Search Result

Results for "

protein synthesis activities

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (25) ADC Cytotoxin (2) Amino Acid Derivatives (2) Amyloid-β (2) Antibiotic (76) Apoptosis (9) Aryl Hydrocarbon Receptor (1) ATP Synthase (1) Aurora Kinase (1) AUTACs (1) Autophagy (1) Bacterial (83) Bcl-2 Family (1) Biochemical Assay Reagents (5) Calcium Channel (2) Caspase (1) CDK (3) COX (2) Dengue Virus (1) Deubiquitinase (1) Drug Derivative (1) Drug Intermediate (4) Drug Metabolite (1) Drug-Linker Conjugates for ADC (2) EBV (1) Endogenous Metabolite (20) Enterovirus (2) Epigenetic Reader Domain (1) Ferroptosis (2) Flavivirus (2) Fluorescent Dye (1) Fungal (4) HCV (3) HDAC (1) Histone Demethylase (1) Histone Methyltransferase (1) HIV (1) HSP (1) HSV (10) Influenza Virus (6) Isotope-Labeled Compounds (10) Keap1-Nrf2 (2) Ligands for Target Protein for PROTAC (6) Lipoxygenase (2) Mitophagy (1) mTOR (3) NF-κB (2) NO Synthase (2) Notch (1) Nucleoside Antimetabolite/Analog (1) PARP (1) PDI (1) Penicillin-binding protein (PBP) (4) Phospholipase (2) Raf (1) RET (1) RSV (2) SOD (1) STING (1) TMV (1) TNF Receptor (1) Topoisomerase (5)
By Research Areas:	Cancer (55) Cardiovascular Disease (1) Infection (100) Inflammation/Immunology (13) Metabolic Disease (10) Neurological Disease (6)
Oligonucleotides:	Nucleotides and their Analogs (1) Nucleosides and their Analogs (1) Polymers (1)

153

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: DNA/RNA Synthesis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2301

Pleuromutilin Drosophilin B; Mutilin 14-glycolate	Antibiotic Bacterial	Infection
Pleuromutilin (Drosophilin B) exhibits antibacterial activity through inhibition of protein synthesis .

HY-20559

4-Chloro-3-nitrobenzoic acid	Biochemical Assay Reagents	Others
4-Chloro-3-nitrobenzoic acid has oral activity，and oral administration can affect the synthesis activity of liver proteins and the activities of urokinase and histidine kinase .

HY-Y0017

L-Norleucine (S)-2-Aminohexanoic acid; (S)-Norleucine	Influenza Virus Endogenous Metabolite	Infection Cancer
L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

HY-N0862

Harringtonine 10+ Cited Publications	Influenza Virus	Infection Cancer
Harringtonine is a natural Cephalotaxus alkaloid that inhibits **protein synthesis. Harringtonine has anti-chikungunya virus (CHIKV)** activities with an EC₅₀ of 0.24 μM.

HY-N7089

Benzoyleneurea 1 Publications Verification quinazolinedione	Bacterial	Infection
Benzoyleneurea possesses anti-bacterial activity. Benzoyleneurea scaffold can be used in the synthesis of novel protein geranylgeranyltransferase-I (PGGTase-I) inhibitors .

HY-N15147

Panax saponin C	DNA/RNA Synthesis	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Panax saponin C is a ginsenoside found in Ginseng with biological activities including regulatory effects on immunomodulation, protection functions in the central nervous and cardiovascular systems, anti-diabetic, anti-aging, anti-carcinogenic, anti-fatigue, anti-pyretic, anti-stress, boosting physical vitality, and promotion of DNA, RNA, and protein synthesis activities .

HY-135130

Bischloroanthrabenzoxocinone (-)-BABX	Bacterial	Infection
Bischloroanthrabenzoxocinone is a potent *Type II fatty acid synthesis* (FASII)** inhibitor. Bischloroanthrabenzoxocinone inhibits fatty acid synthesis. Bischloroanthrabenzoxocinone shows antibacterial activities and inhibits phospholipid, DNA, RNA, protein, and cell wall synthesis .

HY-161805

GNF-2-acid	Flavivirus	Infection
GNF-2-acid is a target protein ligand activity control that can be used for the synthesis of PROTACs (HY-161806) .

HY-120383

Amicetin Sacromycin; U-4761	Antibiotic Bacterial	Infection
Amicetin is a potent antibiotic. Amicetin shows antibiotic activities against gram-positive bacteria. Amicetin inhibits protein synthesis .

HY-120760

L-691831	Lipoxygenase	Others
L-691831 is a ligand for 5-lipoxygenase activating protein binding assays that has utility as a tool for studying 5-lipoxygenase activating protein (FLAP) related activities. L-691831 can be used to measure the affinity of FLAP on the leukocyte membrane for leukotriene synthesis inhibitors, with binding being correlated with inhibition of leukotriene synthesis.

HY-113767

Momordin II	DNA/RNA Synthesis	Metabolic Disease
Momordin II, an oleanane-type triterpene glycoside, is a ribosome inactivating protein. Momordin II inhibits cell-free protein synthesis, releases adenine from rat liver ribosomes and from DNA, and has no RNase activity .

HY-105981

Cefempidone GR 50692; TA 5901	Antibiotic Bacterial	Infection
Cefempidone (GR 50692) is a third-generation cephalosporin antibiotic. Cefempidone exerts antibacterial activity by inhibiting penicillin-binding proteins in bacterial cell wall synthesis .

