1. Signaling Pathways
  2. Anti-infection
  3. HSV

HSV

HSV

Herpes simplex virus

HSV (Herpes simplex virus) can be spread when an infected person is producing and shedding the virus. Herpes simplex can be spread through contact with saliva, such as sharing drinks. Symptoms of herpes simplex virus infection include watery blisters in the skin or mucous membranes of the mouth, lips or genitals. Lesions heal with ascab characteristic of herpetic disease. As neurotropic and neuroinvasive viruses, HSV-1 and -2 persist in the body by becoming latent and hiding from the immune system in the cell bodies of neurons. After the initial or primary infection, some infected people experience sporadic episodes of viral reactivation or outbreaks.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13742
    Ropidoxuridine
    Inhibitor 99.59%
    Ropidoxuridine (IPdR) is a novel orally available, halogenated thymidine analog and is a potential radiosensitizer for use in human tumors.
    Ropidoxuridine
  • HY-117025
    Manzamine A
    Inhibitor 98.2%
    Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1.
    Manzamine A
  • HY-W017522S3
    Adipic acid-13C
    Inhibitor 98.62%
    Adipic acid-13C (Hexanedioic acid-13C) is the 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc.
    Adipic acid-<sup>13</sup>C
  • HY-N4155
    2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid
    Inhibitor ≥98.0%
    2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides)-activated RAW 264.7 cells.
    2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid
  • HY-N8082
    Stearyl gallate
    Inhibitor 99.50%
    Stearyl gallate is an alkyl gallate with a long alkyl chain (carbon number of 18). Stearyl gallate has an antioxidant activity, and a weak antiviral activity against HSV-1.
    Stearyl gallate
  • HY-N7677
    Isookanin
    Inhibitor 99.52%
    Isookanin can be used for the research of various illnesses including cancers, skin rashes, snake and insects bites, diabetes mellitus, diarrhoea. Isookanin acts as an anti-viral agent against HSV and varicella-zoster virus (VZV). Antioxidant activity.
    Isookanin
  • HY-13605S
    Cytarabine-d2
    Inhibitor ≥98.0%
    Cytarabine-d2 is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV[1][2].
    Cytarabine-d<sub>2</sub>
  • HY-N6666
    Vidarabine monohydrate
    Inhibitor 99.96%
    Vidarabine monohydrate is an adenine arabinoside. Vidarabine monohydrate an antiviral agent which is active against herpes simplex viruses (HSV) and varicella zoster viruses.
    Vidarabine monohydrate
  • HY-163529
    HN0037
    Inhibitor 99.46%
    HN0037 is a selective and orally active helicase-primase inhibitor. HN0037 inhibits HSV replication by targeting the viral helicase-primase enzyme complex.
    HN0037
  • HY-U00124
    Tromantadine
    Inhibitor ≥99.0%
    Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication.
    Tromantadine
  • HY-113135R
    5-Methylcytidine (Standard)
    Inhibitor
    5-Methylcytidine (Standard) is the analytical standard of 5-Methylcytidine. This product is intended for research and analytical applications. 5-Methylcytidine is a nucleoside compound. 5-Methylcytidine has antiviral activity, and its IC50 against HSV-1 is 0.06 μM.
    5-Methylcytidine (Standard)
  • HY-N7346
    Lucidadiol
    Inhibitor ≥98.0%
    Lucidadiol is a natural compound isolated from Ganoderma lucidum. Lucidadiol exhibits acetylcholinesterase-inhibitory activity, with IC50 values of 31 μM. Lucidadiol shows antiviral activity against influenza virus type A and HSV type 1.
    Lucidadiol
  • HY-50735
    Fiacitabine
    Inhibitor 99.27%
    Fiacitabine(NSC 382097; FIAC; FOAC) is a selective inhibitior of DNA replication of herpes simplex virus(HSV) with IC50 values of 2.
    Fiacitabine
  • HY-14809R
    Amenamevir (Standard)
    Inhibitor
    Amenamevir (Standard) is the analytical standard of Amenamevir. This product is intended for research and analytical applications. Amenamevir is a helicase-primase inhibitor which has potent antiviral activity against HSVs with an EC50 of 14 ng/mL.
    Amenamevir (Standard)
  • HY-A0181S2
    Adenosine monophosphate-d12 dilithium
    Inhibitor
    Adenosine monophosphate-d12 (AMP-d12) dilithium is deuterium labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
    Adenosine monophosphate-d<sub>12</sub> dilithium
  • HY-W017522S4
    Adipic acid-d8
    Inhibitor 98.64%
    Adipic acid-d8 (Hexanedioic acid-d8) is the deuterium labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc.
    Adipic acid-d<sub>8</sub>
  • HY-17422A
    Acyclovir sodium
    Inhibitor
    Acyclovir (Aciclovir) sodium is a potent, orally active antiviral agent. Acyclovir sodium has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir sodium induces cell cycle perturbation and apoptosis. Acyclovir sodium prevents bacterial infections during induction therapy for acute leukaemia.
    Acyclovir sodium
  • HY-107739
    Penciclovir sodium
    Inhibitor
    Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse.
    Penciclovir sodium
  • HY-13637B
    Ganciclovir hydrate
    Inhibitor
    Ganciclovir (BW 759) hydrate, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir hydrate also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir hydrate inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir hydrate has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain.
    Ganciclovir hydrate
  • HY-17425B
    Valacyclovir hydrochloride hydrate
    Inhibitor
    Valacyclovir hydrochloride hydrate is a potent antiviral agent. Valacyclovir hydrochloride hydrate can be used in the management of herpes simplex, herpes zoster and herpes B. Valacyclovir hydrochloride hydrate can be formulate ocular inserts for the research of ocular herpes. Valacyclovir hydrochloride hydrate is a precursor and can be rapidly converted into acyclovir in vivo.
    Valacyclovir hydrochloride hydrate

