2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Sodium 3-methyl-2-oxobutanoate

Sodium 3-methyl-2-oxobutanoate 

Cat. No.: HY-W006057A Purity: 99.84%
SDS COA Handling Instructions

Molarity Calculator

Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli.

For research use only. We do not sell to patients.

Sodium 3-methyl-2-oxobutanoate Chemical Structure

Sodium 3-methyl-2-oxobutanoate Chemical Structure

CAS No. : 3715-29-5

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1 g USD 80 In-stock
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Sodium 3-methyl-2-oxobutanoate Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli[1][2][3].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

Sodium 3-methyl-2-oxobutanoate (alpha-Ketoisovaleric acid) is a precursor of pantothenic acid in Escherichia coli[1]. Sodium 3-methyl-2-oxobutanoate (alpha-Ketoisovaleric acid) enhances alpha-ketoisocaproic acid and alpha-keto-beta-methyl-n-valeric acid, but diminishes the corresponding amino acids, and causes an early decline of ornithine along with a late augmentation of plasma arginine[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium 3-methyl-2-oxobutanoate Related Antibodies
In Vivo

Sodium 3-methyl-2-oxobutanoate (alpha-Ketoisovaleric acid) induces convulsions through GABAergic and glutamatergic mechanisms in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

138.10

Formula

C5H7NaO3
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

CC(C)C(C(O[Na])=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (724.11 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.2411 mL 36.2056 mL 72.4113 mL
5 mM 1.4482 mL 7.2411 mL 14.4823 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (724.11 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.84%

SDS (393 KB)

COA (247 KB) HNMR (233 KB) RP-HPLC (238 KB) MS (71 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.2411 mL 36.2056 mL 72.4113 mL 181.0282 mL
5 mM 1.4482 mL 7.2411 mL 14.4823 mL 36.2056 mL
10 mM 0.7241 mL 3.6206 mL 7.2411 mL 18.1028 mL
15 mM 0.4827 mL 2.4137 mL 4.8274 mL 12.0685 mL
20 mM 0.3621 mL 1.8103 mL 3.6206 mL 9.0514 mL
25 mM 0.2896 mL 1.4482 mL 2.8965 mL 7.2411 mL
30 mM 0.2414 mL 1.2069 mL 2.4137 mL 6.0343 mL
40 mM 0.1810 mL 0.9051 mL 1.8103 mL 4.5257 mL
50 mM 0.1448 mL 0.7241 mL 1.4482 mL 3.6206 mL
60 mM 0.1207 mL 0.6034 mL 1.2069 mL 3.0171 mL
80 mM 0.0905 mL 0.4526 mL 0.9051 mL 2.2629 mL
100 mM 0.0724 mL 0.3621 mL 0.7241 mL 1.8103 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sodium 3-methyl-2-oxobutanoate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium 3-methyl-2-oxobutanoate3715-29-5Endogenous MetaboliteInhibitorinhibitorinhibit

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