DL-Tartaric acid-d₂

Name: DL-Tartaric acid-d 2
Brand: MedChemExpress
SKU: HY-Y1315S
Rating: 4.5 (1 reviews)

Cat. No.: HY-Y1315S Purity: 98.30%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

DL-Tartaric acid-d₂ is the deuterium labeled DL-Tartaric acid (HY-Y1315)[1].

For research use only. We do not sell to patients.

DL-Tartaric acid-d<sub>2</sub> Chemical Structure

DL-Tartaric acid-d₂ Chemical Structure

CAS No. : 181376-62-5

Size	Price	Stock	Quantity
1 mg	USD 180	Get quote 2-4 weeks 2-4 weeks 2-4 weeks	2-4 weeks
10 mg	USD 390	Get quote 2-4 weeks 2-4 weeks 2-4 weeks	2-4 weeks
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of DL-Tartaric acid-d₂:

DL-Tartaric acid Get quote

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Biological Activity
Purity & Documentation
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Description

DL-Tartaric acid-d₂ is the deuterium labeled DL-Tartaric acid (HY-Y1315)[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

152.10

Formula

C₄H₄D₂O₆

CAS No.

181376-62-5

Appearance

Solid

Color

White to light yellow

SMILES

OC([C@](O)([2H])[C@@](O)([2H])C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (657.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5746 mL	32.8731 mL	65.7462 mL
5 mM	1.3149 mL	6.5746 mL	13.1492 mL
10 mM	0.6575 mL	3.2873 mL	6.5746 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.44 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.44 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (16.44 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Purity & Documentation

Purity: 98.30%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (252 KB) HNMR (379 KB) RP-HPLC (475 KB) MS (508 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-221. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.5746 mL	32.8731 mL	65.7462 mL	164.3655 mL
	5 mM	1.3149 mL	6.5746 mL	13.1492 mL	32.8731 mL
	10 mM	0.6575 mL	3.2873 mL	6.5746 mL	16.4366 mL
	15 mM	0.4383 mL	2.1915 mL	4.3831 mL	10.9577 mL
	20 mM	0.3287 mL	1.6437 mL	3.2873 mL	8.2183 mL
	25 mM	0.2630 mL	1.3149 mL	2.6298 mL	6.5746 mL
	30 mM	0.2192 mL	1.0958 mL	2.1915 mL	5.4789 mL
	40 mM	0.1644 mL	0.8218 mL	1.6437 mL	4.1091 mL
	50 mM	0.1315 mL	0.6575 mL	1.3149 mL	3.2873 mL
	60 mM	0.1096 mL	0.5479 mL	1.0958 mL	2.7394 mL
	80 mM	0.0822 mL	0.4109 mL	0.8218 mL	2.0546 mL
	100 mM	0.0657 mL	0.3287 mL	0.6575 mL	1.6437 mL