AGN 205728

Cat. No.: HY-16683: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.

For research use only. We do not sell to patients.

AGN 205728 Chemical Structure

CAS No. : 859498-05-8

Size	Price	Stock
5 mg	USD 550	Ask For Quote & Lead Time
10 mg	USD 900	Ask For Quote & Lead Time
25 mg	USD 1800	Ask For Quote & Lead Time
50 mg	USD 2900	Ask For Quote & Lead Time
100 mg	USD 4700	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All RAR/RXR Isoform Specific Products:

View All Isoforms

RXRα RXRβ RXRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ. IC50 value: 3 nM/ 0.6 nM(Ki/IC95) Target: RARγ antagonist More information can be found in the following patent, Compound 7a. Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity By Tsang, Kwok Yin; Sinha, Santosh; Liu, Xiaoxia; Bhat, Smita; Chandraratna, Roshantha A. From PCT Int. Appl. (2005), WO 2005066115 A2 20050721.

Molecular Weight

437.53

Formula

C₂₉H₂₇NO₃

CAS No.

859498-05-8

Appearance

Solid

Color

Light yellow to khaki

SMILES

CC(C=C1)=CC=C1C2=CCC(C)(C)C3=C2C=CC(C(/C=C/C4=CC=C(C(O)=O)C=C4)=N/O)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 96.66%

Select Batch:

Data Sheet (268 KB) SDS (0 KB)

COA (249 KB) LCMS (467 KB)

Handling Instructions (2659 KB)

References

[1]. Tsang, Kwok Yin, et al. Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity. Appl. (2005), WO 2005066115 A2 20050721.

AGN 205728 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AGN 205728859498-05-8AGN205728AGN-205728RAR/RXRAutophagyRetinoic acid receptorsRetinoid X receptorsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks