4-Bromo-2-methylpyridine (Synonyms: 4-Bromo-2-picoline; 4-Bromo-2-methylpyridine)

Name: 4-Bromo-2-methylpyridine
Brand: MedChemExpress
SKU: HY-W007447
Rating: 4.5 (1 reviews)

Cat. No.: HY-W007447 Purity: 99.59%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

4-Bromo-2-methylpyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

4-Bromo-2-methylpyridine Chemical Structure

CAS No. : 22282-99-1

Size	Price	Stock	Quantity
5 g	USD 25	In-stock	Estimated Time of Arrival: April 18
10 g	USD 35	In-stock	Estimated Time of Arrival: April 18
25 g	USD 60	In-stock	Estimated Time of Arrival: April 18
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Based on 1 publication(s) in Google Scholar

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Description

4-Bromo-2-methylpyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

In Vitro

4-Bromo-2-methylpyridine is used as a starting material in the preparation of crown-ester-bipyridines and viologens through sodium or nickel reactive coupling, side chain oxidation and esterification. Furthermore, it serves as an important raw material and intermediate in organic synthesis, pharmaceuticals, agrochemicals and in dyes.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

172.02

Formula

C₆H₆BrN

CAS No.

22282-99-1

Appearance

Liquid (Density: 1.450 g/cm³)

Color

Colorless to light yellow

SMILES

C1=C(Br)C=CN=C1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (581.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8133 mL	29.0664 mL	58.1328 mL
5 mM	1.1627 mL	5.8133 mL	11.6266 mL
10 mM	0.5813 mL	2.9066 mL	5.8133 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.53 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.53 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (14.53 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Purity & Documentation

Purity: 99.59%

Select Batch:

Data Sheet (246 KB) SDS (555 KB)

COA (247 KB) HNMR (118 KB) GC (239 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.8133 mL	29.0664 mL	58.1328 mL	145.3319 mL
	5 mM	1.1627 mL	5.8133 mL	11.6266 mL	29.0664 mL
	10 mM	0.5813 mL	2.9066 mL	5.8133 mL	14.5332 mL
	15 mM	0.3876 mL	1.9378 mL	3.8755 mL	9.6888 mL
	20 mM	0.2907 mL	1.4533 mL	2.9066 mL	7.2666 mL
	25 mM	0.2325 mL	1.1627 mL	2.3253 mL	5.8133 mL
	30 mM	0.1938 mL	0.9689 mL	1.9378 mL	4.8444 mL
	40 mM	0.1453 mL	0.7267 mL	1.4533 mL	3.6333 mL
	50 mM	0.1163 mL	0.5813 mL	1.1627 mL	2.9066 mL
	60 mM	0.0969 mL	0.4844 mL	0.9689 mL	2.4222 mL
	80 mM	0.0727 mL	0.3633 mL	0.7267 mL	1.8166 mL
	100 mM	0.0581 mL	0.2907 mL	0.5813 mL	1.4533 mL

4-Bromo-2-methylpyridine Related Classifications

Others

Keywords:

4-Bromo-2-methylpyridine22282-99-14-Bromo-2-picoline 4-Bromo-2-methylpyridineBiochemical Assay Reagentsbiochemical reagentbiological materialorganic compoundlife scienceInhibitorinhibitorinhibit

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4-Bromo-2-methylpyridine (Synonyms: 4-Bromo-2-picoline; 4-Bromo-2-methylpyridine)

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Complete Stock Solution Preparation Table

4-Bromo-2-methylpyridine Related Classifications

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