2. Gene
  3. ATF2 - activating transcription factor 2 Gene

ATF2 - activating transcription factor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HB16; CREB2; TREB7; CREB-2; CRE-BP1

Gene ID: 1386 | Gene type: protein coding

About ATF2

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:175,072,259-175,168,203 (from NCBI)

This gene has 20 transcripts (splice variants), 214 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 19.6), brain (RPKM 14.7) and 25 other tissues.

Summary

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a Histone Acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]

ATF2 Products(6)

mRNA Protein Name
NM_001256090.2 NP_001243019.1 cyclic AMP-dependent transcription factor ATF-2 isoform 1
NM_001256091.2 NP_001243020.1 cyclic AMP-dependent transcription factor ATF-2 isoform 2
NM_001256092.2 NP_001243021.1 cyclic AMP-dependent transcription factor ATF-2 isoform 3
NM_001256093.2 NP_001243022.1 cyclic AMP-dependent transcription factor ATF-2 isoform 4
NM_001256094.2 NP_001243023.1 cyclic AMP-dependent transcription factor ATF-2 isoform 5
NM_001880.4 NP_001871.2 cyclic AMP-dependent transcription factor ATF-2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
16300731 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
8798441 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19861239 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
2516827 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
19861239 GOA
enables cAMP response element binding IDA
IDA: Inferred from direct assay
19861239 GOA
enables cAMP response element binding protein binding IDA
IDA: Inferred from direct assay
19861239 GOA
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
2196176 GOA
enables histone H2B acetyltransferase activity IDA
IDA: Inferred from direct assay
10821277 GOA
enables histone H4 acetyltransferase activity IDA
IDA: Inferred from direct assay
10821277 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16511568 GOA
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
17267404 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8440710 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21098032 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
22304920 GOA
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
15916964 GOA
involved in cellular response to leucine starvation IDA
IDA: Inferred from direct assay
17267404 GOA
involved in mitotic intra-S DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
15916964 GOA
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
28977001 GOA
involved in negative regulation of transcription by RNA polymerase II EXP
EXP: Inferred from Experiment
11231009 GOA
involved in peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
17267404 GOA
involved in positive regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
10821277 GOA
involved in positive regulation of cardiac muscle myoblast proliferation IDA
IDA: Inferred from direct assay
22982025 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
28977001 GOA
involved in positive regulation of mitochondrial membrane permeability involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
22304920 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16300731 GOA
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
22304920 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19861239 GOA
involved in response to osmotic stress IDA
IDA: Inferred from direct assay
21098032 GOA
involved in transcription initiation-coupled chromatin remodeling IDA
IDA: Inferred from direct assay
10821277 GOA
Cellular Component GO Annotation Evidence Reference Source
part of H4 histone acetyltransferase complex IDA
IDA: Inferred from direct assay
10821277 GOA
part of RNA polymerase II transcription regulator complex EXP
EXP: Inferred from Experiment
11231009 GOA
part of RNA polymerase II transcription regulator complex IPI
IPI: Inferred from physical interaction
20102225 GOA
located in chromatin IDA
IDA: Inferred from direct assay
23729669 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
22304920 GOA
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
22304920 GOA
located in nucleus EXP
EXP: Inferred from Experiment
11231009 GOA
located in nucleus IDA
IDA: Inferred from direct assay
8798441 GOA
located in site of double-strand break IDA
IDA: Inferred from direct assay
15916964 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATF2 Protein Structure

bZIP_1

bZIP_1: bZIP transcription factor (352 - 411)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
Protein Preferred Names Protein Names

