antimalarial agent 25 shows cytotoxicity against P. falciparum. Antimalarial agent 25 inhibits P. burghei induced parasitemia in vivo .

HY-149939

Antimalarial agent 26	Parasite	Infection
Antimalarial agent 26 is an orally active 1,4-naphthoquinones derivative with antimalarial activities. Antimalarial agent 26 shows cytotoxicity against P. falciparum and selectivity over mammalian cell lines. Antimalarial agent 26 inhibits P. burghei induced parasitemia in vivo .

HY-N2188

Beta-Acetoxyisovalerylshikonin 1 Publications Verification	Others	Inflammation/Immunology
Beta-Acetoxyisovalerylshikonin is a naphthoquinone derivative isolated from Arnebia euchroma .

HY-N7526

Naphthazarin 1 Publications Verification DHNQ; 5,8-Dihydroxy-1,4-naphthoquinone	Apoptosis	Neurological Disease Cancer
Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects .

HY-N1497

Plumbagin 1 Publications Verification 2-Methyljuglone	Others	Cancer
Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities .

HY-B0332S

Menadione-d3 Vitamin K3-d₃	Endogenous Metabolite	Others
Menadione-d₃ is the deuterium labeled Menadione. Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo.

HY-N2552

Vitamin K5 hydrochloride	Others	Infection
Vitamin K5 (hydrochloride) is a naphthoquinones compound, shows trichomonacidal activity in vitro. Vitamin K5(hydrochloride) can be used for the research of anti-infection .

HY-N2493S

Lawsone-d4	Isotope-Labeled Compounds Fungal	Infection
Lawsone-d₄ is the deuterium labeled Lawsone. Lawsone is a naphthoquinone dye isolated from leaves of Lawsonia inermis that shows antimicrobial and antioxidant activity[1].

HY-N11778

Bequinostatin C	Bacterial	Infection
Bequinostatin C is a naphthoquinone originally isolated from Streptomyces and a glutathione S-transferase pi 1 (GSTP1) inhibitor (IC₅₀=40 μg/mL for human GSTP1).

HY-13555

β-Lapachone 5+ Cited Publications ARQ-501; NSC-26326	Indoleamine 2,3-Dioxygenase (IDO) Topoisomerase Autophagy Apoptosis	Cancer
β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.

HY-N3550

Catalponol	Others	Cancer
Catalponol is a naphthoquinone derivative. Catalponol enhances dopamine biosynthesis by inducing tyrosine hydroxylase activity. Catalponol also increases the levels of cAMP and tyrosine hydroxylase phosphorylation in PC12 cells .

HY-N1497R

Plumbagin (Standard)	Others	Cancer
Plumbagin (Standard) is the analytical standard of Plumbagin. This product is intended for research and analytical applications. Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities .

HY-N8248

Eleutherin (+)-Eleutherin	Topoisomerase	Cardiovascular Disease
Eleutherin is a type of naphthoquinone derivative with the protective effect against the injury ofhuman umbilical vein endothelial cells (HUVECs), which can be isolated from the edible bulbs of Eleutherine americana (Hong-Cong) .

HY-128105

1,2-Dihydroxynaphthalene	Others	Others
1,2-Dihydroxynaphthalene is an intermediate isolated from the metabolism of naphthalene and has been shown to be a precursor to the formation of naphthoquinones. 1,2-Dihydroxynaphthalene can be further metabolized by some bacteria (such as Pseudomonas) to compounds such as coumarins and salicylic acid .

HY-118896

Acequinocyl AKD-2023; DPX-3792	Parasite	Infection
Acequinocyl (CRM) is a certified reference material categorized as a naphthoquinone acaricide.1 Acequinocyl has been found in Cannabis. Formulations containing acequinocyl have been used to control mite populations in agriculture. This product is intended for research and forensic applications.

HY-N2493

Lawsone 1 Publications Verification	Fungal Apoptosis	Infection Cancer
Lawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce apoptosis. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research .

HY-19738

NQTrp	Tau Protein	Neurological Disease
NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide ( ⁴¹GCWMLY ⁴⁶ within the N-terminus of γD-crystallin) as well as full-length γD-crystallin .