HY-B1228

Ribostamycin sulfate 1 Publications Verification Vistamycin sulfate	Bacterial Antibiotic PDI	Infection
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies

HY-W686760A

Bromamphenicol	Bacterial	Infection
Bromamphenicol (Compound Ib) is a derivative of chloramphenicol (HY-B0239), and exhibits antibacterial activity. Bromamphenicol binds to S50 ribosomal subunit, interfers with the activity of peptidyl transferase, and exhibits inhibitory activity against protein synthesis .

HY-149089

Antibacterial agent 138	Bacterial	Infection
Antibacterial agent 138 has excellent antibacterial activity to multi-drug resistant bacteria. Antibacterial agent 138 inhibits bacterial protein synthesis but bacterial cell walls .

HY-122588

Negamycin	Bacterial	Others
Negamycin is a compound with antibacterial activity that inhibits protein synthesis by binding to the head domain of the bacterial ribosomal small subunit, leading to cell death, and also promotes misreading of near-cognate codons.

HY-144830

6BrCaQ	HSP	Cancer
6BrCaQ is a potent *mitochondrial heat shock protein* TRAP1** inhibitor, with antiproliferative activity. 6BrCaQ can be used in the synthesis of 6BrCaQ-TPP conjugates .

HY-163882

CUHK242	Bacterial DNA/RNA Synthesis	Infection
CUHK242 is a bacterial transcription inhibitor, with a MIC of 2 μg/mL for B. subtilis reporter strain BS2019. CUHK242 has antimicrobial activity against Staphylococcus aureus. CUHK242 can inhibit RNA synthesis in cells, thereby simultaneously reducing protein synthesis .

HY-121412

Lankacidin C	Antibiotic Bacterial	Infection Cancer
Lankacidin C is an inhibitor of **protein synthesis** in vitro. Lankacidin C inhibits the activity of L1210 leukemia, B16 melanoma and 6C3 HED/OG lymphosarcoma cell lines. Lankacidin C has antibacterial activity and antitumor activity .

HY-152861

Dazostinag TAK-676 free base	STING	Cancer
Dazostinag (TAK-676 free base) is an agonist of stimulator of interferon genes (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis antibody-drug conjugates (ADCs) .

HY-W074006

Tris(2-cyanoethyl)phosphine	Biochemical Assay Reagents	Others
Tris(2-cyanoethyl)phosphine is a protein crosslinker. Tris(2-cyanoethyl)phosphine can be used to synthesis copper(I) complexes which shows antitumour activity .

HY-128907

MC-Val-Cit-PAB-clindamycin	Drug-Linker Conjugates for ADC	Cancer
MC-Val-Cit-PAB-clindamycin is a agent-linker conjugate for ADC with potent antitumor activity by using clindamycin (a protein synthesis inhibitor), linked via the ADC linker MC-Val-Cit-PAB.

HY-W017851

4-Phenyl-2-pyrrolidinone	Drug Intermediate	Neurological Disease
4-Phenyl-2-pyrrolidinone is a precursor and synthetic intermediate. 4-Phenyl-2-pyrrolidinone can be used as a precursor in the synthesis of compounds with anticonvulsant and nootropic activities and is an intermediate in the synthesis of bromodomain-containing protein 4 (BRD4) bromodomain 1 inhibitors .

HY-44432

Navitoclax-piperazine ABT-263-piperazine	Bcl-2 Family Ligands for Target Protein for PROTAC	Cancer
Navitoclax-piperazine is a Navitoclax analog. Navitoclax is a BCL-XL inhibitor. Navitoclax can be used as a target protein ligand (Ligands for Target Protein for PROTAC) to develop and design PROTAC BCL-XL degraders with anti-tumor activity. Navitoclax can be used in the synthesis of PROTAC DT2216 (HY-130604) .

HY-116010

Oleandomycin 1 Publications Verification	Bacterial Antibiotic	Infection
Oleandomycin is a macrolide antibiotic structurally closely related to Erythromycin. Oleandomycin is similar to Erythromycin with antimicrobial activity. Oleandomycin inhibits protein synthesis by interference with translation of activated amino acids to nascent peptide chains on the ribosomes .

HY-148127

TAM558	Drug-Linker Conjugates for ADC	Cancer
TAM558 is a payload molecule used for the synthesis of OMTX705. OMTX705 is a humanized anti-fibroblast-activating protein (FAP) antibody conjugated to the cytolysin TAM470 (HY-148128), with antitumor activity .

HY-116010A

Oleandomycin phosphate	Antibiotic Bacterial	Infection
Oleandomycin phosphate is a macrolide antibiotic structurally closely related to Erythromycin. Oleandomycin is similar to Erythromycin with antimicrobial activity. Oleandomycin inhibits protein synthesis by interference with translation of activated amino acids to nascent peptide chains on the ribosomes .

HY-Y0017S

L-Norleucine-d9 (S)-2-Aminohexanoic acid-d₉; (S)-Norleucine-d₉	Isotope-Labeled Compounds Influenza Virus Endogenous Metabolite	Infection Cancer
L-Norleucine-d₉ is the deuterium labeled L-Norleucine. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

HY-10392

Sutezolid 4 Publications Verification PNU-100480; U-100480; PF-02341272	Bacterial Antibiotic	Infection
Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis .

HY-129337

Reveromycin A	Antibiotic Fungal Apoptosis	Infection Cancer
Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of **protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis** specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity .

HY-W005308

N-BOC-DL-serine methyl ester	Amino Acid Derivatives	Cancer
N-BOC-DL-serine methyl ester is a Serine derivative. N-BOC-DL-serine methyl ester is used for the synthesis of α,β-dehydro-α-amino acid. N-BOC-DL-serine methyl ester is also used for the synthesis of anti-cancer agent, such as quinazolinone derivative that inhibits PI3K activity, and tricyclic pyrolopyranopyridines that inhibits protein kinase activity .

