CAIX/CAXII-IN-4 

CAIX/CAXII-IN-4 (Compound 7h) is the inhibitor for carbonic anhydrase (CA) that binds CA IX, CA XII and CA II with K_i of 1.324 μM, 0.435 μM and 3.035 μM. CAIX/CAXII-IN-4 exhibits board-spectrum antitumor efficacy, inhibits the proliferation of CNS cancer U251 with GI₅₀ of 0.361 μM^[1].

447.51

C₂₃H₂₁N₅O₃S

CC1=CC(C)=CC(C(NC2=CC=CC(C3=CN(C4=CC=C(S(=O)(N)=O)C=C4)N=N3)=C2)=O)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. El-Damasy AK, et al., Novel N-(3-(1-(4-sulfamoylphenyl)triazol-4-yl)phenyl)benzamide Derivatives as Potent Carbonic Anhydrase Inhibitors with Broad-Spectrum Anticancer Activity: Leveraging Tail and Dual-Tail Approaches. J Med Chem. 2025 Feb 13;68(3):3764-3781.  [Content Brief]