Search Result

Results for "

phosphorylase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Kinase (1) Antibiotic (3) Apoptosis (6) Autophagy (1) Bacterial (2) Biochemical Assay Reagents (2) CaMK (1) DNA/RNA Synthesis (5) Endogenous Metabolite (11) Fluorescent Dye (1) Fungal (1) HIV (2) Influenza Virus (1) Isotope-Labeled Compounds (1) Methionine Adenosyltransferase (MAT) (2) Nucleoside Antimetabolite/Analog (17) Orthopoxvirus (1) Phosphatase (2) PKA (4) PKC (6) Thymidylate Synthase (2) Trk Receptor (1)
By Research Areas:	Cancer (28) Cardiovascular Disease (1) Endocrinology (3) Infection (7) Inflammation/Immunology (4) Metabolic Disease (15) Neurological Disease (3)

By Targets:

Adenosine Kinase (1)

Antibiotic (3)

Apoptosis (6)

Autophagy (1)

Bacterial (2)

Biochemical Assay Reagents (2)

CaMK (1)

DNA/RNA Synthesis (5)

Endogenous Metabolite (11)

Fluorescent Dye (1)

Fungal (1)

HIV (2)

Influenza Virus (1)

Isotope-Labeled Compounds (1)

Methionine Adenosyltransferase (MAT) (2)

Nucleoside Antimetabolite/Analog (17)

Orthopoxvirus (1)

Phosphatase (2)

PKA (4)

PKC (6)

Thymidylate Synthase (2)

Trk Receptor (1)

By Research Areas:

Cancer (28)

Cardiovascular Disease (1)

Endocrinology (3)

Infection (7)

Inflammation/Immunology (4)

Metabolic Disease (15)

Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2757

Phosphorylase kinase PhK	Others	Others
Phosphorylase kinase (PhK) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2735

Phosphorylase b	Others	Metabolic Disease
Phosphorylase b is one of the two forms of phosphorylase present in skeletal muscle. The other is Phosphorylase a, which can be transformed into one another. The conversion process requires the addition of divalent metal ions and ATP .

HY-128029

*Glycogen phosphorylase-IN-1*	Others	Metabolic Disease
Glycogen phosphorylase-IN-1 (Compound 42) is an inhibitor for human liver glycogen phosphorylase (hlGPa) and hepatocyte glycogen-derived glucose production with IC₅₀s of 53 and 380 nM, respectively. Glycogen phosphorylase-IN-1 reveals efficacy towards type 2 diabetes .

HY-P2753

Sucrose phosphorylase SP	Endogenous Metabolite	Others
Sucrose phosphorylase is a bacterial transglucosidase that catalyzes the conversion of sucrose and phosphate into α-D-glucose-1-phosphate and D-fructose. The glucosylated Sucrose phosphorylase can also be hydrolyzed into α-D-glucose, or transfer the glucoyl to the hydroxyl group of the receptor, and then decomposed into new α-D-glucoside products. The enzymatic activity of base phosphorylase to substrate and product is weak .

HY-P2916

Thymidine phosphorylase	Others	Others
Thymidine phosphorylase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2724

*Purine nucleoside phosphorylase, Microorganism* PNP	Endogenous Metabolite	Metabolic Disease
Purine nucleoside phosphorylase, Microorganism (PNP) is a key enzyme in purine metabolism, which is involved in the purine rescue pathway. The deficiency of Purine nucleoside phosphorylase resulted in impaired T cell function. In the presence of inorganic orthophosphate as the second substrate, Purine nucleoside phosphorylase catalyzes the breaking of the glycosidic bond between ribose and deoxyribonucleoside to generate purine base and ribose (deoxyribose) -1-phosphate .

HY-P3178

Pyrimidine nucleoside phosphorylase	Others	Others
Pyrimidine nucleoside phosphorylase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2741

Maltose phosphorylase E.C. 2.4.1.8	Endogenous Metabolite	Metabolic Disease
Maltose phosphorylase is a dimerase which catalyzes the transformation of maltose and inorganic phosphate into β-D-glucose-1-phosphate and glucose. Maltose phosphorylases have been classified in family 65 of the glycoside hydrolases .