HSV-1

HSV-2

HSV

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HSV Inhibitors
Product NameHSV-1HSV-2HSVPurity    
2-Deoxy-D-glucose
HSV-1
  99.93%
Brefeldin A
HSV-1
  99.82%
Cytarabine
HSV-1
  99.98%
Dynasore
HSV-1
HSV-2
 99.66%
Imiquimod
HSV-1
  99.96%
Ivermectin
HSV-1
  98.28%
Ganciclovir
HSV-1
HSV-2
 99.89%
Salubrinal
HSV-1
  99.58%
Acyclovir
HSV-1, IC50: 0.85 μM
HSV-2, IC50: 0.86 μM
 99.34%
Floxuridine  
HSV
99.97%
Ginsenoside Rb1
HSV-1
  99.28%
Imiquimod hydrochloride
HSV-1
  99.77%
Digitoxin
HSV-1
  99.36%
Xanthohumol
HSV-1
HSV-2
 99.97%
Trifluridine
HSV-1
HSV-2
 99.98%
Surfactin
HSV-1
HSV-2
 98.96%
Levamisole hydrochloride
HSV-1
  99.87%
Theaflavin 3,3'-digallate  
HSV
99.73%
Surfen dihydrochloride
HSV-1
  ≥99.0%
Ganciclovir sodium
HSV-1
HSV-2
 99.92%
5-Methylcytidine
HSV-1, IC50: 0.06 μM
  99.72%
Betulonic acid
HSV-1
  98.06%
FSL-1 TFA 
HSV-2
 99.65%
N-Lauroylsarcosine
HSV-1
HSV-2
 99.81%
Pritelivir
HSV-1, IC50: 0.02 μM
HSV-2, IC50: 0.02 μM
 99.94%
Oxyresveratrol
HSV-1
HSV-2
 99.73%
Oxytetracycline
HSV-1
  99.05%
Valacyclovir hydrochloride
HSV-1, IC50: 2.9 μg/mL
  99.85%
Adenosine 5'-monophosphate monohydrate
HSV-1
HSV-2
 99.07%
Penciclovir
HSV-1, EC50: 0.5 μg/mL
HSV-2, EC50: 0.8 μg/mL
 99.92%
Amenamevir
HSV-1, IC50: 7.7-20 ng/mL
HSV-2, IC50: 15-58 ng/mL
 99.89%
Vidarabine
HSV-1, IC50: 9.3 μg/mL
HSV-2, IC50: 11.3 μg/mL
 99.35%
Octyl gallate
HSV-1
  98.01%
Pinostrobin
HSV-1
  99.98%
Brassicasterol
HSV-1, IC50: 1.2 μM
  98.71%
Oxytetracycline hydrochloride
HSV-1
  98.92%
LDC4297
HSV-1, EC50: 0.02 μM
HSV-2, EC50: 0.27 μM
 98.25%
Imiquimod maleate
HSV-1
  99.25%
Soyasaponin II
HSV-1, IC50: 54 μM
  99.81%
BIO-acetoxime
HSV-1
  ≥98.0%
FIT-039
HSV-1, IC50: 0.69 μM
  99.56%
AT-533
HSV-1
  98.86%
SIBA
HSV-1
  99.64%
Isoxanthohumol
HSV-1
HSV-2
 99.91%
Histone H4 (2-21)
HSV-1
  98.17%
LDC4297 hydrochloride
166v VP22-GFP, EC50: 0.02 μM
01-6332, EC50: 0.27 μM
 98.23%
Manzamine A hydrochloride
HSV-1
  99.66%
Isoborneol
HSV-1
  98.45%
Docusate Sodium
HSV-1
HSV-2
 ≥98.0%
Tromantadine hydrochloride
HSV-1
HSV-2
 ≥98.0%
Soyasapogenol C
HSV-1
  ≥99.0%
Pritelivir mesylate hydrate
HSV-1, IC50: 0.02 μM
HSV-2, IC50: 0.02 μM
 99.51%
Valacyclovir
HSV-1, IC50: 2.9 μg/mL
  
