Search Result

Results for "

sponge

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Akt (2) Antibiotic (1) AP-1 (1) Apoptosis (7) Arp2/3 Complex (3) Autophagy (3) Bacterial (13) Biochemical Assay Reagents (4) Calcium Channel (1) CDK (1) Cholinesterase (ChE) (1) DNA/RNA Synthesis (1) Drug Derivative (1) E1/E2/E3 Enzyme (2) Endogenous Metabolite (3) ERK (1) FAK (1) Fluorescent Dye (1) Fungal (2) GLUT (1) HIF/HIF Prolyl-Hydroxylase (1) HIV (5) ICMT (1) Indoleamine 2,3-Dioxygenase (IDO) (1) JNK (1) Liposome (1) MDM-2/p53 (1) Microtubule/Tubulin (1) MMP (1) mTOR (2) NF-κB (1) p38 MAPK (1) Parasite (3) PI3K (2) Proteasome (1) Reactive Oxygen Species (2) Sodium Channel (1) Topoisomerase (1) TRP Channel (1) VEGFR (1) α-synuclein (1)
By Research Areas:	Cancer (32) Cardiovascular Disease (2) Endocrinology (1) Infection (17) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (4)

By Targets:

Adrenergic Receptor (1)

Akt (2)

Antibiotic (1)

AP-1 (1)

Apoptosis (7)

Arp2/3 Complex (3)

Autophagy (3)

Bacterial (13)

Biochemical Assay Reagents (4)

Calcium Channel (1)

CDK (1)

Cholinesterase (ChE) (1)

DNA/RNA Synthesis (1)

Drug Derivative (1)

E1/E2/E3 Enzyme (2)

Endogenous Metabolite (3)

ERK (1)

FAK (1)

Fluorescent Dye (1)

Fungal (2)

GLUT (1)

HIF/HIF Prolyl-Hydroxylase (1)

HIV (5)

ICMT (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

JNK (1)

Liposome (1)

MDM-2/p53 (1)

Microtubule/Tubulin (1)

MMP (1)

mTOR (2)

NF-κB (1)

p38 MAPK (1)

Parasite (3)

PI3K (2)

Proteasome (1)

Reactive Oxygen Species (2)

Sodium Channel (1)

Topoisomerase (1)

TRP Channel (1)

VEGFR (1)

α-synuclein (1)

By Research Areas:

Cancer (32)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (17)

Inflammation/Immunology (7)

Metabolic Disease (1)

Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W038627

3,5-Dibromo-4-methoxybenzoic acid 3,5-Dibromo-p-anisic acid	Others	Others
3,5-Dibromo-4-methoxybenzoic acid (3,5-Dibromo-p-anisic acid) is a brominated alkaloid that can be isolated from sponges such as Amphimedon sp. and Psammaplysilla purpurea .

HY-W834359

(±)-Longamide	Indoleamine 2,3-Dioxygenase (IDO) Endogenous Metabolite	Others
(±)-Longamide is a polycyclic bioactive metabolite isolated from sponges that has several bromopyrrole fragments, as well as a weak inhibitor of IDO1 .

HY-149712

Spermatinamine	ICMT	Cancer
Spermatinamine is a novel alkaloid with a bromotyrosyl-spermine-bromotyrosyl sequence, and a natural ICMT inhibitor. Spermatinamine can be isolated from the Australian sponge Pseudoceratina .

HY-N1662

2,4,6,6-Tetramethyl-3(6H)-pyridinone	Others	Others
2,4,6,6-Tetramethyl-3(6H)-pyridinone is a natural product that can be isolated from the tropical marine sponge Agelas oroides .

HY-N10305

Clionamine B	Autophagy	Cancer
Clionamine B is an autophagy stimulating aminosteroid isolated from the sponge Cliona celata. Clionamine B strongly stimulates autophagy in human breast cancer MCF-7 cells .

HY-116436

Clathrodin	Sodium Channel	Neurological Disease
Clathrodin is a marine alkaloid that can be isolated from sponges of the genus, Agelas. Clathrodin is a modulator of voltage-gated sodium (NaV) channels. Clathrodin is a sodium channel neurotoxin influencing sodium channel ionic conductance .

HY-119729

Axinysterol	Others	Cancer
Axinysterol is a steroidal compound isolated from marine sponges of the genus Axinyssa, possessing anticancer activity. Axinysterol is employed in research within the field of oncology .