HY-127018A

Maltoheptaose hydrate	Others	Metabolic Disease
Maltoheptaose hydrate is an activator of phosphorylase B to prepare heptulose-2-phosphate. Maltoheptaose hydrate is a maltooligosaccharide contanins seven glucose units .

HY-127018

Maltoheptaose	Others	Metabolic Disease
Maltoheptaose is an activator of phosphorylase B to prepare heptulose-2-phosphate. Maltoheptaose is a maltooligosaccharide contanins seven glucose units .

HY-E70033

*D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase* (BiGalHexNAcP)**	Endogenous Metabolite	Metabolic Disease
D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP) is a member of CAZy glycoside hydrolase GH112 family, is often used in biochemical studies. D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP) catalyses the phosphorolysis of lacto-n-biose and galacto-n-biose, to produce Gal-1-P and the corresponding N-acetyl-D-hexosamine .

HY-147969

Antiangiogenic agent 2	Nucleoside Antimetabolite/Analog	Cancer
Antiangiogenic agent 2 (compound 3b) is a potent thymidine phosphorylase inhibitor, with an IC₅₀ of 39.71 μM. Antiangiogenic agent 2 shows anti-angiogenic activity .

HY-106406

Benzylacyclouridine BAU; 5-Benzylacyclouridine	Others	Cancer
Benzylacyclouridine (BAU) is a potent and specific inhibitor of uridine phosphorylase, the first enzyme in the catabolism of uridine. Benzylacyclouridine can modulate the cytotoxic side effects of 5-fluorouracil (5-FU) and its derivatives .

HY-108614

GPi688	Others	Metabolic Disease
GPi688 is a potent and orally active *glycogen phosphorylase* (GPa) inhibitor with IC₅₀**s of 19 nM, 61 nM and 12 nM for human liver GPa, rat liver GPa and human skeletal muscle GPa, respectively . GPi688 can inhibit glucagons-mediated glucose output in rat primary hepatocytes. GPi688 can be used for researching glucagon-mediated hyperglycaemia .

HY-P1821

Myelin Basic Protein MHP4-14	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-W039442

2′-Deoxy-2′-fluoroadenosine	Nucleoside Antimetabolite/Analog	Cancer
2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP .

HY-P1821A

Myelin Basic Protein TFA 1 Publications Verification MHP4-14 TFA	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-106934A

Peldesine dihydrochloride 1 Publications Verification BCX 34 dihydrochloride	Nucleoside Antimetabolite/Analog HIV	Infection Inflammation/Immunology Cancer
Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active *purine nucleoside phosphorylase* (PNP) inhibitor with IC₅₀s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC₅₀ of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV** infection research .

HY-106934

Peldesine BCX 34	Nucleoside Antimetabolite/Analog HIV	Infection Inflammation/Immunology Cancer
Peldesine (BCX 34) is a potent, competitive, reversible and orally active *purine nucleoside phosphorylase* (PNP) inhibitor with IC₅₀s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine is also a T-cell proliferation inhibitor with an IC₅₀ of 800 nM. Peldesine has the potential for cutaneous T-cell lymphoma, psoriasis and HIV** infection research .

HY-B0307A

Idoxuridine hydrate 5-Iodo-2′-deoxyuridine hydrate; 5-IUdR hydrate; IdUrd hydrate	Phosphatase	Infection
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate is an iodinated thymidine analogue that competitively inhibits *phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase* and affecting viral replication. Idoxuridine against feline herpesvirus has the IC₅₀ value of 4.3 μM .

HY-B0307

Idoxuridine 3 Publications Verification 5-Iodo-2′-deoxyuridine; 5-IUdR; IdUrd	Phosphatase Orthopoxvirus	Infection Cancer
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits *phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase* and affecting viral replication. Idoxuridine against feline herpesvirus has the IC₅₀ value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.