Pritelivir mesylate
HSV-1, IC50: 0.02 μM
HSV-2, IC50: 0.02 μM
 99.51%
Oxytetracycline calcium
HSV-1
  
5-Nitrobarbituric acid
HSV-1, IC50: 1.7 μM
  99.91%
Leachianone G
HSV-1, IC50: 1.6 μg/mL
  
B220
HSV-1
HSV-2
 ≥99.0%
Manzamine A
HSV-1
  98.2%
Stearyl gallate
HSV-1
  99.50%
Tromantadine
HSV-1
HSV-2
 ≥99.0%
Fiacitabine
HSV-1
HSV-2
 99.27%
Acyclovir sodium
HSV-1, IC50: 0.85 μM
HSV-2, IC50: 0.86 μM
 
Penciclovir sodium
HSV-1, EC50: 0.5 μg/mL
HSV-2, EC50: 0.8 μg/mL
 
Ganciclovir hydrate
HSV-1
HSV-2
 
Surfen
HSV-1
  
Perillic acid
HSV-1
  
Ganoderone A  
HSV, IC50: 0.3 μg/mL
Kushenol K 
HSV-2, EC50: 147 μM
 
Ginsenoside Rb1 (Standard)
HSV-1
  
Peniterphenyl A
HSV-1
  
WAY-150138
HSV-1, IC50: 0.2 μg/mL
HSV-2, IC50: 6.8 μg/mL
 
HSV-1/HSV-2-IN-2
HSV-1, EC50: 6.8 μM
HSV-2, EC50: 8.9 μM
 
Yatein
HSV-1
  99.76%
HSV-1-IN-1
HSV-1, IC50: 0.5 nM
HSV-2, IC50: 16 nM
 
HSV-1/HSV-2-IN-1
HSV-1
HSV-2
 
Oxytetracycline dihydrate
HSV-1
  
17,17-Ethylendioxyandrost-5-en-3β-ol
HSV-1
  
SCH-43478 
HSV-2, IC50: 1.8 μg/mL
 
BRL44385
HSV-1
HSV-2