2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Desmethylnortriptyline

Desmethylnortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.

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Desmethylnortriptyline Chemical Structure

Desmethylnortriptyline Chemical Structure

CAS No. : 4444-42-2

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Based on 1 publication(s) in Google Scholar

Desmethylnortriptyline Related Antibodies

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Description

Desmethylnortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].

Molecular Weight

249.35

Formula

C18H19N
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (401.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0104 mL 20.0521 mL 40.1043 mL
5 mM 0.8021 mL 4.0104 mL 8.0209 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0104 mL 20.0521 mL 40.1043 mL 100.2607 mL
5 mM 0.8021 mL 4.0104 mL 8.0209 mL 20.0521 mL
10 mM 0.4010 mL 2.0052 mL 4.0104 mL 10.0261 mL
15 mM 0.2674 mL 1.3368 mL 2.6736 mL 6.6840 mL
20 mM 0.2005 mL 1.0026 mL 2.0052 mL 5.0130 mL
25 mM 0.1604 mL 0.8021 mL 1.6042 mL 4.0104 mL
30 mM 0.1337 mL 0.6684 mL 1.3368 mL 3.3420 mL
40 mM 0.1003 mL 0.5013 mL 1.0026 mL 2.5065 mL
50 mM 0.0802 mL 0.4010 mL 0.8021 mL 2.0052 mL
60 mM 0.0668 mL 0.3342 mL 0.6684 mL 1.6710 mL
80 mM 0.0501 mL 0.2507 mL 0.5013 mL 1.2533 mL
100 mM 0.0401 mL 0.2005 mL 0.4010 mL 1.0026 mL
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Desmethylnortriptyline Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Desmethylnortriptyline4444-42-2Drug MetabolitemetaboliteantidepressantdepressionInhibitorinhibitorinhibit

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