HY-19396

Ingliforib 1 Publications Verification CP 368296; GPi 296	Others	Cardiovascular Disease
Ingliforib (CP 368296) is a glycogen phosphorylase inhibitor, with IC₅₀s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.

HY-B0016S

Capecitabine-d11	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Capecitabine-d₁₁ is the deuterium labeled Capecitabine. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase[1][2].

HY-A0063A

Tipiracil 5 Publications Verification	Thymidylate Synthase Nucleoside Antimetabolite/Analog	Cancer
Tipiracil is a thymidine phosphorylase (TPase) inhibitor.

HY-100320

AVE5688	Others	Metabolic Disease
AVE5688 is an inhibitor of *glycogen phosphorylase* (GP), with IC₅₀s of 430 nM and 915 nM and K_d*s of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase* (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.

HY-A0063

Tipiracil hydrochloride 5 Publications Verification	Nucleoside Antimetabolite/Analog	Cancer
Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

HY-108615

CP-316819 GPi 819	Others	Endocrinology
CP 316819 is a potent *glycogen phosphorylase* (GPase) inhibitor with antihyperglycemic effect (IC₅₀** values are 17 and 34 nM against human skeletal muscle glycogen phosphorylase (huSMGPa) and liver glycogen phosphorylase (huLGPa) respectively).CP 316819 causes glycogen accumulation under normoglycemic conditions but permits glycogen utilization when glucose concentrations are low.CP-316819 prevents neuronal cell death and maintains brain electrical currents .

HY-N1932

Bayogenin	Others	Metabolic Disease
Bayogenin is an alfalfa saponin, shows moderate potency of glycogen phosphorylase inhibition .

HY-B0016

Capecitabine 15+ Cited Publications	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.

HY-101496

MT-DADMe-ImmA 2 Publications Verification MTDIA; Methylthio-DADMe-Immucillin A	Others	Cancer
MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a K_i of 90 pM.

HY-121106

9-Deazaguanine 1 Publications Verification	Others	Others
9-Deazaguanine is a nucleoside analog with potent inhibitory activity against purine nucleoside phosphorylase (PNP) .

HY-W008638

2'-Deoxyinosine 1 Publications Verification	Endogenous Metabolite	Metabolic Disease Cancer
2’-deoxyadenosine inhibits the growth of human colon-carcinoma cell lines and is found to be associated with purine nucleoside phosphorylase (PNP) deficiency.

HY-A0063R

Tipiracil hydrochloride (Standard)	Nucleoside Antimetabolite/Analog	Cancer
Tipiracil (hydrochloride) (Standard) is the analytical standard of Tipiracil (hydrochloride). This product is intended for research and analytical applications. Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

HY-15424

5-Iodotubercidin 5+ Cited Publications NSC 113939; 5-ITu	Adenosine Kinase	Cancer
5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC₅₀ of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .

HY-134529

D-Ribofuranose1-dihydrogenphosphate Ribose 1-phosphate	Endogenous Metabolite	Others
D-Ribofuranose1-dihydrogenphosphate, also known as ribose 1-phosphate, is the material for the synthesis of 5-fluorouracil (FUra) by uridine phosphorylase .

HY-19480

Ulodesine BCX4208	Endogenous Metabolite	Metabolic Disease
Ulodesine is a *purine nucleoside phosphorylase* (PNP) inhibitor. Ulodesine inhibits PNP with IC₅₀** value of 2.293 nM/L. Ulodesine can be used for the research of hyporucicemia .

HY-134529A

D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine Ribose 1-phosphate dicyclohexanamine	Endogenous Metabolite	Others
D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine, also known as ribose 1-phosphate, is the material for the synthesis of 5-fluorouracil (FUra) by uridine phosphorylase .

HY-B0016R

Capecitabine (Standard)	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Capecitabine (Standard) is the analytical standard of Capecitabine. This product is intended for research and analytical applications. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.

HY-W008907

5'-O-Tritylthymidine 5-OTT	Biochemical Assay Reagents	Cancer
5'-O-Tritylthymidine is an inhibitor of TK-2 and inhibits angiogenesis . 5'-O-Tritylthymidine targets FAK-Mdm-2 interactions, decreasing cell viability and increasing apoptosis.

