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  6. Histamine phosphate

Histamine phosphate  (Synonyms: Histamine diphosphate)

Cat. No.: HY-A0129 Purity: 99.34%
Data Sheet
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Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

Histamine phosphate is the agonist for histamine receptor and a vasodilator. Histamine phosphate affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities.

For research use only. We do not sell to patients.

Histamine phosphate Chemical Structure

Histamine phosphate Chemical Structure

CAS No. : 51-74-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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 USD 52 In-stock
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Based on 10 publication(s) in Google Scholar

Other Forms of Histamine phosphate:

Top Publications Citing Use of Products

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Akt Akt1 Akt2 Akt3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Histamine phosphate is the agonist for histamine receptor and a vasodilator. Histamine phosphate affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities[1][2][3][4].

In Vitro

Histamine phosphate (0.01-10 µM, 72 h) exhibits a bidirectional regulatory effect on the proliferation of MDA-MB-231, arrests the cell cycle at G2/M phase, induces the formation of lipid droplet, induces differentiation and apoptosis in MDA-MB-231[3].
Histamine phosphate (10 µM, 24 h) increases the generation of ROS, especially H2O2, reduces the activity of antioxidant enzymes (such as catalase), thereby promoting radiosensitivity in MDA-MB-231[3].
Histamine (1-100 µM, 12 h) inhibits the migration of microglia and the release of inflammatory mediator IL-1β in LPS (HY-D1056)-stimulated N9 mouse microglial, exhibits anti-inflammatory activity[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: MDA-MB-231
Concentration: 0.01-10 µM
Incubation Time: 72 h
Result: Promoted cell proliferation at 10 µM, inhibited cell proliferation at 0.01 µM.

Apoptosis Analysis[3]

Cell Line: MDA-MB-231
Concentration: 10 µM
Incubation Time: 48 h
Result: Induced apoptosis.
In Vivo

Histamine phosphate (0.05-100 μg/mouse, icv, single dose) exhibits analgesic effect at high doses of histamine (50-100 μg/mouse), causes hyperalgesia at low doses (0.1-1 μg/mouse) in mouse model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse model[2]
Dosage: 0.05-100 μg/mouse
Administration: icv, single dose
Result: Prolonged the licking latency at the dose of 50 and 100 μg/mouse.
Shortened the licking latency at the dose of 0.1-1 μg/mouse.
Clinical Trial
Molecular Weight

307.14

Formula

C5H15N3O8P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NCCC1=CNC=N1.O=P(O)(O)O.O=P(O)(O)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (325.58 mM; Need ultrasonic)

DMSO : 1.43 mg/mL (4.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2558 mL 16.2792 mL 32.5584 mL
5 mM 0.6512 mL 3.2558 mL 6.5117 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (162.79 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.2558 mL 16.2792 mL 32.5584 mL 81.3961 mL
H2O 5 mM 0.6512 mL 3.2558 mL 6.5117 mL 16.2792 mL
10 mM 0.3256 mL 1.6279 mL 3.2558 mL 8.1396 mL
15 mM 0.2171 mL 1.0853 mL 2.1706 mL 5.4264 mL
20 mM 0.1628 mL 0.8140 mL 1.6279 mL 4.0698 mL
25 mM 0.1302 mL 0.6512 mL 1.3023 mL 3.2558 mL
30 mM 0.1085 mL 0.5426 mL 1.0853 mL 2.7132 mL
40 mM 0.0814 mL 0.4070 mL 0.8140 mL 2.0349 mL
50 mM 0.0651 mL 0.3256 mL 0.6512 mL 1.6279 mL
60 mM 0.0543 mL 0.2713 mL 0.5426 mL 1.3566 mL
80 mM 0.0407 mL 0.2035 mL 0.4070 mL 1.0175 mL
100 mM 0.0326 mL 0.1628 mL 0.3256 mL 0.8140 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Histamine phosphate Related Classifications

Keywords:

Histamine51-74-1Histamine diphosphateHistamine Receptorp38 MAPKAktReactive Oxygen SpeciesApoptosisPKBProtein kinase BantinociceptivehyperalgesicMDA-MB-231Inhibitorinhibitorinhibit

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