HY-168868

RET ligand-2	RET Ligands for Target Protein for PROTAC	Cancer
RET ligand-2 is a selective RET inhibitor. RET ligand-2 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC RET degraders with antitumor activity. RET ligand-2 can be used for the synthesis of RD-23 (HY-168867) .

HY-N2036

Mosloflavone	TNF Receptor Enterovirus Bacterial	Infection
Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity. Mosloflavone? inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

HY-W235043

Methyl 3-oxodecanoate	DNA/RNA Synthesis	Infection
Methyl 3-Oxodecanoate has been shown to have virulence factor activity against human pathogens and is active against fluorescent haplophyllum and culture supernatant. Methyl 3-oxodecanoate has also been shown to inhibit DNA synthesis by inhibiting protein synthesis at the level of translation initiation. Reagent grade, for research purpose.

HY-W010104

L-Methionine sulfoxide H-Met(O)-OH	Endogenous Metabolite	Metabolic Disease
L-Methionine sulfoxide is an orally active oxidation product of Methionine (HY-N0326). L-Methionine sulfoxide can be partially converted into Methionine in the body and participate in the synthesis of glutathione in the liver. L-Methionine sulfoxide provides the body with sulfur activity and can participate in the synthesis of proteins and sulfur-containing compounds .

HY-168864

POI ligand 1	Ligands for Target Protein for PROTAC HDAC	Cancer
POI ligand 1 is a template for the non-selective HDAC inhibitor Vorinostat (HY-10221). POI ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC HDAC degraders with antitumor activity. POI ligand 1 can be used for the synthesis of FF2049 (HY-168863) .

HY-B0220S

Erythromycin-d6	Bacterial Antibiotic	Infection
Erythromycin-d₆ is the deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1].

HY-W555382

Pseudane IX 2-Nonylquinolin-4(1H)-one	HCV	Infection
Pseudane IX, a compound isolated from the leaves of Ruta angustifolia, has strong anti-HCV activity with an IC₅₀ value of 1.4 μg/mL. Pseudane IX reduces HCV RNA replication and viral protein synthesis levels .

HY-168440

Aurora-A ligand 1	Ligands for Target Protein for PROTAC Aurora Kinase	Cancer
Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (K_d) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439). HLB-0532259 shows anti-tumor activity against neuroblastoma .

HY-12480

Lanopepden GSK 1322322	Bacterial	Infection
Lanopepden (GSK 1322322) is a peptidyl peptidase (PDF) inhibitor. Lanopepden inhibits PDF activity, preventing bacterial protein synthesis, thereby exerting antibacterial activity. Lanopepden is primarily effective against Gram-positive bacteria. Lanopepden is used in the study of acute bacterial skin and skin structure infections .

HY-116598

Lanopepden mesylate GSK 1322322 mesylate	Bacterial	Infection
Lanopepden mesylate (GSK 1322322 mesylate) is a peptide deformase (PDF) inhibitor. Lanopepden mesylate has antibacterial activity by inhibiting the activity of PDF, preventing the correct synthesis of bacterial proteins. Lanopepden mesylate mainly targets Gram-positive bacteria. Lanopepden mesylate can be used in the study of acute bacterial skin and skin structural infections .

HY-13744

Rubitecan RFS 2000; 9-Nitrocamptothecin	Topoisomerase	Cancer
Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells .

HY-117682

L-(+)-threo-Chloramphenicol (+)-Chloramphenicol; Dextramycine; Dextromycetin	Antibiotic	Infection
L-(+)-threo-Chloramphenicol ((+)-Chloramphenicol) is the S,S-stereoisomer of Chloramphenicol (HY-B0239). L-(+)-Threo-chloramphenicol inhibits protein synthesis in reticulocytes. L-(+)-threo-Chloramphenicol also inhibits the oxidative activity of isolated mitochondria .

HY-Y0017R

L-Norleucine (Standard)	Influenza Virus Endogenous Metabolite	Infection Cancer
L-Norleucine (Standard) is the analytical standard of L-Norleucine. This product is intended for research and analytical applications. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

HY-B0220

Erythromycin 15+ Cited Publications	Bacterial Antibiotic DNA/RNA Synthesis	Infection Cancer
Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid ^[1][2]. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research ^[3][4].

HY-W042005

H-D-Phe(3,4-DiCl)-OH	Amino Acid Derivatives	Others
H-D-Phe(3,4-DiCl)-OH is D-3,4-Dichlorophenylalanine, a amino acid derivative. H-D-Phe(3,4-DiCl)-OH shows protein synthesis activity .

HY-121268A

Demeclocycline calcium	Antibiotic Bacterial	Infection Inflammation/Immunology Cancer
Demeclocycline (calcium) is an orally active tetracycline antibiotic that inhibits the binding of aminoacyl tRNA by binding to the 30S ribosomal subunit, thereby affecting protein synthesis. Demeclocycline (calcium) exhibits antibacterial activity against a broad spectrum of bacterial infections .

HY-148033

Trimethyl chitosan N,N,N-Trimethylchitosan	Drug Derivative	Others
Trimethyl chitosan (N,N,N-Trimethylchitosan) is a water-soluble multifunctional polymer and a derivative of Chitosan (HY-B2144A). Trimethyl chitosan targets the absorption enhancing proteins of tight junctions of intestinal and mucosal epithelial cells, induces tight junction protein rearrangement, and increases intercellular permeability. Trimethyl chitosan can stimulate the activity of promoting transmembrane transport of hydrophilic drugs (such as peptides and proteins) and can be used for drug delivery and synthesis of nanoparticles .

HY-400690

TAM558 intermediate-4	Drug Intermediate	Cancer
TAM558 intermediate-4 is an intermediate in the synthesis of TAM558 (HY-148127).TAM558 is the payload molecule used in the synthesis of OMTX705.OMTX705 is a humanized anti-fibroblast activation protein (FAP) antibody that binds to the cytolysin TAM470 (HY-148128) and has anti-tumor activity .

HY-48564

TAM558 intermediate-5	ADC Cytotoxin	Cancer
TAM558 intermediate-54 is an intermediate in the synthesis of TAM558 (HY-148127).TAM558 is the payload molecule used in the synthesis of OMTX705.OMTX705 is a humanized anti-fibroblast activation protein (FAP) antibody that binds to the cytolysin TAM470 (HY-148128) and has anti-tumor activity .

Cat. No.	Product Name

HY-L033

Peptidomimetic Library

372 compounds

Peptidomimetics are compounds whose essential elements (pharmacophore) mimic a natural peptide or protein in 3D space and which retain the ability to interact with the biological target and produce the same biological effect. Peptidomimetics are designed to circumvent some of the problems associated with a natural peptide: e.g. stability against proteolysis (duration of activity) and poor bioavailability. Certain other properties, such as receptor selectivity or potency, often can be substantially improved. The design and synthesis of peptidomimetics are most important because of the dominant position peptide and protein-protein interactions play in molecular recognition and signaling, especially in living systems. Hence mimics have great potential in drug discovery.

MCE Peptidomimetic Library contains 372 compounds including peptoid, α-helix mimetics, β-turn/sheets mimetics, etc. This library is an indispensable tool of structure-activity relationships in drug discovery.

HY-L049

Antibacterial Compound Library

1,581 compounds

Antibacterial agents are a group of materials that fight against pathogenic bacteria. Thus, by killing or reducing the metabolic activity of bacteria, their pathogenic effect in the biological environments will be minimized. The most widely used antibacterial agents exert their effects on bacterial cell wall synthesis, protein synthesis, DNA replication and metabolic pathways. However, resistance to antimicrobial agents has become a major source of morbidity and mortality worldwide. The main mechanisms of resistance are limiting uptake of a drug, modification of a drug target, inactivation of a drug, and active efflux of a drug. Therefore, it is an urgent need to develop new drugs targeted at resistant organisms.

MCE offers a unique collection of 1,581 compounds with validated antibacterial activities. MCE antibacterial compound library is an effective tool for drug repurposing screening, combination screening and biological investigation.

HY-L914

Serine/Threonine Focused Covalent Fragment Library

3,300 compounds

In the research of covalent inhibitors targeting serine and threonine, scientists have found that the nucleophilicity of these hydroxyl groups is significantly enhanced due to the influence of their surrounding environment. This results in higher activity during catalytic reactions. Aspirin, which targets the non-catalytic domain serine (Ser529 in human COX1) of cyclooxygenase, exerts its anti-inflammatory effect through covalent binding. β-lactam antibiotics, which targets the catalytic domain serine of penicillin-binding proteins, interferes with bacterial cell wall synthesis.

Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 3,300 fragment molecules which can target serine and threonine residues and can be used for fragment-based covalent drug discovery.

HY-L048

Antifungal Compound Library

431 compounds

The high rates of morbidity and mortality caused by fungal infections are associated with the current limited antifungal arsenal and the high toxicity of the compounds. Additionally, identifying novel drug targets is challenging because there are many similarities between fungal and human cells. The most common antifungal targets include fungal RNA synthesis and cell wall and membrane components, though new antifungal targets are being investigated. Nonetheless, fungi have developed resistance mechanisms, such as overexpression of efflux pump proteins, overexpression and changes in drug targets and biofilm formation, emphasizing the importance of discovering new antifungal drugs and therapies. Due to the limited antifungal arsenal, researchers have sought to improve treatment via different approaches, such as the combination of antifungal drugs, development of new formulations for antifungal agents and modifications to the chemical structures of traditional antifungals, etc.

MCE offers a unique collection of 431 compounds with validated antifungal activities. MCE antifungal compound library is an effective tool for drug repurposing screening, combination screening and biological investigation.

Cat. No.	Product Name	Type

HY-D2477

Sulfo-QSY21-NHS	Fluorescent Dyes/Probes
Sulfo-QSY21-NHS is a fluorescent dye, which contains a NHS group that can react with amine groups (-NH2) in proteins or other molecules to form stable amide bonds. Sulfo-QSY21-NHS can be used in the synthesis of activity-based probes (ABPs) .

Cat. No.	Product Name	Type

HY-20559

4-Chloro-3-nitrobenzoic acid	Cell Assay Reagents
4-Chloro-3-nitrobenzoic acid has oral activity，and oral administration can affect the synthesis activity of liver proteins and the activities of urokinase and histidine kinase .

HY-148033

Trimethyl chitosan

N,N,N-Trimethylchitosan

Drug Delivery

Trimethyl chitosan (N,N,N-Trimethylchitosan) is a water-soluble multifunctional polymer and a derivative of Chitosan (HY-B2144A). Trimethyl chitosan targets the absorption enhancing proteins of tight junctions of intestinal and mucosal epithelial cells, induces tight junction protein rearrangement, and increases intercellular permeability. Trimethyl chitosan can stimulate the activity of promoting transmembrane transport of hydrophilic drugs (such as peptides and proteins) and can be used for drug delivery and synthesis of nanoparticles .