HY-B0021S

Doxifluridine-d2 Ro 21-9738-d₂; 5-Fluoro-5'-deoxyuridine-d₂; 5'-DFUR-d₂	Nucleoside Antimetabolite/Analog	Cancer
Doxifluridine-d₂ is the deuterium labeled Doxifluridine[1]. Doxifluridine is a thymidine phosphorylase activator for PC9-DPE2 cells with IC50 of 0.62 μM.

HY-111627

5-Aza-7-deazaguanine 1 Publications Verification	Nucleoside Antimetabolite/Analog	Cancer
5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides .

HY-118047

CI 972 anhydrous	Nucleoside Antimetabolite/Analog	Inflammation/Immunology
CI 972 anhydrous is a potent, orally active, and competitive inhibitor of *purine nucleoside phosphorylase* (PNP) (K_i**=0.83 μM) under development as a T cell-selective immunosuppressive agent .

HY-13525

CP-91149 2 Publications Verification	Others	Metabolic Disease Cancer
CP-91149 is a GP (glycogen phosphorylase) inhibitor. CP-91149 promotes glycogen resynthesis, but not its overaccumulation. CP-91149 has the potential for Type II (insulin-dependent) diabetes study .

HY-113468

3-O-Methyl-DL-DOPA 3-Methoxytyrosine	Endogenous Metabolite	Neurological Disease
3-O-Methyl-DL-DOPA is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Epilepsy, Purine Nucleoside Phosphorylase Deficiency and Aromatic L Amino Acid Decarboxylase Deficiency .

HY-W010854

*2'-Deoxyadenosine 5'-di-phos-phate disodium* dADP disodium	DNA/RNA Synthesis	Others
2'-Deoxyadenosine 5'-di-phos-phate disodium (dADP disodium) is an inhibitor of bacterial poly(A) polymerase. It can be used to synthesize deoxyadenosine oligonucleotides with Escherichia coli polynucleotide phosphorylase and other enzymes .

HY-D0995

7-Methyl-6-thioguanosine 2 Publications Verification MESG	Fluorescent Dye	Others
7-Methyl-6-thioguanosine (MESG) is a chromophoric substrate which can be used for the quantitation of inorganic phosphate. 7-Methyl-6-thioguanosine is also used to determine the activity of purine nucleoside phosphorylase .

HY-E70373

λ Protein phosphatase	Biochemical Assay Reagents	Others
λ Protein phosphatase is a serine/threonine phosphatase encoded by bacteriophage Lambda. λ Protein phosphatase is activated with requirement for divalent cations, such as Mn ²⁺. λ Protein phosphatase is able to dephosphorylate casein, adenovirus E1A protein, and the α subunit of phosphorylase kinase

HY-111926

N6-Methyladenosine 5'-monophosphate disodium salt	Others	Metabolic Disease
N6-Methyladenosine 5'-monophosphate disodium salt is an activator of *glycogen phosphorylase* b, with a K_a** value of 22 µM . N6-Methyladenosine 5'-monophosphate disodium salt is a non-competitive rat adenylate kinase II inhibitor .

HY-N10518

Celloheptaose	Others	Others
Celloheptaose is an oligosaccharide, consisting of seven glucose residues. Celloheptaose is the substrate of Polysaccharide monooxygenases (PMOs), to generate oxidized cellulo-oligosaccharides .

HY-15141

Staurosporine Maximum Cited Publications 94 Publications Verification Antibiotic AM-2282; STS; AM-2282	PKC PKA Apoptosis Bacterial Fungal Antibiotic	Infection Cancer
Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer .

Cat. No.	Product Name

HY-L044

Nucleotide Compound Library

513 compounds

Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications.

MCE offers a unique collection of 513 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

Cat. No.	Product Name	Type

HY-D0995

7-Methyl-6-thioguanosine 2 Publications Verification MESG	Chromogenic Substrates
7-Methyl-6-thioguanosine (MESG) is a chromophoric substrate which can be used for the quantitation of inorganic phosphate. 7-Methyl-6-thioguanosine is also used to determine the activity of purine nucleoside phosphorylase .

