2,4-D sodium salt (Synonyms: Sodium 2,4-dichlorophenoxyacetate; 2,4-Dichlorophenoxyacetic acid sodium salt)

Name: 2,4-D sodium salt
Brand: MedChemExpress
SKU: HY-18572A
Rating: 4.5 (1 reviews)

Cat. No.: HY-18572A Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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2,4-D sodium salt (Sodium 2,4-dichlorophenoxyacetate) is a selective herbicide that can be orally active for the control of broad-leaved weeds. 2,4-D sodium salt can induce < b>apoptosis. 2,4-D sodium salt inhibits DNA and protein synthesis, thereby preventing normal plant growth and development.

For research use only. We do not sell to patients.

2,4-D sodium salt Chemical Structure

CAS No. : 2702-72-9

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Based on 1 publication(s) in Google Scholar

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Description

In Vitro

2, 4-D sodium salt (25-200 μM, 72 h) inhibits the cell viability of A549 and WI38 with IC₅₀ values of 126 ± 2.25µM and 115 ± 4.39µM, respectively. By influencing cell cycle, apoptosis was induced^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	A549, W138
Concentration:	25, 50, 75, 100, 150, 200 μM
Incubation Time:	72 h
Result:	Inhibited cell viability in a dose-dependent manner.

Cell Cytotoxicity Assay^[2]

Cell Line:	A549
Concentration:	50, 100, 150 μM
Incubation Time:	72 h
Result:	The G0/G1 population decreased to about 57%, 43% and 31%, respectively.

Apoptosis Analysis^[2]

Cell Line:	A549, W138
Concentration:	100, 150 μM
Incubation Time:	72 h
Result:	The early apoptotic population increased to 44% in A549 cells and 57% in WI38 cells, and the late apoptotic population increased to 18% in A549 cells and 10% in WI38 cells.

Western Blot Analysis^[2]

Cell Line:	A549, W138
Concentration:	100, 150 μM
Incubation Time:	72 h
Result:	Up-regulated p53 and Bax proteins, down-regulated Bcl-2 and pro caspase 3.

In Vivo

2,4-D sodium salt (100 or 200 mg/kg, gavage for 30 days) has toxic effects on the reproductive system of male rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult Wistar male rats^[3]
Dosage:	100 or 200 mg/kg
Administration:	i.g.
Result:	Decreased the testis , seminal vesicles and prostate relative weight. Decreased the number of spermatozoa and sperm motility. Increased the level of FSH and LH.

Molecular Weight

243.02

Formula

C₈H₅Cl₂NaO₃

CAS No.

2702-72-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])COC1=CC=C(Cl)C=C1Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (411.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 25 mg/mL (102.87 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1149 mL	20.5744 mL	41.1489 mL
5 mM	0.8230 mL	4.1149 mL	8.2298 mL
10 mM	0.4115 mL	2.0574 mL	4.1149 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (20.57 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (20.57 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (20.57 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (276 KB) SDS (597 KB)

COA (246 KB) HNMR (111 KB)

Handling Instructions (2659 KB)

References

[1]. Germaine KJ, et al. Bacterial endophyte-enhanced phytoremediation of the organochlorine herbicide 2,4-dichlorophenoxyacetic acid. FEMS Microbiol Ecol. 2006 Aug;57(2):302-10. [Content Brief]

[2]. Ganguli A, et al. 2, 4-Dichlorophenoxyacetic acid induced toxicity in lung cells by disruption of the tubulin-microtubule network. Toxicology Research, 2014, 3(2): 118-130.

[3]. Marouani N, et al. Effects of oral administration of 2,4-dichlorophenoxyacetic acid (2,4-D) on reproductive parameters in male Wistar rats. Environ Sci Pollut Res Int. 2017 Jan;24(1):519-526. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	4.1149 mL	20.5744 mL	41.1489 mL	102.8722 mL
	5 mM	0.8230 mL	4.1149 mL	8.2298 mL	20.5744 mL
	10 mM	0.4115 mL	2.0574 mL	4.1149 mL	10.2872 mL
	15 mM	0.2743 mL	1.3716 mL	2.7433 mL	6.8581 mL
	20 mM	0.2057 mL	1.0287 mL	2.0574 mL	5.1436 mL
	25 mM	0.1646 mL	0.8230 mL	1.6460 mL	4.1149 mL
	30 mM	0.1372 mL	0.6858 mL	1.3716 mL	3.4291 mL
	40 mM	0.1029 mL	0.5144 mL	1.0287 mL	2.5718 mL
	50 mM	0.0823 mL	0.4115 mL	0.8230 mL	2.0574 mL
	60 mM	0.0686 mL	0.3429 mL	0.6858 mL	1.7145 mL
	80 mM	0.0514 mL	0.2572 mL	0.5144 mL	1.2859 mL
	100 mM	0.0411 mL	0.2057 mL	0.4115 mL	1.0287 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

2,4-D sodium salt Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,4-D2702-72-9Sodium 2,4-dichlorophenoxyacetate2,4-Dichlorophenoxyacetic acidDNA/RNA SynthesisApoptosisA549W138HerbicideFSH， LHInhibitorinhibitorinhibit

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2,4-D sodium salt (Synonyms: Sodium 2,4-dichlorophenoxyacetate; 2,4-Dichlorophenoxyacetic acid sodium salt)

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Other Forms of 2,4-D sodium salt:

2,4-D sodium salt Related Antibodies

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Biological Activity

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2,4-D sodium salt Related Antibodies

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Complete Stock Solution Preparation Table

2,4-D sodium salt Related Classifications

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