HY-W017232

6-Methoxyquinoline

p-Quinanisole

Biochemical Assay Reagents

6-Methoxyquinoline consists of a quinoline ring system with a methoxy group attached to the sixth carbon atom. This compound occurs naturally in certain plants, such as tobacco and tea, and has been shown to have biological activities, including antioxidant, anti-inflammatory and antitumor properties. Furthermore, 6-Methoxyquinoline can be used as a building block for the synthesis of other organic compounds, especially those with potential pharmaceutical applications. Due to its ability to bind nucleic acids and proteins, it can also be used as a fluorescent probe in biochemical and biomedical research.

Cat. No.	Product Name	Target	Research Area

HY-P5244

Tripeptide-32	Peptides	Metabolic Disease
Tripeptide-32 is a bioactive peptide that targets the PER1 gene. Tripeptide-32 can regulate circadian rhythms and stimulate the synthesis of cellular repair proteins, with anti-aging activity .

HY-W005308

N-BOC-DL-serine methyl ester	Amino Acid Derivatives	Cancer
N-BOC-DL-serine methyl ester is a Serine derivative. N-BOC-DL-serine methyl ester is used for the synthesis of α,β-dehydro-α-amino acid. N-BOC-DL-serine methyl ester is also used for the synthesis of anti-cancer agent, such as quinazolinone derivative that inhibits PI3K activity, and tricyclic pyrolopyranopyridines that inhibits protein kinase activity .

HY-W142092

N-Acetyl-DL-serine	Bacterial Endogenous Metabolite	Others
N-Acetyl-DL-serine is a hydrophobic amino acid that is synthesized in the body and can be found as a free form or as a salt with malonate, phosphate, or acetate. N-Acetyl-DL-serine has antimicrobial activity against Bacillus cereus and Staphylococcus aureus. N-Acetyl-DL-serine has also been used for the immobilization of DNA fragments on solid surfaces and can be used for protein synthesis and optical detection of DNA strands .

HY-P5712

Gramicidin S 1 Publications Verification Gramicidin soviet	Antibiotic Bacterial	Infection
Gramicidin S is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC₅₀s of 41 μM, 24 μM, and 3 μM for Na ⁺/K ⁺-ATPase, tobacco leaf plasma membrane Mg ²⁺/K ⁺-ATPase, and rat heart plasma membrane Ca ²⁺-ATPase, respectively .

HY-W042005

H-D-Phe(3,4-DiCl)-OH	Amino Acid Derivatives	Others
H-D-Phe(3,4-DiCl)-OH is D-3,4-Dichlorophenylalanine, a amino acid derivative. H-D-Phe(3,4-DiCl)-OH shows protein synthesis activity .

Cat. No.	Product Name	Target	Research Area

HY-P99043

Rovalpituzumab	Notch	Cancer
Rovalpituzumab is a humanized monoclonal antibody against *delta-like protein* 3 (DLL3)*. Rovalpituzumab can be used in the synthesis* of antibody-drug conjugate (ADC), Rovalpituzumab Tesirine. Rovalpituzumab has activity against small cell lung cancer (SCLC) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2301

Pleuromutilin Drosophilin B; Mutilin 14-glycolate	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields	Antibiotic Bacterial
Pleuromutilin (Drosophilin B) exhibits antibacterial activity through inhibition of protein synthesis .

HY-Y0017

L-Norleucine (S)-2-Aminohexanoic acid; (S)-Norleucine	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Influenza Virus Endogenous Metabolite
L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

HY-N0862

Harringtonine 10+ Cited Publications	Infection Alkaloids Structural Classification Pyrrole Alkaloids Classification of Application Fields Source classification Plants Cephalotaxaceae Disease Research Fields Cephalotaxus fortunei Hooker	Influenza Virus
Harringtonine is a natural Cephalotaxus alkaloid that inhibits **protein synthesis. Harringtonine has anti-chikungunya virus (CHIKV)** activities with an EC₅₀ of 0.24 μM.

HY-B1228

Ribostamycin sulfate 1 Publications Verification Vistamycin sulfate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Resistance Selection Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic PDI
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies

HY-129337

Reveromycin A	Infection Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Antibiotic Fungal Apoptosis
Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of **protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis** specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity .

HY-N15147

Panax saponin C	Panax ginseng C. A. Meyer Structural Classification Natural Products Source classification Plants Araliaceae	DNA/RNA Synthesis
Panax saponin C is a ginsenoside found in Ginseng with biological activities including regulatory effects on immunomodulation, protection functions in the central nervous and cardiovascular systems, anti-diabetic, anti-aging, anti-carcinogenic, anti-fatigue, anti-pyretic, anti-stress, boosting physical vitality, and promotion of DNA, RNA, and protein synthesis activities .

HY-120383

Amicetin Sacromycin; U-4761	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
Amicetin is a potent antibiotic. Amicetin shows antibiotic activities against gram-positive bacteria. Amicetin inhibits protein synthesis .

HY-113767

Momordin II	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Momordica charantia Linn.	DNA/RNA Synthesis
Momordin II, an oleanane-type triterpene glycoside, is a ribosome inactivating protein. Momordin II inhibits cell-free protein synthesis, releases adenine from rat liver ribosomes and from DNA, and has no RNase activity .

HY-122588

Negamycin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Negamycin is a compound with antibacterial activity that inhibits protein synthesis by binding to the head domain of the bacterial ribosomal small subunit, leading to cell death, and also promotes misreading of near-cognate codons.