Cat. No.	Product Name	Type

HY-W008907

5'-O-Tritylthymidine 5-OTT	Gene Sequencing and Synthesis
5'-O-Tritylthymidine is an inhibitor of TK-2 and inhibits angiogenesis . 5'-O-Tritylthymidine targets FAK-Mdm-2 interactions, decreasing cell viability and increasing apoptosis.

HY-W010854

*2'-Deoxyadenosine 5'-di-phos-phate disodium* dADP disodium	Gene Sequencing and Synthesis
2'-Deoxyadenosine 5'-di-phos-phate disodium (dADP disodium) is an inhibitor of bacterial poly(A) polymerase. It can be used to synthesize deoxyadenosine oligonucleotides with Escherichia coli polynucleotide phosphorylase and other enzymes .

Cat. No.	Product Name	Target	Research Area

HY-P1597

Malantide	PKA PKC	Cancer
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a K_m of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide is also an efficient substrate for PKC with a K_m of 16 μM .

HY-P1873

Phosphorylase Kinase β-Subunit Fragment (420-436)	Peptides	Endocrinology
Phosphorylase Kinase β-Subunit Fragment (420-436) is the β-Subunit fragment (peptide 430-436) of phosphorylase kinase. Phosphorylase kinase is a serine/threonine-specific protein kinase which activates glycogen phosphorylase to release glucose-1-phosphate from glycogen .

HY-P1821

Myelin Basic Protein MHP4-14	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-P1597A

Malantide TFA	PKA PKC	Cancer
Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a K_m of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide TFA is also an efficient substrate for PKC with a K_m of 16 μM .

HY-P3570

Adipokinetic hormone II (Locusta migratoria) Lom-AKH-II	Endogenous Metabolite	Metabolic Disease
Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs) .

HY-P3572

Adipokinetic hormone I (Locusta migratoria) Lom-AKH-I	Endogenous Metabolite	Endocrinology
Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1932

Bayogenin	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Plants Bolbostemma paniculaum (Maxim)Franguet Disease Research Fields	Others
Bayogenin is an alfalfa saponin, shows moderate potency of glycogen phosphorylase inhibition .

HY-W008638

2'-Deoxyinosine 1 Publications Verification	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2’-deoxyadenosine inhibits the growth of human colon-carcinoma cell lines and is found to be associated with purine nucleoside phosphorylase (PNP) deficiency.

HY-19480

Ulodesine BCX4208	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Ulodesine is a *purine nucleoside phosphorylase* (PNP) inhibitor. Ulodesine inhibits PNP with IC₅₀** value of 2.293 nM/L. Ulodesine can be used for the research of hyporucicemia .

HY-134529

D-Ribofuranose1-dihydrogenphosphate Ribose 1-phosphate	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D-Ribofuranose1-dihydrogenphosphate, also known as ribose 1-phosphate, is the material for the synthesis of 5-fluorouracil (FUra) by uridine phosphorylase .

HY-134529A

D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine Ribose 1-phosphate dicyclohexanamine	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine, also known as ribose 1-phosphate, is the material for the synthesis of 5-fluorouracil (FUra) by uridine phosphorylase .

HY-113468

3-O-Methyl-DL-DOPA 3-Methoxytyrosine	Structural Classification Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-O-Methyl-DL-DOPA is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Epilepsy, Purine Nucleoside Phosphorylase Deficiency and Aromatic L Amino Acid Decarboxylase Deficiency .

HY-N10518

Celloheptaose	Structural Classification Natural Products Microorganisms Classification of Application Fields Other Diseases Disease Research Fields	Others
Celloheptaose is an oligosaccharide, consisting of seven glucose residues. Celloheptaose is the substrate of Polysaccharide monooxygenases (PMOs), to generate oxidized cellulo-oligosaccharides .

HY-15141

Staurosporine Maximum Cited Publications 94 Publications Verification Antibiotic AM-2282; STS; AM-2282	Infection Alkaloids Structural Classification Microorganisms Classification of Application Fields Marine natural products Source classification Marine microorganism Disease Research Fields Indole Alkaloids	PKC PKA Apoptosis Bacterial Fungal Antibiotic
Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer .

HY-100126

Tubercidin 4 Publications Verification 7-Deazaadenosine	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic
Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC₅₀ of 0.02 μM . Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis . Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP . Tubercidin has antiviral activity .

HY-N6732

K-252a 10+ Cited Publications SF2370; Antibiotic K 252a; Antibiotic SF 2370	Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Indole Alkaloids	PKC PKA CaMK Trk Receptor Autophagy Antibiotic
K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca ²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively . K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene .

Species:	Human (4)
Tag:	His (4) Tag Free (2) GST (2)
Source:	Sf9 insect cells (2) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P74665

	*Nucleoside phosphorylase/PNP Protein, Human (His)* Purine nucleoside phosphorylase; PNP; Inosine phosphorylase; NP	Human	E. coli
	Nucleoside phosphorylase/PNP proteins play a vital role in cellular processes by catalyzing the phosphate breakdown of β-(deoxy)ribonucleosides, preferably 6-oxopurine nucleosides, such as inosine and guanosine. This enzymatic activity results in the formation of free purine bases and pentose 1-phosphate, highlighting the importance of this protein in regulating nucleoside degradation. Nucleoside phosphorylase/PNP Protein, Human (His) is the recombinant human-derived Nucleoside phosphorylase/PNP protein, expressed by E. coli , with C-10*His labeled tag. The total length of Nucleoside phosphorylase/PNP Protein, Human (His) is 289 a.a., with molecular weight of ~33.5 kDa.

HY-P702665

	PHKG1 Protein, Human (Active, sf9, GST) PHKG1; phosphorylase kinase, gamma 1 (muscle); phosphorylase kinase, gamma 1 (muscle); phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform; phosphorylase kinase gamma; phosphorylase kinase subunit gamma-1; EC 2.7.11.19	Human	Sf9 insect cells

HY-P701740

	PHKG2 Protein, Human (Sf9, GST) PHKG2; phosphorylase b kinase gamma catalytic chain; liver/testis isoform; PHK-gamma-LT; PHK-gamma-T; PSK-C3; phosphorylase kinase subunit gamma-2	Human	Sf9 insect cells
	As the catalytic subunit of phosphorylase b kinase (PHK), PHKG2 plays a crucial role in the neural and hormonal regulation of glycogenolysis (glycogen breakdown) by phosphorylating and activating glycogen phosphorylase. Furthermore, PHKG2 has a potential role in regulating testicular glycogenolysis. PHKG2 Protein, Human (Sf9, GST) is the recombinant human-derived PHKG2 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of PHKG2 Protein, Human (Sf9, GST) is 405 a.a., .

HY-P701897

	*glycogen phosphorylase* Protein, Pyrococcus furiosus** Glycogen phosphorylase	Others	E. coli

HY-P701898

	*glycogen phosphorylase* Protein, Pyrococcus furiosus (His)** Glycogen phosphorylase	Others	E. coli

HY-P701869

	*Purine nucleoside phosphorylase* Protein, Thermus thermophilus** Purine nucleoside phosphorylase	Others	E. coli

HY-P701870

	*Purine nucleoside phosphorylase* Protein, Thermus thermophilus (His)** Purine nucleoside phosphorylase	Others	E. coli

HY-P71416

	UPP1 Protein, Human (His) UPP1 Protein; Uridine phosphorylase 1; UPP1	Human	E. coli
	UPP1 protein is a key member of the PNP/UDP phosphorylase family and plays an important role in cellular processes, especially nucleotide metabolism. UPP1 shares conserved features with related proteins and is involved in phosphorylase activity. UPP1 Protein, Human (His) is the recombinant human-derived UPP1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of UPP1 Protein, Human (His) is 173 a.a., with molecular weight of ~21 kDa.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure