Parp1 - poly (ADP-ribose) polymerase family, member 1 Gene

Mus musculus

Also known as PARP; PPOL; ARTD1; Adprp; Adprt1; msPARP; parp-1; sPARP-1; 5830444G22Rik

Gene ID: 11545 | Gene type: protein coding

About Parp1

Chromosome 1: 180,396,489-180,428,819 forward strand.GRCm39:CM000994.3

This gene has 8 transcripts (splice variants), 211 orthologues, 2 paralogues and is associated with 48 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 6.8), CNS E14 (RPKM 38.) and 25 other tissues.

Summary

Enables NAD+ ADP-ribosyltransferase activity; chromatin binding activity; and protein ADP-ribosylase activity. Involved in negative regulation of telomere maintenance via telomere lengthening; positive regulation of single strand break repair; and voluntary musculoskeletal movement. Acts upstream of or within several processes, including DNA metabolic process; behavioral response to cocaine; and protein poly-ADP-ribosylation. Located in cytoplasm; nucleolus; and nucleoplasm. Part of protein-containing complex. Is expressed in several structures, including Peyer's patch; brain; gut; immune system; and retina. Human ortholog(s) of this gene implicated in several diseases, including arthritis; Bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). [provided by Alliance of Genome Resources, Apr 2022]

Parp1 Products(1)

mRNA	Protein	Name
NM_007415.3	NP_031441.2	poly [ADP-ribose] polymerase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	32822587	MGI
enables NAD+-protein ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	24550317	MGI
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	22736760	MGI
enables NAD+-protein poly-ADP-ribosyltransferase activity	IMP IMP: Inferred from mutant phenotype	24449909	MGI
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	32822587	MGI
enables NAD+-protein-glutamate ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	32822587	MGI
enables NAD+-protein-glutamate ADP-ribosyltransferase activity	IMP IMP: Inferred from mutant phenotype	35460603	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	24449909	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16979186	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA metabolic process	IMP IMP: Inferred from mutant phenotype	11756244	MGI
involved in DNA repair	IDA IDA: Inferred from direct assay	22736760	MGI
acts upstream of or within base-excision repair	IMP IMP: Inferred from mutant phenotype	11948190	MGI
acts upstream of or within behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	24449909	MGI
acts upstream of or within cellular response to superoxide	IDA IDA: Inferred from direct assay	24191052	MGI
involved in decidualization	IMP IMP: Inferred from mutant phenotype	34580230	MGI
acts upstream of or within double-strand break repair	IGI IGI: Inferred from genetic interaction	21270334	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	25378300	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	32822587	MGI
involved in negative regulation of adipose tissue development	IDA IDA: Inferred from direct assay	32822587	MGI
involved in negative regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	35460603	MGI
acts upstream of or within negative regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	25470037	MGI
involved in negative regulation of telomere maintenance via telomere lengthening	IMP IMP: Inferred from mutant phenotype	26586427	MGI
involved in positive regulation of necroptotic process	IDA IDA: Inferred from direct assay	12114629	MGI
involved in positive regulation of single strand break repair	IGI IGI: Inferred from genetic interaction	28002403	MGI
acts upstream of or within protein poly-ADP-ribosylation	IDA IDA: Inferred from direct assay	24449909	MGI
involved in protein poly-ADP-ribosylation	IDA IDA: Inferred from direct assay	28991266	MGI
involved in regulation of circadian sleep/wake cycle, non-REM sleep	IMP IMP: Inferred from mutant phenotype	34798058	MGI
acts upstream of or within regulation of growth rate	IMP IMP: Inferred from mutant phenotype	12707040	MGI
acts upstream of or within regulation of single strand break repair	IMP IMP: Inferred from mutant phenotype	25378300	MGI
acts upstream of or within telomere maintenance	IMP IMP: Inferred from mutant phenotype	12707040	MGI
involved in voluntary musculoskeletal movement	IGI IGI: Inferred from genetic interaction	28002403	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in chromatin	IDA IDA: Inferred from direct assay	20647423	MGI
located in chromatin	IDA IDA: Inferred from direct assay	20647423	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	19470756	MGI
located in nucleolus	IDA IDA: Inferred from direct assay	15615785	MGI
located in nucleoplasm	IDA IDA: Inferred from direct assay	15615785	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	28991266	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19470756	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	19796622	MGI
is active in site of DNA damage	IDA IDA: Inferred from direct assay	22736760	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Parp1 Protein Structure

PLN03123

0
200
400
600
800
1014 a.a.

