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Results for "

sponge

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Akt (2) Antibiotic (1) Apoptosis (5) Arp2/3 Complex (3) Autophagy (3) Bacterial (9) Biochemical Assay Reagents (3) CDK (1) DNA/RNA Synthesis (1) ERK (1) FAK (1) Fungal (3) HIF/HIF Prolyl-Hydroxylase (1) HIV (3) ICMT (1) JNK (1) Microtubule/Tubulin (3) mTOR (2) p38 MAPK (1) Parasite (3) PI3K (2) Reactive Oxygen Species (1) Sodium Channel (1) Topoisomerase (1) TRP Channel (1) VEGFR (1) α-synuclein (1)
By Research Areas:	Cancer (30) Cardiovascular Disease (2) Endocrinology (1) Infection (13) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (4)

By Targets:

Adrenergic Receptor (1)

Akt (2)

Antibiotic (1)

Apoptosis (5)

Arp2/3 Complex (3)

Autophagy (3)

Bacterial (9)

Biochemical Assay Reagents (3)

CDK (1)

DNA/RNA Synthesis (1)

ERK (1)

FAK (1)

Fungal (3)

HIF/HIF Prolyl-Hydroxylase (1)

HIV (3)

ICMT (1)

JNK (1)

Microtubule/Tubulin (3)

mTOR (2)

p38 MAPK (1)

Parasite (3)

PI3K (2)

Reactive Oxygen Species (1)

Sodium Channel (1)

Topoisomerase (1)

TRP Channel (1)

VEGFR (1)

α-synuclein (1)

By Research Areas:

Cancer (30)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (13)

Inflammation/Immunology (5)

Metabolic Disease (1)

Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119500

Ilimaquinone	HIV Bacterial	Infection Inflammation/Immunology Cancer
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus . Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects .

HY-P0027

Jasplakinolide 4 Publications Verification	Arp2/3 Complex Fungal	Infection Cancer
Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a K_d of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity .

HY-149712

Spermatinamine	ICMT	Cancer
Spermatinamine is a novel alkaloid with a bromotyrosyl-spermine-bromotyrosyl sequence, and a natural ICMT inhibitor. Spermatinamine can be isolated from the Australian sponge Pseudoceratina .

HY-N1662

2,4,6,6-Tetramethyl-3(6H)-pyridinone	Others	Others
2,4,6,6-Tetramethyl-3(6H)-pyridinone is a natural product that can be isolated from the tropical marine sponge Agelas oroides .

HY-N10305

Clionamine B	Autophagy	Cancer
Clionamine B is an autophagy stimulating aminosteroid isolated from the sponge Cliona celata. Clionamine B strongly stimulates autophagy in human breast cancer MCF-7 cells .

HY-116436

Clathrodin	Sodium Channel	Neurological Disease
Clathrodin is a marine alkaloid that can be isolated from sponges of the genus, Agelas. Clathrodin is a modulator of voltage-gated sodium (NaV) channels. Clathrodin is a sodium channel neurotoxin influencing sodium channel ionic conductance .

HY-119729

Axinysterol	Others	Cancer
Axinysterol is a steroidal compound isolated from marine sponges of the genus Axinyssa, possessing anticancer activity. Axinysterol is employed in research within the field of oncology .

HY-121794

Avarol (+)-Avarol	Others	Cancer
Avarol is a sesquiterpene hydroquinone that can be isolated from Dysidea avara sponge. Avarol has the potential for the research of ehrlich carcinoma (EC) and cervical cancer (CC-5) .

HY-123161

JBIR-15	Others	Others
JBIR-15 is a new aspochracin derivative. JBIR-15 is isolated from a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04 .

HY-W268334

1,2,3,4-Tetrahydronorharman-1-one	Bacterial Parasite Antibiotic	Infection
1,2,3,4-Tetrahydronorharman-1-one is a manzamine alkaloid with activity against infectious and tropical parasitic diseases from an Indonesian sponge .

HY-N10330

7-Hydroxyneolamellarin A	HIF/HIF Prolyl-Hydroxylase VEGFR	Cancer
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer .

HY-123036

Renierone	Bacterial	Infection
Renierone is an antibacterial metabolite found in the sponge Reniera sp. .

HY-N7747

Sceptrin dihydrochloride	Others	Infection
Sceptrin dihydrochloride is a compound isolated from the sea sponge Agelas sceptrum that is an antimicrobial agent .

HY-N10241

Hortein	Others	Others
Hortein is a natural product from the fungus Hortaea werneckii associated with the sponge Aplysina aerophoba .

HY-121995

(14Z)-14-Eicosenoic acid	Others	Others
(14Z)-14-Eicosenoic acid is an unsaturated fatty acid isolated from sponges .

HY-127085

Acanthifolicin Acanthifolic acid	Others	Cancer
Acanthifolicin (Acanthifolic acid) is a tumor promoter that can be isolated from the marine sponge Pandaros acanthifolium .

