2. Gene
  3. Igf1 - insulin-like growth factor 1 Gene

Igf1 - insulin-like growth factor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Igf-1; Igf-I; C730016P09Rik

Gene ID: 16000 | Gene type: protein coding

About Igf1

Summary

This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. This gene is predominantly expressed in the liver and the encoded protein undergoes proteolytic processing to generate a disulfide-linked mature polypeptide. Transgenic disruption of this gene in mice results in reduced postnatal survival and severe growth retardation. Mice lacking the encoded protein exhibit generalized organ hypoplasia including underdevelopment of the central nervous system and developmental defects in bone, muscle and reproductive systems. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

Igf1 Products(5)

mRNA Protein Name
NM_001111274.1 NP_001104744.1 insulin-like growth factor I isoform 3 precursor
NM_001111275.2 NP_001104745.1 insulin-like growth factor I isoform 4 preproprotein
NM_001111276.1 NP_001104746.1 insulin-like growth factor I isoform 5 precursor
NM_001314010.1 NP_001300939.1 insulin-like growth factor I isoform 4 preproprotein
NM_010512.5 NP_034642.2 insulin-like growth factor I isoform 1
Protein Preferred Names Protein Names

insulin-like growth factor I

somatomedin

Recombinant Igf1 Proteins

Cat. No. Product Name Accession Purity
HY-P7070 IGF-I/IGF-1 Protein, Mouse P05017-1 (G49-A118) ≥95%
HY-P70698 IGF-I/IGF-1 Protein, Mouse (His) P05017-1 (G49-A118) ≥95%
HY-P74843 IGF-I/IGF-1 Protein, Mouse (P.pastoris) P05017-1 (G49-A118) ≥95%
HY-P70698AF Animal-Free IGF-I/IGF-1 Protein, Mouse (His) P05017-1 (G49-A118) ≥95%
HY-P70698A IGF-I/IGF-1 Protein, Mouse (N-His) P05017-1 (G49-A118) ≥95%

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15656 Ceritinib Inhibitor 99.98% Yes
HY-15656A Ceritinib dihydrochloride Inhibitor 99.57% Yes
HY-B0025 Voglibose Inhibitor ≥98.0% Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99165 Teprotumumab Inhibitor 99.46% Unkown
Clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Phase
HY-10191 Linsitinib Inhibitor 99.84% Phase 3
HY-109155 Paltusotine Agonist 99.52% Phase 3
HY-15494 Picropodophyllin 99.85% Phase 2
HY-10200 BMS-754807 Inhibitor 99.41% Phase 2
HY-153485 Cimdelirsen Inhibitor / Phase 2
HY-153485A Cimdelirsen sodium Inhibitor / Phase 2
HY-15749 XL228 Inhibitor 99.64% Phase 1
HY-B0794B AZ7550 Mesylate Inhibitor 99.24% Phase 1
HY-13326 ASP3026 99.88% Phase 1
HY-B0794A AZ7550 hydrochloride Inhibitor 98.66% Phase 1
HY-135749 BN201 / Phase 1
Inhibitory Antibodies (8)
Cat. No. Product Name Effect
Purity Phase
HY-P99294 Ganitumab Inhibitor 96.00% Phase 3
HY-P99197 Figitumumab Inhibitor 96.89% Phase 3
HY-P99274 Xentuzumab Antagonist 95.00% Phase 2
HY-P99284 Dalotuzumab 97.43% Phase 2
HY-P99218 Robatumumab Inhibitor / Phase 2
HY-P99712 Lonigutamab Inhibitor 95.00% Phase 2
HY-P99867 Dusigitumab / Phase 2
HY-P99672 Istiratumab Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (41)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108477 TMPyP4 tosylate Inhibitor ≥98.0% Unkown
HY-116624 MAZ51 99.96% Unkown
HY-10262 BMS-536924 99.83% Unkown
HY-50866 NVP-AEW541 99.92% Unkown
HY-15609 AZD-3463 99.58% Unkown
HY-10252 NVP-ADW742 99.54% Unkown
HY-N0908 Ginsenoside Rg5 99.87% Unkown
HY-10524 GSK1904529A 99.66% Unkown
HY-10253 AG1024 99.82% Unkown
HY-13203 NVP-TAE 226 99.77% Unkown
HY-W074890 Palmitoylglycine Modulator 99.74% Unkown
HY-18785 Indirubin Derivative E804 Inhibitor 98.54% Unkown
HY-100349 SU4312 Inhibitor 99.76% Unkown
HY-135680 I-OMe-Tyrphostin AG 538 Inhibitor 98.03% Unkown
HY-P2090A Angiopeptin TFA 99.71% Unkown
HY-145110 IGF-1R inhibitor-2 Inhibitor 98.36% Unkown
HY-RS06614 IGF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-135436 AG 538 Inhibitor 99.80% Unkown
HY-B0794 AZ7550 Inhibitor / Unkown
HY-139783 3-Campholenyl-2-butanol Inhibitor ≥98.0% Unkown
HY-125102 AZ12253801 Inhibitor / Unkown
HY-50866B NVP-AEW541 dihydrochloride / Unkown
HY-108230 ALK-IN-12 Inhibitor / Unkown
HY-15494S1 Picropodophyllin-d6 / Unkown
HY-156914 IGF-1R/SRC-IN-1 Inhibitor 99.86% Unkown
HY-162506 IGF-1R inhibitor-3 Inhibitor / Unkown
HY-167854 KW-2450 free base / Unkown
HY-402309 IGF-1R modulator 1 Modulator / Unkown
HY-B0794S AZ7550-d5 Inhibitor / Unkown
HY-P2090 Angiopeptin / Unkown
HY-RS06615 IGF1R Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06616 Igf1r Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06617 Igf1r Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-100349A cis-SU4312 Inhibitor / Unkown
HY-109155A Paltusotine hydrochloride Agonist / Unkown
HY-117885 PF-5177624 Inhibitor / Unkown
HY-119112A LY 379196 Inhibitor / Unkown
HY-138257A (R)-Indeloxazine benzenesulfonate Inhibitor / Unkown
HY-14357 BMS 695735 Inhibitor / Unkown
HY-21291 SU-4313 Modulator / Unkown
HY-N6611 Chimaphilin Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990084 Veligrotug Inhibitor 99.25% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Igf1 NCBI NCBI:3479
Macaca fascicularis Igf1 NCBI NCBI:102128018
Rattus norvegicus Igf1 NCBI NCBI:24482