HY-121412

Lankacidin C	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer	Antibiotic Bacterial
Lankacidin C is an inhibitor of **protein synthesis** in vitro. Lankacidin C inhibits the activity of L1210 leukemia, B16 melanoma and 6C3 HED/OG lymphosarcoma cell lines. Lankacidin C has antibacterial activity and antitumor activity .

HY-N2036

Mosloflavone	Infection Structural Classification Monophenols Flavonoids Classification of Application Fields Flavones Labiatae Source classification Phenols Plants Medicago truncatula Gaertn. Disease Research Fields	TNF Receptor Enterovirus Bacterial
Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity. Mosloflavone? inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

HY-W010104

L-Methionine sulfoxide H-Met(O)-OH	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Methionine sulfoxide is an orally active oxidation product of Methionine (HY-N0326). L-Methionine sulfoxide can be partially converted into Methionine in the body and participate in the synthesis of glutathione in the liver. L-Methionine sulfoxide provides the body with sulfur activity and can participate in the synthesis of proteins and sulfur-containing compounds .

HY-W555382

Pseudane IX 2-Nonylquinolin-4(1H)-one	Structural Classification Alkaloids Ketones, Aldehydes, Acids Source classification Ruta graveolens Linn. Rutaceae Quinoline Alkaloids Plants	HCV
Pseudane IX, a compound isolated from the leaves of Ruta angustifolia, has strong anti-HCV activity with an IC₅₀ value of 1.4 μg/mL. Pseudane IX reduces HCV RNA replication and viral protein synthesis levels .

HY-13744

Rubitecan RFS 2000; 9-Nitrocamptothecin	Alkaloids Structural Classification Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Cancer	Topoisomerase
Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells .

HY-Y0017R

L-Norleucine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Influenza Virus Endogenous Metabolite
L-Norleucine (Standard) is the analytical standard of L-Norleucine. This product is intended for research and analytical applications. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

HY-B0220

Erythromycin 15+ Cited Publications	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Infection Microorganisms Macrolide Antibiotics Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields	Bacterial Antibiotic DNA/RNA Synthesis
Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid ^[1][2]. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research ^[3][4].

HY-B0958

Mupirocin BRL-4910A; Pseudomonic acid	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic
Mupirocin (BRL-4910A, Pseudomonic acid) is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis .

HY-B0220D

Erythromycin thiocyanate 15+ Cited Publications	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Disease Research Fields	Bacterial Antibiotic DNA/RNA Synthesis
Erythromycin thiocyanate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin thiocyanate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid ^[1][2]. Erythromycin thiocyanate also exhibits antitumor and neuroprotective effect in different fields of research ^[3][4].

HY-N7068

Mupirocin calcium hydrate BRL-4910A calcium hydrate; Pseudomonic acid calcium hydrate	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Inflammation/Immunology Disease Research Fields Other Antibiotics	Bacterial Antibiotic
Mupirocin (BRL-4910A, Pseudomonic acid) calcium hydrate is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin calcium hydrate apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis .

HY-18979

Lactimidomycin 1 Publications Verification	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Flavivirus Dengue Virus
Lactimidomycin is a glutarimide-containing compound isolated from Streptomyces. Lactimidomycin is a potent inhibitor of eukaryotic translation elongation. Lactimidomycin has a potent antiproliferative effect on tumor cell lines and selectively inhibit protein translation. Lactimidomycin inhibits protein synthesis with an IC₅₀ value of 37.82 nM. Lactimidomycin is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Anticancer and antiviral activities .

HY-B0275

Oxytetracycline 5 Publications Verification	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Endogenous metabolite Other Antibiotics Plant agriculture research Infection Monophenols Microorganisms Antibiotics Resistance Selection Animal Husbandry Phenols Disease Research Fields	Bacterial HSV Endogenous Metabolite Antibiotic
Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a **protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1** activity .

HY-B0275A

Oxytetracycline hydrochloride 5 Publications Verification	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Endogenous metabolite Other Antibiotics Infection Monophenols Microorganisms Antibiotics Phenols Disease Research Fields	Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline hydrochloride is an antibiotic belonging to the tetracycline class. Oxytetracycline hydrochloride potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline hydrochloride is a **protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1** activity .

HY-B0220R

Erythromycin (Standard)	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Infection Microorganisms Macrolide Antibiotics Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields	Bacterial Antibiotic DNA/RNA Synthesis
Erythromycin (Standard) is the analytical standard of Erythromycin. This product is intended for research and analytical applications. Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid . Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research .

HY-N6712R

Thiolutin (Standard)	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research Other Antibiotics	Bacterial Antibiotic Endogenous Metabolite Deubiquitinase
Erythromycin (Standard) is the analytical standard of Erythromycin. This product is intended for research and analytical applications. Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid . Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research .

HY-B0275C

Oxytetracycline calcium	Infection Quinones Structural Classification Classification of Application Fields Anthraquinones Source classification Endogenous metabolite Disease Research Fields	Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline calcium is an antibiotic belonging to the tetracycline class. Oxytetracycline calcium potently inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline calcium is a **protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline calcium also possesses anti-HSV-1** activity .

HY-B0275B

Oxytetracycline dihydrate 5 Publications Verification	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Endogenous metabolite Other Antibiotics Infection Monophenols Microorganisms Antibiotics Phenols Disease Research Fields	Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a **protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1** activity .