HY-N1032

(+)-12α-Hydroxyisodrimenin	Others	Others
(+)-12α-Hydroxyisodrimenin (compound 7) is a drimanic sesquiterpene that can be found in sponge Dysidea fusca .

HY-N12524

Cyclo(prolyltyrosyl)	Bacterial	Infection Cancer
Cyclo(prolyltyrosyl) is a natural compound that can be found in various microorganisms and marine sponges. Cyclo(prolyltyrosyl) has antibacterial, phytotoxic and cytotoxic properties .

HY-125429

Lokysterolamine B	Others	Cancer
Lokysterolamine B is a steroidal alkaloid which can be extracted from sponge genus Corticium. Lokysterolamine B can be utilized in cancer research .

HY-127042

6,7-Epoxy-latrunculin A 6,7-Epoxy-LAT-A	Arp2/3 Complex	Others
6,7-Epoxy-latrunculin A can be isolated from the Red Sea sponge Negombata magnifica and is initially identified as an inhibitor of actin polymerization by its morphological effects .

HY-N1224

(22E,24R)-Stigmasta-4,22-dien-3-one	Others	Others
(22E,24R)-Stigmasta-4,22-dien-3-one (compound 28) is a steroid isolated from sponges .

HY-W411439

1-O-p-Coumaroyl-β-D-glucose	Others	Metabolic Disease
1-O-p-Coumaroyl-β-D-glucose can promote glucose uptake in HuH7 cells, and be be extracted from Luffa cylindrica (L.) Roem (sponge gourds) .

HY-125660

Leucettamol A	Others	Infection
Leucettamol A is an inhibitor of Ubc13-Uev1A interaction, with an IC₅₀ of 50 μg/mL. Leucettamol A can be isolated from a marine sponge, Leucetta aff. Microrhaphis .

HY-N6997

Ceratamine A	Microtubule/Tubulin	Cancer
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent. Ceratamine A exhibits cytotoxicity against human cancer cell lines .

HY-N13095

(+)-Plakevulin A	DNA/RNA Synthesis Apoptosis	Cancer
(+)-Plakevulin A (Plakevulin A) is an oxylipin and can be isolated from an Okinawan sponge Plakortis sp. (+)-Plakevulin A inhibits the enzymatic activity of DNA polymerases α and δ. (+)-Plakevulin A induces apoptosis and shows anticancer activity .

HY-N4225

Aaptamine	Adrenergic Receptor	Endocrinology Cancer
Aaptamine, a spongean alkaloid isolated from a sea sponge Aaptos aaptos, is a competitive antagonist of α-adrenoceptor and activates the p21 promoter in a p53-independent manner .

HY-N12605

hTRPA1-IN-1	TRP Channel	Neurological Disease
hTRPA1-IN-1 (19), a norsesterterpenoid that can be isolated from the Marine Sponge Diacarnus spinipoculum, is an inhibitor of transient receptor potential Ankyrin 1 (TRPA1), with an IC₅₀ of 2 μM .

HY-N3845

Ergosterol peroxide	Bacterial	Inflammation/Immunology Cancer
Ergosterol peroxide is a steroid derivative and can be isolated from a variety of fungi, yeast, lichens or sponges. Ergosterol peroxide has anti-tumour, proapoptotic, anti-inflammatory, anti-mycobacterial, and anti-proliferative activities .

HY-19922

Plocabulin PM060184	Microtubule/Tubulin	Cancer
Plocabulin (PM060184) is a potent microtubule inhibitor. Plocabulin is a natural product that could be isolated from the marine sponge Lithoplocamia lithistoides. Plocabulin suppresses microtubule shortening and growth. Plocabulin has anticancer activity .

HY-111266

Halenaquinone	PI3K Apoptosis	Inflammation/Immunology Cancer
Halenaquinone is a phosphatidylinositol 3-kinase inhibitor and can be isolated from the marine sponge Petrosia alfiani. Halenaquinone inhibits RANKL-induced osteoclastogenesis, and induces cell apoptosis in PC12 cells .

HY-123888

Viomellein	Others	Cancer
Viomellein is an anticancer compound produced by the fungus Aspergillus ochraceus isolated from the Mediterranean sponge Agelas oroides. Viomellein exhibits cytotoxicity against A2780 human ovarian cancer cells with an IC₅₀ value of 5.0 μM .

HY-125580

Makaluvamine A	Topoisomerase	Cancer
Makaluvamine A is a member of Makaluvamines. Makaluvamines can be isolated from Fijian sponges of the genus Zyzzya, and possess inhibitory activity toward topoisomerase II along with cytotoxic activity against HCT-116 human colon cancer cells .

HY-N7234

Sarasinoside C1	Others	Others
Sarasinoside C1 is a 30-norlanostane saponin isolated from the sea sponge Melophlus sarasinorum collected from Kimbe Bay, Papua New Guinea. Sarasinoside C1 has potential roles in marine ecology and pharmacological applications .