HY-121794

Avarol (+)-Avarol	Bacterial HIV	Cancer
Avarol is a sesquiterpene hydroquinone that can be isolated from Dysidea avara sponge. Avarol has the potential for the research of ehrlich carcinoma (EC) and cervical cancer (CC-5) .

HY-123161

JBIR-15	Drug Derivative	Others
JBIR-15 is a new aspochracin derivative. JBIR-15 is isolated from a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04 .

HY-W268334

1,2,3,4-Tetrahydronorharman-1-one	Bacterial Parasite Antibiotic	Infection
1,2,3,4-Tetrahydronorharman-1-one is a manzamine alkaloid with activity against infectious and tropical parasitic diseases from an Indonesian sponge .

HY-119500

Ilimaquinone	HIV Bacterial	Infection Inflammation/Immunology Cancer
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus . Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects .

HY-P0027

Jasplakinolide 5 Publications Verification	Arp2/3 Complex Fungal	Infection Cancer
Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a K_d of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity .

HY-N10330

7-Hydroxyneolamellarin A	HIF/HIF Prolyl-Hydroxylase VEGFR	Cancer
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer .

HY-123036

Renierone	Bacterial	Infection
Renierone is an antibacterial metabolite found in the sponge Reniera sp. .

HY-113621B

Ageladine A dihydrochloride	Fluorescent Dye MMP	Cancer
Ageladine A dihydrochloride is an inhibitor of matrix metalloproteinase (MMP) isolated from the marine sponge Agelas nakamurai, possessing anti-angiogenic activity. Ageladine A dihydrochloride not only inhibits MMP-2 but also MMP-1, MMP-8, MMP-9, MMP-12, and MMP-13, with IC₅₀ values of 4.65 μM, 2.79 μM, 907.12 nM, 1.83 μM, 767.57 nM, and 1.09 μM, respectively. Additionally, Ageladine A dihydrochloride is a pH-sensitive membrane-permeable dye that emits fluorescence in the blue-green range upon UV excitation, featuring a maximum absorption peak at 370 nm. Furthermore, Ageladine A dihydrochloride serves as a reliable and stable fluorescent pH sensor for detecting changes in intracellular pH values .

HY-N7747

Sceptrin dihydrochloride	Others	Infection
Sceptrin dihydrochloride is a compound isolated from the sea sponge Agelas sceptrum that is an antimicrobial agent .

HY-N10241

Hortein	Others	Others
Hortein is a natural product from the fungus Hortaea werneckii associated with the sponge Aplysina aerophoba .

HY-121995

(14Z)-14-Eicosenoic acid	Others	Others
(14Z)-14-Eicosenoic acid is an unsaturated fatty acid isolated from sponges .

HY-N1032

(+)-12α-Hydroxyisodrimenin	Others	Others
(+)-12α-Hydroxyisodrimenin (compound 7) is a drimanic sesquiterpene that can be found in sponge Dysidea fusca .

HY-N1051

Zarzissine	Bacterial	Infection Cancer
Zarzissine is a cytotoxic guanidine alkaloid that can be isolated from the Mediterranean sponge Anchinoe paupertas. Zarzissine shows antimicrobial and anticancer activities .

HY-125429

Lokysterolamine B	Others	Cancer
Lokysterolamine B is a steroidal alkaloid which can be extracted from sponge genus Corticium. Lokysterolamine B can be utilized in cancer research .

HY-N12524

Cyclo(prolyltyrosyl)	Bacterial	Infection Cancer
Cyclo(prolyltyrosyl) is a natural compound that can be found in various microorganisms and marine sponges. Cyclo(prolyltyrosyl) has antibacterial, phytotoxic and cytotoxic properties .

HY-N15283

Baculiferin A	HIV	Infection
Baculiferins A is a DOPA-derived pyrrole alkaloid. Baculiferins A can be isolated from the Chinese marine sponge Iotrochota baculifera. Baculiferins A have anti-HIV activity .

HY-N15321

Norselic acid B	Parasite	Infection Inflammation/Immunology
Norselic acid B is a natural compound that can be isolated from the sponge Crella sp. collected in Antarctica. T. Norselic acid B is active against the Leishmania parasite .

