2. Gene
  3. FAM3C - FAM3 metabolism regulating signaling molecule C Gene

FAM3C - FAM3 metabolism regulating signaling molecule C Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ILEI; GS3786

Gene ID: 10447 | Gene type: protein coding

About FAM3C

Cytogenetic location: 7q31.31 Genomic coordinates (GRCh38): 7:121,348,878-121,396,396 (from NCBI)

This gene has 5 transcripts (splice variants), 219 orthologues and 3 paralogues. Ubiquitous expression in duodenum (RPKM 76.8), small intestine (RPKM 69.8) and 24 other tissues.

Summary

This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]

FAM3C Products(2)

mRNA Protein Name
NM_001040020.2 NP_001035109.1 protein FAM3C precursor
NM_014888.3 NP_055703.1 protein FAM3C precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein FAM3C

family with sequence similarity 3 member C

FAM3C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FAM3C Q92520 RELL2 Homo sapiens Q8NC24
Y2H Array
32296183
Intra
FAM3C Q92520 RELL2 Homo sapiens Q8NC24
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 TMEM248 Homo sapiens Q9NWD8
Validated Y2H
32296183
Intra
FAM3C Q92520 TMEM248 Homo sapiens Q9NWD8
Y2H Array
32296183
Intra
FAM3C Q92520 TMEM248 Homo sapiens Q9NWD8
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra
FAM3C Q92520 RMDN3 Homo sapiens Q96TC7
Validated Y2H
32296183
Intra
FAM3C Q92520 RMDN3 Homo sapiens Q96TC7
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 RMDN3 Homo sapiens Q96TC7
Y2H Array
32296183
Intra
FAM3C Q92520 SORT1 Homo sapiens Q99523
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 SORT1 Homo sapiens Q99523
Validated Y2H
32296183
Intra
FAM3C Q92520 SORT1 Homo sapiens Q99523
Y2H Array
32296183
Intra
FAM3C Q92520 LRRC25 Homo sapiens Q8N386
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 LRRC25 Homo sapiens Q8N386
Y2H Array
32296183
Intra
FAM3C Q92520 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
FAM3C Q92520 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
FAM3C Q92520 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
FAM3C Q92520 CLEC2D Homo sapiens Q9UHP7-3
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 CLEC2D Homo sapiens Q9UHP7-3
Validated Y2H
32296183
Intra
FAM3C Q92520 CLEC2D Homo sapiens Q9UHP7-3
Y2H Array
32296183
Intra
FAM3C Q92520 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
FAM3C Q92520 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
FAM3C Q92520 CLEC17A Homo sapiens Q6ZS10
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 CLEC17A Homo sapiens Q6ZS10
Y2H Array
32296183
Intra
FAM3C Q92520 KCNA2 Homo sapiens P16389-2
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 KCNA2 Homo sapiens P16389-2
Y2H Array
32296183
Intra
FAM3C Q92520 SPINT1 Homo sapiens O43278-2
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 SPINT1 Homo sapiens O43278-2
Y2H Array
32296183
Intra
FAM3C Q92520 AHNAK2 Homo sapiens Q8IVF2-3
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 AHNAK2 Homo sapiens Q8IVF2-3
Y2H Array
32296183
Intra
FAM3C Q92520 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
FAM3C Q92520 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra
FAM3C Q92520 AQP2 Homo sapiens P41181
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 AQP2 Homo sapiens P41181
Y2H Array
32296183
Intra
FAM3C Q92520 CLEC4E Homo sapiens Q9ULY5
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 CLEC4E Homo sapiens Q9ULY5
Validated Y2H
32296183
Intra
FAM3C Q92520 CLEC4E Homo sapiens Q9ULY5
Y2H Array
32296183
Intra
FAM3C Q92520 TMEM71 Homo sapiens Q6P5X7-2
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 TMEM71 Homo sapiens Q6P5X7-2
Y2H Array
32296183
Intra
FAM3C Q92520 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra
FAM3C Q92520 SLC39A2 Homo sapiens Q9NP94
Y2H Array
32296183
Intra
FAM3C Q92520 SLC39A2 Homo sapiens Q9NP94
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 TM4SF18 Homo sapiens Q96CE8
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 TM4SF18 Homo sapiens Q96CE8
Validated Y2H
32296183
Intra
FAM3C Q92520 TM4SF18 Homo sapiens Q96CE8
Y2H Array
32296183
Intra
FAM3C Q92520 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
FAM3C Q92520 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
FAM3C Q92520 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
FAM3C Q92520 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
FAM3C Q92520 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
FAM3C Q92520 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra
FAM3C Q92520 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra
FAM3C Q92520 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 NECTIN1 Homo sapiens Q15223
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 NECTIN1 Homo sapiens Q15223
Y2H Array
32296183
Intra
FAM3C Q92520 ERVFRD-1 Homo sapiens P60508
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 ERVFRD-1 Homo sapiens P60508
Y2H Array
32296183
Intra
FAM3C Q92520 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
FAM3C Q92520 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
FAM3C Q92520 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra
FAM3C Q92520 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
FAM3C Q92520 TEX29 Homo sapiens Q8N6K0
Y2H Array
32296183
Intra
FAM3C Q92520 TEX29 Homo sapiens Q8N6K0
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra
FAM3C Q92520 RNASEH1 Homo sapiens O60930
Y2H Array
32296183
Intra
FAM3C Q92520 RNASEH1 Homo sapiens O60930
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
FAM3C Q92520 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 FCGRT Homo sapiens P55899
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 FCGRT Homo sapiens P55899
Y2H Array
32296183
Intra
FAM3C Q92520 HHLA2 Homo sapiens Q9UM44
Y2H Array
32296183
Intra
FAM3C Q92520 HHLA2 Homo sapiens Q9UM44
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 HHLA2 Homo sapiens Q9UM44
Validated Y2H
32296183
Intra
FAM3C Q92520 GGT6 Homo sapiens Q6P531
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 GGT6 Homo sapiens Q6P531
Y2H Array
32296183
Intra
FAM3C Q92520 FCGR1A Homo sapiens P12314
Y2H Array
32296183
Intra
FAM3C Q92520 FCGR1A Homo sapiens P12314
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 GJB5 Homo sapiens O95377
Y2H Array
32296183
Intra
FAM3C Q92520 GJB5 Homo sapiens O95377
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
FAM3C Q92520 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra
FAM3C Q92520 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra
FAM3C Q92520 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
FAM3C Q92520 TMEM45B Homo sapiens Q96B21
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 TMEM45B Homo sapiens Q96B21
Validated Y2H
32296183
Intra
FAM3C Q92520 TMEM45B Homo sapiens Q96B21
Y2H Array
32296183
Intra
FAM3C Q92520 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
FAM3C Q92520 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
FAM3C Q92520 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
25416956
Intra
FAM3C Q92520 CREB3L1 Homo sapiens Q96BA8
Y2H Array
31515488
Intra
FAM3C Q92520 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
FAM3C Q92520 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
FAM3C Q92520 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
FAM3C Q92520 CXADR Homo sapiens P78310
Y2H Array
32296183
Intra
FAM3C Q92520 CXADR Homo sapiens P78310
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 BNIP3 Homo sapiens Q12983
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 BNIP3 Homo sapiens Q12983
Y2H Array
32296183
Intra
FAM3C Q92520 BNIP2 Homo sapiens Q12982
Y2H Array
32296183
Intra
FAM3C Q92520 BNIP2 Homo sapiens Q12982
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
FAM3C Q92520 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
FAM3C Q92520 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 IL7R Homo sapiens P16871
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 IL7R Homo sapiens P16871
Y2H Array
32296183
Intra
FAM3C Q92520 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
FAM3C Q92520 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FAM3C Proteins

Cat. No. Product Name Accession Purity
HY-P70885 FAM3C Protein, Human (HEK293, His) Q92520 (Q25-D227) ≥95%

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 17

DFNB17

Autosomal Recessive Nonsyndromic Deafness 17

Autosomal Recessive Deafness 17
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy

Fuchs Endothelial Dystrophy

Fuchs Dystrophy

Fced

Fuchs' Corneal Dystrophy

Fuchs' Endothelial Corneal Dystrophy

Fuchs Atrophy

Fuchs Corneal Dystrophy

Endoepithelial Corneal Dystrophy

Fecd

Late Hereditary Endothelial Dystrophy

Corneal Dystrophy, Fuchs Endothelial

Dystrophy, Corneal, Fuchs Endothelial

Corneal Dystrophy, Fuchs' Endothelial, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04713 FAM3C Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FAM3C RGD RGD:735193
Mus musculus FAM3C MGD MGI:107892
Macaca mulatta FAM3C VGNC VGNC:72296
Bos taurus FAM3C VGNC VGNC:28811
Canis familiaris FAM3C VGNC VGNC:40679
Felis catus FAM3C VGNC VGNC:62112
Others FAM3C NCBI