HY-116615

Methyl 2-hydroxytetracosanoate Methyl cerebronate	Biochemical Assay Reagents	Others
Methyl (+/-)-2-hydroxytetracosanoate, a hydroxylated fatty acid methyl ester, has been found in mature and immature strawberry homogenates, Pseudosuberites and S. massa sponges, sediment samples from Hani River and Lake Kivu, and aerial parts of Escherichia coli found in. sun mirror.

HY-130398

Aerophobin-2	α-synuclein	Neurological Disease
Aerophobin-2 is a bromine compound, which can be isolated from sponge Verongia aerophoba. Aerophobin-2 inhibits aggregation of α-synuclein (α-syn) and phosphorylated α-synuclein (pSyn), exhibits neuroprotective efficacy .

HY-W065835

2-Bromoaldisine	HIV	Infection
2-Bromoaldisine is a pyrrole alkaloid that can be isolated from the Red Sea: marine sponge Stylissa carter. 2-Bromoaldisine inhibits HIV-1 vector infection. 2-Bromoaldisine inhibits Raf/MEK/MAPK pathway .

HY-N10558

PM050489	Microtubule/Tubulin	Cancer
PM050489 is an effective polyketone inhibitor of Microtubule/Tubulin that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC₅₀ value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research .

HY-Y0543

5-Methylfurfural 1 Publications Verification	Biochemical Assay Reagents	Others
5-Methylfurfural is a naturally occurring substance, found in cigarette smoke condensate, licorice essential oil, stored dehydrated orange powder, baked potato flour, volatile compounds of roast beef, aroma concentrate of sponge cake. bread and in coffee, tea and cocoa . A flavoring agent.

HY-121014

Amphimedine	Others	Cancer
Amphimedine is a polycyclic alkaloid isolated from the marine sponge Amphimedon sp. and belongs to the pyridoindole alkaloid class. Amphimedine has cytotoxic activity and has been studied as an anticancer metabolite along with neoamphimedine. Studies have shown that deoxyamphimedine damages DNA by generating reactive oxygen species, a mechanism different from that of amphimedine.

HY-112328

Fascaplysin	Apoptosis Autophagy Reactive Oxygen Species CDK	Infection Cancer
Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity .

HY-N6652

1-beta-D-Arabinofuranosyluracil 1 Publications Verification Uracil 1-β-D-arabinofuranoside	Others	Cardiovascular Disease Inflammation/Immunology Cancer
1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties . 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells .

HY-19827

Aeroplysinin 1 (+)-Aeroplysinin-1	Bacterial HIV Apoptosis	Infection Cancer
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC₅₀=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells .

HY-Y0543R

5-Methylfurfural (Standard)	Biochemical Assay Reagents	Others
5-Methylfurfural (Standard) is the analytical standard of 5-Methylfurfural. This product is intended for research and analytical applications. 5-Methylfurfural is a naturally occurring substance, found in cigarette smoke condensate, licorice essential oil, stored dehydrated orange powder, baked potato flour, volatile compounds of roast beef, aroma concentrate of sponge cake. bread and in coffee, tea and cocoa . A flavoring agent.

HY-119387

Chevalone B	Bacterial	Infection
Chevalone B was isolated from the ethyl acetate extract of the marine sponge-associated fungus Aspergillus similanensis. The structure of Chevalone B was confirmed by 1D and 2D NMR spectroscopy. Chevalone B showed antimicrobial activity against Gram-positive and Gram-negative bacteria, Candida albicans, and multidrug-resistant strains from the environment. Studies on Chevalone B have shown its potential value in antimicrobial applications.

HY-N10401

Batzelladine D	Fungal Bacterial Parasite	Infection Cancer
Batzelladine D (Compound 1) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Batzelladine D inhibits Pdr5p ATPase activity with an IC₅₀ of 7.1 µM. Batzelladine D shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

HY-N10402

Norbatzelladine L	Fungal Bacterial Parasite	Infection Cancer
Norbatzelladine L (Compound 2) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Norbatzelladine L inhibits Pdr5p ATPase activity with an IC₅₀ of 3.8 µM. Norbatzelladine L shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

HY-16929

Latrunculin A Maximum Cited Publications 7 Publications Verification LAT-A	Arp2/3 Complex	Cancer
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with K_ds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration .

HY-N12561

Pestanoid A	ERK p38 MAPK JNK	Others
Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC₅₀ of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis .

HY-120985

Araguspongin B	Others	Neurological Disease
Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores.2 Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC₅₀ of 0.6 μM. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.

HY-N6652R

1-beta-D-Arabinofuranosyluracil (Standard)	Others	Cardiovascular Disease Inflammation/Immunology Cancer
1-beta-D-Arabinofuranosyluracil (Standard) is the analytical standard of 1-beta-D-Arabinofuranosyluracil. This product is intended for research and analytical applications. 1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties . 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells .

Cat. No.	Product Name

HY-L143

Marine-Sourced Natural Product Library

42 compounds

Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria.

Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union.

MCE offers a unique collection of 42 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Cat. No.	Product Name	Type