Protein Preferred Names

Protein Names

poly [ADP-ribose] polymerase 1

ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1	ADP-ribosyltransferase diphtheria toxin-like 1
ADPRT 1	DNA ADP-ribosyltransferase PARP1
NAD(+) ADP-ribosyltransferase 1	poly(ADP-ribose) polymerase
poly[ADP-ribose] synthase 1	poly[ADP-ribose] synthetase 1
protein poly-ADP-ribosyltransferase PARP1

Recombinant Parp1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73337	PARP Protein, Mouse (sf9, His)	Q921K2 (M1-W1014)	≥95%

Related Agents

Approval

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10162	Olaparib	Inhibitor	99.98%	Yes
HY-16106	Talazoparib	Inhibitor	99.89%	Unkown
HY-10619	Niraparib	Inhibitor	99.96%	Yes
HY-10617A	Rucaparib	Inhibitor	99.97%	Yes
HY-114778	Fluzoparib	Inhibitor	99.85%	Unkown
HY-10619B	Niraparib tosylate	Inhibitor	99.99%	Yes
HY-10617	Rucaparib phosphate	Inhibitor	99.76%	Yes
HY-10619A	Niraparib hydrochloride	Inhibitor	99.41%	Yes
HY-102003	Rucaparib monocamsylate	Inhibitor	99.82%	Yes
HY-10619E	Niraparib tosylate hydrate	Inhibitor	99.97%	Yes
HY-10617C	Rucaparib tartrate	Inhibitor	/	Unkown
HY-102003A	Rucaparib camsylate	Inhibitor	/	Unkown
HY-10617D	Rucaparib acetate	Inhibitor	/	Unkown
HY-10617B	Rucaparib hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10129	Veliparib	Inhibitor	99.78%	Phase 3
HY-12032	AG14361	Inhibitor	99.44%	Phase 3
HY-12015	Iniparib	Inhibitor	99.82%	Phase 3
HY-10130	Veliparib dihydrochloride	Inhibitor	99.98%	Phase 3
HY-132167	Saruparib	Inhibitor	99.76%	Phase 2
HY-12418	Stenoparib	Inhibitor	≥98.0%	Phase 2
HY-137457A	Venadaparib hydrochloride	Inhibitor	/	Phase 2
HY-105303	CEP-9722	Inhibitor	/	Phase 2
HY-13536	AZD-2461	Inhibitor	99.88%	Phase 1
HY-13326	ASP3026		99.88%	Phase 1
HY-115552	Simmiparib	Inhibitor	99.51%	Phase 1

Pre-clinical Phase

Bioactive Molecules (80)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15147	XAV-939	Inhibitor	99.91%	Unkown
HY-13594	Chlorin e6		98.31%	Unkown
HY-13688A	PJ34	Inhibitor	98.11%	Unkown
HY-139156	SK-575	Inhibitor	99.51%	Unkown
HY-150207	RBN-3143	Inhibitor	99.24%	Unkown
HY-13688	PJ34 hydrochloride	Inhibitor	99.91%	Unkown
HY-N3584	Paris saponin VII	Inhibitor	99.96%	Unkown
HY-N0213	Peiminine		99.94%	Unkown
HY-130644	iRucaparib-AP6	Degrader	99.27%	Unkown
HY-14478	UPF 1069	Inhibitor	99.10%	Unkown
HY-100225	ME0328	Inhibitor	99.64%	Unkown
HY-148566	OUL232	Inhibitor	99.86%	Unkown
HY-12975	AZ6102	Inhibitor	99.65%	Unkown
HY-137457	Venadaparib	Inhibitor	98.11%	Unkown
HY-19351	MN-64	Inhibitor	99.61%	Unkown
HY-18954	NMS-P118	Inhibitor	99.78%	Unkown
HY-10619D	Niraparib (R-enantiomer)	Inhibitor	99.69%	Unkown
HY-156419	PARP7-IN-16	Inhibitor	99.91%	Unkown
HY-132297A	PARP1-IN-5 dihydrochloride	Inhibitor	97.21%	Unkown
HY-123851	MSC2504877	Inhibitor	98.50%	Unkown
HY-16106A	(8R,9S)-Talazoparib	Inhibitor	98.28%	Unkown
HY-122661	Mefuparib hydrochloride	Inhibitor	98.94%	Unkown
HY-108632	BYK204165	Inhibitor	98.66%	Unkown
HY-117889	PARP14 inhibitor H10	Inhibitor	98.04%	Unkown
HY-10614	A-966492	Inhibitor	99.95%	Unkown
HY-114324	PROTAC PARP1 degrader	Inhibitor	99.74%	Unkown
HY-128599	NMS-P515	Inhibitor	98.18%	Unkown
HY-148754	PARP10-IN-3	Inhibitor	98.89%	Unkown
HY-164475	PARP1-IN-29	Inhibitor	/	Unkown
HY-147886	PARP1-IN-11	Inhibitor	98.58%	Unkown
HY-156419A	PARP7-IN-16 free base	Inhibitor	/	Unkown
HY-149800	PARP-1-IN-3	Inhibitor	99.30%	Unkown
HY-105692	DR2313	Inhibitor	99.66%	Unkown
HY-155993	YCH1899	Inhibitor	99.39%	Unkown
HY-133124	PARP/PI3K-IN-1	Inhibitor	99.43%	Unkown
HY-147027	PARP-1-IN-2	Inhibitor	98.80%	Unkown
HY-158045	PROTAC PARP1 degrader-1	Inhibitor	99.86%	Unkown
HY-148753	PARP10-IN-2	Inhibitor	98.02%	Unkown
HY-132297	PARP1-IN-5	Inhibitor	/	Unkown
HY-161372	PARP1/c-Met-IN-1	Inhibitor	/	Unkown
HY-158680	PARP1-IN-21	Inhibitor	/	Unkown
HY-163817	PARP1/2-IN-3	Inhibitor	/	Unkown
HY-162114	PARP1-IN-18	Inhibitor	/	Unkown
HY-149001	PARP1-IN-9	Inhibitor	/	Unkown
HY-W294889	OUL245	Inhibitor	/	Unkown
HY-155766	PARP1-IN-14	Inhibitor	/	Unkown
HY-146336	PARP1/2/TNKS1/2-IN-1	Inhibitor	/	Unkown
HY-136489A	KU-0058948 hydrochloride	Inhibitor	/	Unkown
HY-169170	PARP1/BRD4-IN-3	Inhibitor	/	Unkown
HY-150613	PARP1/BRD4-IN-2	Inhibitor	/	Unkown
HY-150765	PARP1-IN-12	Inhibitor	/	Unkown
HY-100847	AZ0108	Inhibitor	/	Unkown
HY-148709	ARTD10/PARP10-IN-1	Inhibitor	/	Unkown
HY-147101	SK-575-NEG	Inhibitor	/	Unkown
HY-148710	ARTD10/PARP10-IN-2	Inhibitor	/	Unkown
HY-169299	TOPOI/PARP-1-IN-2	Inhibitor	/	Unkown
HY-158681	PARP1-IN-22	Inhibitor	/	Unkown
HY-163658	PARP-1-IN-23	Inhibitor	/	Unkown
HY-157137	PARP1-IN-17		/	Unkown
HY-144338	PARP1/BRD4-IN-1	Inhibitor	/	Unkown
HY-146160	PARP-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-158334	NDs-IN-1	Inhibitor	/	Unkown
HY-161083	PARP/EZH2-IN-2	Inhibitor	/	Unkown
HY-161517	PARP1-IN-20	Inhibitor	/	Unkown
HY-145471A	KSQ-4279 (gentisate)	Inhibitor	/	Unkown
HY-147030	PARP1-IN-8	Inhibitor	99.29%	Unkown
HY-149003	PARP1-IN-10	Inhibitor	/	Unkown
HY-161868	DLC-50	Inhibitor	/	Unkown
HY-168094	PARP1-IN-30	Inhibitor	/	Unkown
HY-105253	PARP-2/1-IN-2	Inhibitor	/	Unkown
HY-15046	EB-47	Inhibitor	/	Unkown
HY-146548	Anticancer agent 43	Inducer	98.58%	Unkown
HY-132885	PARP/EZH2-IN-1	Inhibitor	/	Unkown
HY-145749	PARPYnD	Inhibitor	/	Unkown
HY-161606	PARP-1/2/7-IN-1	Inhibitor	/	Unkown
HY-115862	Benzo[c][1,8]naphthyridin-6(5H)-one	Inhibitor	/	Unkown
HY-14477	UPF-1035	Inhibitor	/	Unkown
HY-117423	ST7710AA1	Inhibitor	/	Unkown
HY-123232	KU-0058684	Inhibitor	/	Unkown
HY-U00223	WD2000-012547	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Parp1	NCBI	NCBI:142

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