Cdk6 - cyclin-dependent kinase 6 Gene

Mus musculus

Also known as Crk2

Gene ID: 12571 | Gene type: protein coding

About Cdk6

Chromosome 5: 3,391,485-3,581,008 forward strand.GRCm39:CM000998.3

This gene has 6 transcripts (splice variants), 199 orthologues, 25 paralogues and is associated with 48 phenotypes. Ubiquitous expression in thymus adult (RPKM 7.), lung adult (RPKM 3.6) and 26 other tissues.

Summary

This gene encodes a member of the cyclin dependent kinase family of proteins that play important roles in the progression and regulation of the cell cycle. The encoded protein binds to a D-type cyclin to form an active kinase complex to regulate progression through the G1 phase of the cell cycle. Mice lacking the encoded protein exhibit thymic and splenic hypoplasia, and hematopoietic defects such as reduced number of megakaryocytes and erythrocytes. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2015]

Cdk6 Products(2)

mRNA	Protein	Name
NM_009873.3	NP_034003.1	cyclin-dependent kinase 6
NM_009873.3	NP_034003.1	cyclin-dependent kinase 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase activity	IDA IDA: Inferred from direct assay	21508411	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7651726	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	21508411	MGI
acts upstream of or within Notch signaling pathway	IGI IGI: Inferred from genetic interaction	21508411	MGI
acts upstream of or within T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	21508411	MGI
acts upstream of or within cell quiescence	IMP IMP: Inferred from mutant phenotype	25342715	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	21508411	MGI
acts upstream of or within hematopoietic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	21508411	MGI
involved in hemopoiesis	IMP IMP: Inferred from mutant phenotype	15315761	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25342715	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	21508411	MGI
acts upstream of or within regulation of hematopoietic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	25342715	MGI
acts upstream of or within response to 5-fluorouracil	IMP IMP: Inferred from mutant phenotype	25342715	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of cyclin D2-CDK6 complex	IDA IDA: Inferred from direct assay	7739547	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk6 Protein Structure

STKc_CDK6

0
100
200
300
326 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 6

CR2 protein kinase	cell division protein kinase 6
serine/threonine-protein kinase PLSTIRE

Cdk6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cdk6	Q64261	Jun	Mus musculus	P05627	Anti Bait CoIP	23948297
Intra	Cdk6	Q64261	Ccnd3	Mus musculus	P30282	Anti Bait CoIP	23948297
Intra	Cdk6	Q64261	Ccnd3	Mus musculus	P30282	Anti Bait CoIP	23079656

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50767	Palbociclib	Inhibitor	99.94%	Unkown
HY-16297A	Abemaciclib	Inhibitor	99.97%	Yes
HY-15777	Ribociclib	Inhibitor	99.94%	Unkown
HY-50767A	Palbociclib monohydrochloride	Inhibitor	99.98%	Unkown
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	Yes
HY-A0065	Palbociclib isethionate	Inhibitor	99.99%	Unkown
HY-50767C	Palbociclib hydrochloride	Inhibitor	99.93%	Unkown
HY-15777A	Ribociclib hydrochloride	Inhibitor	99.95%	Unkown
HY-15777B	Ribociclib succinate	Inhibitor	99.93%	Unkown
HY-101467A	Trilaciclib hydrochloride	Inhibitor	99.69%	Unkown
HY-114338	Dalpiciclib	Inhibitor	99.40%	Unkown
HY-15777C	Ribociclib succinate hydrate	Inhibitor	99.96%	Unkown
HY-50767D	Palbociclib orotate	Inhibitor	/	Unkown
HY-50767B	Palbociclib dihydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Phase
HY-114338A	Dalpiciclib hydrochloride	Inhibitor	98.22%	Phase 3
HY-112272	Lerociclib	Inhibitor	98.35%	Phase 3
HY-101563	GSK3326595		99.83%	Phase 2
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Phase 2
HY-50940	AT7519	Inhibitor	99.76%	Phase 2
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.11%	Phase 2
HY-103712B	Samuraciclib hydrochloride dihydrate	Inhibitor	99.08%	Phase 2
HY-50943	AT7519 Hydrochloride	Inhibitor	99.42%	Phase 2
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	Phase 2
HY-50940A	AT7519 TFA	Inhibitor	98.53%	Phase 2
HY-103712	Samuraciclib	Inhibitor	/	Phase 2
HY-16559A	Riviciclib	Inhibitor	/	Phase 2
HY-10012	AZD-5438	Inhibitor	99.91%	Phase 1
HY-10014	R547	Inhibitor	99.57%	Phase 1
HY-12624	Narazaciclib	Inhibitor	99.12%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.70%	Phase 1
HY-12422	Voruciclib	Inhibitor	99.77%	Phase 1
HY-111361	FN-1501	Inhibitor	99.08%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.07%	Phase 1
HY-12422A	Voruciclib hydrochloride	Inhibitor	99.23%	Phase 1

