2. Gene
  3. Cdk6 - cyclin-dependent kinase 6 Gene

Cdk6 - cyclin-dependent kinase 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Crk2

Gene ID: 12571 | Gene type: protein coding

About Cdk6

Chromosome 5: 3,391,485-3,581,008 forward strand.GRCm39:CM000998.3

This gene has 6 transcripts (splice variants), 199 orthologues, 25 paralogues and is associated with 48 phenotypes. Ubiquitous expression in thymus adult (RPKM 7.), lung adult (RPKM 3.6) and 26 other tissues.

Summary

This gene encodes a member of the cyclin dependent kinase family of proteins that play important roles in the progression and regulation of the cell cycle. The encoded protein binds to a D-type cyclin to form an active kinase complex to regulate progression through the G1 phase of the cell cycle. Mice lacking the encoded protein exhibit thymic and splenic hypoplasia, and hematopoietic defects such as reduced number of megakaryocytes and erythrocytes. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2015]

Cdk6 Products(2)

mRNA Protein Name
NM_009873.3 NP_034003.1 cyclin-dependent kinase 6
NM_009873.3 NP_034003.1 cyclin-dependent kinase 6

Cdk6 Protein Structure

STKc_CDK6

STKc_CDK6: cd07862 (10 - 299)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 6

CR2 protein kinase

cell division protein kinase 6

serine/threonine-protein kinase PLSTIRE

Related Agents

Approval
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50767 Palbociclib Inhibitor 99.94% Unkown
HY-16297A Abemaciclib Inhibitor 99.94% Yes
HY-15777 Ribociclib Inhibitor 99.94% Unkown
HY-50767A Palbociclib monohydrochloride Inhibitor 99.98% Unkown
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
HY-A0065 Palbociclib isethionate Inhibitor 99.99% Unkown
HY-50767C Palbociclib hydrochloride Inhibitor 99.93% Unkown
HY-15777A Ribociclib hydrochloride Inhibitor 99.95% Unkown
HY-15777B Ribociclib succinate Inhibitor 99.93% Unkown
HY-101467A Trilaciclib hydrochloride Inhibitor 99.69% Unkown
HY-114338 Dalpiciclib Inhibitor 99.40% Unkown
HY-15777C Ribociclib succinate hydrate Inhibitor 99.96% Unkown
HY-50767B Palbociclib dihydrochloride Inhibitor / Unkown
HY-50767D Palbociclib orotate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Phase
HY-139450 Atirmociclib Inhibitor 99.87% Phase 3
HY-114338A Dalpiciclib hydrochloride Inhibitor 98.22% Phase 3
HY-101563 GSK3326595 99.97% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-50940 AT7519 Inhibitor 99.76% Phase 2
HY-112272A Lerociclib dihydrochloride Inhibitor 98.11% Phase 2
HY-103712B Samuraciclib hydrochloride hydrate Inhibitor 99.08% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-112272 Lerociclib Inhibitor 98.35% Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10012 AZD-5438 Inhibitor 99.85% Phase 1
HY-10014 R547 Inhibitor 99.57% Phase 1
HY-12624 Narazaciclib Inhibitor 99.12% Phase 1
HY-111361 FN-1501 Inhibitor 99.08% Phase 1
HY-15504 RGB-286638 Inhibitor 99.70% Phase 1
HY-12422 Voruciclib Inhibitor 99.77% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.07% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.23% Phase 1
HY-50940A AT7519 TFA Inhibitor 98.53% Phase 1
Pre-clinical Phase
Bioactive Molecules (64)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103248 Toyocamycin Inhibitor 99.90% Unkown
HY-10329 JNJ-7706621 Inhibitor 99.91% Unkown
HY-111556 BSJ-03-123 Inhibitor 98.12% Unkown
HY-136252 BSJ-04-132 Inhibitor 99.07% Unkown
HY-136250 BSJ-03-204 Inhibitor 99.76% Unkown
HY-114177 Ebvaciclib Inhibitor 99.98% Unkown
HY-116035 Nimbolide Inhibitor 99.72% Unkown
HY-138946 XY028-140 Inhibitor 98.42% Unkown
HY-128669 Abemaciclib metabolite M2 Inhibitor 99.94% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.80% Unkown
HY-125835 CP-10 Inhibitor 98.22% Unkown
HY-126534A Abemaciclib metabolite M18 hydrochloride Inhibitor 98.01% Unkown
HY-119940 MC180295 Inhibitor 98.89% Unkown
HY-129336 Abemaciclib metabolite M20 Inhibitor 96.02% Unkown
HY-148530 YX-2-107 Degrader 99.79% Unkown
HY-16559 Riviciclib hydrochloride 98.89% Unkown
HY-50767S Palbociclib-d8 Inhibitor 99.84% Unkown
HY-129180 XY028-133 Inhibitor 98.62% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-15889 AMG 925 Inhibitor 98.20% Unkown
HY-112243A Cimpuciclib tosylate Inhibitor 99.16% Unkown
HY-148063 DB0614 98.80% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.91% Unkown
HY-114339 CDK4/6-IN-2 Inhibitor 99.82% Unkown
HY-126251 CDK9-IN-7 Inhibitor 98.05% Unkown
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Unkown
HY-142076 CDK4/6-IN-15 Inhibitor 96.15% Unkown
HY-112346 RGB-286147 Inhibitor 98.60% Unkown
HY-129336S Abemaciclib metabolite M20-d8 Inhibitor 97.01% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-163786 PROTAC CDK4/6 degrader 1 Degrader 98.88% Unkown
HY-152263 HEMTAC CDK4/6 degrader 1 Inhibitor / Unkown
HY-15889A AMG 925 HCl Inhibitor / Unkown
HY-136726 CGP-82996 Inhibitor 98.12% Unkown
HY-112243 Cimpuciclib Inhibitor / Unkown
HY-131063 CDK6/9-IN-1 Inhibitor / Unkown
HY-103712 Samuraciclib Inhibitor / Unkown
HY-126244 CDK4/6-IN-3 Inhibitor / Unkown
HY-112418 CDK4/6-IN-18 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-148213 CDK2/4/6-IN-1 Inhibitor / Unkown
HY-115992 CDK4/6-IN-9 Inhibitor / Unkown
HY-163856 CDK7-IN-30 Inhibitor / Unkown
HY-115993 CDK4/6-IN-10 Inhibitor / Unkown
HY-164376A CDK4/6-IN-21 maleate Inhibitor / Unkown
HY-164376 CDK4/6-IN-21 Inhibitor / Unkown
HY-148214 CDK2/4/6-IN-2 Inhibitor / Unkown
HY-143257 CDK4/6-IN-7 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-147409 Ulecaciclib Inhibitor / Unkown
HY-162529 CDK4/6-IN-19 Inhibitor / Unkown
HY-153336 CDK-IN-12 Inhibitor / Unkown
HY-153088 CDK4/6-IN-16 Inhibitor / Unkown
HY-146213 CDK4/6-IN-12 Inhibitor / Unkown
HY-143258 CDK4/6-IN-8 Inhibitor / Unkown
HY-162530 CDK4/6-IN-20 Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-126534 Abemaciclib metabolite M18 Inhibitor / Unkown
HY-155787 SHR5428 Inhibitor / Unkown
HY-115942 Anticancer agent 29 Inhibitor / Unkown
HY-162619 CDK9-IN-33 Inhibitor / Unkown
HY-163787 YY173 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk6 NCBI NCBI:1021