HY-127042

6,7-Epoxy-latrunculin A 6,7-Epoxy-LAT-A	Arp2/3 Complex	Others
6,7-Epoxy-latrunculin A can be isolated from the Red Sea sponge Negombata magnifica and is initially identified as an inhibitor of actin polymerization by its morphological effects .

HY-N1224

(22E,24R)-Stigmasta-4,22-dien-3-one	Endogenous Metabolite	Others
(22E,24R)-Stigmasta-4,22-dien-3-one (compound 28) is a steroid isolated from sponges .

HY-W411439

1-O-p-Coumaroyl-β-D-glucose	GLUT	Metabolic Disease
1-O-p-Coumaroyl-β-D-glucose can promote glucose uptake in HuH7 cells, and be be extracted from Luffa cylindrica (L.) Roem (sponge gourds) .

HY-W006646

Methyl 5-bromo-1H-pyrrole-2-carboxylate	Biochemical Assay Reagents	Others
Methyl 5-bromo-1H-pyrrole-2-carboxylate (Compound 7) is a pyrrole that can be isolated from marine sponges Lissodendotyx sp.

HY-N13095

(+)-Plakevulin A	DNA/RNA Synthesis Apoptosis	Cancer
(+)-Plakevulin A (Plakevulin A) is an oxylipin and can be isolated from an Okinawan sponge Plakortis sp. (+)-Plakevulin A inhibits the enzymatic activity of DNA polymerases α and δ. (+)-Plakevulin A induces apoptosis and shows anticancer activity .

HY-159859

IZ-Chol	Liposome	Others
IZ-Chol (IZ-Cholesterol) is an ionizable cationic lipid containing cholesterol. IZ-Chol-LNPs is highly potential to effectively complex with DNA, and endosome escape mechanisms mediated by proton sponge effect .

HY-N6997

Ceratamine A	Microtubule/Tubulin	Cancer
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent. Ceratamine A exhibits cytotoxicity against human cancer cell lines .

HY-125132

Agelastatin A (-)-Agelastatin A; AglA	Apoptosis	Cancer
Agelastatin A ((-)-Agelastatin A; AglA), a tetracyclic alkaloid isolated from the sponge Agelas dendromorpha, induces apoptosis and arrests cells in the G2/M phase of the cell cycle, exhibiting antitumor activity .

HY-N12605

hTRPA1-IN-1	TRP Channel	Neurological Disease
hTRPA1-IN-1 (19), a norsesterterpenoid that can be isolated from the Marine Sponge Diacarnus spinipoculum, is an inhibitor of transient receptor potential Ankyrin 1 (TRPA1), with an IC₅₀ of 2 μM .

HY-N3845

Ergosterol peroxide	Bacterial	Inflammation/Immunology Cancer
Ergosterol peroxide is a steroid derivative and can be isolated from a variety of fungi, yeast, lichens or sponges. Ergosterol peroxide has anti-tumour, proapoptotic, anti-inflammatory, anti-mycobacterial, and anti-proliferative activities .

HY-111266

Halenaquinone	PI3K Apoptosis	Inflammation/Immunology Cancer
Halenaquinone is a phosphatidylinositol 3-kinase inhibitor and can be isolated from the marine sponge Petrosia alfiani. Halenaquinone inhibits RANKL-induced osteoclastogenesis, and induces cell apoptosis in PC12 cells .

HY-125580

Makaluvamine A	Topoisomerase	Cancer
Makaluvamine A is a member of Makaluvamines. Makaluvamines can be isolated from Fijian sponges of the genus Zyzzya, and possess inhibitory activity toward topoisomerase II along with cytotoxic activity against HCT-116 human colon cancer cells .

HY-N7234

Sarasinoside C1	Others	Others
Sarasinoside C1 is a 30-norlanostane saponin isolated from the sea sponge Melophlus sarasinorum collected from Kimbe Bay, Papua New Guinea. Sarasinoside C1 has potential roles in marine ecology and pharmacological applications .

HY-W065835

2-Bromoaldisine	HIV	Infection
2-Bromoaldisine is a pyrrole alkaloid that can be isolated from the Red Sea: marine sponge Stylissa carter. 2-Bromoaldisine inhibits HIV-1 vector infection. 2-Bromoaldisine inhibits Raf/MEK/MAPK pathway .