HY-121684

Ramentaceone 7-Methyljuglon	PI3K Apoptosis	Cancer
Ramentaceone (7-Methyljuglon), a naphthoquinone that can be isolated from Drosera sp., inhibits PI3K activity. Ramentaceone (7-Methyljuglon) reduces the expression of the PI3K protein and inhibits the phosphorylation of the Akt protein in breast cancer cells. Ramentaceone (7-Methyljuglon) induces apoptosis .

HY-118896R

Acequinocyl (Standard)	Parasite	Infection
Acequinocyl (Standard) is the analytical standard of Acequinocyl. This product is intended for research and analytical applications. Acequinocyl (CRM) is a certified reference material categorized as a naphthoquinone acaricide.1 Acequinocyl has been found in Cannabis. Formulations containing acequinocyl have been used to control mite populations in agriculture. This product is intended for research and forensic applications.

HY-N5112B

β,β-Dimethylacrylshikonin 1 Publications Verification Isoarnebin I	HIF/HIF Prolyl-Hydroxylase	Cancer
β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative isolated from Lithospermum erythrorhizon Sieb. et Zucc. , promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway.β,β-Dimethylacrylshikonin has anti-tumor activity .

HY-N8248A

(-)-Eleutherin	Others	Cancer
(-)-Eleutherin is a pyranonaphthoquinone derivative that exhibits cytotoxic activity by inhibiting DNA topoisomerase II. (-)-Eleutherin has been shown to have promising potential as a medicinal compound due to its association with naphthoquinones. (-)-Eleutherin demonstrates significant DNA fragmentation rates, indicating its strong cytotoxic effects on cells. Additionally, (-)-Eleutherin possesses higher antioxidant potential compared to control samples, contributing to its therapeutic efficacy.

HY-P0009A

Cetrorelix Acetate 1 Publications Verification SB-75 acetate	GnRH Receptor	Neurological Disease Endocrinology
Cetrorelix Acetate (SB-75 acetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC₅₀ of 1.21 nM .

HY-P0009B

Cetrorelix diacetate SB-75 diacetate	GnRH Receptor	Neurological Disease Endocrinology
Cetrorelix diacetate (SB-075 diacetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC₅₀ of 1.21 nM .

HY-126596

Angelylalkannin	Apoptosis	Cancer
Angelylalkannin is a naphthoquinone compound isolated from the root of Alkanna tinctoria. Angelylalkannin showed significant inhibitory effects in the antiproliferative effect test on human colon cancer cells HCT-116 and SW-480. The median inhibitory concentration (IC50) of Angelylalkannin was 4.76 mM for HCT-116 cells and 7.03 mM for SW-480 cells. Like alkannin, Angelylalkannin can arrest the cell cycle in the G1 phase and induce apoptosis at a concentration of 1-10 mM.

HY-131374

TN14003	CXCR	Cancer
TN14003 is a CXCR4 inhibitor. TN14003 has antitumor activity .

HY-P0171

Motixafortide 2 Publications Verification BKT140 (4-fluorobenzoyl); BL-8040; TF14016	CXCR	Endocrinology Cancer
Motixafortide (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC₅₀ vakue of ～1 nM.

HY-146489

Anti-infective agent 3	Bacterial Parasite	Infection
Anti-infective agent 3 (compound 3l) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC₅₀ values of 0.47 and 0.13 μM, respectively. Anti-infective agent 3 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 4 μg/mL .

HY-P4452

PRL 2915	Somatostatin Receptor Urotensin Receptor	Endocrinology
PRL 2915 is a potent human somatostatin subtype 2 receptor (hsst₂) antagonist with a K_i of 12 nM .

HY-146487

Anti-infective agent 1	Bacterial Parasite	Infection
Anti-infective agent 1 (compound 3a) is a potent and selective antiprotozoal and antimycobacterial agent. Anti-infective agent 1 shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC₅₀ values of 10.95 and 0.06 μM, respectively. Anti-infective agent 1 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 8 μg/mL .

HY-146488

Anti-infective agent 2	Parasite Bacterial	Infection
Anti-infective agent 2 (compound 3k) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC₅₀ values of 0.07 and 2.20 μM, respectively. Anti-infective agent 2 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 32 μg/mL .

Cat. No.	Product Name	Category	Target	Chemical Structure