ATF2 - activating transcription factor 2 Gene

Homo sapiens

Also known as HB16; CREB2; TREB7; CREB-2; CRE-BP1

Gene ID: 1386 | Gene type: protein coding

About ATF2

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:175,072,259-175,168,203 (from NCBI)

This gene has 20 transcripts (splice variants), 214 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 19.6), brain (RPKM 14.7) and 25 other tissues.

Summary

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a Histone Acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]

ATF2 Products(6)

mRNA	Protein	Name
NM_001256090.2	NP_001243019.1	cyclic AMP-dependent transcription factor ATF-2 isoform 1
NM_001256091.2	NP_001243020.1	cyclic AMP-dependent transcription factor ATF-2 isoform 2
NM_001256092.2	NP_001243021.1	cyclic AMP-dependent transcription factor ATF-2 isoform 3
NM_001256093.2	NP_001243022.1	cyclic AMP-dependent transcription factor ATF-2 isoform 4
NM_001256094.2	NP_001243023.1	cyclic AMP-dependent transcription factor ATF-2 isoform 5
NM_001880.4	NP_001871.2	cyclic AMP-dependent transcription factor ATF-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16300731	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8798441	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19861239	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	2516827	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19861239	GOA
enables cAMP response element binding	IDA IDA: Inferred from direct assay	19861239	GOA
enables cAMP response element binding protein binding	IDA IDA: Inferred from direct assay	19861239	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	2196176	GOA
enables histone H2B acetyltransferase activity	IDA IDA: Inferred from direct assay	10821277	GOA
enables histone H4 acetyltransferase activity	IDA IDA: Inferred from direct assay	10821277	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16511568	GOA
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	17267404	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8440710	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21098032	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	22304920	GOA
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	15916964	GOA
involved in cellular response to leucine starvation	IDA IDA: Inferred from direct assay	17267404	GOA
involved in mitotic intra-S DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	15916964	GOA
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	28977001	GOA
involved in negative regulation of transcription by RNA polymerase II	EXP EXP: Inferred from Experiment	11231009	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	17267404	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	10821277	GOA
involved in positive regulation of cardiac muscle myoblast proliferation	IDA IDA: Inferred from direct assay	22982025	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28977001	GOA
involved in positive regulation of mitochondrial membrane permeability involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	22304920	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16300731	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	22304920	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19861239	GOA
involved in response to osmotic stress	IDA IDA: Inferred from direct assay	21098032	GOA
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	10821277	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of H4 histone acetyltransferase complex	IDA IDA: Inferred from direct assay	10821277	GOA
part of RNA polymerase II transcription regulator complex	EXP EXP: Inferred from Experiment	11231009	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA
located in chromatin	IDA IDA: Inferred from direct assay	23729669	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22304920	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	22304920	GOA
located in nucleus	EXP EXP: Inferred from Experiment	11231009	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8798441	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	15916964	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATF2 Protein Structure

bZIP_1

0
100
200
300
400
505 a.a.

Protein Preferred Names

Protein Names

cyclic AMP-dependent transcription factor ATF-2

cAMP response element-binding protein CRE-BP1

Recombinant ATF2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74408	ATF2 Protein, Human (sf9, His-GST)	P15336 (M1-S505)	≥95%

Related Diseases

Diseases

Alias

Cardiomyopathy, Familial Hypertrophic, 25

Hypertrophic Cardiomyopathy 25	CMH25
Cardiomyopathy, Hypertrophic, 25	Cardiomyopathy Familial Hypertrophic 25
Cardiomyopathy, Familial Hypertrophic 25	Cardiomyopathy, Hypertrophic, Type 25

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Epidermolysis Bullosa Simplex

Ebs	Epidermolysis Bullosa Intraepidermic
Epidermolytic Epidermolysis Bullosa

Pick Disease Of Brain

Pick Disease	Pick'S Disease
Pick Disease Of The Brain	Lobar Atrophy Of Brain
Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions	Behavioral Variant Of Frontotemporal Dementia
Dementia In Pick'S Disease	Lobar Atrophy Of The Brain
Bvftd	Bv-Ftd
PIDB	Picks Disease

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1	PKD1
Adpkd	Polycystic Kidney Disease, Adult, Type I
Apkd1	Potter Type Iii Polycystic Kidney Disease
Polycystic Kidney Disease, Adult	Potter Type Iii Polycystic Kidney Disease, Formerly
Polycystic Kidney Disease, Type 1	Adpkd1
Adult Polycystic Kidney Disease Type 1	Autosomal Dominant Polycystic Kidney Disease 1
Pkd-1	Polycystic Kidney Disease Adult
Polycystic Kidney Disease Type I	Polycystic Kidneys
Polycystic Kidney Disease, Adult Type I	Polycystic Kidney Type 1 Autosomal Dominant Disease
Kidney Disease, Polycystic, Type 1	Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Type 1 Autosomal Dominant Disease	Polycystic Kidney Diseases

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1198	Piperonyl butoxide	Inhibitor	≥98.0%	Unkown
HY-B1198R	Piperonyl butoxide (Standard)	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13241	Ralimetinib dimesylate		99.91%	Phase 2
HY-13241A	Ralimetinib	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152860	Darizmetinib		99.94%	Unkown
HY-117987	CPS-11		99.39%	Unkown
HY-B1198S	Piperonyl butoxide-d9	Inhibitor	/	Unkown
HY-RS01128	ATF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ATF2	VGNC	VGNC:68500
Macaca mulatta	ATF2	VGNC	VGNC:70169
Bos taurus	ATF2	VGNC	VGNC:26240
Mus musculus	ATF2	MGD	MGI:109349
Rattus norvegicus	ATF2	RGD	RGD:621862
Canis familiaris	ATF2	VGNC	VGNC:38208
Others	ATF2	NCBI

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