HY-116615

Methyl 2-hydroxytetracosanoate Methyl cerebronate	Biochemical Assay Reagents	Others
Methyl (+/-)-2-hydroxytetracosanoate, a hydroxylated fatty acid methyl ester, has been found in mature and immature strawberry homogenates, Pseudosuberites and S. massa sponges, sediment samples from Hani River and Lake Kivu, and aerial parts of Escherichia coli found in. sun mirror.

HY-130398

Aerophobin-2	α-synuclein	Neurological Disease
Aerophobin-2 is a bromine compound, which can be isolated from sponge Verongia aerophoba. Aerophobin-2 inhibits aggregation of α-synuclein (α-syn) and phosphorylated α-synuclein (pSyn), exhibits neuroprotective efficacy .

HY-Y0543

5-Methylfurfural 1 Publications Verification	Biochemical Assay Reagents	Others
5-Methylfurfural is a naturally occurring substance, found in cigarette smoke condensate, licorice essential oil, stored dehydrated orange powder, baked potato flour, volatile compounds of roast beef, aroma concentrate of sponge cake. bread and in coffee, tea and cocoa . A flavoring agent.

HY-N15359

Germicidin C	Bacterial	Infection
Germicidin C is a microbial metabolite with antibacterial activity, which is found in the marine sponge-derived fungus Aspergillus niger. Germicidin C can inhibit the growth of various pathogenic bacteria such as Staphylococcus aureus, Escherichia coli, and Bacillus subtilis with MIC values ranging from 32 to 64 µg/mL .

HY-N15345

Menominin A	Others	Cancer
Menominin A is a cyclic peptide identified from the freshwater sponge-associated cyanobacterium Nostoc sp., exhibiting cytotoxic properties. It displays antiproliferative activity against the ovarian cancer cell line OVCAR3, with an IC₅₀ value of 3.1 μM. Menominin A holds promise for research in the field of anticancer therapeutics .

HY-N15346

Menominin B	Others	Cancer
Menominin B is a cyclic peptide found in the freshwater sponge-associated cyanobacterium Nostoc sp. with cytotoxic properties. Menominin B exhibits antiproliferative activity against the ovarian cancer cell line OVCAR3 (with IC₅₀ of 2.4 μM). Menominin B holds promise for research in the field of anticancer therapy .

HY-121014

Amphimedine	Reactive Oxygen Species	Cancer
Amphimedine is a polycyclic alkaloid isolated from the marine sponge Amphimedon sp. and belongs to the pyridoindole alkaloid class. Amphimedine has cytotoxic activity and has been studied as an anticancer metabolite along with neoamphimedine. Studies have shown that deoxyamphimedine damages DNA by generating reactive oxygen species, a mechanism different from that of amphimedine.

HY-125660

Leucettamol A	E1/E2/E3 Enzyme MDM-2/p53	Infection
Leucettamol A is an inhibitor of Ubc13 (ubiquitin E2 enzyme)-Uev1A interaction, with an IC₅₀ of 50 μg/mL. Leucettamol A can potentially activate the expression of cancer suppressor p53 and is a precursor of anticancer agents. Leucettamol A can be isolated from a marine sponge, Leucetta aff. Microrhaphis .

HY-112328

Fascaplysin	Apoptosis Autophagy Reactive Oxygen Species CDK	Infection Cancer
Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity .

HY-19827

Aeroplysinin 1 (+)-Aeroplysinin-1	Bacterial HIV Apoptosis	Infection Cancer
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC₅₀=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells .

HY-N6652

1-beta-D-Arabinofuranosyluracil 1 Publications Verification Uracil 1-β-D-arabinofuranoside	Others	Cardiovascular Disease Inflammation/Immunology Cancer
1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties . 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells .

HY-Y0543R

5-Methylfurfural (Standard)	Biochemical Assay Reagents	Others
5-Methylfurfural (Standard) is the analytical standard of 5-Methylfurfural. This product is intended for research and analytical applications. 5-Methylfurfural is a naturally occurring substance, found in cigarette smoke condensate, licorice essential oil, stored dehydrated orange powder, baked potato flour, volatile compounds of roast beef, aroma concentrate of sponge cake. bread and in coffee, tea and cocoa . A flavoring agent.

Cat. No.	Product Name

HY-L143

Marine-Sourced Natural Product Library

55 compounds

Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria.

Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union.

MCE offers a unique collection of 55 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Cat. No.	Product Name	Type