Pre-clinical Phase

Bioactive Molecules (68)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103248	Toyocamycin	Inhibitor	99.78%	Unkown
HY-10329	JNJ-7706621	Inhibitor	99.91%	Unkown
HY-116035	Nimbolide	Inhibitor	99.79%	Unkown
HY-136252	BSJ-04-132	Inhibitor	99.07%	Unkown
HY-111556	BSJ-03-123	Inhibitor	98.12%	Unkown
HY-114177	Ebvaciclib	Inhibitor	99.98%	Unkown
HY-136250	BSJ-03-204	Inhibitor	99.76%	Unkown
HY-138946	XY028-140	Inhibitor	98.52%	Unkown
HY-12445	Asnuciclib	Inhibitor	99.76%	Unkown
HY-128669	Abemaciclib metabolite M2	Inhibitor	99.94%	Unkown
HY-13266A	BS-181 hydrochloride	Inhibitor	99.80%	Unkown
HY-119940	MC180295	Inhibitor	98.89%	Unkown
HY-125835	CP-10	Inhibitor	98.41%	Unkown
HY-126534A	Abemaciclib metabolite M18 hydrochloride	Inhibitor	98.01%	Unkown
HY-148530	YX-2-107	Degrader	99.79%	Unkown
HY-16559	Riviciclib hydrochloride		98.89%	Unkown
HY-129180	XY028-133	Inhibitor	98.62%	Unkown
HY-129336	Abemaciclib metabolite M20	Inhibitor	96.02%	Unkown
HY-50767S	Palbociclib-d8	Inhibitor	99.84%	Unkown
HY-148062	RSS0680		98.03%	Unkown
HY-15889	AMG 925	Inhibitor	98.20%	Unkown
HY-114339	CDK4/6-IN-2	Inhibitor	99.82%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-112243A	Cimpuciclib tosylate	Inhibitor	99.16%	Unkown
HY-142076	CDK4/6-IN-15	Inhibitor	96.15%	Unkown
HY-15241	NVP-LCQ195	Inhibitor	98.81%	Unkown
HY-126251	CDK9-IN-7	Inhibitor	98.05%	Unkown
HY-152263	HEMTAC CDK4/6 degrader 1	Inhibitor	98.18%	Unkown
HY-163786	PROTAC CDK4/6 degrader 1	Degrader	98.88%	Unkown
HY-112346	RGB-286147	Inhibitor	98.60%	Unkown
HY-136726	CGP-82996	Inhibitor	98.12%	Unkown
HY-13266	BS-181	Inhibitor	98.10%	Unkown
HY-15889A	AMG 925 (HCl)	Inhibitor	/	Unkown
HY-129336S	Abemaciclib metabolite M20-d8	Inhibitor	99.26%	Unkown
HY-126534	Abemaciclib metabolite M18	Inhibitor	/	Unkown
HY-112243	Cimpuciclib	Inhibitor	/	Unkown
HY-126244	CDK4/6-IN-3	Inhibitor	/	Unkown
HY-131063	CDK6/9-IN-1	Inhibitor	/	Unkown
HY-112418	CDK4/6-IN-18	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-143258	CDK4/6-IN-8	Inhibitor	/	Unkown
HY-115992	CDK4/6-IN-9	Inhibitor	/	Unkown
HY-163856	CDK7-IN-30	Inhibitor	/	Unkown
HY-164906	TMX-2138	Degrader	/	Unkown
HY-162530	CDK4/6-IN-20	Inhibitor	/	Unkown
HY-164376	CDK4/6-IN-21	Inhibitor	/	Unkown
HY-172128	NUAK1-IN-2	Inhibitor	/	Unkown
HY-151898	CDK4/6-IN-14	Inhibitor	/	Unkown
HY-147409	Ulecaciclib	Inhibitor	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-155787	SHR5428	Inhibitor	/	Unkown
HY-153336	CDK-IN-12	Inhibitor	/	Unkown
HY-162619	CDK9-IN-33	Inhibitor	/	Unkown
HY-153088	CDK4/6-IN-16	Inhibitor	/	Unkown
HY-168444	CDK4/6-IN-23	Inhibitor	/	Unkown
HY-170651	CDK4/6/HDAC-IN-1	Inhibitor	/	Unkown
HY-115993	CDK4/6-IN-10	Inhibitor	/	Unkown
HY-148213	CDK2/4/6-IN-1	Inhibitor	/	Unkown
HY-151069	TMX-2039	Inhibitor	/	Unkown
HY-164376A	CDK4/6-IN-21 maleate	Inhibitor	/	Unkown
HY-148214	CDK2/4/6-IN-2	Inhibitor	/	Unkown
HY-151878	CDK7-IN-20	Inhibitor	/	Unkown
HY-162529	CDK4/6-IN-19	Inhibitor	/	Unkown
HY-143257	CDK4/6-IN-7	Inhibitor	/	Unkown
HY-115942	Anticancer agent 29	Inhibitor	/	Unkown
HY-163787	YY173	Inhibitor	/	Unkown
HY-146213	CDK4/6-IN-12	Inhibitor	/	Unkown
HY-151071	TMX-3013	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdk6	NCBI	NCBI:1021

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