2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. Pivalopril

Pivalopril  (Synonyms: Pivopril; RHC 3659(S))

Cat. No.: HY-U00041 Purity: 99.19%
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Pivalopril is a new orally active angiotensin converting enzyme (ACE) inhibitor.

For research use only. We do not sell to patients.

Pivalopril Chemical Structure

Pivalopril Chemical Structure

CAS No. : 81045-50-3

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5 mg USD 510 In-stock
10 mg USD 820 In-stock
25 mg USD 1680 In-stock
50 mg USD 2650 In-stock
100 mg USD 4200 In-stock
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Based on 1 publication(s) in Google Scholar

Pivalopril Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Pivalopril

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pivalopril is a new orally active angiotensin converting enzyme (ACE) inhibitor.

IC50 & Target

ACE[1]
In Vivo

Pivalopril is a new compound with a hindered sulfur group that has been compared to Captopril for oral angiotensin-converting enzyme (ACE) inhibition in rats and dogs and antihypertensive activity in rats. In separate groups of conscious normotensive rats, Pivalopril (0.03-1.0 mg/kg, orally [p.o.]) produces a dose-related antagonism of angiotensin I (AngI)-induced pressor effects. The ED50 for Pivalopril and Captopril is 0.1 mg/kg. In conscious normotensive dogs, Pivalopril (incremental doses of 0.01-1.0 mg/kg, p.o.) produces a dose-related antagonism of AngI pressor effects. The ED50 is 0.17 mg/kg for Pivalopril and 0.06 mg/kg for Captopril. At equieffective doses the two compounds have similar durations of action. In sodium-deficient, conscious spontaneously hypertensive rats (SHR), Pivalopril (1-100 mg/kg, p.o.) produces a dose-related reduction in mean arterial pressure. The potency and duration are similar to those of Captopril. In the sodium-replete SHR, 5 days of oral dosing with Pivalopril (100 mg/kg per day) decreases mean arterial pressure more effectively than Captopril (100 mg/kg per day). It is concluded that Pivalopril is a potent, orally effective ACE inhibitor and antihypertensive agent[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

329.45

Formula

C16H27NO4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CN(C1CCCC1)C([C@H](C)CSC(C(C)(C)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 90 mg/mL (273.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0354 mL 15.1768 mL 30.3536 mL
5 mM 0.6071 mL 3.0354 mL 6.0707 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0354 mL 15.1768 mL 30.3536 mL 75.8840 mL
5 mM 0.6071 mL 3.0354 mL 6.0707 mL 15.1768 mL
10 mM 0.3035 mL 1.5177 mL 3.0354 mL 7.5884 mL
15 mM 0.2024 mL 1.0118 mL 2.0236 mL 5.0589 mL
20 mM 0.1518 mL 0.7588 mL 1.5177 mL 3.7942 mL
25 mM 0.1214 mL 0.6071 mL 1.2141 mL 3.0354 mL
30 mM 0.1012 mL 0.5059 mL 1.0118 mL 2.5295 mL
40 mM 0.0759 mL 0.3794 mL 0.7588 mL 1.8971 mL
50 mM 0.0607 mL 0.3035 mL 0.6071 mL 1.5177 mL
60 mM 0.0506 mL 0.2529 mL 0.5059 mL 1.2647 mL
80 mM 0.0379 mL 0.1897 mL 0.3794 mL 0.9486 mL
100 mM 0.0304 mL 0.1518 mL 0.3035 mL 0.7588 mL
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Pivalopril Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pivalopril81045-50-3Pivopril RHC 3659(S)Angiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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