HY-B0958R

Mupirocin (Standard)	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research Other Antibiotics	Bacterial Antibiotic
Mupirocin (Standard) is the analytical standard of Mupirocin. This product is intended for research and analytical applications. Mupirocin (BRL-4910A, Pseudomonic acid) is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis .

HY-B0470

Neomycin sulfate 40+ Cited Publications	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields	Bacterial Antibiotic Phospholipase
Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis .

HY-N7068R

Mupirocin (calcium hydrate) (Standard)	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research Other Antibiotics	Bacterial Antibiotic
Mupirocin (calcium hydrate) (Standard) is the analytical standard of Mupirocin (calcium hydrate). This product is intended for research and analytical applications. Mupirocin (BRL-4910A, Pseudomonic acid) calcium hydrate is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin calcium hydrate apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis .

HY-B0275AR

Oxytetracycline (hydrochloride) (Standard)	Structural Classification Monophenols Microorganisms Antibiotics Source classification Phenols Antibacterial Disease Research Endogenous metabolite Other Antibiotics	Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline (hydrochloride) (Standard) is the analytical standard of Oxytetracycline (hydrochloride). This product is intended for research and analytical applications. Oxytetracycline hydrochloride is an antibiotic belonging to the tetracycline class. Oxytetracycline hydrochloride potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity .

HY-N7224

N-Formylfortimicin A SF-1854	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Bacterial Antibiotic
N-Formylfortimicin A (SF-1854) is an aminoglycoside antibiotic with broad-spectrum antibacterial activity. It primarily acts on bacterial ribosomes to inhibit protein synthesis and exhibits notable inhibitory effects against various Gram-positive and Gram-negative bacteria (e.g., E. coli with a MIC of 12.5-50 μg/mL), making it a potential candidate for research on bacterial infection-related diseases .

HY-B0275R

Oxytetracycline (Standard)	Structural Classification Source classification Antibacterial Disease Research Endogenous metabolite Other Antibiotics Plant agriculture research Monophenols Microorganisms Antibiotics Resistance Selection Animal Husbandry Phenols	Bacterial HSV Endogenous Metabolite Antibiotic
Oxytetracycline (Standard) is the analytical standard of Oxytetracycline. This product is intended for research and analytical applications. Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .

HY-100126

Tubercidin 5 Publications Verification 7-Deazaadenosine	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic
Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC₅₀ of 0.02 μM . Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis . Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP . Tubercidin has antiviral activity .

HY-B0275BR

Oxytetracycline (dihydrate) (Standard)	Structural Classification Monophenols Microorganisms Antibiotics Source classification Phenols Antibacterial Disease Research Endogenous metabolite Other Antibiotics	Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline (dihydrate) (Standard) is the analytical standard of Oxytetracycline (dihydrate). This product is intended for research and analytical applications. Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity .

HY-N6680

Virginiamycin S1	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields	Bacterial Antibiotic
Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections ^[1][2].

HY-B0470R

Neomycin (sulfate) (Standard)	Structural Classification Microorganisms Antibiotics Source classification Animal Husbandry Mammalian Cell Culture Antibacterial Disease Research Anticancer Other Antibiotics	Bacterial Antibiotic Phospholipase
Neomycin (sulfate) (Standard) is the analytical standard of Neomycin (sulfate). This product is intended for research and analytical applications. Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis .

HY-A0098

Tunicamycin Maximum Cited Publications 110 Publications Verification	Structural Classification Antifungal Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Microorganisms Antibiotics Antiviral Anticancer Inflammation/Immunology Disease Research Fields	Bacterial Fungal Influenza Virus Antibiotic
Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity .Tunicamycin increases exosome release in cervical cancer cells .

HY-N2513

β-Boswellic acid	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Boswellia serrata Plants Burseraceae Disease Research Fields Cancer	Lipoxygenase DNA/RNA Synthesis
β-Boswellic acid is isolated from the gum resin of Boswellia serrata with anticancer, antioxidant activity, anti-inflammatory activity and anti-arthritic pain.β-Boswellic acid is an orally active nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells with IC₅₀ values ranging from 0.6 to 7.1 μM. β-Boswellic acid is promising for research of diabetes, inflammatory and arthritic diseases .

HY-N6680R

Virginiamycin S1 (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Antibacterial Disease Research	Bacterial Antibiotic
Virginiamycin S1 (Standard) is the analytical standard of Virginiamycin S1. This product is intended for research and analytical applications. Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections .

HY-N0097R

Guanosine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Source classification Disease markers Endocrine diseases Endogenous metabolite	HSV Endogenous Metabolite
Guanosine (Standard) is the analytical standard of Guanosine. This product is intended for research and analytical applications. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity. In Vitro: Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These forms play important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction (cGMP).

HY-111355B

Cholesteryl sulfate sodium	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Cholesteryl sulfate sodium is an orally available, NPC2-targeted cholesterol biosynthesis agonist. Cholesteryl sulfate sodium activates SREBP2 by competitively binding to NPC2, promoting cholesterol synthesis (EC₅₀=50 μM). Cholesteryl sulfate sodium enhances the self-assembly ability of Mitoxantrone hydrochloride (HY-13502A), while repairing the intestinal mucosal barrier and inhibiting inflammation by regulating serine protease activity and PKCη signaling pathway. Cholesteryl sulfate sodium is a component of the platelet cell membrane and supports platelet adhesion. Cholesteryl sulfate sodium also regulates the activity of selective protein kinase C isoforms and modulates the specificity of PI3K, playing a role in keratinocyte differentiation .