cyclic AMP-dependent transcription factor ATF-2

cAMP response element-binding protein CRE-BP1

ATF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ATF2 P15336 FOS Homo sapiens Q6FG41
Y2H Prey Pooling
25416956
Intra
ATF2 P15336 FOS Homo sapiens Q6FG41
Validated Y2H
25416956
Intra
ATF2 P15336 FOS Homo sapiens Q6FG41
Y2H Array
25416956
Intra
ATF2 P15336 BATF3 Homo sapiens Q9NR55
Peptide Array
20102225
Intra
ATF2 P15336 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra
ATF2 P15336 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra
ATF2 P15336 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra
ATF2 P15336 JUN Homo sapiens P05412
Anti Tag CoIP
33961781
Intra
ATF2 P15336 JUN Homo sapiens P05412
Anti Tag CoIP
28514442
Intra
ATF2 P15336 JUN Homo sapiens P05412
FRET
23661758
Intra
ATF2 P15336 JUN Homo sapiens P05412
PLA
20511396
Intra
ATF2 P15336 JUN Homo sapiens P05412
Display Tech
20195357
Intra
ATF2 P15336 FOS Homo sapiens P01100
Peptide Array
20102225
Intra
ATF2 P15336 JUN Homo sapiens P05412
TAP
20195357
Intra
ATF2 P15336 JUN Homo sapiens P05412
CoIP
10327051
Intra
ATF2 P15336 JUN Homo sapiens P05412
Peptide Array
20102225
Intra
ATF2 P15336 BACH1 Homo sapiens O14867
FRET
23661758
Intra
ATF2 P15336 BACH1 Homo sapiens O14867
Peptide Array
20102225
Intra
ATF2 P15336 KIFC3 Homo sapiens Q9BVG8-5
Y2H Prey Pooling
32296183
Intra
ATF2 P15336 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
ATF2 P15336 KIFC3 Homo sapiens Q9BVG8-5
Y2H Array
32296183
Intra
ATF2 P15336 VRK1 Homo sapiens Q99986
Anti Tag CoIP
15105425
Intra
ATF2 P15336 VRK1 Homo sapiens Q99986
IF
15105425
Intra
ATF2 P15336 KIFC3 Homo sapiens Q9BVG8
Y2H Prey Pooling
25416956
Intra
ATF2 P15336 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
ATF2 P15336 RNF4 Homo sapiens P78317
Validated Y2H
32296183
Intra
ATF2 P15336 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
ATF2 P15336 CENPQ Homo sapiens Q7L2Z9
Validated Y2H
32296183
Intra
ATF2 P15336 CENPQ Homo sapiens Q7L2Z9
Y2H Array
32296183
Intra
ATF2 P15336 CITED1 Homo sapiens Q99966
CoIP
10327051
Intra
ATF2 P15336 JUND Homo sapiens P17535
Anti Tag CoIP
33961781
Intra
ATF2 P15336 JUND Homo sapiens P17535
Anti Tag CoIP
28514442
Intra
ATF2 P15336 JUND Homo sapiens P17535
Peptide Array
20102225
Intra
ATF2 P15336 FOSB Homo sapiens P53539
Validated Y2H
32296183
Intra
ATF2 P15336 FOSB Homo sapiens P53539
Y2H Prey Pooling
32296183
Intra
ATF2 P15336 FOSB Homo sapiens P53539
Y2H Array
32296183
Intra
ATF2 P15336 SPOPL Homo sapiens Q6IQ16
Validated Y2H
32296183
Intra
ATF2 P15336 SPOPL Homo sapiens Q6IQ16
Y2H Array
32296183
Intra
ATF2 P15336 SPOPL Homo sapiens Q6IQ16
Y2H Prey Pooling
32296183
Intra
ATF2 P15336 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra
ATF2 P15336 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra
ATF2 P15336 EXOSC8 Homo sapiens Q96B26
Y2H Array
25416956
Intra
ATF2 P15336 EXOSC8 Homo sapiens Q96B26
Validated Y2H
25416956
Intra
ATF2 P15336 FOSL2 Homo sapiens P15408
Y2H Prey Pooling
32296183
Intra
ATF2 P15336 FOSL2 Homo sapiens P15408
Peptide Array
20102225
Intra
ATF2 P15336 FOSL2 Homo sapiens P15408
Validated Y2H
32296183
Intra
ATF2 P15336 FOSL2 Homo sapiens P15408
Y2H Array
32296183
Intra
ATF2 P15336 ATF4 Homo sapiens P18848
FRET
23661758
Intra
ATF2 P15336 ZDHHC17 Homo sapiens Q8IUH5
Y2H Array
24705354
Intra
ATF2 P15336 ZDHHC17 Homo sapiens Q8IUH5
Lumier
24705354
Intra
ATF2 P15336 SYT-SSX2 Homo sapiens A4PIW0
Anti Bait CoIP
22439931
Intra
ATF2 P15336 SYT-SSX2 Homo sapiens A4PIW0
Anti Tag CoIP
22439931
Intra
ATF2 P15336 NFATC1 Homo sapiens O95644
Pull Down
25609649
Intra
ATF2 P15336 ATF3 Homo sapiens P18847
FRET
23661758
Intra
ATF2 P15336 ATF3 Homo sapiens P18847
Peptide Array
20102225
Intra
ATF2 P15336 MAPK9 Homo sapiens P45984
Y2H Array
31515488
Intra
ATF2 P15336 MAPK9 Homo sapiens P45984
Y2H Prey Pooling
25416956
Intra
ATF2 P15336 MAPK9 Homo sapiens P45984
Validated Y2H
25416956
Intra
ATF2 P15336 MAPK9 Homo sapiens P45984
Y2H Prey Pooling
32296183
Intra
ATF2 P15336 MAPK9 Homo sapiens P45984
Validated Y2H
32296183
Intra
ATF2 P15336 MAPK9 Homo sapiens P45984
Y2H Array
25416956
Intra
ATF2 P15336 MAPK9 Homo sapiens P45984
Y2H Array
32296183
Intra
ATF2 P15336 CEBPG Homo sapiens P53567
Peptide Array
20102225
Intra
ATF2 P15336 DDIT3 Homo sapiens P35638
Peptide Array
20102225
Intra
ATF2 P15336 FOSL1 Homo sapiens P15407
FRET
23661758
Intra
ATF2 P15336 JUNB Homo sapiens P17275
Anti Tag CoIP
33961781
Intra
ATF2 P15336 JUNB Homo sapiens P17275
Complementation
16511568
Intra
ATF2 P15336 BATF Homo sapiens Q16520
FRET
23661758
Intra
ATF2 P15336 ATF7 Homo sapiens P17544
Peptide Array
20102225
Intra
ATF2 P15336 ATF7 Homo sapiens P17544
Anti Tag CoIP
33961781
Intra
ATF2 P15336 SUMO1 Homo sapiens P63165
Y2H Array
32296183
Intra
ATF2 P15336 SUMO1 Homo sapiens P63165
Validated Y2H
32296183
Intra
ATF2 P15336 SUMO1 Homo sapiens P63165
Y2H Prey Pooling
32296183
Intra
ATF2 P15336 LHX8 Homo sapiens Q68G74
Y2H Prey Pooling
32296183
Intra
ATF2 P15336 LHX8 Homo sapiens Q68G74
Validated Y2H
32296183
Intra
ATF2 P15336 LHX8 Homo sapiens Q68G74
Y2H Array
32296183
Intra
ATF2 P15336 FOS Homo sapiens P01100
TAP
20195357
Intra
ATF2 P15336 FOS Homo sapiens P01100
Y2H Array
32296183
Intra
ATF2 P15336 FOS Homo sapiens P01100
Y2H Prey Pooling
32296183
Cross
ATF2 P15336 MDV005 Gallid herpesvirus 2 Q9DGW5
Peptide Array
20102225
Cross
ATF2 P15336 HBZ Human T-cell leukemia virus 1 P0C746
Peptide Array
20102225
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATF2 Proteins

