Ido1 - indoleamine 2,3-dioxygenase 1 Gene

Mus musculus

Also known as Ido; Indo

Gene ID: 15930 | Gene type: protein coding

About Ido1

Chromosome 8: 25,074,152-25,087,025 reverse strand.GRCm39:CM001001.3

This gene has 2 transcripts (splice variants), 98 orthologues and is associated with 34 phenotypes. Biased expression in genital fat pad adult (RPKM 37.1), mammary gland adult (RPKM 7.7) and 2 other tissues.

Summary

Enables tryptophan 2,3-dioxygenase activity. Acts upstream of or within several processes, including carboxylic acid metabolic process; regulation of apoptotic process; and regulation of cytokine production. Located in smooth muscle contractile fiber and stereocilium bundle. Is expressed in cerebral cortex; corpus striatum; embryo; extraembryonic component; and hippocampus. Used to study pre-eclampsia. Orthologous to human IDO1 (indoleamine 2,3-dioxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ido1 Products(2)

mRNA	Protein	Name
NM_008324.3	NP_032350.1	indoleamine 2,3-dioxygenase 1 isoform 1
NM_001293690.2	NP_001280619.1	indoleamine 2,3-dioxygenase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21804557	MGI
enables tryptophan 2,3-dioxygenase activity	IDA IDA: Inferred from direct assay	11751753	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	18077788	MGI
acts upstream of or within cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	19234212	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	18480171	MGI
acts upstream of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	19234212	MGI
acts upstream of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	19234212	MGI
acts upstream of or within kynurenic acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	19234212	MGI
acts upstream of or within multicellular organismal response to stress	IMP IMP: Inferred from mutant phenotype	19234218	MGI
acts upstream of or within negative regulation of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	18077788	MGI
acts upstream of or within negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	18077788	MGI
acts upstream of or within negative regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	18077788	MGI
acts upstream of or within negative regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	19234212	MGI
acts upstream of or within positive regulation of T cell tolerance induction	IMP IMP: Inferred from mutant phenotype	9712583	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18480171	MGI
acts upstream of or within positive regulation of chronic inflammatory response	IMP IMP: Inferred from mutant phenotype	18436652	MGI
acts upstream of or within positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	19234212	MGI
acts upstream of or within positive regulation of type 2 immune response	IMP IMP: Inferred from mutant phenotype	18436652	MGI
involved in quinolinate biosynthetic process	IDA IDA: Inferred from direct assay	2419335	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	19234212	MGI
acts upstream of or within swimming behavior	IMP IMP: Inferred from mutant phenotype	19234218	MGI
acts upstream of or within tryptophan catabolic process to kynurenine	IDA IDA: Inferred from direct assay	2419335	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17671174	MGI
located in smooth muscle contractile fiber	IDA IDA: Inferred from direct assay	19741271	MGI
located in stereocilium bundle	IDA IDA: Inferred from direct assay	19741271	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ido1 Protein Structure

IDO

0
100
200
300
407 a.a.

Protein Preferred Names

Protein Names

indoleamine 2,3-dioxygenase 1

IDO-1	indole 2,3-dioxygenase
indoleamine-pyrrole 2,3 dioxygenase

Ido1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ido1	P28776	Ptpn11	Mus musculus	P35235	Pull Down	21804557
Intra	Ido1	P28776	Ptpn11	Mus musculus	P35235	Anti Bait CoIP	21804557

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Ido1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72616	IDO-1 Protein, Mouse (His)	P28776 (M1-P407)	≥95%

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0110	Palmatine chloride	Inhibitor	99.81%	Unkown
HY-N0110A	Palmatine	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15689	Epacadostat	Inhibitor	99.66%	Phase 3
HY-101560	Linrodostat	Inhibitor	99.81%	Phase 3
HY-101111	PF-06840003	Inhibitor	99.87%	Phase 1

Pre-clinical Phase

Bioactive Molecules (30)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13983	IDO-IN-7	Inhibitor	99.93%	Unkown
HY-148383	DP00477	Inhibitor	99.03%	Unkown
HY-N0110B	Palmatine hydroxide	Inhibitor	99.64%	Unkown
HY-151108	IDO1/TDO-IN-4	Inhibitor	99.23%	Unkown
HY-111540	LY-3381916	Inhibitor	99.92%	Unkown
HY-151093	IDO2-IN-1	Inhibitor	98.86%	Unkown
HY-131911	PROTAC IDO1 Degrader-1	Inhibitor	98.17%	Unkown
HY-144652	IDO1-IN-19	Inhibitor	98.52%	Unkown
HY-145280	IDO1/2-IN-1	Inhibitor	98.06%	Unkown
HY-18769	BMS-978587	Inhibitor	99.92%	Unkown
HY-139204	BMS-986242	Inhibitor	98.85%	Unkown
HY-112147	IDO1 and HDAC1 Inhibitor	Inhibitor	/	Unkown
HY-120742	MMG-0358	Inhibitor	/	Unkown
HY-147772	ZC0101	Inhibitor	/	Unkown
HY-144274	IDO1-IN-14	Inhibitor	/	Unkown
HY-144468	IDO1-IN-17	Inhibitor	/	Unkown
HY-161348	AT-0174	Inhibitor	/	Unkown
HY-144465	IDO1-IN-15	Inhibitor	/	Unkown
HY-151886	NU223612	Inhibitor	/	Unkown
HY-144778	IDO1/TDO-IN-1	Inhibitor	/	Unkown
HY-144466	IDO1-IN-16	Inhibitor	/	Unkown
HY-158334	NDs-IN-1	Inhibitor	/	Unkown
HY-144273	IDO1-IN-13	Inhibitor	/	Unkown
HY-130607	IDO1-IN-2	Inhibitor	/	Unkown
HY-149227	IDO1-IN-21	Inhibitor	/	Unkown
HY-148572	NAMPT/IDO1-IN-1	Inhibitor	/	Unkown
HY-D0033	Roxyl-9	Inhibitor	99.22%	Unkown
HY-154387	1-Isopropyltryptophan	Inhibitor	/	Unkown
HY-101560A	Linrodostat mesylate	Inhibitor	/	Unkown
HY-78699	2-Hydrazinobenzothiazole	Inhibitor	99.95%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ido1	NCBI	NCBI:3620

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