HY-W017113

2-Mercaptobenzothiazole	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Aryl Hydrocarbon Receptor
2-Mercaptobenzothiazole is an activator of the aryl hydrocarbon receptor (AhR) , inhibiting thyroid hormone synthesis and dopamine beta-hydroxylase activity . 2-Mercaptobenzothiazole promotes bladder cancer cell invasion by altering the conformation of the AhR ligand binding domain (LBD), activating AhR transcription, and upregulating the mRNA and protein expression of target genes CYP1A1 and CYP1B1 . 2-Mercaptobenzothiazole inhibits thyroid peroxidase (TPO) with an IC₅₀ value of 11.5 μM, induces histological changes such as follicular cell hypertrophy in Xenopus laevis tadpoles, delaying metamorphosis . 2-Mercaptobenzothiazole increases chromosomal aberrations and sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells, and enhances carcinogenicity in F344/N rats . 2-Mercaptobenzothiazole inhibits norepinephrine synthesis in mice and completely blocks the conversion of exogenous dopamine to norepinephrine in rat cardiomyocytes .

HY-W012722

4-Methyl-2-oxopentanoic acid 1 Publications Verification α-Ketoisocaproic acid	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite	Endogenous Metabolite Autophagy mTOR SOD
4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid also causes oxidative damage, leading to cognitive deficits, inhibits α-ketoglutarate dehydrogenase activity, acts as an oxidative phosphorylation uncoupler and metabolic inhibitor. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis. 4-Methyl-2-oxopentanoic acid can be used in the study of maple syrup urine disease .

Cat. No.	Product Name	Chemical Structure

HY-B0220S

Erythromycin-d6

Erythromycin-d₆ is the deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1].

HY-B0220S2

Erythromycin-d3

Erythromycin-d3 is the deuterium labeled Erythromycin[1]. Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research[2][3][4][5].

HY-B0905S

Tilmicosin-d3

Tilmicosin-d₃ is the deuterium labeled Tilmicosin. Tilmicosin (LY-177370) is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin has immunomodulatory and anti-inflammatory effects .

HY-Y0017S

L-Norleucine-d9
L-Norleucine-d₉ is the deuterium labeled L-Norleucine. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

HY-B0220S1

Erythromycin-13C,d3

Erythromycin- ¹³C,d₃ is the ¹³C- and deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1].

HY-W755036

Oxytetracycline-13C,d3 hydrochloride

Oxytetracycline-13C,d3 hydrochloride is the 13C- and deuterium labeled Oxytetracycline hydrochloride (HY-B0275A). Oxytetracycline hydrochloride is an antibiotic that exhibits board-spectrum antibacterial activity. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity .

HY-10392S

Sutezolid-13C4
Sutezolid- ¹³C₄ (PNU-100480- ¹³C₄) is ¹³C labeled Sutezolid. Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis .

HY-B0275S

Oxytetracycline-d6
Oxytetracycline-d₆ is deuterium labeled Oxytetracycline. Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a **protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1** activity .

HY-137315S

TML-6-d3
TML-6-d₃ is the deuterium labeled TML-6. TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-

HY-W555382S

Pseudane IX-d4
Pseudane IX-d₄ (2-Nonylquinolin-4(1H)-one-d₄) is deuterium labeled Pseudane IX. Pseudane IX, a compound isolated from the leaves of Ruta angustifolia, has strong anti-HCV activity with an IC₅₀ value of 1.4 μg/mL. Pseudane IX reduces HCV RNA replication and viral protein synthesis levels .

HY-N7101S1

Cefpodoxime Proxetil-d6

Cefpodoxime Proxetil-d₆ (U-76,252-d₆) is deuterium labeled Cefpodoxime Proxetil. Cefpodoxime proxetil is an orally administered broad spectrum third-generation cephalosporin. Cefpodoxime proxetil has anti-bacterial activity. Cefpodoxime proxetil binds to penicillin binding proteins (PBPs) which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis .

HY-10250S1

Triciribine phosphate-d3

Triciribine phosphate-d3 (TCN-P-d3) is a deuterated compound of Triciribine phosphate (TCN-P). TCN-P inhibits adenosine monophosphate (AMP)-activated protein kinase through an allosteric mechanism, affecting the first key step in de novo purine biosynthesis. Triciribine phosphate also inhibits inosine monophosphate dehydrogenase, which is the first key step in guanosine nucleotide synthesis. Triciribine phosphate does not affect ligase activity .

Cat. No.	Product Name		Classification

HY-148033

Trimethyl chitosan N,N,N-Trimethylchitosan		Polymers
Trimethyl chitosan (N,N,N-Trimethylchitosan) is a water-soluble multifunctional polymer and a derivative of Chitosan (HY-B2144A). Trimethyl chitosan targets the absorption enhancing proteins of tight junctions of intestinal and mucosal epithelial cells, induces tight junction protein rearrangement, and increases intercellular permeability. Trimethyl chitosan can stimulate the activity of promoting transmembrane transport of hydrophilic drugs (such as peptides and proteins) and can be used for drug delivery and synthesis of nanoparticles .

HY-F0003

NADPH tetrasodium salt 5+ Cited Publications		Nucleotides and their Analogs
NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication. The demand for NADPH tetrasodium salt is particularly high in proliferating cancer cells, where it acts as a cofactor for the synthesis of nucleotides, proteins, and fatty acids. NADPH tetrasodium salt is also essential for the neutralization of the dangerously high levels of reactive oxygen species (ROS) generated by increased metabolic activity. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis .

HY-148170

L-I-OddU		Nucleosides and their Analogs
L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC₅₀ value of 0.03μM. L-I-OddU has low cytotoxicity with a CC₅₀ value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

protein synthesis activities

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products