Cat. No. Product Name Accession Purity
HY-P74408 ATF2 Protein, Human (sf9, His-GST) P15336 (M1-S505) ≥95%

ATF2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80793 Phospho-ATF2 (Thr71) Antibody WB, ICC/IF, IP Human, Mouse

Related Diseases

Diseases Alias
Cardiomyopathy, Familial Hypertrophic, 25

Hypertrophic Cardiomyopathy 25

CMH25

Cardiomyopathy, Hypertrophic, 25

Cardiomyopathy Familial Hypertrophic 25

Cardiomyopathy, Familial Hypertrophic 25

Cardiomyopathy, Hypertrophic, Type 25
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant
Epidermolysis Bullosa Simplex

Ebs

Epidermolysis Bullosa Intraepidermic

Epidermolytic Epidermolysis Bullosa
Pick Disease Of Brain

Pick Disease

Pick'S Disease

Pick Disease Of The Brain

Lobar Atrophy Of Brain

Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions

Behavioral Variant Of Frontotemporal Dementia

Dementia In Pick'S Disease

Lobar Atrophy Of The Brain

Bvftd

Bv-Ftd

PIDB

Picks Disease
Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1

PKD1

Adpkd

Polycystic Kidney Disease, Adult, Type I

Apkd1

Potter Type Iii Polycystic Kidney Disease

Polycystic Kidney Disease, Adult

Potter Type Iii Polycystic Kidney Disease, Formerly

Polycystic Kidney Disease, Type 1

Adpkd1

Adult Polycystic Kidney Disease Type 1

Autosomal Dominant Polycystic Kidney Disease 1

Pkd-1

Polycystic Kidney Disease Adult

Polycystic Kidney Disease Type I

Polycystic Kidneys

Polycystic Kidney Disease, Adult Type I

Polycystic Kidney Type 1 Autosomal Dominant Disease

Kidney Disease, Polycystic, Type 1

Polycystic Kidney, Autosomal Dominant

Polycystic Kidney, Type 1 Autosomal Dominant Disease

Polycystic Kidney Diseases
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1198 Piperonyl butoxide Inhibitor ≥98.0% Unkown
HY-B1198R Piperonyl butoxide (Standard) Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-13241 Ralimetinib dimesylate 99.94% Phase 2
HY-13241A Ralimetinib Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-152860 Darizmetinib 99.94% Unkown
HY-117987 CPS-11 99.39% Unkown
HY-B1198S Piperonyl butoxide-d9 Inhibitor / Unkown
HY-134963 SBI-0087702 / Unkown
HY-RS01128 ATF2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ATF2 VGNC VGNC:68500
Macaca mulatta ATF2 VGNC VGNC:70169
Bos taurus ATF2 VGNC VGNC:26240
Mus musculus ATF2 MGD MGI:109349
Rattus norvegicus ATF2 RGD RGD:621862
Canis familiaris ATF2 VGNC VGNC:38208
Others ATF2 NCBI