Desmethylnortriptyline

Cat. No.: HY-100651 Purity: 99.95%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Desmethylnortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.

For research use only. We do not sell to patients.

Desmethylnortriptyline Chemical Structure

CAS No. : 4444-42-2

Size	Price	Stock	Quantity
5 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 700	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1120	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1750	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Molecular Weight

249.35

Formula

C₁₈H₁₉N

CAS No.

4444-42-2

Appearance

Solid

Color

White to off-white

SMILES

NCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (401.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0104 mL	20.0521 mL	40.1043 mL
5 mM	0.8021 mL	4.0104 mL	8.0209 mL
10 mM	0.4010 mL	2.0052 mL	4.0104 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.95%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (257 KB) HNMR (135 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. Burch JE, et al. Determination of desmethyl nortriptyline in plasma by gas chromatography before and after treatment with salicylaldehyde. J Chromatogr. 1983 May 13;274:350-4. [Content Brief]

[2]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.0104 mL	20.0521 mL	40.1043 mL	100.2607 mL
	5 mM	0.8021 mL	4.0104 mL	8.0209 mL	20.0521 mL
	10 mM	0.4010 mL	2.0052 mL	4.0104 mL	10.0261 mL
	15 mM	0.2674 mL	1.3368 mL	2.6736 mL	6.6840 mL
	20 mM	0.2005 mL	1.0026 mL	2.0052 mL	5.0130 mL
	25 mM	0.1604 mL	0.8021 mL	1.6042 mL	4.0104 mL
	30 mM	0.1337 mL	0.6684 mL	1.3368 mL	3.3420 mL
	40 mM	0.1003 mL	0.5013 mL	1.0026 mL	2.5065 mL
	50 mM	0.0802 mL	0.4010 mL	0.8021 mL	2.0052 mL
	60 mM	0.0668 mL	0.3342 mL	0.6684 mL	1.6710 mL
	80 mM	0.0501 mL	0.2507 mL	0.5013 mL	1.2533 mL
	100 mM	0.0401 mL	0.2005 mL	0.4010 mL	1.0026 mL