2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Autophagy
  3. RAR/RXR Autophagy
  4. AGN 205728

AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.

For research use only. We do not sell to patients.

AGN 205728 Chemical Structure

AGN 205728 Chemical Structure

CAS No. : 859498-05-8

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AGN 205728 Related Antibodies

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Description

AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ. IC50 value: 3 nM/ 0.6 nM(Ki/IC95) Target: RARγ antagonist More information can be found in the following patent, Compound 7a. Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity By Tsang, Kwok Yin; Sinha, Santosh; Liu, Xiaoxia; Bhat, Smita; Chandraratna, Roshantha A. From PCT Int. Appl. (2005), WO 2005066115 A2 20050721.

Molecular Weight

437.53

Formula

C29H27NO3
CAS No.
Appearance

Solid

Color

Light yellow to khaki

SMILES

CC(C=C1)=CC=C1C2=CCC(C)(C)C3=C2C=CC(C(/C=C/C4=CC=C(C(O)=O)C=C4)=N/O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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AGN 205728 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AGN 205728859498-05-8AGN205728AGN-205728RAR/RXRAutophagyRetinoic acid receptorsRetinoid X receptorsInhibitorinhibitorinhibit

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